RIGHT 0 conversion Disassociation RC AB 4 RC A
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

C61559
type: unificationXref
ID: C61559
DB: NCIt

RIGHT 1 conversion Disassociation RC AB 4 R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

GO:0006412
type: unificationXref
ID: GO:0006412
DB: Gene Ontology

conversion Binding C R A
type: complexAssembly
XREF: C40536
LEFT: LEFT 0 conversion Binding C R A C free
LEFT: LEFT 1 conversion Binding C R A R A
SPONTANEOUS: L_R
RIGHT: RIGHT 0 conversion Binding C R A RC A

LEFT 0 conversion Distribution C Central C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

http://identifiers.org/pubmed/30480383
type: publicationXref
ID: 30480383
DB: PubMed

Central
type: openControlledVocabulary
XREF: BTO:0000131
XREF: UBERON:0000479
TERM: Central

C40536
type: unificationXref
ID: C40536
DB: NCIt

conversion Binding C R B
type: complexAssembly
XREF: C40536
LEFT: LEFT 0 conversion Binding C R B C free
LEFT: LEFT 1 conversion Binding C R B R B
SPONTANEOUS: L_R
RIGHT: RIGHT 0 conversion Binding C R B RC B

GO:0007588
type: unificationXref
ID: GO:0007588
DB: Gene Ontology

LEFT 0 conversion Internalisation RC A RC A
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Degradation R B R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion Internalisation RC AB
type: complexAssembly
XREF: GO:0031623
LEFT: LEFT 0 conversion Internalisation RC AB RC AB
SPONTANEOUS: R_L

http://identifiers.org/taxonomy/9606
type: unificationXref
ID: 9606
DB: Taxonomy

LEFT 0 conversion Internalisation RC AB RC AB
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC AB
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Binding RC B R A RC B
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Association AD C C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Internalisation RC B RC B
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

BIOMD0000000788
type: unificationXref
ID: BIOMD0000000788
DB: BioModels Database

MAMO_0000046
type: unificationXref
ID: MAMO_0000046
DB: Mathematical Modelling Ontology

RIGHT 0 conversion Disassociation RC AB 3 RC B
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

BTO:0000553
type: unificationXref
ID: BTO:0000553

LEFT 0 conversion Distribution AP Peripheral AP
type: physicalEntityParticipant
PHYSICAL-ENTITY: AP
CELLULAR-LOCATION: Peripheral
STOICHIOMETRIC-COEFFICIENT: 1.0

Peripheral
type: openControlledVocabulary
XREF: UBERON:0000479
TERM: Peripheral

RIGHT 0 conversion Distribution C Peripheral C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Elimination C C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Binding C R A C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 1 conversion Binding RC B R A R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 1 conversion Disassociation RC B R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 0 conversion Association AD AD
type: physicalEntityParticipant
PHYSICAL-ENTITY: AD
CELLULAR-LOCATION: Peripheral
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Binding C R A RC A
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

MODEL1907240003
type: unificationXref
ID: MODEL1907240003
DB: BioModels Database

GO:0008015
type: unificationXref
ID: GO:0008015
DB: Gene Ontology

LEFT 1 conversion Binding C R B R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

BTO:0000131
type: unificationXref
ID: BTO:0000131
DB: Brenda Tissue Ontology

RIGHT 1 conversion Disassociation RC A R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Disassociation RC A C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Disassociation RC B C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Binding RC B R A RC AB
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC AB
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Binding RC A R B RC AB
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC AB
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Synthesis R A R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

Schropp2019 Target Mediated Drug Disposition Model for Bispecific Antibodies
type: pathway
XREF: MODEL1907240003
XREF: http://identifiers.org/pubmed/30480383
XREF: BIOMD0000000788
XREF: C1454
XREF: MAMO_0000046
PATHWAY-COMPONENTS: conversion Distribution C Central
PATHWAY-COMPONENTS: conversion Internalisation RC B
PATHWAY-COMPONENTS: conversion Internalisation RC A
PATHWAY-COMPONENTS: conversion Synthesis R A
PATHWAY-COMPONENTS: conversion Degradation R B
PATHWAY-COMPONENTS: conversion Synthesis R B
PATHWAY-COMPONENTS: conversion Binding C R A
PATHWAY-COMPONENTS: conversion Distribution AP Central
PATHWAY-COMPONENTS: conversion Binding RC B R A
PATHWAY-COMPONENTS: conversion Binding C R B
PATHWAY-COMPONENTS: conversion Elimination C
PATHWAY-COMPONENTS: conversion Association AD
PATHWAY-COMPONENTS: conversion Disassociation RC AB 4
PATHWAY-COMPONENTS: conversion Disassociation RC AB 3
PATHWAY-COMPONENTS: conversion Distribution C Peripheral
PATHWAY-COMPONENTS: conversion Degradation R A
PATHWAY-COMPONENTS: conversion Association AD C
PATHWAY-COMPONENTS: conversion Disassociation RC A
PATHWAY-COMPONENTS: conversion Distribution AP Peripheral
PATHWAY-COMPONENTS: conversion Disassociation RC B
PATHWAY-COMPONENTS: conversion Binding RC A R B
PATHWAY-COMPONENTS: conversion Internalisation RC AB
COMMENT: This BioPAX Level2 file was automatically generated on Apr 22, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
COMMENT: The original model, 'Schropp2019___Target_Mediated_Drug_Disposition_Model_for_Bispecific_Antibodies', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
ORGANISM: biosource 1
DATA-SOURCE: datasource 2
DATA-SOURCE: datasource 1

RIGHT 0 conversion Binding C R B RC B
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 0 conversion Distribution AP Central AP
type: physicalEntityParticipant
PHYSICAL-ENTITY: AP
CELLULAR-LOCATION: Peripheral
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 1 conversion Binding C R A R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

datasource 2
type: dataSource
XREF: BIOMD0000000788
NAME: BioModels Database

C1454
type: unificationXref
ID: C1454
DB: NCIt

C28227
type: unificationXref
ID: C28227

RIGHT 0 conversion Synthesis R B R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

conversion Internalisation RC A
type: complexAssembly
XREF: GO:0031623
LEFT: LEFT 0 conversion Internalisation RC A RC A
SPONTANEOUS: R_L

datasource 1
type: dataSource
XREF: MODEL1907240003
NAME: BioModels Database

conversion Internalisation RC B
type: complexAssembly
XREF: GO:0031623
LEFT: LEFT 0 conversion Internalisation RC B RC B
SPONTANEOUS: R_L

LEFT 0 conversion Binding RC A R B RC A
type: physicalEntityParticipant
PHYSICAL-ENTITY: RC A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

RIGHT 1 conversion Disassociation RC AB 3 R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

LEFT 1 conversion Binding RC A R B R B
type: physicalEntityParticipant
PHYSICAL-ENTITY: R B
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

C38299
type: unificationXref
ID: C38299

LEFT 0 conversion Binding C R B C free
type: physicalEntityParticipant
PHYSICAL-ENTITY: C free
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

C18106
type: unificationXref
ID: C18106

LEFT 0 conversion Degradation R A R A
type: physicalEntityParticipant
PHYSICAL-ENTITY: R A
CELLULAR-LOCATION: Central
STOICHIOMETRIC-COEFFICIENT: 1.0

UBERON:0000479
type: unificationXref
ID: UBERON:0000479
DB: UBERON

conversion Disassociation RC AB 3
type: complexAssembly
SPONTANEOUS: L_R
RIGHT: RIGHT 1 conversion Disassociation RC AB 3 R B
RIGHT: RIGHT 0 conversion Disassociation RC AB 3 RC B

GO:0031623
type: unificationXref
ID: GO:0031623
DB: Gene Ontology

conversion Disassociation RC AB 4
type: complexAssembly
SPONTANEOUS: L_R
RIGHT: RIGHT 0 conversion Disassociation RC AB 4 RC A
RIGHT: RIGHT 1 conversion Disassociation RC AB 4 R A