This model presents a general target-mediated drug disposition (TMDD) model for bispecific antibodies (BsAbs), which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, turnover of the targets, and internalization of the complexes. In addition, a quasi-equilibrium (QE) approximation with decreased number of binding parameters is also present.
 Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-07-05T15:50:54Z 2019-07-05T15:50:54Z 2019-07-05T15:50:54Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI 2019-07-05T15:50:54Z v v RC_AB k_off_3 k_off_3 RC_AB AP V k_21 k_21 AP V C_free V k_12 k_12 C_free V RC_A k_int_A k_off_1 k_off_1 k_int_A RC_A RC_AB k_off_4 k_off_4 RC_AB RC_B k_off_2 k_off_2 RC_B RC_B k_int_B k_off_2 k_off_2 k_int_B RC_B RC_AB k_int_AB k_off_3 k_off_4 k_off_3 k_off_4 k_int_AB RC_AB AD V k_a k_a AD V 2019-07-09T15:08:56Z RC_A k_off_1 k_off_1 RC_A 
The central compartment consists of the plasma and tissues where the distribution of the drug is practically instantaneous.
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The peripheral compartment consists of tissues where the distribution of the drug is slower.
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