PCNP_0
type: PhysicalEntity
member physical entity: PCNP
cellular location: Mammalian Cell

IN_0
type: PhysicalEntity
member physical entity: IN
cellular location: Mammalian Cell

PCP_0
type: PhysicalEntity
member physical entity: PCP
cellular location: Mammalian Cell

LEFT 0 conversion Dephosphorylation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCNP_0
stoichiometric coefficient: 1.0

PCCP_0
type: PhysicalEntity
member physical entity: PCCP
cellular location: Mammalian Cell

MB_0
type: PhysicalEntity
member physical entity: MB
cellular location: Mammalian Cell

LEFT 0 conversion Degradation of Per mRNA MP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MP_0
stoichiometric coefficient: 1.0

CTot
type: PhysicalEntity
xref: C25697

PCN_0
type: PhysicalEntity
member physical entity: PCN
cellular location: Mammalian Cell

CC
type: Protein
xref: Q16526

PCC_0
type: PhysicalEntity
member physical entity: PCC
cellular location: Mammalian Cell

PC_0
type: PhysicalEntity
member physical entity: PC
cellular location: Mammalian Cell

BC_0
type: PhysicalEntity
member physical entity: BC
cellular location: Mammalian Cell

MC_0
type: PhysicalEntity
member physical entity: MC
cellular location: Mammalian Cell

LEFT 0 conversion Non specific degradation of Per mRNA MP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MP_0
stoichiometric coefficient: 1.0

Non-specific degradation of PER-CRY protein complex in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER CRY protein complex in cytosol PCC 0 STOICHIOMETRY
xref: C61559
left: PCC_0

MB
type: Rna
xref: ENST00000403290

RIGHT 0 conversion Phosphorylation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCNP_0
stoichiometric coefficient: 1.0

PCP_0
type: PhysicalEntity
member physical entity: PCP
cellular location: Mammalian Cell

Dephosphorylation of BMAL1 in cytosol
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of BMAL1 in cytosol BC 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Dephosphorylation of BMAL1 in cytosol BCP 0 STOICHIOMETRY
xref: C20612
right: BC_0
left: BCP_0

LEFT 0 conversion Non specific degradation of Bmal1 mRNA MB 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MB_0
stoichiometric coefficient: 1.0

RIGHT 0 conversion Dephosphorylation of BMAL1 in cytosol BC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Phosphorylation of PER CRY complex in cytosol PCC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCC_0
stoichiometric coefficient: 1.0

BNP_0
type: PhysicalEntity
member physical entity: BNP
cellular location: Mammalian Cell

LEFT 0 conversion Non specific degradation of CRY protein in cytosol CC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Reversible reaction between PER CRY complex in cytosol and nucleus PCC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCC_0
stoichiometric coefficient: 1.0

Leloup2004 CircadianRhythms
type: Pathway
pathway component: Non-specific degradation of Per mRNA
pathway component: Degradation of BMAL1-P in cytosol
pathway component: Degradation of PER-CRY complex in nucleus
pathway component: Non-specific degradation of BMAL1 protein in cytosol
pathway component: Phosphorylation of PER-CRY complex in nucleus
pathway component: Translation of Cry mRNA to CRY protein in cytosol
pathway component: Degradation of BMAL1-P in nucleus
pathway component: Non-specific degradation of BMAL1-P protein in nucleus
pathway component: Degradation of Per mRNA
pathway component: Degradation of Cry mRNA
pathway component: Degradation of PER-CRY complex in cytosol
pathway component: Degradation of PER-P in cytosol
pathway component: Phosphorylation of PER-CRY complex in cytosol
pathway component: Degradation of CRY-P protein in cytosol
pathway component: Phosphorylation of CRY in cytosol
pathway component: Non-specific degradation of CRY-P protein in cytosol
pathway component: Non-specific degradation of BMAL1-P protein in cytosol
pathway component: Reversible reation between BMAL1 in cytosol and nucleus
pathway component: Non-specific degradation of CRY protein in cytosol
pathway component: Non-specific degradation of PER-CRY-BMAL1-CLOCK complex in nucleus
pathway component: Non-specific degradation of PER-CRY protein complex in nucleus
pathway component: Dephosphorylation of CRY in cytosol
pathway component: Degradation of the PER-CRY-CLOCK-BMAL1 complex
pathway component: Reversible reaction between PER-CRY complex and PER-CRY-CLOCK-BMAL1 in nuclues
pathway component: Translation of Per mRNA to PER protein
pathway component: Non-specific degradation of PER-CRY protein complex in cytosol
pathway component: Non-specific degradation of Cry mRNA
pathway component: Reversible reaction between PER-CRY complex in cytosol and nucleus
pathway component: Dephosphorylation of BMAL1 in nucleus
pathway component: Dephosphorylation of PER-CRY complex in cytosol
pathway component: Non-specific degradation of PER protein in cytosol
pathway component: Non-specific degradation of PER-CRY-P protein complex in nucleus
pathway component: Dephosphorylation of PER in cytosol
pathway component: Transcription of Bmal1 gene to Bmal1 mRNA
pathway component: Non-specific degradation of PER-P protein in cytosol
pathway component: Phosphorylation of BMAL1 in nucleus
pathway component: Phosphorylation of PER in cytosol
pathway component: Transcription of Cry gene to Cry mRNA
pathway component: Translation of Bmal1 mRNA to BMAL1 protein
pathway component: Phosphorylation of BMAL1 in cytosol
pathway component: Dephosphorylation of BMAL1 in cytosol
pathway component: Non-specific degradation of BMAL1 protein in nucleus
pathway component: Transcription of Per gene to Per mRNA
pathway component: Non-specific degradation of Bmal1 mRNA
pathway component: Reversible reaction between PER, CRY and PER-CRY complex in cytosol
pathway component: Degradation of Bmal1 mRNA
pathway component: Dephosphorylation of PER-CRY complex in nucleus
pathway component: Non-specific degradation of PER-CRY-P protein complex in cytosol
xref: BIOMD0000000078
xref: http://identifiers.org/pubmed/15363675
xref: GO:0043153
xref: BIOMD0000000074
xref: BIOMD0000000073
xref: BIOMD0000000083
xref: MODEL0478895291
organism: biosource 2
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.

CC_0
type: PhysicalEntity
member physical entity: CC
cellular location: Mammalian Cell

LEFT 0 conversion Non specific degradation of PER CRY P protein complex in cytosol PCCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCCP_0
stoichiometric coefficient: 1.0

C80450
type: UnificationXref
id: C80450
db: NCIt

BIOMD0000000083
type: UnificationXref
id: BIOMD0000000083
db: BioModels Database

BCP_0
type: PhysicalEntity
member physical entity: BCP
cellular location: Mammalian Cell

Translation of Cry mRNA to CRY protein in cytosol
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Translation of Cry mRNA to CRY protein in cytosol CC 0 STOICHIOMETRY
xref: C80450
right: CC_0

LEFT 0 conversion Phosphorylation of BMAL1 in cytosol BC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Dephosphorylation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCCP_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Dephosphorylation of BMAL1 in cytosol BCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BCP_0
stoichiometric coefficient: 1.0

MP_0
type: PhysicalEntity
member physical entity: MP
cellular location: Mammalian Cell

BCP_0
type: PhysicalEntity
member physical entity: BCP
cellular location: Mammalian Cell

LEFT 0 conversion Dephosphorylation of BMAL1 in nucleus BNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BNP_0
stoichiometric coefficient: 1.0

BN_0
type: PhysicalEntity
member physical entity: BN
cellular location: Mammalian Cell

PC_0
type: PhysicalEntity
member physical entity: PC
cellular location: Mammalian Cell

Degradation of CRY-P protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of CRY P protein in cytosol CCP 0 STOICHIOMETRY
xref: C61559
left: CCP_0

Phosphorylation of CRY in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Phosphorylation of CRY in cytosol CC 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Phosphorylation of CRY in cytosol CCP 0 STOICHIOMETRY
right: CCP_0
left: CC_0

Degradation of the PER-CRY-CLOCK-BMAL1 complex
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Degradation of the PER CRY CLOCK BMAL1 complex IN 0 STOICHIOMETRY
xref: C61559
spontaneous: true
left: IN_0
conversion direction: RIGHT_TO_LEFT

Translation of Per mRNA to PER protein
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Translation of Per mRNA to PER protein PC 0 STOICHIOMETRY
xref: C80450
right: PC_0

LEFT 0 conversion Non specific degradation of CRY P protein in cytosol CCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CCP_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Non specific degradation of PER CRY BMAL1 CLOCK complex in nucleus IN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: IN_0
stoichiometric coefficient: 1.0

Non-specific degradation of PER-CRY-P protein complex in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER CRY P protein complex in nucleus PCNP 0 STOICHIOMETRY
xref: C61559
left: PCNP_0

CCP
type: Protein
xref: Q16526
xref: PATO:0002220

LEFT 0 conversion Non specific degradation of Cry mRNA MC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MC_0
stoichiometric coefficient: 1.0

RIGHT 0 conversion Phosphorylation of BMAL1 in nucleus BNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BNP_0
stoichiometric coefficient: 1.0

PCN_0
type: PhysicalEntity
member physical entity: PCN
cellular location: Mammalian Cell

Non-specific degradation of BMAL1 protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of BMAL1 protein in cytosol BC 0 STOICHIOMETRY
xref: C61559
left: BC_0

BCP_0
type: PhysicalEntity
member physical entity: BCP
cellular location: Mammalian Cell

C17208
type: UnificationXref
id: C17208
db: NCIt

Non-specific degradation of CRY protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of CRY protein in cytosol CC 0 STOICHIOMETRY
xref: C61559
left: CC_0

Dephosphorylation of CRY in cytosol
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of CRY in cytosol CC 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Dephosphorylation of CRY in cytosol CCP 0 STOICHIOMETRY
xref: C20612
right: CC_0
left: CCP_0

Reversible reaction between PER-CRY complex and PER-CRY-CLOCK-BMAL1 in nuclues
type: ComplexAssembly
participant stoichiometry: LEFT 1 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues BN 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues IN 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues PCN 0 STOICHIOMETRY
right: IN_0
spontaneous: true
left: BN_0
left: PCN_0
conversion direction: LEFT_TO_RIGHT

RIGHT 0 conversion Translation of Cry mRNA to CRY protein in cytosol CC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CC_0
stoichiometric coefficient: 1.0

PCN_0
type: PhysicalEntity
member physical entity: PCN
cellular location: Mammalian Cell

PCP_0
type: PhysicalEntity
member physical entity: PCP
cellular location: Mammalian Cell

LEFT 0 conversion Dephosphorylation of CRY in cytosol CCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CCP_0
stoichiometric coefficient: 1.0

Phosphorylation of BMAL1 in nucleus
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Phosphorylation of BMAL1 in nucleus BNP 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Phosphorylation of BMAL1 in nucleus BN 0 STOICHIOMETRY
right: BNP_0
left: BN_0

MP
type: Rna
xref: http://identifiers.org/pubmed/24005054
xref: ENST00000317276

PCC_0
type: PhysicalEntity
member physical entity: PCC
cellular location: Mammalian Cell

BN_0
type: PhysicalEntity
member physical entity: BN
cellular location: Mammalian Cell

PCNP_0
type: PhysicalEntity
member physical entity: PCNP
cellular location: Mammalian Cell

ENST00000403290
type: UnificationXref
id: ENST00000403290
db: Ensembl

IN_0
type: PhysicalEntity
member physical entity: IN
cellular location: Mammalian Cell

Dephosphorylation of PER-CRY complex in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Dephosphorylation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of PER CRY complex in nucleus PCN 0 STOICHIOMETRY
right: PCN_0
left: PCNP_0

ENST00000317276
type: UnificationXref
id: ENST00000317276
db: Ensembl

RIGHT 0 conversion Phosphorylation of CRY in cytosol CCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CCP_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues PCN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCN_0
stoichiometric coefficient: 1.0

PC
type: Protein
xref: O15534

PCCP_0
type: PhysicalEntity
member physical entity: PCCP
cellular location: Mammalian Cell

LEFT 0 conversion Phosphorylation of CRY in cytosol CC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CC_0
stoichiometric coefficient: 1.0

PC_0
type: PhysicalEntity
member physical entity: PC
cellular location: Mammalian Cell

PTot
type: PhysicalEntity
xref: C25697

LEFT 1 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol PC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PC_0
stoichiometric coefficient: 1.0

Degradation of PER-CRY complex in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
xref: C61559
left: PCCP_0

LEFT 0 conversion Non specific degradation of PER CRY protein complex in cytosol PCC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCC_0
stoichiometric coefficient: 1.0

RIGHT 0 conversion Reversible reaction between PER CRY complex in cytosol and nucleus PCN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCN_0
stoichiometric coefficient: 1.0

LEFT 1 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues BN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BN_0
stoichiometric coefficient: 1.0

BNP_0
type: PhysicalEntity
member physical entity: BNP
cellular location: Mammalian Cell

LEFT 0 conversion Phosphorylation of PER in cytosol PC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Non specific degradation of BMAL1 protein in nucleus BN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BN_0
stoichiometric coefficient: 1.0

BN
type: Protein
xref: O00327

PCC
type: Protein
xref: GO:1990512
xref: O15534
xref: Q16526

Non-specific degradation of PER protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER protein in cytosol PC 0 STOICHIOMETRY
xref: C61559
left: PC_0

LEFT 0 conversion Degradation of Cry mRNA MC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Degradation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCNP_0
stoichiometric coefficient: 1.0

PATO:0002220
type: UnificationXref
id: PATO:0002220

LEFT 0 conversion Degradation of CRY P protein in cytosol CCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CCP_0
stoichiometric coefficient: 1.0

Non-specific degradation of PER-P protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER P protein in cytosol PCP 0 STOICHIOMETRY
xref: C61559
left: PCP_0

Phosphorylation of PER in cytosol
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Phosphorylation of PER in cytosol PCP 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Phosphorylation of PER in cytosol PC 0 STOICHIOMETRY
right: PCP_0
left: PC_0

C20612
type: UnificationXref
id: C20612
db: NCIt

O15534
type: UnificationXref
id: O15534
db: UniProt Knowledgebase

RIGHT 0 conversion Phosphorylation of PER in cytosol PCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCP_0
stoichiometric coefficient: 1.0

BN_0
type: PhysicalEntity
member physical entity: BN
cellular location: Mammalian Cell

RIGHT 0 conversion Dephosphorylation of PER CRY complex in nucleus PCN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCN_0
stoichiometric coefficient: 1.0

PC_0
type: PhysicalEntity
member physical entity: PC
cellular location: Mammalian Cell

LEFT 0 conversion Non specific degradation of PER CRY P protein complex in nucleus PCNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCNP_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol CC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CC_0
stoichiometric coefficient: 1.0

Non-specific degradation of Per mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of Per mRNA MP 0 STOICHIOMETRY
xref: C61559
left: MP_0

PCCP
type: Protein
xref: GO:1990512
xref: O15534
xref: Q16526
xref: PATO:0002220

Phosphorylation of PER-CRY complex in nucleus
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Phosphorylation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Phosphorylation of PER CRY complex in nucleus PCN 0 STOICHIOMETRY
right: PCNP_0
left: PCN_0

PCCP_0
type: PhysicalEntity
member physical entity: PCCP
cellular location: Mammalian Cell

RIGHT 0 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol PCC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Phosphorylation of BMAL1 in nucleus BN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BN_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Degradation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCCP_0
stoichiometric coefficient: 1.0

RIGHT 0 conversion Translation of Bmal1 mRNA to BMAL1 protein BC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BC_0
stoichiometric coefficient: 1.0

CCP_0
type: PhysicalEntity
member physical entity: CCP
cellular location: Mammalian Cell

PCNP_0
type: PhysicalEntity
member physical entity: PCNP
cellular location: Mammalian Cell

LEFT 0 conversion Degradation of BMAL1 P in nucleus BNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BNP_0
stoichiometric coefficient: 1.0

Non-specific degradation of PER-CRY-BMAL1-CLOCK complex in nucleus
type: ComplexAssembly
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER CRY BMAL1 CLOCK complex in nucleus IN 0 STOICHIOMETRY
xref: C61559
spontaneous: true
left: IN_0
conversion direction: RIGHT_TO_LEFT

LEFT 0 conversion Non specific degradation of PER P protein in cytosol PCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCP_0
stoichiometric coefficient: 1.0

GO:1990512
type: UnificationXref
id: GO:1990512
db: Gene Ontology

LEFT 0 conversion Non specific degradation of BMAL1 protein in cytosol BC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BC_0
stoichiometric coefficient: 1.0

GO:1990513
type: UnificationXref
id: GO:1990513
db: Gene Ontology

Dephosphorylation of PER-CRY complex in cytosol
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of PER CRY complex in cytosol PCC 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Dephosphorylation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
xref: C20612
right: PCC_0
left: PCCP_0

PCN
type: Protein
xref: GO:1990512
xref: O15534
xref: Q16526

MB_0
type: PhysicalEntity
member physical entity: MB
cellular location: Mammalian Cell

LEFT 0 conversion Degradation of Bmal1 mRNA MB 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MB_0
stoichiometric coefficient: 1.0

Non-specific degradation of BMAL1 protein in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of BMAL1 protein in nucleus BN 0 STOICHIOMETRY
xref: C61559
left: BN_0

MC_0
type: PhysicalEntity
member physical entity: MC
cellular location: Mammalian Cell

Transcription of Per gene to Per mRNA
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Transcription of Per gene to Per mRNA MP 0 STOICHIOMETRY
xref: C17208
right: MP_0

Non-specific degradation of Bmal1 mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of Bmal1 mRNA MB 0 STOICHIOMETRY
xref: C61559
left: MB_0

Reversible reaction between PER, CRY and PER-CRY complex in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol CC 0 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol PC 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Reversible reaction between PER CRY and PER CRY complex in cytosol PCC 0 STOICHIOMETRY
right: PCC_0
left: CC_0
left: PC_0

BN_0
type: PhysicalEntity
member physical entity: BN
cellular location: Mammalian Cell

CC_0
type: PhysicalEntity
member physical entity: CC
cellular location: Mammalian Cell

PCNP
type: Protein
xref: GO:1990512
xref: O15534
xref: Q16526
xref: PATO:0002220

ENST00000008527
type: UnificationXref
id: ENST00000008527
db: Ensembl

LEFT 0 conversion Degradation of the PER CRY CLOCK BMAL1 complex IN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: IN_0
stoichiometric coefficient: 1.0

PCNP_0
type: PhysicalEntity
member physical entity: PCNP
cellular location: Mammalian Cell

RIGHT 0 conversion Dephosphorylation of CRY in cytosol CC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: CC_0
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/15363675
type: PublicationXref
id: 15363675
db: PubMed

PCCP_0
type: PhysicalEntity
member physical entity: PCCP
cellular location: Mammalian Cell

MODEL0478895291
type: UnificationXref
id: MODEL0478895291
db: BioModels Database

Degradation of BMAL1-P in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of BMAL1 P in nucleus BNP 0 STOICHIOMETRY
xref: C61559
left: BNP_0

Degradation of Per mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of Per mRNA MP 0 STOICHIOMETRY
xref: C61559
left: MP_0

CC_0
type: PhysicalEntity
member physical entity: CC
cellular location: Mammalian Cell

RIGHT 0 conversion Dephosphorylation of PER CRY complex in cytosol PCC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Phosphorylation of PER CRY complex in nucleus PCN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCN_0
stoichiometric coefficient: 1.0

Non-specific degradation of CRY-P protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of CRY P protein in cytosol CCP 0 STOICHIOMETRY
xref: C61559
left: CCP_0

Non-specific degradation of BMAL1-P protein in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of BMAL1 P protein in cytosol BCP 0 STOICHIOMETRY
xref: C61559
left: BCP_0

RIGHT 0 conversion Phosphorylation of BMAL1 in cytosol BCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BCP_0
stoichiometric coefficient: 1.0

Non-specific degradation of PER-CRY protein complex in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER CRY protein complex in nucleus PCN 0 STOICHIOMETRY
xref: C61559
left: PCN_0

RIGHT 0 conversion Dephosphorylation of BMAL1 in nucleus BN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BN_0
stoichiometric coefficient: 1.0

Non-specific degradation of Cry mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of Cry mRNA MC 0 STOICHIOMETRY
xref: C61559
left: MC_0

PCC_0
type: PhysicalEntity
member physical entity: PCC
cellular location: Mammalian Cell

PCC_0
type: PhysicalEntity
member physical entity: PCC
cellular location: Mammalian Cell

LEFT 0 conversion Dephosphorylation of PER in cytosol PCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCP_0
stoichiometric coefficient: 1.0

Dephosphorylation of PER in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Dephosphorylation of PER in cytosol PCP 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of PER in cytosol PC 0 STOICHIOMETRY
xref: C20612
right: PC_0
left: PCP_0

PCC_0
type: PhysicalEntity
member physical entity: PCC
cellular location: Mammalian Cell

Transcription of Cry gene to Cry mRNA
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Transcription of Cry gene to Cry mRNA MC 0 STOICHIOMETRY
xref: C17208
right: MC_0

LEFT 0 conversion Non specific degradation of BMAL1 P protein in nucleus BNP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BNP_0
stoichiometric coefficient: 1.0

PCN_0
type: PhysicalEntity
member physical entity: PCN
cellular location: Mammalian Cell

Degradation of Bmal1 mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of Bmal1 mRNA MB 0 STOICHIOMETRY
xref: C61559
left: MB_0

Non-specific degradation of PER-CRY-P protein complex in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of PER CRY P protein complex in cytosol PCCP 0 STOICHIOMETRY
xref: C61559
left: PCCP_0

RIGHT 0 conversion Transcription of Cry gene to Cry mRNA MC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MC_0
stoichiometric coefficient: 1.0

Degradation of BMAL1-P in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of BMAL1 P in cytosol BCP 0 STOICHIOMETRY
xref: C61559
left: BCP_0

LEFT 0 conversion Reversible reation between BMAL1 in cytosol and nucleus BC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BC_0
stoichiometric coefficient: 1.0

LEFT 0 conversion Degradation of PER P in cytosol PCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCP_0
stoichiometric coefficient: 1.0

C61559
type: UnificationXref
id: C61559
db: NCIt

Mammalian Cell
type: CellularLocationVocabulary
xref: C12958
xref: http://identifiers.org/pubmed/15363675

BNP_0
type: PhysicalEntity
member physical entity: BNP
cellular location: Mammalian Cell

Degradation of PER-CRY complex in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of PER CRY complex in nucleus PCNP 0 STOICHIOMETRY
xref: C61559
left: PCNP_0

MC_0
type: PhysicalEntity
member physical entity: MC
cellular location: Mammalian Cell

BC_0
type: PhysicalEntity
member physical entity: BC
cellular location: Mammalian Cell

BCP_0
type: PhysicalEntity
member physical entity: BCP
cellular location: Mammalian Cell

PCN_0
type: PhysicalEntity
member physical entity: PCN
cellular location: Mammalian Cell

BN_0
type: PhysicalEntity
member physical entity: BN
cellular location: Mammalian Cell

Non-specific degradation of BMAL1-P protein in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Non specific degradation of BMAL1 P protein in nucleus BNP 0 STOICHIOMETRY
xref: C61559
left: BNP_0

LEFT 0 conversion Non specific degradation of BMAL1 P protein in cytosol BCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BCP_0
stoichiometric coefficient: 1.0

CC_0
type: PhysicalEntity
member physical entity: CC
cellular location: Mammalian Cell

RIGHT 0 conversion Reversible reation between BMAL1 in cytosol and nucleus BN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BN_0
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

RIGHT 0 conversion Transcription of Per gene to Per mRNA MP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MP_0
stoichiometric coefficient: 1.0

CCP_0
type: PhysicalEntity
member physical entity: CCP
cellular location: Mammalian Cell

BNP_0
type: PhysicalEntity
member physical entity: BNP
cellular location: Mammalian Cell

RIGHT 0 conversion Reversible reaction between PER CRY complex and PER CRY CLOCK BMAL1 in nuclues IN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: IN_0
stoichiometric coefficient: 1.0

Reversible reation between BMAL1 in cytosol and nucleus
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Reversible reation between BMAL1 in cytosol and nucleus BN 0 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion Reversible reation between BMAL1 in cytosol and nucleus BC 0 STOICHIOMETRY
right: BN_0
left: BC_0

PCP_0
type: PhysicalEntity
member physical entity: PCP
cellular location: Mammalian Cell

BIOMD0000000078
type: UnificationXref
id: BIOMD0000000078
db: BioModels Database

Dephosphorylation of BMAL1 in nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Dephosphorylation of BMAL1 in nucleus BNP 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Dephosphorylation of BMAL1 in nucleus BN 0 STOICHIOMETRY
xref: C20612
right: BN_0
left: BNP_0

BIOMD0000000074
type: UnificationXref
id: BIOMD0000000074
db: BioModels Database

BIOMD0000000073
type: UnificationXref
id: BIOMD0000000073
db: BioModels Database

BTot
type: PhysicalEntity
xref: C25697

PCP
type: Protein
xref: O15534
xref: PATO:0002220

MP_0
type: PhysicalEntity
member physical entity: MP
cellular location: Mammalian Cell

BC
type: Protein
xref: O00327

C25697
type: UnificationXref
id: C25697

LEFT 0 conversion Non specific degradation of PER CRY protein complex in nucleus PCN 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCN_0
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/24005054
type: UnificationXref
id: 24005054
db: PubMed

LEFT 0 conversion Degradation of BMAL1 P in cytosol BCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: BCP_0
stoichiometric coefficient: 1.0

Phosphorylation of BMAL1 in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Phosphorylation of BMAL1 in cytosol BC 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Phosphorylation of BMAL1 in cytosol BCP 0 STOICHIOMETRY
right: BCP_0
left: BC_0

IN
type: Complex
xref: GO:1990512
xref: GO:1990513

RIGHT 0 conversion Dephosphorylation of PER in cytosol PC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PC_0
stoichiometric coefficient: 1.0

CCP_0
type: PhysicalEntity
member physical entity: CCP
cellular location: Mammalian Cell

BC_0
type: PhysicalEntity
member physical entity: BC
cellular location: Mammalian Cell

RIGHT 0 conversion Transcription of Bmal1 gene to Bmal1 mRNA MB 0 STOICHIOMETRY
type: Stoichiometry
physical entity: MB_0
stoichiometric coefficient: 1.0

Q16526
type: UnificationXref
id: Q16526
db: UniProt Knowledgebase

LEFT 0 conversion Non specific degradation of PER protein in cytosol PC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PC_0
stoichiometric coefficient: 1.0

CC_0
type: PhysicalEntity
member physical entity: CC
cellular location: Mammalian Cell

Degradation of Cry mRNA
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of Cry mRNA MC 0 STOICHIOMETRY
xref: C61559
left: MC_0

Degradation of PER-P in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Degradation of PER P in cytosol PCP 0 STOICHIOMETRY
xref: C61559
left: PCP_0

Phosphorylation of PER-CRY complex in cytosol
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Phosphorylation of PER CRY complex in cytosol PCC 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Phosphorylation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
right: PCCP_0
left: PCC_0

PC_0
type: PhysicalEntity
member physical entity: PC
cellular location: Mammalian Cell

IN_0
type: PhysicalEntity
member physical entity: IN
cellular location: Mammalian Cell

BC_0
type: PhysicalEntity
member physical entity: BC
cellular location: Mammalian Cell

MP_0
type: PhysicalEntity
member physical entity: MP
cellular location: Mammalian Cell

BC_0
type: PhysicalEntity
member physical entity: BC
cellular location: Mammalian Cell

BCP
type: Protein
xref: O00327
xref: PATO:0002220

C12958
type: UnificationXref
id: C12958
db: NCIt

MC
type: Rna
xref: ENST00000008527

MB_0
type: PhysicalEntity
member physical entity: MB
cellular location: Mammalian Cell

Reversible reaction between PER-CRY complex in cytosol and nucleus
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Reversible reaction between PER CRY complex in cytosol and nucleus PCC 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion Reversible reaction between PER CRY complex in cytosol and nucleus PCN 0 STOICHIOMETRY
right: PCN_0
left: PCC_0

GO:0043153
type: UnificationXref
id: GO:0043153
db: Gene Ontology

CCP_0
type: PhysicalEntity
member physical entity: CCP
cellular location: Mammalian Cell

RIGHT 0 conversion Phosphorylation of PER CRY complex in cytosol PCCP 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PCCP_0
stoichiometric coefficient: 1.0

Transcription of Bmal1 gene to Bmal1 mRNA
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Transcription of Bmal1 gene to Bmal1 mRNA MB 0 STOICHIOMETRY
xref: C17208
right: MB_0

Translation of Bmal1 mRNA to BMAL1 protein
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Translation of Bmal1 mRNA to BMAL1 protein BC 0 STOICHIOMETRY
xref: C80450
right: BC_0

BNP
type: Protein
xref: O00327
xref: PATO:0002220

RIGHT 0 conversion Translation of Per mRNA to PER protein PC 0 STOICHIOMETRY
type: Stoichiometry
physical entity: PC_0
stoichiometric coefficient: 1.0

O00327
type: UnificationXref
id: O00327
db: UniProt Knowledgebase