Mouse Iron Distribution Dynamics

Dynamic model of iron distribution in mice. This model includes only normal iron with the parameters that fit the data from Lopes et al. 2010 for mice fed a deficient iron diet.

This model does not include the radioiron tracer species. It is appropriate to study the properties in conditions where no tracers are used (for example for steady state analysis).

 Tiwari Krishna tiwarik@babraham.ac.uk BioModels Grey Davis grey.davis.93@gmail.com University Tennessee, Knoxville Hope Shevchuck hdshevchuk@WPI.EDU Worcester Polytechnic Institute Parmar Jigneshkumar jparmar@uchc.edu UConn Health Pedro Mendes pmendes@uchc.edu UConn Health 2015-06-12T09:42:50Z 2015-06-12T09:42:50Z 2015-06-12T09:42:50Z tiwarik@babraham.ac.uk Tiwari Krishna BioModels grey.davis.93@gmail.com Grey Davis University Tennessee, Knoxville hdshevchuk@WPI.EDU Hope Shevchuck Worcester Polytechnic Institute pmendes@uchc.edu Pedro Mendes UConn Health jparmar@uchc.edu Parmar Jigneshkumar UConn Health 2016-02-02T15:30:26Z v v 2016-02-01T13:53:03Z k VolCompart Substrate k Substrate VolCompart 2016-05-03T11:09:23Z v volume substrate Km noncompet_inhib Ki v volume substrate Km substrate 1 noncompet_inhib Ki 2015-07-17T14:23:03Z 2015-07-17T15:51:30Z 2015-07-23T16:13:59Z 2016-03-28T09:59:05Z 2016-03-28T09:59:05Z 2015-07-17T14:19:59Z 2015-07-17T14:12:53Z 2015-07-15T15:57:39Z 2015-07-17T14:47:09Z 2015-08-17T21:33:31Z 2015-07-17T14:47:17Z 2015-08-14T09:47:41Z 2016-03-17T09:21:28Z 2016-03-28T09:57:47Z 2016-02-19T12:26:22Z 2016-03-28T09:57:52Z 2015-08-17T21:34:34Z 2016-02-19T12:26:11Z 2015-07-17T14:13:01Z 2016-03-28T09:58:15Z 2015-07-17T14:17:58Z 2016-03-28T09:58:13Z 2015-08-14T10:16:10Z 2015-08-18T09:55:49Z 2016-03-28T09:58:15Z 2016-03-28T09:58:10Z 2016-03-28T09:58:37Z 2016-03-28T09:58:38Z 2016-03-28T09:58:39Z 2015-07-17T14:11:46Z 2015-07-17T14:17:56Z 2015-07-16T12:27:24Z 2016-03-17T09:30:16Z 2015-07-17T14:50:05Z 2015-07-17T14:50:42Z 2015-07-16T12:39:19Z 2015-07-17T14:10:59Z 2016-02-19T11:26:21Z 2015-08-17T15:12:20Z 2015-08-17T15:21:55Z 2015-08-17T15:23:01Z 2015-08-17T15:41:08Z 2016-03-28T09:58:35Z 2016-03-17T10:10:02Z 2016-05-03T15:58:00Z 2016-05-03T15:59:56Z Avogadro FeDuo Avogadro Duodenum FeLiver Avogadro Liver FeSpleen Avogadro Spleen FeRBC Avogadro RBC FeRest Avogadro RestOfBody 2 Fe2Tf Avogadro Plasma Fe1Tf Avogadro Plasma NTBI Avogadro Plasma FeBM Avogadro BoneMarrow FeDuo Avogadro Duodenum FeLiver Avogadro Liver FeSpleen Avogadro Spleen FeRBC Avogadro RBC FeRest Avogadro RestOfBody 2 Fe2Tf Avogadro Plasma Fe1Tf Avogadro Plasma NTBI Avogadro Plasma FeBM Avogadro BoneMarrow ModelValue_28 Duodenum Liver Plasma RBC RestOfBody Spleen 2 Fe2Tf Avogadro Plasma Fe1Tf Avogadro Plasma NTBI Avogadro Plasma Total_Fe__particle 55.845 ModelValue_28 Tf Avogadro Plasma Fe1Tf Avogadro Plasma Fe2Tf Avogadro Plasma Total_Tf__particle ModelValue_28 Plasma Total_Tf__conc 80 FePlasma__particle Plasma ModelValue_28 100 2 Fe2Tf Avogadro Plasma Fe1Tf Avogadro Plasma 2 Tf Avogadro Plasma Fe2Tf Avogadro Plasma Fe1Tf Avogadro Plasma 2015-07-16T11:41:42Z Duodenum Constant_flux__irreversible vDiet 2015-08-14T10:05:10Z Plasma Constant_flux__irreversible v 2015-08-14T10:05:06Z Plasma k1 Hepcidin 2015-08-14T10:04:25Z non_competitive_inhibition VDuoNTBI Duodenum FeDuo Km Hepcidin Ki 2015-07-17T14:09:46Z mass_action__dif_compartments__explicit_volume___1 kInBM Plasma Fe2Tf 2015-07-16T11:44:30Z mass_action__dif_compartments__explicit_volume___1 vRBCSpleen RBC FeRBC 2015-08-14T10:05:11Z non_competitive_inhibition VSpleenNTBI Spleen FeSpleen Km Hepcidin Ki 2015-08-14T10:04:57Z non_competitive_inhibition VLiverNTBI Liver FeLiver Km Hepcidin Ki 2015-08-14T10:05:19Z Plasma kNTBI_Fe1Tf NTBI Tf 2015-08-14T10:04:54Z mass_action__dif_compartments__explicit_volume___1 kDuoLoss Duodenum FeDuo 2015-08-14T10:03:22Z mass_action__dif_compartments__explicit_volume___1 kInLiver Plasma Fe2Tf 2015-08-14T10:04:17Z mass_action__dif_compartments__explicit_volume___1 kInRest Plasma Fe2Tf 2015-07-16T12:06:32Z RestOfBody kRestLoss FeRest 2015-08-14T10:03:15Z mass_action__dif_compartments__explicit_volume___1 kInDuo Plasma Fe2Tf 2015-08-14T10:05:26Z non_competitive_inhibition VRestNTBI RestOfBody FeRest Km Hepcidin Ki 2015-07-16T11:41:43Z Plasma kFe1Tf_Fe2Tf Fe1Tf NTBI 2015-08-14T10:02:31Z mass_action__dif_compartments__explicit_volume___1 kInLiver Plasma Fe1Tf 2015-07-17T14:07:39Z mass_action__dif_compartments__explicit_volume___1 kInBM Plasma Fe1Tf 2015-08-14T10:02:37Z mass_action__dif_compartments__explicit_volume___1 kInRest Plasma Fe1Tf 2015-08-14T10:02:20Z mass_action__dif_compartments__explicit_volume___1 kInDuo Plasma Fe1Tf 2015-07-17T14:07:51Z mass_action__dif_compartments__explicit_volume___1 kInRBC BoneMarrow FeBM 2015-08-14T09:48:55Z mass_action__dif_compartments__explicit_volume___1 kBMSpleen BoneMarrow FeBM