This is a mathematical model of pancreatic cancer which includes descriptions of regulatory T cell activity and inhibition therapy. Descriptions of cytokine induced killer immunotherapy are also included.
 Meyer Johannes johannes.p.meyer@gmail.com EMBL-EBI 2019-09-10T12:50:31Z 2019-09-10T12:50:31Z 2019-09-10T12:50:31Z johannes.p.meyer@gmail.com Meyer Johannes EMBL-EBI 2019-09-12T09:24:42Z v v 2019-09-10T15:28:25Z k_p f_p C mu_p P a_p k_p f_p C mu_p C P 1 a_p P 2019-09-10T15:15:45Z d_c E C r_1 R r_2 gamma_2_tau_3 d_c E C 1 r_1 R 1 r_2 gamma_2_tau_3 C 2019-09-10T16:01:27Z r_e N C r_e N C 2019-09-10T14:49:19Z b_c N C b_c N C 2019-09-10T15:56:53Z c_e E C c_e E C 2019-09-10T16:20:53Z p_e H E g_e tau_1_alpha_1 p_e H E g_e tau_1_alpha_1 H 2019-09-10T16:41:42Z f_e E beta_1_tau_2 beta_2_tau_2 N beta_3_tau_2 H h_e f_e E beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H h_e beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H 2019-09-10T16:47:57Z delta_e R E delta_e R E 2019-09-12T09:28:55Z p_n N g_n H tau_1_alpha_1 p_n H N g_n tau_1_alpha_1 H 2019-09-12T09:34:11Z f_n N beta_1_tau_2 E beta_2_tau_2 beta_3_tau_2 H h_n f_n N beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H h_n beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H 2019-09-12T09:55:43Z f_h H beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 h_h f_h H beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H h_h beta_1_tau_2 E beta_2_tau_2 N beta_3_tau_2 H 2019-09-12T09:51:58Z p_h H g_h tau_1_alpha_1 p_h H H g_h tau_1_alpha_1 H 2019-09-12T09:25:57Z c_n N C c_n N C 2019-09-12T10:14:57Z a_r E a_r E 2019-09-12T10:34:31Z k_c mu_c P C a_c k_c mu_c P C 1 a_c C 2019-09-12T10:01:54Z delta_h R H delta_h R H 2019-09-12T10:20:46Z r N R r N R 2019-09-12T10:19:30Z p_r H R g_r tau_1_alpha_1 p_r H R g_r tau_1_alpha_1 H 2019-09-12T10:13:30Z b_r H b_r H 2019-09-12T11:42:22Z 2019-09-10T15:15:49Z 2019-09-12T11:07:24Z 2019-09-12T11:05:24Z 2019-09-12T10:39:28Z 2019-09-12T10:39:13Z 2019-09-12T10:39:34Z 2019-09-12T10:35:10Z 2019-09-10T13:27:45Z 2019-09-10T13:29:06Z 2019-09-10T13:29:29Z 2019-09-10T13:24:13Z 2019-09-12T09:29:33Z a_c a_p k_c 0.1 ModelValue_2 ModelValue_8 0.1 ModelValue_0 2019-09-10T13:39:44Z compartment Function_for_Tumor_Growth k_c mu_c P_PSC C_PCC a_c 2019-09-10T14:48:18Z compartment Function_for_Tumor_Interaction_NK b_c N_Killer C_PCC 2019-09-10T15:15:25Z compartment Function_for_Tumor_Removal_CD8 d_c E_CD8 C_PCC r_1 R_T_Regulatory r_2 gamma_2_tau_3 2019-09-10T15:27:54Z compartment Function_for_PSC_Growth k_p f_p C_PCC mu_p P_PSC a_p 2019-09-10T15:33:33Z compartment lambda_p P_PSC 2019-09-10T15:35:58Z compartment Constant_flux__irreversible a_e 2019-09-10T15:44:26Z compartment b_e E_CD8 2019-09-10T15:56:23Z compartment Function_for_CD8_Inactivation c_e E_CD8 C_PCC 2019-09-10T16:01:10Z compartment Function_for_CD8_Recruitment_NK r_e N_Killer C_PCC 2019-09-10T16:07:38Z compartment Function_for_CD8_Proliferation_Stimulation_IL_2 p_e H_T_Helper E_CD8 g_e tau_1_alpha_1 2019-09-10T16:37:10Z compartment Function_for_CD8_Proliferation_Stimulation_IFNG f_e E_CD8 beta_1_tau_2 beta_2_tau_2 N_Killer beta_3_tau_2 H_T_Helper h_e 2019-09-10T16:47:44Z compartment Function_for_CD8_Death_Treg delta_e R_T_Regulatory E_CD8 compartment Constant_flux__irreversible a_n 2019-09-12T09:24:55Z compartment b_n N_Killer 2019-09-12T09:25:30Z compartment Function_for_NK_Inactivation c_n N_Killer C_PCC 2019-09-12T09:28:36Z compartment Function_for_NK_Proliferation_Stimulation_IL_2 p_n N_Killer g_n H_T_Helper tau_1_alpha_1 2019-09-12T09:34:04Z compartment Function_for_NK_Proliferation_Stimulation_IFNG f_n N_Killer beta_1_tau_2 E_CD8 beta_2_tau_2 beta_3_tau_2 H_T_Helper h_n 2019-09-12T09:39:14Z compartment delta_n N_Killer 2019-09-12T09:49:09Z compartment Constant_flux__irreversible a_h 2019-09-12T09:50:38Z compartment b_h H_T_Helper 2019-09-12T09:51:46Z compartment Function_for_Thelp_Proliferation_Stimulation_IL_2 p_h H_T_Helper g_h tau_1_alpha_1 2019-09-12T09:53:13Z compartment Function_for_Thelp_Proliferation_Stimulation_IFNG f_h H_T_Helper beta_1_tau_2 E_CD8 beta_2_tau_2 N_Killer beta_3_tau_2 h_h 2019-09-12T09:58:53Z compartment Function_for_Thelp_Death_Treg delta_h R_T_Regulatory H_T_Helper 2019-09-12T10:04:46Z compartment Constant_flux__irreversible a 2019-09-12T10:06:24Z compartment delta_r R_T_Regulatory 2019-09-12T10:10:03Z compartment Function_for_Treg_Origination_Thelp b_r H_T_Helper 2019-09-12T10:14:07Z compartment Function_for_Treg_Origination_CD8 a_r E_CD8 2019-09-12T10:19:08Z compartment Function_for_Treg_Proliferation_Stimulation_IL_2 p_r H_T_Helper R_T_Regulatory g_r tau_1_alpha_1 2019-09-12T10:20:33Z compartment Function_for_Treg_Lysis_NK r N_Killer R_T_Regulatory