species_13
type: PhysicalEntity
member physical entity: P90RskInactive
cellular location: compartment

species_23
type: PhysicalEntity
member physical entity: bRafActive
cellular location: compartment

LEFT 0 conversion reaction 10 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

Q9Z1I2
type: UnificationXref
id: Q9Z1I2
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 22 species 20 STOICHIOMETRY
type: Stoichiometry
physical entity: species_20
stoichiometric coefficient: 1.0

Q9Z1I1
type: UnificationXref
id: Q9Z1I1
db: UniProt Knowledgebase

F1LV89
type: UnificationXref
id: F1LV89
db: UniProt Knowledgebase

species_6
type: PhysicalEntity
member physical entity: Raf1Active
cellular location: compartment

species_15
type: PhysicalEntity
member physical entity: PI3KInactive
cellular location: compartment

DOID:162
type: UnificationXref
id: DOID:162
db: Human Disease Ontology

species_20
type: PhysicalEntity
member physical entity: C3GInactive
cellular location: compartment

LEFT 0 conversion reaction 27 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

species_14
type: PhysicalEntity
member physical entity: PI3KActive
cellular location: compartment

RIGHT 0 conversion reaction 21 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

species_21
type: PhysicalEntity
member physical entity: Rap1Active
cellular location: compartment

RIGHT 0 conversion reaction 15 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

species_24
type: PhysicalEntity
member physical entity: bRafInactive
cellular location: compartment

species_18
type: PhysicalEntity
member physical entity: degradedEGFReceptor
cellular location: compartment

RIGHT 0 conversion reaction 19 species 7 STOICHIOMETRY
type: Stoichiometry
physical entity: species_7
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 23 species 22 STOICHIOMETRY
type: Stoichiometry
physical entity: species_22
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 10 species 11 STOICHIOMETRY
type: Stoichiometry
physical entity: species_11
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: SosInactive
cellular location: compartment

GO:0007173
type: UnificationXref
id: GO:0007173
db: Gene Ontology

LEFT 0 conversion reaction 28 species 30 STOICHIOMETRY
type: Stoichiometry
physical entity: species_30
stoichiometric coefficient: 1.0

Q63484
type: UnificationXref
id: Q63484
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 4 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 11 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

species_16
type: PhysicalEntity
member physical entity: AktActive
cellular location: compartment

LEFT 0 conversion reaction 25 species 24 STOICHIOMETRY
type: Stoichiometry
physical entity: species_24
stoichiometric coefficient: 1.0

species_8
type: PhysicalEntity
member physical entity: MekActive
cellular location: compartment

species_9
type: PhysicalEntity
member physical entity: MekInactive
cellular location: compartment

RIGHT 0 conversion reaction 28 species 1 STOICHIOMETRY
type: Stoichiometry
physical entity: species_1
stoichiometric coefficient: 1.0

http://identifiers.org/taxonomy/10116
type: UnificationXref
id: 10116
db: Taxonomy

species_17
type: PhysicalEntity
member physical entity: AktInactive
cellular location: compartment

RIGHT 0 conversion reaction 12 species 13 STOICHIOMETRY
type: Stoichiometry
physical entity: species_13
stoichiometric coefficient: 1.0

species_25
type: PhysicalEntity
member physical entity: EGF
cellular location: compartment

RIGHT 0 conversion reaction 1 species 2 STOICHIOMETRY
type: Stoichiometry
physical entity: species_2
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 26 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

species_3
type: PhysicalEntity
member physical entity: SosInactive
cellular location: compartment

Q63531
type: UnificationXref
id: Q63531
db: UniProt Knowledgebase

LEFT 0 conversion reaction 22 species 19 STOICHIOMETRY
type: Stoichiometry
physical entity: species_19
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 2 species 2 STOICHIOMETRY
type: Stoichiometry
physical entity: species_2
stoichiometric coefficient: 1.0

species_20
type: PhysicalEntity
member physical entity: C3GInactive
cellular location: compartment

Rap1Gap
type: Protein
xref: F1LV89

LEFT 0 conversion reaction 3 species 5 STOICHIOMETRY
type: Stoichiometry
physical entity: species_5
stoichiometric coefficient: 1.0

RasGapActive
type: Protein
xref: P50904

Raf1PPtase
type: PhysicalEntity
xref: GO:1903293

PP2AActive
type: PhysicalEntity
xref: GO:0000159

EGF
type: Protein
xref: P07522

bRafInactive
type: Protein
xref: F1M9C3

bRafActive
type: Protein
xref: F1M9C3

species_15
type: PhysicalEntity
member physical entity: PI3KInactive
cellular location: compartment

species_30
type: PhysicalEntity
member physical entity: proEGFReceptor
cellular location: compartment

Rap1Inactive
type: Protein
xref: Q62636

Rap1Active
type: Protein
xref: Q62636

C3GInactive
type: Protein
xref: Q9QYV3

species_7
type: PhysicalEntity
member physical entity: Raf1Inactive
cellular location: compartment

RIGHT 0 conversion reaction 8 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 13 species 2 STOICHIOMETRY
type: Stoichiometry
physical entity: species_2
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 17 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 24 species 22 STOICHIOMETRY
type: Stoichiometry
physical entity: species_22
stoichiometric coefficient: 1.0

species_14
type: PhysicalEntity
member physical entity: PI3KActive
cellular location: compartment

LEFT 0 conversion reaction 29 species 1 STOICHIOMETRY
type: Stoichiometry
physical entity: species_1
stoichiometric coefficient: 1.0

C3GActive
type: Protein
xref: Q9QYV3

degradedEGFReceptor
type: Protein
xref: Q9QX70

AktInactive
type: Protein
xref: Q63484
xref: P47196
xref: P47197

AktActive
type: Protein
xref: Q63484
xref: P47196
xref: P47197

PI3KInactive
type: Protein
xref: Q63787

PI3KActive
type: Protein
xref: Q63787

P90RskInactive
type: Protein
xref: Q9Z1I2
xref: Q63531

P90RskActive
type: Protein
xref: Q9Z1I2
xref: Q63531

ErkInactive
type: Protein
xref: P21708
xref: P63086

ErkActive
type: Protein
xref: P21708
xref: P63086

RIGHT 0 conversion reaction 26 species 24 STOICHIOMETRY
type: Stoichiometry
physical entity: species_24
stoichiometric coefficient: 1.0

species_10
type: PhysicalEntity
member physical entity: ErkActive
cellular location: compartment

species_11
type: PhysicalEntity
member physical entity: ErkInactive
cellular location: compartment

species_23
type: PhysicalEntity
member physical entity: bRafActive
cellular location: compartment

species_0
type: PhysicalEntity
member physical entity: boundEGFReceptor
cellular location: compartment

RIGHT 0 conversion reaction 2 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 15 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

species_1
type: PhysicalEntity
member physical entity: freeEGFReceptor
cellular location: compartment

GO:0005623
type: UnificationXref
id: GO:0005623
db: Gene Ontology

LEFT 0 conversion reaction 8 species 8 STOICHIOMETRY
type: Stoichiometry
physical entity: species_8
stoichiometric coefficient: 1.0

Q63787
type: UnificationXref
id: Q63787
db: UniProt Knowledgebase

species_2
type: PhysicalEntity
member physical entity: SosActive
cellular location: compartment

RIGHT 0 conversion reaction 30 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

species_24
type: PhysicalEntity
member physical entity: bRafInactive
cellular location: compartment

LEFT 0 conversion reaction 11 species 13 STOICHIOMETRY
type: Stoichiometry
physical entity: species_13
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 29 species 18 STOICHIOMETRY
type: Stoichiometry
physical entity: species_18
stoichiometric coefficient: 1.0

species_11
type: PhysicalEntity
member physical entity: ErkInactive
cellular location: compartment

species_19
type: PhysicalEntity
member physical entity: C3GActive
cellular location: compartment

species_4
type: PhysicalEntity
member physical entity: RasActive
cellular location: compartment

GO:1903293
type: UnificationXref
id: GO:1903293
db: Gene Ontology

proEGFReceptor
type: Protein
xref: Q9QX70

species_12
type: PhysicalEntity
member physical entity: P90RskActive
cellular location: compartment

GO:0000159
type: UnificationXref
id: GO:0000159
db: Gene Ontology

LEFT 0 conversion reaction 14 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

species_14
type: PhysicalEntity
member physical entity: PI3KActive
cellular location: compartment

MekActive
type: Protein
xref: P36506
xref: Q01986

Raf1Inactive
type: Protein
xref: P11345

LEFT 0 conversion reaction 5 species 7 STOICHIOMETRY
type: Stoichiometry
physical entity: species_7
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 4 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

MekInactive
type: Protein
xref: Q01986
xref: P36506

RasActive
type: Protein
xref: IPR020849

SosInactive
type: Protein
xref: Q9Z1I1

RIGHT 0 conversion reaction 9 species 10 STOICHIOMETRY
type: Stoichiometry
physical entity: species_10
stoichiometric coefficient: 1.0

Raf1Active
type: Protein
xref: P11345

RasInactive
type: Protein
xref: IPR020849

boundEGFReceptor
type: Protein
xref: Q9QX70

LEFT 0 conversion reaction 21 species 20 STOICHIOMETRY
type: Stoichiometry
physical entity: species_20
stoichiometric coefficient: 1.0

SosActive
type: Protein
xref: Q9Z1I1

freeEGFReceptor
type: Protein
xref: Q9QX70

species_2
type: PhysicalEntity
member physical entity: SosActive
cellular location: compartment

RIGHT 0 conversion reaction 25 species 23 STOICHIOMETRY
type: Stoichiometry
physical entity: species_23
stoichiometric coefficient: 1.0

Q62636
type: UnificationXref
id: Q62636
db: UniProt Knowledgebase

species_7
type: PhysicalEntity
member physical entity: Raf1Inactive
cellular location: compartment

species_2
type: PhysicalEntity
member physical entity: SosActive
cellular location: compartment

Raf1_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 6 species 7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 6 species 6 STOICHIOMETRY
right: species_7
left: species_6

Raf1_Activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 5 species 6 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 5 species 7 STOICHIOMETRY
right: species_6
left: species_7

Mek_Deactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 8 species 8 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 8 species 9 STOICHIOMETRY
right: species_9
left: species_8

Mek_Activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 7 species 8 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 7 species 9 STOICHIOMETRY
right: species_8
left: species_9

BIOMD0000000033
type: UnificationXref
id: BIOMD0000000033
db: BioModels Database

Erk_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 9 species 11 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 9 species 10 STOICHIOMETRY
right: species_10
left: species_11

RIGHT 0 conversion reaction 5 species 6 STOICHIOMETRY
type: Stoichiometry
physical entity: species_6
stoichiometric coefficient: 1.0

species_22
type: PhysicalEntity
member physical entity: Rap1Inactive
cellular location: compartment

EGF_Binding_Unbinding
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 0 species 0 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion reaction 0 species 1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 0 species 25 STOICHIOMETRY
right: species_0
left: species_1
left: species_25

RIGHT 0 conversion reaction 17 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 24 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

Sos_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 2 species 3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 2 species 2 STOICHIOMETRY
right: species_3
left: species_2

Sos_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 1 species 3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 1 species 2 STOICHIOMETRY
right: species_2
left: species_3

species_5
type: PhysicalEntity
member physical entity: RasInactive
cellular location: compartment

Ras_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 4 species 5 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 4 species 4 STOICHIOMETRY
right: species_5
left: species_4

Ras_Activation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 3 species 4 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 3 species 5 STOICHIOMETRY
right: species_4
left: species_5

LEFT 0 conversion reaction 19 species 6 STOICHIOMETRY
type: Stoichiometry
physical entity: species_6
stoichiometric coefficient: 1.0

species_8
type: PhysicalEntity
member physical entity: MekActive
cellular location: compartment

LEFT 0 conversion reaction 0 species 25 STOICHIOMETRY
type: Stoichiometry
physical entity: species_25
stoichiometric coefficient: 1.0

P11345
type: UnificationXref
id: P11345
db: UniProt Knowledgebase

P21708
type: UnificationXref
id: P21708
db: UniProt Knowledgebase

P07522
type: UnificationXref
id: P07522
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 7 species 8 STOICHIOMETRY
type: Stoichiometry
physical entity: species_8
stoichiometric coefficient: 1.0

LEFT 1 conversion reaction 0 species 1 STOICHIOMETRY
type: Stoichiometry
physical entity: species_1
stoichiometric coefficient: 1.0

species_9
type: PhysicalEntity
member physical entity: MekInactive
cellular location: compartment

species_15
type: PhysicalEntity
member physical entity: PI3KInactive
cellular location: compartment

bRaf_Activation_Ras
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 30 species 24 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 30 species 23 STOICHIOMETRY
right: species_23
left: species_24

species_16
type: PhysicalEntity
member physical entity: AktActive
cellular location: compartment

species_10
type: PhysicalEntity
member physical entity: ErkActive
cellular location: compartment

P50904
type: UnificationXref
id: P50904
db: UniProt Knowledgebase

species_1
type: PhysicalEntity
member physical entity: freeEGFReceptor
cellular location: compartment

species_6
type: PhysicalEntity
member physical entity: Raf1Active
cellular location: compartment

species_23
type: PhysicalEntity
member physical entity: bRafActive
cellular location: compartment

Q9QX70
type: UnificationXref
id: Q9QX70
db: UniProt Knowledgebase

species_24
type: PhysicalEntity
member physical entity: bRafInactive
cellular location: compartment

P36506
type: UnificationXref
id: P36506
db: UniProt Knowledgebase

P47196
type: UnificationXref
id: P47196
db: UniProt Knowledgebase

MODEL1611280000
type: Pathway
pathway component: Akt_Activation
pathway component: PI3K_Deactivation
pathway component: PI3K_Activation_Ras
pathway component: PI3K_Activation_EGFR
pathway component: Raf1_Deactivation_Akt
pathway component: Akt_Deactivation
pathway component: bRaf_Activation_Ras
pathway component: Sos_Feedback_Deactivation
pathway component: P90Rsk_Deactivation
pathway component: P90Rsk_Activation
pathway component: Erk_Deactivation
pathway component: Raf1_Deactivation
pathway component: Raf1_Activation
pathway component: Mek_Deactivation
pathway component: Mek_Activation
pathway component: Erk_Activation
pathway component: EGFReceptor_Production
pathway component: Mek_Activation_bRaf
pathway component: EGF_Binding_Unbinding
pathway component: bRaf_Deactivation
pathway component: bRaf_Activation
pathway component: Sos_Deactivation
pathway component: Sos_Activation
pathway component: Ras_Deactivation
pathway component: Ras_Activation
pathway component: EGFReceptor_Degradtion_Free
pathway component: EGFReceptor_Degradation
pathway component: Rap1_Deactivation
pathway component: Rap1_Activation
pathway component: C3G_Deactivation
pathway component: C3G_Activation
xref: http://identifiers.org/pubmed/19804630
xref: BIOMD0000000033
xref: GO:0007173
xref: BTO:0001009
xref: DOID:162
xref: MODEL1611280000
xref: BIOMD0000000623
organism: biosource 1
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'MODEL1611280000', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

P47197
type: UnificationXref
id: P47197
db: UniProt Knowledgebase

species_7
type: PhysicalEntity
member physical entity: Raf1Inactive
cellular location: compartment

species_17
type: PhysicalEntity
member physical entity: AktInactive
cellular location: compartment

LEFT 0 conversion reaction 18 species 16 STOICHIOMETRY
type: Stoichiometry
physical entity: species_16
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 14 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

Akt_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 17 species 17 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 17 species 16 STOICHIOMETRY
right: species_16
left: species_17

PI3K_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 16 species 15 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 16 species 14 STOICHIOMETRY
right: species_15
left: species_14

PI3K_Activation_Ras
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 15 species 14 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 15 species 15 STOICHIOMETRY
right: species_14
left: species_15

PI3K_Activation_EGFR
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 14 species 15 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 14 species 14 STOICHIOMETRY
right: species_14
left: species_15

Raf1_Deactivation_Akt
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 19 species 6 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 19 species 7 STOICHIOMETRY
right: species_7
left: species_6

species_13
type: PhysicalEntity
member physical entity: P90RskInactive
cellular location: compartment

Akt_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 18 species 17 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 18 species 16 STOICHIOMETRY
right: species_17
left: species_16

RIGHT 0 conversion reaction 3 species 4 STOICHIOMETRY
type: Stoichiometry
physical entity: species_4
stoichiometric coefficient: 1.0

species_22
type: PhysicalEntity
member physical entity: Rap1Inactive
cellular location: compartment

Sos_Feedback_Deactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 13 species 2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 13 species 3 STOICHIOMETRY
right: species_3
left: species_2

P90Rsk_Deactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 12 species 12 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 12 species 13 STOICHIOMETRY
right: species_13
left: species_12

P90Rsk_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 11 species 13 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 11 species 12 STOICHIOMETRY
right: species_12
left: species_13

Erk_Deactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 10 species 10 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 10 species 11 STOICHIOMETRY
right: species_11
left: species_10

RIGHT 0 conversion reaction 16 species 15 STOICHIOMETRY
type: Stoichiometry
physical entity: species_15
stoichiometric coefficient: 1.0

BIOMD0000000623
type: UnificationXref
id: BIOMD0000000623
db: BioModels Database

species_4
type: PhysicalEntity
member physical entity: RasActive
cellular location: compartment

species_1
type: PhysicalEntity
member physical entity: freeEGFReceptor
cellular location: compartment

LEFT 0 conversion reaction 6 species 6 STOICHIOMETRY
type: Stoichiometry
physical entity: species_6
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 20 species 0 STOICHIOMETRY
type: Stoichiometry
physical entity: species_0
stoichiometric coefficient: 1.0

BTO:0001009
type: UnificationXref
id: BTO:0001009
db: Brenda Tissue Ontology

IPR020849
type: UnificationXref
id: IPR020849
db: InterPro

RIGHT 0 conversion reaction 20 species 18 STOICHIOMETRY
type: Stoichiometry
physical entity: species_18
stoichiometric coefficient: 1.0

EGFReceptor_Production
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 28 species 30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 28 species 1 STOICHIOMETRY
right: species_1
left: species_30

Mek_Activation_bRaf
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 27 species 8 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 27 species 9 STOICHIOMETRY
right: species_8
left: species_9

bRaf_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 26 species 24 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 26 species 23 STOICHIOMETRY
right: species_24
left: species_23

bRaf_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 25 species 24 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 25 species 23 STOICHIOMETRY
right: species_23
left: species_24

LEFT 0 conversion reaction 7 species 9 STOICHIOMETRY
type: Stoichiometry
physical entity: species_9
stoichiometric coefficient: 1.0

EGFReceptor_Degradtion_Free
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 29 species 18 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 29 species 1 STOICHIOMETRY
right: species_18
left: species_1

EGFReceptor_Degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 20 species 0 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 20 species 18 STOICHIOMETRY
right: species_18
left: species_0

http://identifiers.org/pubmed/19804630
type: PublicationXref
id: 19804630
db: PubMed

LEFT 0 conversion reaction 30 species 24 STOICHIOMETRY
type: Stoichiometry
physical entity: species_24
stoichiometric coefficient: 1.0

Rap1_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 24 species 22 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 24 species 21 STOICHIOMETRY
right: species_22
left: species_21

Rap1_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 23 species 22 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 23 species 21 STOICHIOMETRY
right: species_21
left: species_22

C3G_Deactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion reaction 22 species 20 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion reaction 22 species 19 STOICHIOMETRY
right: species_20
left: species_19

C3G_Activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion reaction 21 species 20 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion reaction 21 species 19 STOICHIOMETRY
right: species_19
left: species_20

Q01986
type: UnificationXref
id: Q01986
db: UniProt Knowledgebase

species_6
type: PhysicalEntity
member physical entity: Raf1Active
cellular location: compartment

species_21
type: PhysicalEntity
member physical entity: Rap1Active
cellular location: compartment

P63086
type: UnificationXref
id: P63086
db: UniProt Knowledgebase

RIGHT 0 conversion reaction 23 species 21 STOICHIOMETRY
type: Stoichiometry
physical entity: species_21
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 18 species 17 STOICHIOMETRY
type: Stoichiometry
physical entity: species_17
stoichiometric coefficient: 1.0

species_5
type: PhysicalEntity
member physical entity: RasInactive
cellular location: compartment

LEFT 0 conversion reaction 12 species 12 STOICHIOMETRY
type: Stoichiometry
physical entity: species_12
stoichiometric coefficient: 1.0

species_9
type: PhysicalEntity
member physical entity: MekInactive
cellular location: compartment

MODEL1611280000
type: UnificationXref
id: MODEL1611280000
db: BioModels Database

RIGHT 0 conversion reaction 27 species 8 STOICHIOMETRY
type: Stoichiometry
physical entity: species_8
stoichiometric coefficient: 1.0

RIGHT 0 conversion reaction 13 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: BIOMD0000000623

species_18
type: PhysicalEntity
member physical entity: degradedEGFReceptor
cellular location: compartment

LEFT 0 conversion reaction 1 species 3 STOICHIOMETRY
type: Stoichiometry
physical entity: species_3
stoichiometric coefficient: 1.0

species_19
type: PhysicalEntity
member physical entity: C3GActive
cellular location: compartment

RIGHT 0 conversion reaction 0 species 0 STOICHIOMETRY
type: Stoichiometry
physical entity: species_0
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 9 species 11 STOICHIOMETRY
type: Stoichiometry
physical entity: species_11
stoichiometric coefficient: 1.0

LEFT 0 conversion reaction 16 species 14 STOICHIOMETRY
type: Stoichiometry
physical entity: species_14
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: MODEL1611280000

RIGHT 0 conversion reaction 6 species 7 STOICHIOMETRY
type: Stoichiometry
physical entity: species_7
stoichiometric coefficient: 1.0

Q9QYV3
type: UnificationXref
id: Q9QYV3
db: UniProt Knowledgebase

F1M9C3
type: UnificationXref
id: F1M9C3
db: UniProt Knowledgebase

species_3
type: PhysicalEntity
member physical entity: SosInactive
cellular location: compartment

species_0
type: PhysicalEntity
member physical entity: boundEGFReceptor
cellular location: compartment

species_8
type: PhysicalEntity
member physical entity: MekActive
cellular location: compartment

compartment
type: CellularLocationVocabulary
xref: GO:0005623

species_12
type: PhysicalEntity
member physical entity: P90RskActive
cellular location: compartment