RIGHT 0 conversion PSC Growth P PSC STOICHIOMETRY
type: Stoichiometry
physical entity: P_PSC
stoichiometric coefficient: 1.0

CD8_Growth_Constant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CD8 Growth Constant E CD8 STOICHIOMETRY
xref: C18081
right: E_CD8

LEFT 0 conversion CD8 Inactivation E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

E_CD8
type: PhysicalEntity
xref: C12542

GO:0072683
type: UnificationXref
id: GO:0072683
db: Gene Ontology

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

BTO:0000584
type: UnificationXref
id: BTO:0000584

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

NK_Proliferation_Stimulation_IL-2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion NK Proliferation Stimulation IL 2 N Killer STOICHIOMETRY
xref: C18081
right: N_Killer

RIGHT 0 conversion NK Proliferation Stimulation IFNG N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

CL:0002410
type: UnificationXref
id: CL:0002410

LEFT 0 conversion NK Death Treg N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

RIGHT 0 conversion Tumor Growth C PCC STOICHIOMETRY
type: Stoichiometry
physical entity: C_PCC
stoichiometric coefficient: 1.0

LEFT 0 conversion Tumor Removal CD8 C PCC STOICHIOMETRY
type: Stoichiometry
physical entity: C_PCC
stoichiometric coefficient: 1.0

Tumor_Growth
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Tumor Growth C PCC STOICHIOMETRY
xref: C36294
right: C_PCC

H_T_Helper
type: PhysicalEntity
member physical entity: H_T_Helper
cellular location: compartment

LEFT 0 conversion Treg Death Natural R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

compartment
type: CellularLocationVocabulary
xref: C94498

CD8_Proliferation_Stimulation_IL-2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CD8 Proliferation Stimulation IL 2 E CD8 STOICHIOMETRY
xref: C18081
right: E_CD8

Tumor_Removal_CD8
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Tumor Removal CD8 C PCC STOICHIOMETRY
xref: GO:0002419
left: C_PCC

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

RIGHT 0 conversion Thelp Proliferation Stimulation IFNG H T Helper STOICHIOMETRY
type: Stoichiometry
physical entity: H_T_Helper
stoichiometric coefficient: 1.0

RIGHT 0 conversion Thelp Growth Constant H T Helper STOICHIOMETRY
type: Stoichiometry
physical entity: H_T_Helper
stoichiometric coefficient: 1.0

RIGHT 0 conversion Thelp Proliferation Stimulation IL 2 H T Helper STOICHIOMETRY
type: Stoichiometry
physical entity: H_T_Helper
stoichiometric coefficient: 1.0

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

CD8_Death_Treg
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion CD8 Death Treg E CD8 STOICHIOMETRY
xref: GO:0001906
left: E_CD8

Treg_Death_Natural
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Treg Death Natural R T Regulatory STOICHIOMETRY
xref: GO:0008219
left: R_T_Regulatory

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

C36294
type: UnificationXref
id: C36294
db: NCIt

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

BTO:0002417
type: UnificationXref
id: BTO:0002417

H_T_Helper
type: PhysicalEntity
member physical entity: H_T_Helper
cellular location: compartment

CL:0000623
type: UnificationXref
id: CL:0000623

PSC_Death
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion PSC Death P PSC STOICHIOMETRY
xref: GO:0008219
left: P_PSC

Thelp_Growth_Constant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Thelp Growth Constant H T Helper STOICHIOMETRY
xref: C18081
right: H_T_Helper

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

Thelp_Proliferation_Stimulation_IFNG
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Thelp Proliferation Stimulation IFNG H T Helper STOICHIOMETRY
xref: C18081
right: H_T_Helper

Treg_Origination_CD8
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Treg Origination CD8 R T Regulatory STOICHIOMETRY
xref: GO:0030217
right: R_T_Regulatory

C3305
type: UnificationXref
id: C3305
db: NCIt

LEFT 0 conversion CD8 Death Natural E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

NK_Inactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion NK Inactivation N Killer STOICHIOMETRY
xref: GO:0008219
left: N_Killer

R_T_Regulatory
type: PhysicalEntity
xref: BTO:0004520

LEFT 0 conversion NK Inactivation N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

C_PCC
type: PhysicalEntity
member physical entity: C_PCC
cellular location: compartment

GO:0001906
type: UnificationXref
id: GO:0001906
db: Gene Ontology

PSC_Growth
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion PSC Growth P PSC STOICHIOMETRY
xref: C18081
right: P_PSC

LEFT 0 conversion Treg Lysis NK R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

CD8_Inactivation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion CD8 Inactivation E CD8 STOICHIOMETRY
xref: GO:0008219
left: E_CD8

Treg_Growth_Constant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Treg Growth Constant R T Regulatory STOICHIOMETRY
xref: C18081
right: R_T_Regulatory

H_T_Helper
type: PhysicalEntity
member physical entity: H_T_Helper
cellular location: compartment

LEFT 0 conversion PSC Death P PSC STOICHIOMETRY
type: Stoichiometry
physical entity: P_PSC
stoichiometric coefficient: 1.0

H_T_Helper
type: PhysicalEntity
member physical entity: H_T_Helper
cellular location: compartment

LEFT 0 conversion Thelp Death Natural H T Helper STOICHIOMETRY
type: Stoichiometry
physical entity: H_T_Helper
stoichiometric coefficient: 1.0

C_PCC
type: PhysicalEntity
xref: BTO:0000584

Tumor_Interaction_NK
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Tumor Interaction NK C PCC STOICHIOMETRY
xref: GO:0002420
left: C_PCC

Thelp_Death_Natural
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Thelp Death Natural H T Helper STOICHIOMETRY
xref: GO:0008219
left: H_T_Helper

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

CD8_Death_Natural
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion CD8 Death Natural E CD8 STOICHIOMETRY
xref: GO:0008219
left: E_CD8

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

BIOMD0000000811
type: UnificationXref
id: BIOMD0000000811
db: BioModels Database

GO:0030217
type: UnificationXref
id: GO:0030217
db: Gene Ontology

N_Killer
type: PhysicalEntity
member physical entity: N_Killer
cellular location: compartment

Treg_Lysis_NK
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Treg Lysis NK R T Regulatory STOICHIOMETRY
xref: GO:0001906
left: R_T_Regulatory

Thelp_Death_Treg
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion Thelp Death Treg H T Helper STOICHIOMETRY
xref: GO:0001906
left: H_T_Helper

GO:0002419
type: UnificationXref
id: GO:0002419
db: Gene Ontology

NK_Death_Treg
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion NK Death Treg N Killer STOICHIOMETRY
xref: GO:0001906
left: N_Killer

NK_Proliferation_Stimulation_IFNG
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion NK Proliferation Stimulation IFNG N Killer STOICHIOMETRY
xref: C18081
right: N_Killer

C71757
type: UnificationXref
id: C71757
db: NCIt

RIGHT 0 conversion CD8 Recruitment NK E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

CD8_Proliferation_Stimulation_IFNG
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CD8 Proliferation Stimulation IFNG E CD8 STOICHIOMETRY
xref: C18081
right: E_CD8

Treg_Origination_Thelp
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Treg Origination Thelp R T Regulatory STOICHIOMETRY
xref: GO:0030217
right: R_T_Regulatory

Treg_Proliferation_Stimulation_IL-2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Treg Proliferation Stimulation IL 2 R T Regulatory STOICHIOMETRY
xref: C18081
right: R_T_Regulatory

RIGHT 0 conversion Treg Proliferation Stimulation IL 2 R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

MAMO_0000046
type: UnificationXref
id: MAMO_0000046
db: Mathematical Modelling Ontology

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

P_PSC
type: PhysicalEntity
xref: CL:0002410

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

P_PSC
type: PhysicalEntity
member physical entity: P_PSC
cellular location: compartment

LEFT 0 conversion Thelp Death Treg H T Helper STOICHIOMETRY
type: Stoichiometry
physical entity: H_T_Helper
stoichiometric coefficient: 1.0

C_PCC
type: PhysicalEntity
member physical entity: C_PCC
cellular location: compartment

MODEL1909120001
type: UnificationXref
id: MODEL1909120001
db: BioModels Database

C18081
type: UnificationXref
id: C18081
db: NCIt

GO:0002420
type: UnificationXref
id: GO:0002420
db: Gene Ontology

BTO:0004520
type: UnificationXref
id: BTO:0004520

RIGHT 0 conversion CD8 Growth Constant E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

C_PCC
type: PhysicalEntity
member physical entity: C_PCC
cellular location: compartment

RIGHT 0 conversion Treg Origination Thelp R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

H_T_Helper
type: PhysicalEntity
member physical entity: H_T_Helper
cellular location: compartment

C12542
type: UnificationXref
id: C12542

LEFT 0 conversion CD8 Death Treg E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

N_Killer
type: PhysicalEntity
xref: CL:0000623

RIGHT 0 conversion CD8 Proliferation Stimulation IL 2 E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

RIGHT 0 conversion CD8 Proliferation Stimulation IFNG E CD8 STOICHIOMETRY
type: Stoichiometry
physical entity: E_CD8
stoichiometric coefficient: 1.0

CD8_Recruitment_NK
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion CD8 Recruitment NK E CD8 STOICHIOMETRY
xref: GO:0072683
right: E_CD8

LEFT 0 conversion Tumor Interaction NK C PCC STOICHIOMETRY
type: Stoichiometry
physical entity: C_PCC
stoichiometric coefficient: 1.0

GO:0008219
type: UnificationXref
id: GO:0008219
db: Gene Ontology

R_T_Regulatory
type: PhysicalEntity
member physical entity: R_T_Regulatory
cellular location: compartment

He2017 A mathematical model of pancreatic cancer with two kinds of treatments
type: Pathway
pathway component: CD8_Growth_Constant
pathway component: PSC_Death
pathway component: Treg_Lysis_NK
pathway component: Thelp_Death_Treg
pathway component: CD8_Recruitment_NK
pathway component: NK_Death_Treg
pathway component: Thelp_Growth_Constant
pathway component: Thelp_Proliferation_Stimulation_IL-2
pathway component: Thelp_Proliferation_Stimulation_IFNG
pathway component: Treg_Origination_CD8
pathway component: NK_Proliferation_Stimulation_IL-2
pathway component: NK_Proliferation_Stimulation_IFNG
pathway component: NK_Inactivation
pathway component: Tumor_Growth
pathway component: CD8_Proliferation_Stimulation_IL-2
pathway component: CD8_Proliferation_Stimulation_IFNG
pathway component: Treg_Origination_Thelp
pathway component: NK_Growth_Constant
pathway component: Treg_Proliferation_Stimulation_IL-2
pathway component: Tumor_Removal_CD8
pathway component: PSC_Growth
pathway component: CD8_Inactivation
pathway component: Treg_Growth_Constant
pathway component: Tumor_Interaction_NK
pathway component: Thelp_Death_Natural
pathway component: CD8_Death_Natural
pathway component: CD8_Death_Treg
pathway component: Treg_Death_Natural
pathway component: NK_Death
xref: C71757
xref: S021833901750005X
xref: C36294
xref: MODEL1909120001
xref: http://identifiers.org/pubmed/8186756
xref: BIOMD0000000811
xref: MAMO_0000046
xref: C3305
comment: This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
comment: The original model, 'He2017___A_mathematical_model_of_pancreatic_cancer_with_two_kinds_of_treatments', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
data source: BioModels Database

Thelp_Proliferation_Stimulation_IL-2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion Thelp Proliferation Stimulation IL 2 H T Helper STOICHIOMETRY
xref: C18081
right: H_T_Helper

http://identifiers.org/pubmed/8186756
type: PublicationXref
id: 8186756
db: PubMed

H_T_Helper
type: PhysicalEntity
xref: BTO:0002417

RIGHT 0 conversion NK Growth Constant N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

S021833901750005X
type: PublicationXref
id: 10.1142/S021833901750005X
db: DOI

RIGHT 0 conversion Treg Origination CD8 R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

C94498
type: UnificationXref
id: C94498
db: NCIt

NK_Growth_Constant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion NK Growth Constant N Killer STOICHIOMETRY
right: N_Killer

P_PSC
type: PhysicalEntity
member physical entity: P_PSC
cellular location: compartment

BioModels Database
type: Provenance
xref: BIOMD0000000811

RIGHT 0 conversion NK Proliferation Stimulation IL 2 N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

LEFT 0 conversion NK Death N Killer STOICHIOMETRY
type: Stoichiometry
physical entity: N_Killer
stoichiometric coefficient: 1.0

RIGHT 0 conversion Treg Growth Constant R T Regulatory STOICHIOMETRY
type: Stoichiometry
physical entity: R_T_Regulatory
stoichiometric coefficient: 1.0

BioModels Database
type: Provenance
xref: MODEL1909120001

NK_Death
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion NK Death N Killer STOICHIOMETRY
xref: GO:0008219
left: N_Killer

E_CD8
type: PhysicalEntity
member physical entity: E_CD8
cellular location: compartment