This is a dynamic pathway model examining the roles of of the two transcriptional negative feedback regulators of the suppressor of cytokine signaling (SOCS) family, CIS and SOCS3, in JAK/STAT5 signaling, within the context of primary erythroid progenitor cells.
 Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-11-14T09:13:48Z 2019-11-14T09:13:48Z 2019-11-14T09:13:48Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI EpoRActJAK2 EpoRCISInh EpoRJAK2_CIS EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh 3 EpoRActJAK2 EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRCISInh EpoRJAK2_CIS 1 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p2EpoRpJAK2 JAK2EpoRDeaSHP1 SHP1Act p2EpoRpJAK2 init_SHP1 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh EpoRActJAK2 EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRActJAK2 EpoRCISInh EpoRJAK2_CIS SOCS3 SOCS3Eqc SOCS3Inh p1EpoRpJAK2 3 EpoRActJAK2 p1EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRCISInh EpoRJAK2_CIS 1 EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p2EpoRpJAK2 EpoRActJAK2 p2EpoRpJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p12EpoRpJAK2 JAK2EpoRDeaSHP1 SHP1Act p12EpoRpJAK2 init_SHP1 EpoRCISRemove EpoRJAK2_CIS init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 EpoRCISRemove EpoRJAK2_CIS p12EpoRpJAK2 p1EpoRpJAK2 init_EpoRJAK2 EpoRpJAK2 SHP1 SHP1ActEpoR init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 SHP1ActEpoR SHP1 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 init_EpoRJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActJAK2 init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 STAT5ActJAK2 STAT5 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 init_EpoRJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Eqc SOCS3Inh JAK2ActEpo Epo EpoRJAK2 SOCS3Inh SOCS3 SOCS3Eqc 1 EpoRpJAK2 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 JAK2EpoRDeaSHP1 SHP1Act EpoRpJAK2 init_SHP1 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p1EpoRpJAK2 JAK2EpoRDeaSHP1 SHP1Act p1EpoRpJAK2 init_SHP1 SOCS3Eqc SOCS3EqcOE SOCS3Turn SOCS3oe cyt SOCS3oe SOCS3Eqc SOCS3Turn SOCS3EqcOE cyt SOCS3Eqc SOCS3RNA SOCS3RNAEqc SOCS3Turn SOCS3Eqc SOCS3Turn SOCS3RNA SOCS3RNAEqc CIS CISEqc CISInh SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActEpoR init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 STAT5ActEpoR STAT5 p12EpoRpJAK2 p1EpoRpJAK2 2 init_EpoRJAK2 2 CISInh CIS CISEqc 1 SOCS3Inh SOCS3 SOCS3Eqc 1 STAT5Exp npSTAT5 nuc STAT5Exp npSTAT5 nuc ActD CISRNAEqc CISRNATurn init_STAT5 npSTAT5 nuc CISRNAEqc CISRNATurn npSTAT5 ActD 1 init_STAT5 nuc nuc ActD SOCS3RNAEqc SOCS3RNATurn init_STAT5 npSTAT5 nuc SOCS3RNAEqc SOCS3RNATurn npSTAT5 ActD 1 init_STAT5 nuc nuc SOCS3RNADelay SOCS3nRNA5 nuc SOCS3RNADelay SOCS3nRNA5 nuc 2019-11-14T09:41:29Z CISEqc CISRNA CISRNAEqc CISTurn CISEqc CISTurn CISRNA CISRNAEqc STAT5Imp cyt pSTAT5 STAT5Imp pSTAT5 cyt CISRNADelay CISnRNA5 nuc CISRNADelay CISnRNA5 nuc 2019-11-14T09:41:13Z CISEqc CISEqcOE CISTurn CISoe cyt CISoe CISEqc CISTurn CISEqcOE cyt 2019-11-14T09:33:07Z 2019-11-14T09:33:28Z 2019-11-14T10:05:23Z 2019-11-14T10:05:53Z 2019-11-14T09:38:44Z 2019-11-14T09:38:51Z 2019-11-14T09:38:39Z 2019-11-14T10:05:42Z 2019-11-14T10:13:10Z 2019-11-14T10:08:45Z 2019-11-14T10:04:27Z 2019-11-14T09:37:23Z 2019-11-14T09:37:31Z 2019-11-14T09:41:16Z 2019-11-14T09:41:19Z 2019-11-14T09:16:47Z 2019-11-14T09:41:21Z 2019-11-14T09:41:22Z 2019-11-14T09:41:24Z 2019-11-14T09:35:47Z 2019-11-14T09:44:59Z 2019-11-14T09:45:04Z 2019-11-14T09:45:10Z 2019-11-14T09:45:15Z 2019-11-14T09:45:20Z 2019-11-14T09:45:20Z 2019-11-14T09:36:44Z 2019-11-14T10:03:54Z 2019-11-14T10:54:42Z 2019-11-14T10:20:58Z cyt Function_for_reaction_1 Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Eqc SOCS3Inh 2019-11-14T10:24:19Z cyt Function_for_reaction_2 EpoRpJAK2 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 2019-11-14T10:24:30Z cyt Function_for_reaction_3 EpoRActJAK2 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh 2019-11-14T10:24:45Z cyt Function_for_reaction_4 EpoRActJAK2 EpoRCISInh EpoRJAK2_CIS EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh 2019-11-14T10:24:55Z cyt Function_for_reaction_5 EpoRActJAK2 EpoRCISInh EpoRJAK2_CIS SOCS3 SOCS3Eqc SOCS3Inh p1EpoRpJAK2 2019-11-14T10:25:29Z cyt Function_for_reaction_6 EpoRActJAK2 SOCS3 SOCS3Eqc SOCS3Inh p2EpoRpJAK2 2019-11-14T10:25:39Z cyt Function_for_reaction_7 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p1EpoRpJAK2 2019-11-14T10:25:42Z cyt Function_for_reaction_8 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p2EpoRpJAK2 2019-11-14T10:25:43Z cyt Function_for_reaction_9 JAK2EpoRDeaSHP1 SHP1Act init_SHP1 p12EpoRpJAK2 2019-11-14T10:21:48Z cyt Function_for_reaction_10 EpoRCISRemove EpoRJAK2_CIS init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 2019-11-14T10:21:51Z cyt Function_for_reaction_11 EpoRpJAK2 SHP1 SHP1ActEpoR init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 2019-11-14T10:21:54Z cyt SHP1Dea SHP1Act 2019-11-14T10:21:56Z cyt Function_for_reaction_13 EpoRpJAK2 SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActJAK2 init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 2019-11-14T10:22:35Z cyt Function_for_reaction_14 CIS CISEqc CISInh SOCS3 SOCS3Eqc SOCS3Inh STAT5 STAT5ActEpoR init_EpoRJAK2 p12EpoRpJAK2 p1EpoRpJAK2 2019-11-14T10:24:09Z Function_for_reaction_15 STAT5Imp cyt pSTAT5 2019-11-14T10:24:09Z Function_for_reaction_16 STAT5Exp npSTAT5 nuc 2019-11-14T10:24:15Z nuc Function_for_reaction_17 ActD CISRNAEqc CISRNATurn init_STAT5 npSTAT5 nuc 2019-11-14T10:24:17Z nuc CISRNADelay CISnRNA1 2019-11-14T10:24:19Z nuc CISRNADelay CISnRNA2 2019-11-14T10:24:19Z nuc CISRNADelay CISnRNA3 2019-11-14T10:24:23Z nuc CISRNADelay CISnRNA4 2019-11-14T10:24:24Z Function_for_reaction_22 CISRNADelay CISnRNA5 nuc 2019-11-14T10:24:24Z cyt CISRNATurn CISRNA 2019-11-14T10:24:25Z cyt Function_for_reaction_24 CISEqc CISRNA CISRNAEqc CISTurn 2019-11-14T10:24:25Z cyt CISTurn CIS 2019-11-14T10:24:26Z cyt Function_for_reaction_26 CISEqc CISEqcOE CISTurn CISoe cyt 2019-11-14T10:24:26Z nuc Function_for_reaction_27 ActD SOCS3RNAEqc SOCS3RNATurn init_STAT5 npSTAT5 nuc 2019-11-14T10:24:26Z nuc SOCS3RNADelay SOCS3nRNA1 2019-11-14T10:24:29Z nuc SOCS3RNADelay SOCS3nRNA2 2019-11-14T10:24:30Z nuc SOCS3RNADelay SOCS3nRNA3 2019-11-14T10:24:41Z nuc SOCS3RNADelay SOCS3nRNA4 2019-11-14T10:24:42Z Function_for_reaction_32 SOCS3RNADelay SOCS3nRNA5 nuc 2019-11-14T10:24:42Z cyt SOCS3RNATurn SOCS3RNA 2019-11-14T10:24:43Z cyt Function_for_reaction_34 SOCS3Eqc SOCS3RNA SOCS3RNAEqc SOCS3Turn 2019-11-14T10:24:44Z cyt SOCS3Turn SOCS3 2019-11-14T10:24:45Z cyt Function_for_reaction_36 SOCS3Eqc SOCS3EqcOE SOCS3Turn SOCS3oe cyt