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                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:45:46Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:hasPart rdf:resource="urn:miriam:uniprot:P24864"/>
                <CopasiMT:hasPart rdf:resource="urn:miriam:uniprot:P24941"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="compartment" constant="false" id="RB" initialConcentration="0.55" metaid="COPASI7" name="RB">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI7">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P06400"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI7">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:45:49Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:uniprot:P06400"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="compartment" constant="false" id="miR449" initialConcentration="0" metaid="COPASI8" name="miR449">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI8">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/mirbase.mature/MIMAT0001541"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI8">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:45:48Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:mirbase.mature:MIMAT0001541"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="true" compartment="compartment" constant="true" id="S" initialConcentration="3" metaid="COPASI9" name="S">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI9">
	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/ncit/C20424"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	</rdf:Description>
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI9">
                <bqbiol:hasProperty rdf:resource="urn:miriam:ncit:C20424"/>
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:45:50Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="compartment" constant="false" id="PRB" initialConcentration="0" metaid="COPASI10" name="PRB">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI10">
              <bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P06400"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	
	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/ncit/C1897"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	</rdf:Description>
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI10">
                <bqbiol:hasProperty rdf:resource="urn:miriam:ncit:C1897"/>
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:45:48Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:uniprot:P06400"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter constant="true" id="ksE1" name="ksE1" value="0.4"/>
      <parameter constant="true" id="JM" name="JM" value="0.15"/>
      <parameter constant="true" id="JE" name="JE" value="0.15"/>
      <parameter constant="true" id="ksE2" name="ksE2" value="0.003"/>
      <parameter constant="true" id="kP1" name="kP1" value="18"/>
      <parameter constant="true" id="JCD" name="JCD" value="0.92"/>
      <parameter constant="true" id="kP2" name="kP2" value="18"/>
      <parameter constant="true" id="JCE" name="JCE" value="0.92"/>
      <parameter constant="true" id="kdE" name="kdE" value="0.25"/>
      <parameter constant="true" id="kRE" name="kRE" value="180"/>
      <parameter constant="true" id="ksmiR" name="ksmiR" value="1.4"/>
      <parameter constant="true" id="kdmiR" name="kdmiR" value="0.02"/>
      <parameter constant="true" id="ksM" name="ksM" value="1"/>
      <parameter constant="true" id="JS" name="JS" value="0.5"/>
      <parameter constant="true" id="kdM1" name="kdM1" value="0.7"/>
      <parameter constant="true" id="kdM2" name="kdM2" value="0.6"/>
      <parameter constant="true" id="ksCD1" name="ksCD1" value="0.45"/>
      <parameter constant="true" id="ksCD2" name="ksCD2" value="0.03"/>
      <parameter constant="true" id="kdCD1" name="kdCD1" value="1.5"/>
      <parameter constant="true" id="kdCD2" name="kdCD2" value="1"/>
      <parameter constant="true" id="ksCE" name="ksCE" value="0.35"/>
      <parameter constant="true" id="kdCE1" name="kdCE1" value="1.5"/>
      <parameter constant="true" id="kdCE2" name="kdCE2" value="0.7"/>
      <parameter constant="true" id="ksR" name="ksR" value="0.18"/>
      <parameter constant="true" id="kP" name="kP" value="3.6"/>
      <parameter constant="true" id="JP" name="JP" value="0.01"/>
      <parameter constant="true" id="kdR" name="kdR" value="0.06"/>
      <parameter constant="true" id="kdP" name="kdP" value="0.06"/>
      <parameter constant="true" id="kdRE" name="kdRE" value="0.03"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="reaction" metaid="COPASI11" name="reaction" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI11">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:17:27Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfProducts>
          <speciesReference species="E2F" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Myc"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> self_promoting_michaelis_menten </ci>
                <ci> ksE1 </ci>
                <ci> Myc </ci>
                <ci> JM </ci>
                <ci> E2F </ci>
                <ci> JE </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_1" metaid="COPASI12" name="reaction_1" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI12">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:17:46Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfProducts>
          <speciesReference species="E2F" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Myc"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function </ci>
                <ci> ksE2 </ci>
                <ci> Myc </ci>
                <ci> JM </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_2" metaid="COPASI13" name="reaction_2" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI13">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:19:53Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="RE" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="E2F" stoichiometry="1"/>
          <speciesReference species="PRB" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="CycD"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function_1 </ci>
                <ci> kP1 </ci>
                <ci> CycD </ci>
                <ci> RE </ci>
                <ci> JCD </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_3" metaid="COPASI14" name="reaction_3" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI14">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:24:13Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="RE" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="E2F" stoichiometry="1"/>
          <speciesReference species="PRB" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="CycE"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function_1 </ci>
                <ci> kP2 </ci>
                <ci> CycE </ci>
                <ci> RE </ci>
                <ci> JCE </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_4" metaid="COPASI15" name="reaction_4" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI15">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:24:34Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="E2F" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> kdE </ci>
              <ci> E2F </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_5" metaid="COPASI16" name="reaction_5" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI16">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:24:43Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="E2F" stoichiometry="1"/>
          <speciesReference species="RB" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RE" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> kRE </ci>
              <ci> E2F </ci>
              <ci> RB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_6" metaid="COPASI17" name="reaction_6" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI17">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:24:52Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfProducts>
          <speciesReference species="miR449" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="E2F"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function </ci>
                <ci> ksmiR </ci>
                <ci> E2F </ci>
                <ci> JE </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_7" metaid="COPASI18" name="reaction_7" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI18">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:25:48Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="miR449" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> kdmiR </ci>
              <ci> miR449 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_8" metaid="COPASI19" name="reaction_8" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI19">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:25:59Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="miR449" stoichiometry="1"/>
          <speciesReference species="Myc" stoichiometry="1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference species="miR449"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function_1 </ci>
                <ci> kdM2 </ci>
                <ci> miR449 </ci>
                <ci> Myc </ci>
                <ci> JM </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_9" metaid="COPASI20" name="reaction_9" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI20">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:28:12Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="miR449" stoichiometry="1"/>
          <speciesReference species="CycD" stoichiometry="1"/>
        </listOfReactants>
        <listOfModifiers>
          <modifierSpeciesReference species="miR449"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> function_1 </ci>
                <ci> kdCD2 </ci>
                <ci> miR449 </ci>
                <ci> CycD </ci>
                <ci> JCD </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="reaction_10" metaid="COPASI21" name="reaction_10" reversible="false">
        <annotation>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI21">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2018-09-27T16:28:42Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="miR449" stoichiometry="1"/>
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