This is a mathematical model that describes the interactions between cytotoxic T cells and tumor cells as influenced by B7-H1 (PD-L1) activity, with a focus on how B7-H1 affects cancer cells apoptosis.

Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-09-12T13:21:49Z 2019-09-12T13:21:49Z 2019-09-12T13:21:49Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI 2019-09-12T13:54:42Z

k T k T

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k1 C E k1 C E

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k_5 C k_5 C 2

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k_p E k_m_1 k_m_2 C k_p E k_m_1 E k_m_2 C

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k C k C

2019-09-16T09:17:16Z 2019-09-12T16:09:26Z 2019-09-12T13:59:58Z 2019-09-12T16:07:20Z 2019-09-12T15:02:39Z 2019-09-12T13:57:47Z 2019-09-12T15:02:50Z 2019-09-12T15:08:21Z 2019-09-12T15:03:18Z 2019-09-12T13:57:37Z 2019-09-12T13:57:38Z 2019-09-12T15:03:20Z 2019-09-12T15:07:05Z 2019-09-12T15:08:22Z

E_init

ModelValue_11 X_Complex

C_Cancer_Uncomplexed X_Complex

100 T_ast T_Cancer_Cell_Total T_ast

10 P_Perforin

X_Complex 1000

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compartment Function_for_X_Complex_Formation k_1 C_Cancer_Uncomplexed E_CTL

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compartment k_2 X_Complex

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compartment k_3 X_Complex

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compartment Function_for_P_Production k_p E_CTL k_m_1 k_m_2 C_Cancer_Uncomplexed

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compartment k_4 P_Perforin C_Cancer_Uncomplexed

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compartment Function_for_C_Growth k C_Cancer_Uncomplexed

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compartment Function_for_C_Carrying_Capacity_Limit k_5 C_Cancer_Uncomplexed

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compartment Function_for_T_Growth k T_ast

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compartment Function_for_C_Carrying_Capacity_Limit k_5 T_ast