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        <pre>a dynamic description for the core molecular mechanisms steering Th17 cell differentiation and use mathematical modeling to quantitatively predict the resulting molecular dynamics</pre>
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      <species boundaryCondition="false" compartment="compartment" constant="false" id="FOXP3prot_star" initialConcentration="1" metaid="COPASI10" name="FOXP3_act">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI10">
              <bqbiol:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q99JB6"/>
	</rdf:Bag>
	</bqbiol:is>
	
	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/ncit/C45329"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI10">
                <bqbiol:hasProperty rdf:resource="urn:miriam:ncit:C45329"/>
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2021-02-26T12:49:31Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:is rdf:resource="urn:miriam:uniprot:Q99JB6"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="compartment" constant="false" id="FOXP3mRNA" initialConcentration="0.145" metaid="COPASI11" name="FOXP3_mRNA">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI11">
              <bqbiol:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/Q99JB6"/>
	</rdf:Bag>
	</bqbiol:is>
	
	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/ncit/C813"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI11">
                <bqbiol:hasProperty rdf:resource="urn:miriam:ncit:C813"/>
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2021-02-26T12:49:31Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:is rdf:resource="urn:miriam:uniprot:Q99JB6"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
    </listOfSpecies>
    <listOfReactions>
      <reaction id="IL6_conversion" metaid="COPASI12" name="IL6 conversion" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI12">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0031623"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI12">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:21:32Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0031623"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="IL6ext" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="IL6int" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> IL6ext </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0627"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_basal_expression" metaid="COPASI13" name="STAT3 basal expression" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI13">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI13">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:22:38Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfProducts>
          <speciesReference species="STAT3mRNA" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> Constant_flux__irreversible </ci>
                <ci> v </ci>
              </apply>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="v" name="v" value="1.0222"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_autoactivation" metaid="COPASI14" name="STAT3 autoactivation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI14">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000656"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI14">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T14:46:35Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000656"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="STAT3mRNA" stoichiometry="1"/>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="14.8148"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_mRNA_degradation" metaid="COPASI15" name="STAT3 mRNA degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI15">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI15">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:23:30Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3mRNA" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3mRNA </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="2.2047"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_translation" metaid="COPASI16" name="STAT3 translation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI16">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI16">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:24:37Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3mRNA" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="STAT3mRNA" stoichiometry="1"/>
          <speciesReference species="STAT3prot" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3mRNA </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0846"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_activation" metaid="COPASI17" name="STAT3 activation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI17">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000656"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI17">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T14:46:44Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000656"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3prot" stoichiometry="1"/>
          <speciesReference species="IL6int" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
          <speciesReference species="IL6int" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3prot </ci>
              <ci> IL6int </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="16.3647"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_protein_degradation" metaid="COPASI18" name="STAT3 protein degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI18">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI18">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:25:41Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3prot" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3prot </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0221"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="STAT3_phosphoprotein_degradation" metaid="COPASI19" name="STAT3 phosphoprotein degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI19">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI19">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:25:52Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> STAT3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="2.7893"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="TGFb_conversion" metaid="COPASI20" name="TGFb conversion" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI20">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0031623"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI20">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:26:13Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:go:GO:0031623"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="TGFbext" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="TGFbint" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> TGFbext </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="19.3743"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="RORgt_inhibition_by_FOXP3" metaid="COPASI21" name="RORgt inhibition by FOXP3" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI21">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000169"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI21">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:27:42Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000169"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="RORgtmRNA" stoichiometry="1"/>
          <speciesReference species="FOXP3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="FOXP3prot_star" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> RORgtmRNA </ci>
              <ci> FOXP3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="773.782"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="RORgt_degradation" metaid="COPASI22" name="RORgt degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI22">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI22">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:28:34Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="RORgtmRNA" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> RORgtmRNA </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0479"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_basal_expression" metaid="COPASI23" name="FOXP3 basal expression" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI23">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000393"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI23">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:28:54Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000393"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfProducts>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <apply>
                <ci> Constant_flux__irreversible </ci>
                <ci> v </ci>
              </apply>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="v" name="v" value="0"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_activation_by_TGFb" metaid="COPASI24" name="FOXP3 activation by TGFb" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI24">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000656"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI24">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:21:04Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000656"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="TGFbint" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
          <speciesReference species="TGFbint" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> TGFbint </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0734"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_inhibition_by_STAT3" metaid="COPASI25" name="FOXP3 inhibition by STAT3" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI25">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000169"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI25">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:29:30Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000169"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> FOXP3mRNA </ci>
              <ci> STAT3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="7.4237"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_mRNA_degradation" metaid="COPASI26" name="FOXP3 mRNA degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI26">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI26">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T14:59:29Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> FOXP3mRNA </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.8092"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_translation_activation" metaid="COPASI27" name="FOXP3 translation/activation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI27">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000184"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI27">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:32:02Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000184"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="FOXP3mRNA" stoichiometry="1"/>
          <speciesReference species="FOXP3prot_star" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> FOXP3mRNA </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="0.0053"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="FOXP3_protein_degradation" metaid="COPASI28" name="FOXP3 protein degradation" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI28">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000179"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI28">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:32:08Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000179"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="FOXP3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> FOXP3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="1.3205"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="RORgt_activation_by_TGFb_and_STAT3" metaid="COPASI29" name="RORgt activation by TGFb and STAT3" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI29">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/sbo/SBO:0000656"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI29">
                <dcterms:created>
                  <rdf:Description>
                    <dcterms:W3CDTF>2015-07-01T15:27:04Z</dcterms:W3CDTF>
                  </rdf:Description>
                </dcterms:created>
                <CopasiMT:isVersionOf rdf:resource="urn:miriam:sbo:SBO:0000656"/>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference species="TGFbint" stoichiometry="1"/>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="RORgtmRNA" stoichiometry="1"/>
          <speciesReference species="TGFbint" stoichiometry="1"/>
          <speciesReference species="STAT3prot_star" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> compartment </ci>
              <ci> k1 </ci>
              <ci> TGFbint </ci>
              <ci> STAT3prot_star </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k1" name="k1" value="4.967"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>