Model reproduces the various plots in Figure 6 and 7 of the paper. It was successfully tested on MathSBML.


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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Dharuri Harish hdharuri@cds.caltech.edu California Institute of Technology 2007-08-06T15:09:19Z 2014-10-10T10:25:03Z k9_stimulated k9_basal x12 PI3K k9_basal 0.1 kminus11 x13 0.31 3.1 0.31 0.1 kminus12 x13 0.31 3.1 0.31 0.2 x17 0.8 x19 APequil 40 60 4 96 kminus13 Effect x4 x5 CellSurface k1 x1 x2 kminus1 x3 CellSurface k3 x3 CellSurface k2 x1 x5 kminus2 x4 CellSurface kminus3 PTP x5 CellSurface k4 x2 kminus4 x6 CellSurface k4prime x4 kminus4prime x7 CellSurface k4prime x5 kminus4prime x8 Intracellular k5 Intracellular kminus5 x6 Intracellular k6 PTP x7 Intracellular k6 PTP x8 Intracellular k7 x9 x4 x5 IRp kminus7 PTP x10 Intracellular k8 x10 x11 kminus8 x12 Intracellular k9 x14 kminus9 PTEN x13 Intracellular k10 x15 kminus10 SHIP x13 Intracellular k11 x16 kminus11 x17 Intracellular k12 x18 kminus12 x19 Intracellular k14 Intracellular kminus14 x20 Intracellular k13 k13prime x20 kminus13 x21

When time is greater than or equal to 15 minutes Insulin input is set to zero

 t 15 0

This is the condition to assign values to k5 as given in the appendix

 x6 x7 x8 100 1.67 -2 x6 x7 x8 100 0.1002