TGFbint
type: PhysicalEntity
member physical entity: TGFb_int
cellular location: compartment

LEFT 0 conversion FOXP3 inhibition by STAT3 FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

P42227
type: UnificationXref
id: P42227
db: UniProt Knowledgebase

LEFT 0 conversion FOXP3 protein degradation FOXP3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3prot_star
stoichiometric coefficient: 1.0

STAT3mRNA
type: PhysicalEntity
member physical entity: STAT3_mRNA
cellular location: compartment

LEFT 0 conversion RORgt degradation RORgtmRNA STOICHIOMETRY
type: Stoichiometry
physical entity: RORgtmRNA
stoichiometric coefficient: 1.0

LEFT 0 conversion STAT3 translation STAT3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3mRNA
stoichiometric coefficient: 1.0

IL6_ext
type: Protein
xref: P08505
xref: C44280

STAT3 basal expression
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion STAT3 basal expression STAT3mRNA STOICHIOMETRY
right: STAT3mRNA

STAT3 mRNA degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion STAT3 mRNA degradation STAT3mRNA STOICHIOMETRY
left: STAT3mRNA

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

LEFT 1 conversion STAT3 activation IL6int STOICHIOMETRY
type: Stoichiometry
physical entity: IL6int
stoichiometric coefficient: 1.0

FOXP3_mRNA
type: Protein
xref: Q99JB6
xref: C813

STAT3mRNA
type: PhysicalEntity
member physical entity: STAT3_mRNA
cellular location: compartment

RIGHT 1 conversion FOXP3 activation by TGFb TGFbint STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbint
stoichiometric coefficient: 1.0

compartment
type: CellularLocationVocabulary

RIGHT 0 conversion FOXP3 activation by TGFb FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

IL6int
type: PhysicalEntity
member physical entity: IL6_int
cellular location: compartment

BIOMD0000001004
type: UnificationXref
id: BIOMD0000001004
db: BioModels Database

TGFbext
type: PhysicalEntity
member physical entity: TGFb_ext
cellular location: compartment

RORgt_mRNA
type: Protein
xref: C813
xref: P51450

GO:0019221
type: UnificationXref
id: GO:0019221
db: Gene Ontology

IL6ext
type: PhysicalEntity
member physical entity: IL6_ext
cellular location: compartment

STAT3 autoactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion STAT3 autoactivation STAT3prot star STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion STAT3 autoactivation STAT3mRNA STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion STAT3 autoactivation STAT3prot star STOICHIOMETRY
right: STAT3prot_star
right: STAT3mRNA
left: STAT3prot_star

LEFT 0 conversion STAT3 mRNA degradation STAT3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3mRNA
stoichiometric coefficient: 1.0

RIGHT 0 conversion FOXP3 basal expression FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

STAT3prot
type: PhysicalEntity
member physical entity: STAT3
cellular location: compartment

LEFT 0 conversion STAT3 protein degradation STAT3prot STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot
stoichiometric coefficient: 1.0

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

FOXP3_act
type: Protein
xref: Q99JB6
xref: C45329

STAT3_mRNA
type: Protein
xref: C813
xref: P42227

RIGHT 0 conversion STAT3 activation STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

FOXP3 protein degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion FOXP3 protein degradation FOXP3prot star STOICHIOMETRY
left: FOXP3prot_star

LEFT 0 conversion TGFb conversion TGFbext STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbext
stoichiometric coefficient: 1.0

RORgt activation by TGFb and STAT3
type: BiochemicalReaction
participant stoichiometry: RIGHT 2 conversion RORgt activation by TGFb and STAT3 STAT3prot star STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion RORgt activation by TGFb and STAT3 STAT3prot star STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion RORgt activation by TGFb and STAT3 TGFbint STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion RORgt activation by TGFb and STAT3 TGFbint STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RORgt activation by TGFb and STAT3 RORgtmRNA STOICHIOMETRY
right: TGFbint
right: STAT3prot_star
right: RORgtmRNA
left: TGFbint
left: STAT3prot_star

STAT3mRNA
type: PhysicalEntity
member physical entity: STAT3_mRNA
cellular location: compartment

STAT3mRNA
type: PhysicalEntity
member physical entity: STAT3_mRNA
cellular location: compartment

FOXP3 basal expression
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion FOXP3 basal expression FOXP3mRNA STOICHIOMETRY
right: FOXP3mRNA

Q99JB6
type: UnificationXref
id: Q99JB6
db: UniProt Knowledgebase

RORgtmRNA
type: PhysicalEntity
member physical entity: RORgt_mRNA
cellular location: compartment

LEFT 0 conversion STAT3 autoactivation STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

IL6_int
type: Protein
xref: C25234
xref: P08505

LEFT 0 conversion FOXP3 translation activation FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

STAT3prot
type: PhysicalEntity
member physical entity: STAT3
cellular location: compartment

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

BTO:0005655
type: UnificationXref
id: BTO:0005655
db: Brenda Tissue Ontology

MODEL2102260001
type: UnificationXref
id: MODEL2102260001
db: BioModels Database

LEFT 0 conversion RORgt activation by TGFb and STAT3 TGFbint STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbint
stoichiometric coefficient: 1.0

LEFT 0 conversion RORgt inhibition by FOXP3 RORgtmRNA STOICHIOMETRY
type: Stoichiometry
physical entity: RORgtmRNA
stoichiometric coefficient: 1.0

C44280
type: UnificationXref
id: C44280

RIGHT 1 conversion STAT3 autoactivation STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

LEFT 0 conversion FOXP3 activation by TGFb TGFbint STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbint
stoichiometric coefficient: 1.0

Intosalmi2015 Th17 core network model
type: Pathway
pathway component: FOXP3 basal expression
pathway component: FOXP3 mRNA degradation
pathway component: TGFb conversion
pathway component: STAT3 protein degradation
pathway component: RORgt inhibition by FOXP3
pathway component: STAT3 autoactivation
pathway component: STAT3 phosphoprotein degradation
pathway component: STAT3 translation
pathway component: RORgt degradation
pathway component: STAT3 basal expression
pathway component: STAT3 mRNA degradation
pathway component: IL6 conversion
pathway component: FOXP3 inhibition by STAT3
pathway component: FOXP3 translation/activation
pathway component: FOXP3 protein degradation
pathway component: RORgt activation by TGFb and STAT3
pathway component: STAT3 activation
pathway component: FOXP3 activation by TGFb
xref: BTO:0005655
xref: BIOMD0000001004
xref: MODEL2102260001
xref: GO:0002250
xref: GO:0019221
xref: GO:0072539
xref: http://identifiers.org/pubmed/26578352
xref: MAMO_0000046
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'Intosalmi2015___Th17_core_network_model', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

RORgt inhibition by FOXP3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion RORgt inhibition by FOXP3 RORgtmRNA STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion RORgt inhibition by FOXP3 FOXP3prot star STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion RORgt inhibition by FOXP3 FOXP3prot star STOICHIOMETRY
right: FOXP3prot_star
left: RORgtmRNA
left: FOXP3prot_star

P08505
type: UnificationXref
id: P08505
db: UniProt Knowledgebase

P51450
type: UnificationXref
id: P51450
db: UniProt Knowledgebase

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

FOXP3prot_star
type: PhysicalEntity
member physical entity: FOXP3_act
cellular location: compartment

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

RIGHT 0 conversion IL6 conversion IL6int STOICHIOMETRY
type: Stoichiometry
physical entity: IL6int
stoichiometric coefficient: 1.0

LEFT 0 conversion STAT3 phosphoprotein degradation STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

RIGHT 1 conversion FOXP3 translation activation FOXP3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3prot_star
stoichiometric coefficient: 1.0

RIGHT 1 conversion RORgt activation by TGFb and STAT3 TGFbint STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbint
stoichiometric coefficient: 1.0

RIGHT 0 conversion STAT3 basal expression STAT3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3mRNA
stoichiometric coefficient: 1.0

TGFbint
type: PhysicalEntity
member physical entity: TGFb_int
cellular location: compartment

RIGHT 1 conversion STAT3 translation STAT3prot STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot
stoichiometric coefficient: 1.0

IL6int
type: PhysicalEntity
member physical entity: IL6_int
cellular location: compartment

STAT3 translation
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion STAT3 translation STAT3prot STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion STAT3 translation STAT3mRNA STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion STAT3 translation STAT3mRNA STOICHIOMETRY
right: STAT3prot
right: STAT3mRNA
left: STAT3mRNA

FOXP3prot_star
type: PhysicalEntity
member physical entity: FOXP3_act
cellular location: compartment

TGFb_ext
type: Protein
xref: P04202
xref: C44280

TGFbint
type: PhysicalEntity
member physical entity: TGFb_int
cellular location: compartment

FOXP3prot_star
type: PhysicalEntity
member physical entity: FOXP3_act
cellular location: compartment

RIGHT 0 conversion RORgt activation by TGFb and STAT3 RORgtmRNA STOICHIOMETRY
type: Stoichiometry
physical entity: RORgtmRNA
stoichiometric coefficient: 1.0

FOXP3 inhibition by STAT3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion FOXP3 inhibition by STAT3 FOXP3mRNA STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion FOXP3 inhibition by STAT3 STAT3prot star STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion FOXP3 inhibition by STAT3 STAT3prot star STOICHIOMETRY
right: STAT3prot_star
left: FOXP3mRNA
left: STAT3prot_star

RIGHT 0 conversion STAT3 autoactivation STAT3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3mRNA
stoichiometric coefficient: 1.0

LEFT 0 conversion STAT3 activation STAT3prot STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot
stoichiometric coefficient: 1.0

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

STAT3 activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion STAT3 activation IL6int STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion STAT3 activation IL6int STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion STAT3 activation STAT3prot star STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion STAT3 activation STAT3prot STOICHIOMETRY
right: IL6int
right: STAT3prot_star
left: STAT3prot
left: IL6int

LEFT 0 conversion IL6 conversion IL6ext STOICHIOMETRY
type: Stoichiometry
physical entity: IL6ext
stoichiometric coefficient: 1.0

RORgtmRNA
type: PhysicalEntity
member physical entity: RORgt_mRNA
cellular location: compartment

C813
type: UnificationXref
id: C813

RORgtmRNA
type: PhysicalEntity
member physical entity: RORgt_mRNA
cellular location: compartment

STAT3
type: Protein
xref: P42227

LEFT 1 conversion RORgt activation by TGFb and STAT3 STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

RIGHT 0 conversion FOXP3 translation activation FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

P04202
type: UnificationXref
id: P04202
db: UniProt Knowledgebase

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

STAT3_act
type: Protein
xref: P42227
xref: C45329

RORgt degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion RORgt degradation RORgtmRNA STOICHIOMETRY
left: RORgtmRNA

IL6 conversion
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion IL6 conversion IL6int STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion IL6 conversion IL6ext STOICHIOMETRY
xref: GO:0031623
right: IL6int
left: IL6ext

RIGHT 0 conversion FOXP3 inhibition by STAT3 STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

LEFT 1 conversion FOXP3 inhibition by STAT3 STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/10095
type: UnificationXref
id: 10095
db: Taxonomy

TGFb_int
type: Protein
xref: C25234
xref: P04202

FOXP3 activation by TGFb
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion FOXP3 activation by TGFb TGFbint STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion FOXP3 activation by TGFb FOXP3mRNA STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion FOXP3 activation by TGFb TGFbint STOICHIOMETRY
right: FOXP3mRNA
right: TGFbint
left: TGFbint

RIGHT 1 conversion STAT3 activation IL6int STOICHIOMETRY
type: Stoichiometry
physical entity: IL6int
stoichiometric coefficient: 1.0

FOXP3 mRNA degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion FOXP3 mRNA degradation FOXP3mRNA STOICHIOMETRY
left: FOXP3mRNA

TGFb conversion
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion TGFb conversion TGFbext STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion TGFb conversion TGFbint STOICHIOMETRY
xref: GO:0031623
right: TGFbint
left: TGFbext

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

C45329
type: UnificationXref
id: C45329

FOXP3prot_star
type: PhysicalEntity
member physical entity: FOXP3_act
cellular location: compartment

RIGHT 2 conversion RORgt activation by TGFb and STAT3 STAT3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3prot_star
stoichiometric coefficient: 1.0

RIGHT 0 conversion STAT3 translation STAT3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: STAT3mRNA
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000001004

TGFbint
type: PhysicalEntity
member physical entity: TGFb_int
cellular location: compartment

FOXP3mRNA
type: PhysicalEntity
member physical entity: FOXP3_mRNA
cellular location: compartment

LEFT 0 conversion FOXP3 mRNA degradation FOXP3mRNA STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3mRNA
stoichiometric coefficient: 1.0

STAT3 protein degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion STAT3 protein degradation STAT3prot STOICHIOMETRY
left: STAT3prot

C25234
type: UnificationXref
id: C25234

STAT3 phosphoprotein degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion STAT3 phosphoprotein degradation STAT3prot star STOICHIOMETRY
left: STAT3prot_star

TGFbint
type: PhysicalEntity
member physical entity: TGFb_int
cellular location: compartment

BioModels Database
type: Provenance
xref: MODEL2102260001

IL6int
type: PhysicalEntity
member physical entity: IL6_int
cellular location: compartment

GO:0002250
type: UnificationXref
id: GO:0002250
db: Gene Ontology

FOXP3 translation/activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion FOXP3 translation activation FOXP3mRNA STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion FOXP3 translation activation FOXP3prot star STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion FOXP3 translation activation FOXP3mRNA STOICHIOMETRY
right: FOXP3mRNA
right: FOXP3prot_star
left: FOXP3mRNA

STAT3prot
type: PhysicalEntity
member physical entity: STAT3
cellular location: compartment

GO:0072539
type: UnificationXref
id: GO:0072539
db: Gene Ontology

STAT3prot_star
type: PhysicalEntity
member physical entity: STAT3_act
cellular location: compartment

LEFT 1 conversion RORgt inhibition by FOXP3 FOXP3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3prot_star
stoichiometric coefficient: 1.0

RIGHT 0 conversion TGFb conversion TGFbint STOICHIOMETRY
type: Stoichiometry
physical entity: TGFbint
stoichiometric coefficient: 1.0

RIGHT 0 conversion RORgt inhibition by FOXP3 FOXP3prot star STOICHIOMETRY
type: Stoichiometry
physical entity: FOXP3prot_star
stoichiometric coefficient: 1.0

http://identifiers.org/pubmed/26578352
type: PublicationXref
id: 26578352
db: PubMed

GO:0031623
type: UnificationXref
id: GO:0031623
db: Gene Ontology

STAT3mRNA
type: PhysicalEntity
member physical entity: STAT3_mRNA
cellular location: compartment