THis is a simple ordinary differential equation model describing chemoimmunotherapy of chronic lymphocytic leukemia, including descriptions of the combinatorial effects of chemotherapy and adoptive cellular immunotherapy.

Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-11-28T12:21:32Z 2019-11-28T12:21:32Z 2019-11-28T12:21:32Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI 2019-11-28T12:32:17Z

v v

2019-11-28T12:31:44Z

c_1 N I c_1 N I

2019-11-28T12:35:27Z

c_2 N I c_2 N I

2019-11-28T12:34:37Z

rho N I gamma rho N I gamma N

2019-11-28T12:36:08Z

delta I Q b delta I Q b Q

2019-11-28T12:25:06Z

r N k r N 1 N k

2019-11-28T12:32:18Z

mu N Q a mu N Q a Q

2019-11-28T13:26:02Z 2019-11-28T13:26:11Z 2019-11-28T13:18:25Z 2019-11-28T13:27:00Z 2019-11-28T12:51:57Z 2019-11-28T12:37:37Z 2019-11-28T12:40:52Z 2019-11-28T12:42:41Z 2019-11-28T12:37:38Z 2019-11-28T12:37:46Z 2019-11-28T12:46:20Z 2019-11-28T12:46:38Z 2019-11-28T12:46:59Z

18

Infusion_Dose Infusion_Duration

Infusion_Rate time Infusion_Duration Infusion_Rate time 21 time 21 Infusion_Duration Infusion_Rate time 42 time 42 Infusion_Duration Infusion_Rate time 63 time 63 Infusion_Duration Infusion_Rate time 84 time 84 Infusion_Duration Infusion_Rate time 105 time 105 Infusion_Duration Infusion_Rate time 126 time 126 Infusion_Duration 0

2019-11-28T12:23:57Z

compartment Function_for_Cancer_Growth r N k

2019-11-28T12:25:34Z

compartment Function_for_Cancer_Death_Immune c_1 N I

2019-11-28T12:32:03Z

compartment Function_for_Cancer_Death_Chemotherapy mu N Q a

2019-11-28T12:33:46Z

compartment Constant_flux__irreversible s_0

2019-11-28T12:34:01Z

compartment d I

2019-11-28T12:34:25Z

compartment Function_for_Immune_Growth_Cancer_Stimulation rho N I gamma

2019-11-28T12:35:19Z

compartment Function_for_Immune_Death_Cancer c_2 N I

2019-11-28T12:35:57Z

compartment Function_for_Immune_Death_Chemotherapy delta I Q b

2019-11-28T12:36:35Z

compartment lambda Q

2019-11-28T12:37:29Z

compartment Constant_flux__irreversible Immunotherapy_Input

2019-11-28T12:38:00Z

compartment Constant_flux__irreversible Chemotherapy_Input