<?xml version="1.0" encoding="UTF-8"?>
<!-- Created by libAntimony version v2.0 on 2013-11-01 09:10 with libSBML version 5.8.0. -->
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" level="3" version="1">
  <model id="Schittler2010_Osteochondroswitch" name="Schittler2010_Osteochondroswitch">
    <listOfCompartments>
      <compartment sboTerm="SBO:0000410" id="default_compartment" spatialDimensions="3" size="1" constant="true"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="P" compartment="default_compartment" initialConcentration="12.03" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
      <species id="O" compartment="default_compartment" initialConcentration="0.14" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
      <species id="C" compartment="default_compartment" initialConcentration="0.14" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="aP" value="0.2" constant="true"/>
      <parameter id="n" value="2" constant="true"/>
      <parameter id="bP" value="0.5" constant="true"/>
      <parameter id="mP" value="10" constant="true"/>
      <parameter id="zD" value="0" constant="false"/>
      <parameter id="cPP" value="0.1" constant="true"/>
      <parameter id="kP" value="0.1" constant="true"/>
      <parameter id="aO" value="0.1" constant="true"/>
      <parameter id="bO" value="1" constant="true"/>
      <parameter id="zO" value="0" constant="false"/>
      <parameter id="mO" value="1" constant="true"/>
      <parameter id="cOC" value="0.1" constant="true"/>
      <parameter id="cOP" value="0.5" constant="true"/>
      <parameter id="cOO" value="0.1" constant="true"/>
      <parameter id="kO" value="0.1" constant="true"/>
      <parameter id="aC" value="0.1" constant="true"/>
      <parameter id="bC" value="1" constant="true"/>
      <parameter id="zC" value="0" constant="true"/>
      <parameter id="mC" value="1" constant="true"/>
      <parameter id="cCO" value="0.1" constant="true"/>
      <parameter id="cCP" value="0.5" constant="true"/>
      <parameter id="cCC" value="0.1" constant="true"/>
      <parameter id="kC" value="0.1" constant="true"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="a1" reversible="true" fast="false">
        <listOfProducts>
          <speciesReference species="P" stoichiometry="1" constant="true"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <ci> aP </ci>
                  <apply>
                    <power/>
                    <ci> P </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <ci> bP </ci>
              </apply>
              <apply>
                <plus/>
                <ci> mP </ci>
                <ci> zD </ci>
                <apply>
                  <times/>
                  <ci> cPP </ci>
                  <apply>
                    <power/>
                    <ci> P </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="a2" reversible="true" fast="false">
        <listOfReactants>
          <speciesReference species="P" stoichiometry="1" constant="true"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kP </ci>
              <ci> P </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="a3" reversible="true" fast="false">
        <listOfProducts>
          <speciesReference species="O" stoichiometry="1" constant="true"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="P"/>
          <modifierSpeciesReference species="C"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <ci> aO </ci>
                  <apply>
                    <power/>
                    <ci> O </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <ci> bO </ci>
                <ci> zO </ci>
              </apply>
              <apply>
                <plus/>
                <ci> mO </ci>
                <apply>
                  <times/>
                  <ci> cOC </ci>
                  <apply>
                    <power/>
                    <ci> C </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <ci> cOP </ci>
                  <apply>
                    <power/>
                    <ci> P </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <ci> cOO </ci>
                  <apply>
                    <power/>
                    <ci> O </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="a4" reversible="true" fast="false">
        <listOfReactants>
          <speciesReference species="O" stoichiometry="1" constant="true"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kO </ci>
              <ci> O </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="a5" reversible="true" fast="false">
        <listOfProducts>
          <speciesReference species="C" stoichiometry="1" constant="true"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="P"/>
          <modifierSpeciesReference species="O"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <ci> aC </ci>
                  <apply>
                    <power/>
                    <ci> C </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <ci> bC </ci>
                <ci> zC </ci>
              </apply>
              <apply>
                <plus/>
                <ci> mC </ci>
                <apply>
                  <times/>
                  <ci> cCO </ci>
                  <apply>
                    <power/>
                    <ci> O </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <ci> cCP </ci>
                  <apply>
                    <power/>
                    <ci> P </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <ci> cCC </ci>
                  <apply>
                    <power/>
                    <ci> C </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="a6" reversible="true" fast="false">
        <listOfReactants>
          <speciesReference species="C" stoichiometry="1" constant="true"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kC </ci>
              <ci> C </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
    <listOfEvents>
      <event id="_E0" useValuesFromTriggerTime="true">
        <trigger initialValue="true" persistent="true">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <gt/>
              <ci> P </ci>
              <cn> 12.03 </cn>
            </apply>
          </math>
        </trigger>
        <delay>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <cn type="integer"> 500 </cn>
          </math>
        </delay>
        <listOfEventAssignments>
          <eventAssignment variable="zD">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <cn> 0.8 </cn>
            </math>
          </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="_E2" useValuesFromTriggerTime="true">
        <trigger initialValue="true" persistent="true">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <gt/>
              <ci> P </ci>
              <cn> 12.03 </cn>
            </apply>
          </math>
        </trigger>
        <delay>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <cn type="integer"> 100 </cn>
          </math>
        </delay>
        <listOfEventAssignments>
          <eventAssignment variable="zO">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <cn type="integer"> 1 </cn>
            </math>
          </eventAssignment>
        </listOfEventAssignments>
      </event>
      <event id="_E1" useValuesFromTriggerTime="true">
        <trigger initialValue="true" persistent="true">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <gt/>
              <ci> P </ci>
              <cn> 12.03 </cn>
            </apply>
          </math>
        </trigger>
        <delay>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <cn type="integer"> 800 </cn>
          </math>
        </delay>
        <listOfEventAssignments>
          <eventAssignment variable="zO">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <cn type="integer"> 0 </cn>
            </math>
          </eventAssignment>
          <eventAssignment variable="zD">
            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <cn type="integer"> 0 </cn>
            </math>
          </eventAssignment>
        </listOfEventAssignments>
      </event>
    </listOfEvents>
  </model>
</sbml>
