Proinsulin
type: Protein
xref: P01308

LEFT 0 conversion Insulin elimination Insulin STOICHIOMETRY
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 1.0

RIGHT 0 conversion proinsulin sec up f STOICHIOMETRY
type: Stoichiometry
physical entity: f
stoichiometric coefficient: 1.0

a1c7
type: PhysicalEntity

a1c8
type: PhysicalEntity

a1c9
type: PhysicalEntity

Glucose
type: SmallMolecule
xref: CHEBI:17234

a1c3
type: PhysicalEntity

a1c4
type: PhysicalEntity

a1c5
type: PhysicalEntity

IL1b
type: PhysicalEntity
member physical entity: IL1b
cellular location: default_compartment

Glucose_production
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Glucose production Glucose STOICHIOMETRY
right: Glucose

a1c6
type: PhysicalEntity

CL:0000232
type: UnificationXref
id: CL:0000232

IL1Ra
type: Protein
xref: P18510

Bcell_replication
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Bcell replication B STOICHIOMETRY
right: B

Proinsulin_elimination
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Proinsulin elimination Proinsulin STOICHIOMETRY
left: Proinsulin

LEFT 0 conversion Anakinra elimination Anakinra STOICHIOMETRY
type: Stoichiometry
physical entity: Anakinra
stoichiometric coefficient: 1.0

LEFT 0 conversion Basal glucose uptake Glucose STOICHIOMETRY
type: Stoichiometry
physical entity: Glucose
stoichiometric coefficient: 1.0

RIGHT 0 conversion IL1b treatment IL1b STOICHIOMETRY
type: Stoichiometry
physical entity: IL1b
stoichiometric coefficient: 1.0

Bcell_apoptosis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Bcell apoptosis B STOICHIOMETRY
left: B

MODEL1604270002
type: UnificationXref
id: MODEL1604270002
db: BioModels Database

default_compartment
type: CellularLocationVocabulary

Insulin
type: Protein
xref: P01308

LEFT 0 conversion AnakinraSC elimination Anakinrasc STOICHIOMETRY
type: Stoichiometry
physical entity: Anakinrasc
stoichiometric coefficient: 1.0

Basal_glucose_uptake
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Basal glucose uptake Glucose STOICHIOMETRY
left: Glucose

GO:0030073
type: UnificationXref
id: GO:0030073
db: Gene Ontology

LEFT 0 conversion Proinsulin dependent glucose uptake Glucose STOICHIOMETRY
type: Stoichiometry
physical entity: Glucose
stoichiometric coefficient: 1.0

a1c1
type: PhysicalEntity

a1c2
type: PhysicalEntity

P18510
type: UnificationXref
id: P18510
db: UniProt Knowledgebase

TigB
type: PhysicalEntity
xref: GO:0030073

LEFT 0 conversion Insulin dependent glucose uptake Glucose STOICHIOMETRY
type: Stoichiometry
physical entity: Glucose
stoichiometric coefficient: 1.0

Glucose_dependent_insulin_secretion
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Glucose dependent insulin secretion Insulin STOICHIOMETRY
right: Insulin

GO:0050702
type: UnificationXref
id: GO:0050702
db: Gene Ontology

f
type: PhysicalEntity
member physical entity: f
cellular location: default_compartment

B
type: PhysicalEntity
xref: BTO:0000783

LEFT 0 conversion proinsulin sec down f STOICHIOMETRY
type: Stoichiometry
physical entity: f
stoichiometric coefficient: 1.0

LEFT 0 conversion Bcell apoptosis B STOICHIOMETRY
type: Stoichiometry
physical entity: B
stoichiometric coefficient: 1.0

RIGHT 0 conversion IL1b placebo IL1b STOICHIOMETRY
type: Stoichiometry
physical entity: IL1b
stoichiometric coefficient: 1.0

rbc8
type: PhysicalEntity
xref: CL:0000232

Anakinrasc
type: Protein
xref: P18510

rbc7
type: PhysicalEntity
xref: CL:0000232

RIGHT 0 conversion Glucose dependent proinsulin secretion Proinsulin STOICHIOMETRY
type: Stoichiometry
physical entity: Proinsulin
stoichiometric coefficient: 1.0

rbc9
type: PhysicalEntity
xref: CL:0000232

Glucose
type: PhysicalEntity
member physical entity: Glucose
cellular location: default_compartment

rbc4
type: PhysicalEntity
xref: CL:0000232

IL1b_placebo
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion IL1b placebo IL1b STOICHIOMETRY
right: IL1b

rbc3
type: PhysicalEntity
xref: CL:0000232

Proinsulin
type: PhysicalEntity
member physical entity: Proinsulin
cellular location: default_compartment

rbc6
type: PhysicalEntity
xref: CL:0000232

MODEL1604270002
type: Pathway
pathway component: proinsulin_sec_up
pathway component: Insulin_dependent_glucose_uptake
pathway component: Bcell_apoptosis
pathway component: Glucose_dependent_proinsulin_secretion
pathway component: Insulin_elimination
pathway component: IL1b_degradation
pathway component: TigB_up
pathway component: Basal_glucose_uptake
pathway component: Glucose_production
pathway component: proinsulin_sec_down
pathway component: Anakinra_absorption
pathway component: TigB_down
pathway component: IL1b_treatment
pathway component: IL1b_placebo
pathway component: Bcell_replication
pathway component: AnakinraSC_elimination
pathway component: Proinsulin_elimination
pathway component: Anakinra_elimination
pathway component: Glucose_dependent_insulin_secretion
pathway component: Proinsulin_dependent_glucose_uptake
xref: BIOMD0000000620
xref: http://identifiers.org/pubmed/24918743
xref: DOID:9352
xref: MODEL1604270002
xref: MODEL1112110003
xref: GO:0050702
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on 23-Jun-2017 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'MODEL1604270002', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

rbc5
type: PhysicalEntity
xref: CL:0000232

Glucose
type: PhysicalEntity
member physical entity: Glucose
cellular location: default_compartment

MODEL1112110003
type: UnificationXref
id: MODEL1112110003
db: BioModels Database

http://identifiers.org/pubmed/24918743
type: PublicationXref
id: 24918743
db: PubMed

Glucose
type: PhysicalEntity
member physical entity: Glucose
cellular location: default_compartment

Glucose_dependent_proinsulin_secretion
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Glucose dependent proinsulin secretion Proinsulin STOICHIOMETRY
right: Proinsulin

CHEBI:52217
type: UnificationXref
id: CHEBI:52217
db: ChEBI

f
type: PhysicalEntity
xref: GO:0030073

IL1b
type: PhysicalEntity
member physical entity: IL1b
cellular location: default_compartment

Insulin_elimination
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Insulin elimination Insulin STOICHIOMETRY
left: Insulin

rbc2
type: PhysicalEntity
xref: CL:0000232

rbc1
type: PhysicalEntity
xref: CL:0000232

P01308
type: UnificationXref
id: P01308
db: UniProt Knowledgebase

CHEBI:17234
type: UnificationXref
id: CHEBI:17234
db: ChEBI

Anakinra
type: PhysicalEntity
member physical entity: Anakinra
cellular location: default_compartment

Anakinra
type: SmallMolecule
xref: P18510
xref: CHEBI:52217

RIGHT 0 conversion Glucose dependent insulin secretion Insulin STOICHIOMETRY
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 1.0

BIOMD0000000620
type: UnificationXref
id: BIOMD0000000620
db: BioModels Database

LEFT 0 conversion IL1b degradation IL1b STOICHIOMETRY
type: Stoichiometry
physical entity: IL1b
stoichiometric coefficient: 1.0

BTO:0000783
type: UnificationXref
id: BTO:0000783

TigB
type: PhysicalEntity
member physical entity: TigB
cellular location: default_compartment

TigB_down
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion TigB down TigB STOICHIOMETRY
left: TigB

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

IL1b
type: PhysicalEntity
member physical entity: IL1b
cellular location: default_compartment

IL1b
type: Protein
xref: P01584

RIGHT 0 conversion Bcell replication B STOICHIOMETRY
type: Stoichiometry
physical entity: B
stoichiometric coefficient: 1.0

Proinsulin_dependent_glucose_uptake
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Proinsulin dependent glucose uptake Glucose STOICHIOMETRY
left: Glucose

Insulin
type: PhysicalEntity
member physical entity: Insulin
cellular location: default_compartment

proinsulin_sec_up
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion proinsulin sec up f STOICHIOMETRY
right: f

IL1b_degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion IL1b degradation IL1b STOICHIOMETRY
left: IL1b

TigB_up
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion TigB up TigB STOICHIOMETRY
right: TigB

Anakinra_absorption
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Anakinra absorption Anakinra STOICHIOMETRY
right: Anakinra

B
type: PhysicalEntity
member physical entity: B
cellular location: default_compartment

Proinsulin
type: PhysicalEntity
member physical entity: Proinsulin
cellular location: default_compartment

a1c12
type: PhysicalEntity

Anakinra
type: PhysicalEntity
member physical entity: Anakinra
cellular location: default_compartment

a1c10
type: PhysicalEntity

a1c11
type: PhysicalEntity

RIGHT 0 conversion TigB up TigB STOICHIOMETRY
type: Stoichiometry
physical entity: TigB
stoichiometric coefficient: 1.0

B
type: PhysicalEntity
member physical entity: B
cellular location: default_compartment

f
type: PhysicalEntity
member physical entity: f
cellular location: default_compartment

LEFT 0 conversion Proinsulin elimination Proinsulin STOICHIOMETRY
type: Stoichiometry
physical entity: Proinsulin
stoichiometric coefficient: 1.0

DOID:9352
type: UnificationXref
id: DOID:9352
db: Human Disease Ontology

P01584
type: UnificationXref
id: P01584
db: UniProt Knowledgebase

AnakinraSC_elimination
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion AnakinraSC elimination Anakinrasc STOICHIOMETRY
left: Anakinrasc

RIGHT 0 conversion Anakinra absorption Anakinra STOICHIOMETRY
type: Stoichiometry
physical entity: Anakinra
stoichiometric coefficient: 1.0

Anakinra_elimination
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Anakinra elimination Anakinra STOICHIOMETRY
left: Anakinra

hba1c
type: PhysicalEntity

BioModels Database
type: Provenance
xref: BIOMD0000000620

rbc12
type: PhysicalEntity
xref: CL:0000232

Insulin_dependent_glucose_uptake
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Insulin dependent glucose uptake Glucose STOICHIOMETRY
left: Glucose

Insulin
type: PhysicalEntity
member physical entity: Insulin
cellular location: default_compartment

rbc10
type: PhysicalEntity
xref: CL:0000232

rbc11
type: PhysicalEntity
xref: CL:0000232

Anakinrasc
type: PhysicalEntity
member physical entity: Anakinrasc
cellular location: default_compartment

LEFT 0 conversion TigB down TigB STOICHIOMETRY
type: Stoichiometry
physical entity: TigB
stoichiometric coefficient: 1.0

TigB
type: PhysicalEntity
member physical entity: TigB
cellular location: default_compartment

BioModels Database
type: Provenance
xref: MODEL1604270002

Glucose
type: PhysicalEntity
member physical entity: Glucose
cellular location: default_compartment

proinsulin_sec_down
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion proinsulin sec down f STOICHIOMETRY
left: f

IL1b_treatment
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion IL1b treatment IL1b STOICHIOMETRY
right: IL1b

RIGHT 0 conversion Glucose production Glucose STOICHIOMETRY
type: Stoichiometry
physical entity: Glucose
stoichiometric coefficient: 1.0