Pathak2013 - MAPK activation in response to various biotic stresses

MAPK activation mechanism in response to various biotic (fungal and bacterial pathogens) stress conditions in plants

This model is described in the article:

Modeling of the MAPK machinery activation in response to various abiotic and biotic stresses in plants by a system biology approach.
Pathak RK, Taj G, Pandey D, Arora S, Kumar A.
Bioinformation 2013; 9(9): 443-449

Abstract:

Mitogen-Activated Protein Kinases (MAPKs) cascade plays an important role in regulating plant growth and development, generating cellular responses to the extracellular stimuli. MAPKs cascade mainly consist of three sub-families i.e. mitogen-activated protein kinase kinase kinase (MAPKKK), mitogen-activated protein kinase kinase (MAPKK) and mitogen activated protein kinase (MAPK), several cascades of which are activated by various abiotic and biotic stresses. In this work we have modeled the holistic molecular mechanisms essential to MAPKs activation in response to several abiotic and biotic stresses through a system biology approach and performed its simulation studies. As extent of abiotic and biotic stresses goes on increasing, the process of cell division, cell growth and cell differentiation slow down in time dependent manner. The models developed depict the combinatorial and multicomponent signaling triggered in response to several abiotic and biotic factors. These models can be used to predict behavior of cells in event of various stresses depending on their time and exposure through activation of complex signaling cascades.

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4.0 SQUARE OVAL inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive active active active active active inactive active active active active active active active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active inactive active active active active active inactive Chelliah Vijayalakshmi viji@ebi.ac.uk EMBL-EBI Pathak Rajesh Kumar rkpathakbt@gmail.com Department of Molecular Biology & Genetic Engineering, College of Basic Sciences & Humanities, G. B. Pant University of Agriculture & Technology, Pantnagar-263145, India 2013-11-15T12:03:14Z 2015-02-25T12:11:47Z Cytosol Nucleus inside SIMPLE_MOLECULE Fungal pathogen inside SIMPLE_MOLECULE Bacterial pathogen transmembrane PROTEIN pr1 transmembrane PROTEIN pr2 transmembrane PROTEIN pr3 transmembrane PROTEIN pr4 inside PROTEIN pr5 inside PROTEIN pr5 inside PROTEIN pr6 inside PROTEIN pr7 inside PROTEIN pr8 inside PROTEIN pr9 inside PROTEIN pr10 inside PROTEIN pr11 inside PROTEIN pr11 inside PROTEIN pr12 inside PROTEIN pr13 inside PROTEIN pr14 inside PROTEIN pr15 inside PROTEIN pr16 inside PROTEIN pr16 inside PROTEIN pr17 inside PROTEIN pr18 inside PROTEIN pr19 inside PROTEIN pr20 inside PROTEIN pr23 inside PROTEIN pr23 inside PROTEIN pr24 inside PROTEIN pr24 inside PROTEIN pr25 inside PROTEIN pr25 inside PROTEIN pr26 inside PROTEIN pr26 inside PROTEIN pr27 inside PROTEIN pr27 inside PROTEIN pr28 inside PROTEIN pr28 inside PROTEIN pr29 inside PROTEIN pr29 inside PROTEIN pr30 inside PROTEIN pr30 inside PROTEIN pr31 inside PROTEIN pr31 inside PROTEIN pr32 inside PROTEIN pr32 inside PROTEIN pr33 inside PROTEIN pr34 inside PROTEIN pr35 inside PROTEIN pr36 inside PHENOTYPE Response inside PROTEIN pr21 inside PROTEIN pr22 STATE_TRANSITION sa1 sa3 re1 kass_re1 s1 kdiss_re1 s3 STATE_TRANSITION sa1 sa4 re2 kass_re2 s1 kdiss_re2 s4 STATE_TRANSITION sa1 sa5 re3 kass_re3 s1 kdiss_re3 s5 STATE_TRANSITION sa2 sa4 re4 kass_re4 s2 kdiss_re4 s4 STATE_TRANSITION sa2 sa5 re5 kass_re5 s2 kdiss_re5 s5 STATE_TRANSITION sa2 sa6 re6 kass_re6 s2 kdiss_re6 s6 STATE_TRANSITION sa7 sa8 re7 kass_re7 s7 kdiss_re7 s8 STATE_TRANSITION sa3 sa7 re8 kass_re8 s3 kdiss_re8 s7 STATE_TRANSITION sa4 sa7 re9 kass_re9 s4 kdiss_re9 s7 STATE_TRANSITION sa5 sa7 re10 kass_re10 s5 kdiss_re10 s7 STATE_TRANSITION sa6 sa7 re11 kass_re11 s6 kdiss_re11 s7 STATE_TRANSITION sa8 sa9 re12 kass_re12 s8 kdiss_re12 s9 STATE_TRANSITION sa8 sa10 re13 kass_re13 s8 kdiss_re13 s10 STATE_TRANSITION sa8 sa11 re14 kass_re14 s8 kdiss_re14 s11 STATE_TRANSITION sa8 sa12 re15 kass_re15 s8 kdiss_re15 s12 STATE_TRANSITION sa6 sa9 re16 kass_re16 s6 kdiss_re16 s9 STATE_TRANSITION sa8 sa13 re17 kass_re17 s8 kdiss_re17 s13 STATE_TRANSITION sa5 sa13 re18 kass_re18 s5 kdiss_re18 s13 STATE_TRANSITION sa5 sa11 re19 kass_re19 s5 kdiss_re19 s11 STATE_TRANSITION sa14 sa15 re20 kass_re20 s14 kdiss_re20 s15 STATE_TRANSITION sa8 sa14 re21 kass_re21 s8 kdiss_re21 s14 STATE_TRANSITION sa15 sa16 re22 kass_re22 s15 kdiss_re22 s16 STATE_TRANSITION sa15 sa17 re23 kass_re23 s15 kdiss_re23 s17 STATE_TRANSITION sa15 sa18 re24 kass_re24 s15 kdiss_re24 s18 STATE_TRANSITION sa15 sa19 re25 kass_re25 s15 kdiss_re25 s19 STATE_TRANSITION sa9 sa16 re26 kass_re26 s9 kdiss_re26 s16 STATE_TRANSITION sa9 sa17 re27 kass_re27 s9 kdiss_re27 s17 STATE_TRANSITION sa9 sa18 re28 kass_re28 s9 kdiss_re28 s18 STATE_TRANSITION sa11 sa19 re29 kass_re29 s11 kdiss_re29 s19 STATE_TRANSITION sa20 sa21 re30 kass_re30 s20 kdiss_re30 s21 STATE_TRANSITION sa15 sa20 re31 kass_re31 s15 kdiss_re31 s20 STATE_TRANSITION sa21 sa22 re32 kass_re32 s21 kdiss_re32 s22 STATE_TRANSITION sa21 sa23 re33 kass_re33 s21 kdiss_re33 s23 STATE_TRANSITION sa21 sa24 re34 kass_re34 s21 kdiss_re34 s24 STATE_TRANSITION sa21 sa25 re35 kass_re35 s21 kdiss_re35 s25 STATE_TRANSITION sa21 sa26 re36 kass_re36 s21 kdiss_re36 s26 STATE_TRANSITION sa21 sa27 re37 kass_re37 s21 kdiss_re37 s27 STATE_TRANSITION sa16 sa22 re38 kass_re38 s16 kdiss_re38 s22 STATE_TRANSITION sa17 sa22 re39 kass_re39 s17 kdiss_re39 s22 STATE_TRANSITION sa17 sa23 re40 kass_re40 s17 kdiss_re40 s23 STATE_TRANSITION sa18 sa23 re41 kass_re41 s18 kdiss_re41 s23 STATE_TRANSITION sa17 sa25 re42 kass_re42 s17 kdiss_re42 s25 STATE_TRANSITION sa16 sa24 re43 kass_re43 s16 kdiss_re43 s24 STATE_TRANSITION sa18 sa25 re44 kass_re44 s18 kdiss_re44 s25 STATE_TRANSITION sa28 sa29 re45 kass_re45 s28 kdiss_re45 s29 STATE_TRANSITION sa30 sa31 re46 kass_re46 s30 kdiss_re46 s31 STATE_TRANSITION sa32 sa33 re47 kass_re47 s32 kdiss_re47 s33 STATE_TRANSITION sa34 sa35 re48 kass_re48 s34 kdiss_re48 s35 STATE_TRANSITION sa36 sa37 re49 kass_re49 s36 kdiss_re49 s37 STATE_TRANSITION sa38 sa39 re50 kass_re50 s38 kdiss_re50 s39 STATE_TRANSITION sa40 sa41 re51 kass_re51 s40 kdiss_re51 s41 STATE_TRANSITION sa42 sa43 re52 kass_re52 s42 kdiss_re52 s43 STATE_TRANSITION sa44 sa45 re53 kass_re53 s44 kdiss_re53 s45 STATE_TRANSITION sa46 sa47 re54 kass_re54 s46 kdiss_re54 s47 STATE_TRANSITION sa22 sa28 re55 kass_re55 s22 kdiss_re55 s28 STATE_TRANSITION sa24 sa28 re56 kass_re56 s24 kdiss_re56 s28 STATE_TRANSITION sa23 sa32 re57 kass_re57 s23 kdiss_re57 s32 STATE_TRANSITION sa24 sa32 re58 kass_re58 s24 kdiss_re58 s32 STATE_TRANSITION sa24 sa38 re59 kass_re59 s24 kdiss_re59 s38 STATE_TRANSITION sa23 sa42 re60 kass_re60 s23 kdiss_re60 s42 STATE_TRANSITION sa25 sa42 re61 kass_re61 s25 kdiss_re61 s42 STATE_TRANSITION sa25 sa46 re62 kass_re62 s25 kdiss_re62 s46 STATE_TRANSITION sa25 sa32 re63 kass_re63 s25 kdiss_re63 s32 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