S30
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~u,alpha!1,beta,loc~m)
cellular location: Vol_cell

S24
type: PhysicalEntity
member physical entity: Ras(state~GDP)
cellular location: Vol_cell

LEFT 0 conversion R20 S14 STOICHIOMETRY
type: Stoichiometry
physical entity: S14
stoichiometric coefficient: 1.0

P14672
type: UnificationXref
id: P14672
db: UniProt Knowledgebase

RIGHT 0 conversion R16 S11 STOICHIOMETRY
type: Stoichiometry
physical entity: S11
stoichiometric coefficient: 1.0

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

LEFT 0 conversion R13 S10 STOICHIOMETRY
type: Stoichiometry
physical entity: S10
stoichiometric coefficient: 1.0

S33
type: PhysicalEntity
member physical entity: IRS1(S636~p,Y~u,Y896,YXXM)
cellular location: Vol_cell

RIGHT 0 conversion R51 S24 STOICHIOMETRY
type: Stoichiometry
physical entity: S24
stoichiometric coefficient: 1.0

S60
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~c)
cellular location: Vol_cell

LEFT 0 conversion R43 S38 STOICHIOMETRY
type: Stoichiometry
physical entity: S38
stoichiometric coefficient: 1.0

RIGHT 0 conversion R40 S6 STOICHIOMETRY
type: Stoichiometry
physical entity: S6
stoichiometric coefficient: 1.0

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

S35
type: PhysicalEntity
member physical entity: PKC(T410~p)
cellular location: Vol_cell

LEFT 0 conversion R59 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

RIGHT 0 conversion R25 S42 STOICHIOMETRY
type: Stoichiometry
physical entity: S42
stoichiometric coefficient: 1.0

S57
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~c)
cellular location: Vol_cell

LEFT 0 conversion R38 S34 STOICHIOMETRY
type: Stoichiometry
physical entity: S34
stoichiometric coefficient: 1.0

S54
type: PhysicalEntity
member physical entity: Raf(state~aa)
cellular location: Vol_cell

LEFT 0 conversion R58 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

S61
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY!3,Y999~p,alpha!1,beta!2,loc~m).RasGAP(bs!3)
cellular location: Vol_cell

S34
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~p)
cellular location: Vol_cell

RIGHT 0 conversion R15 S11 STOICHIOMETRY
type: Stoichiometry
physical entity: S11
stoichiometric coefficient: 1.0

S58
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY!2,Y999~p,alpha!1,beta,loc~m).RasGAP(bs!2)
cellular location: Vol_cell

S28
type: PhysicalEntity
member physical entity: SynthG4()
cellular location: Vol_cell

S17
type: PhysicalEntity
member physical entity: mTORC2(S2481~u)
cellular location: Vol_cell

Lipid formation rate
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R11 S8 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R11 S9 STOICHIOMETRY
right: S9
left: S8

LEFT 0 conversion R30 S27 STOICHIOMETRY
type: Stoichiometry
physical entity: S27
stoichiometric coefficient: 1.0

Lipids formation 134
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R10 S8 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R10 S9 STOICHIOMETRY
right: S8
left: S9

PKC phosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R13 S10 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R13 S35 STOICHIOMETRY
right: S35
left: S10

Akt phosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R12 S15 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R12 S34 STOICHIOMETRY
right: S34
left: S15

S12
type: PhysicalEntity
member physical entity: GLUT4(loc~m)
cellular location: Vol_cell

GLUT4 translocation internalize
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R15 S12 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R15 S11 STOICHIOMETRY
right: S11
left: S12

S43
type: PhysicalEntity
member physical entity: Src(state~a)
cellular location: Vol_cell

GLUT4 translocation externalize
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R14 S12 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R14 S11 STOICHIOMETRY
right: S12
left: S11

GLUT4 degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R17 S11 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R17 S31 STOICHIOMETRY
right: S31
left: S11

GLUT4 synthesis
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R16 S11 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R16 S28 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R16 S28 STOICHIOMETRY
right: S11
right: S28
left: S28

IRS1 phosphorylation by P70S6K
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R19 S33 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R19 S4 STOICHIOMETRY
right: S33
left: S4

PI3k variant phosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R18 S36 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R18 S6 STOICHIOMETRY
right: S36
left: S6

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

RIGHT 0 conversion R30 S47 STOICHIOMETRY
type: Stoichiometry
physical entity: S47
stoichiometric coefficient: 1.0

S29
type: PhysicalEntity
member physical entity: SynthIR()
cellular location: Vol_cell

LEFT 0 conversion R72 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

S45
type: PhysicalEntity
member physical entity: Raf(state~a)
cellular location: Vol_cell

S22
type: PhysicalEntity
member physical entity: SHP2(SH2)
cellular location: Vol_cell

AMPK_T172 phosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R20 S14 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R20 S37 STOICHIOMETRY
right: S37
left: S14

TSC1-TSC2 S1387_phosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R22 S39 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R22 S19 STOICHIOMETRY
right: S39
left: S19

Akt phosphorylation in Ser mediated by mTORC2_pS2481
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R21 S38 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R21 S15 STOICHIOMETRY
right: S38
left: S15

mTORC2 phosphorylation mediated by phosphorylated PI3K_variant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R24 S41 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R24 S17 STOICHIOMETRY
right: S41
left: S17

mTORC1 phosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R23 S16 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R23 S40 STOICHIOMETRY
right: S40
left: S16

Src module active
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R26 S43 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R26 S23 STOICHIOMETRY
right: S43
left: S23

p70S6K phosphorylation mediated by mTORC1_pS2448
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R25 S18 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R25 S42 STOICHIOMETRY
right: S42
left: S18

RAF module active
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R28 S45 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R28 S25 STOICHIOMETRY
right: S45
left: S25

S2
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~m)
cellular location: Vol_cell

RAS module GTP
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R27 S24 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R27 S44 STOICHIOMETRY
right: S44
left: S24

RIGHT 0 conversion R60 S5 STOICHIOMETRY
type: Stoichiometry
physical entity: S5
stoichiometric coefficient: 1.0

RIGHT 0 conversion R14 S12 STOICHIOMETRY
type: Stoichiometry
physical entity: S12
stoichiometric coefficient: 1.0

Mek phosphorylated
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R29 S26 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R29 S46 STOICHIOMETRY
right: S46
left: S26

LEFT 0 conversion R5 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

RIGHT 0 conversion R67 S25 STOICHIOMETRY
type: Stoichiometry
physical entity: S25
stoichiometric coefficient: 1.0

RIGHT 1 conversion R77 S50 STOICHIOMETRY
type: Stoichiometry
physical entity: S50
stoichiometric coefficient: 1.0

RIGHT 0 conversion R8 S8 STOICHIOMETRY
type: Stoichiometry
physical entity: S8
stoichiometric coefficient: 1.0

RIGHT 0 conversion R2 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

RIGHT 1 conversion R76 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

GS inhibition
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R31 S48 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R31 S20 STOICHIOMETRY
right: S48
left: S20

ERK module phosphorylated 1
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R30 S47 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R30 S27 STOICHIOMETRY
right: S47
left: S27

Receptor phosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R33 S30 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R33 S49 STOICHIOMETRY
right: S49
left: S30

Receptor releasing1st insulin molecule
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R32 S30 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R32 S2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R32 S1 STOICHIOMETRY
right: S2
right: S1
left: S30

IRS-1 dephosphorylation in Ser
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R35 S33 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R35 S4 STOICHIOMETRY
right: S4
left: S33

IRS-1 dephosphorylation in Tyr
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R34 S4 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R34 S32 STOICHIOMETRY
right: S4
left: S32

RIGHT 1 conversion R32 S2 STOICHIOMETRY
type: Stoichiometry
physical entity: S2
stoichiometric coefficient: 1.0

Akt phosphorylation in Tyr
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R37 S51 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R37 S38 STOICHIOMETRY
right: S51
left: S38

S60
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~c)
cellular location: Vol_cell

IRS-1_PI3-K complex formation (PI3-K activation)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R36 S5 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R36 S32 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R36 S50 STOICHIOMETRY
right: S50
left: S5
left: S32

S1
type: PhysicalEntity
member physical entity: I(bs)
cellular location: Vol_cell

LEFT 0 conversion R21 S15 STOICHIOMETRY
type: Stoichiometry
physical entity: S15
stoichiometric coefficient: 1.0

LEFT 0 conversion R39 S35 STOICHIOMETRY
type: Stoichiometry
physical entity: S35
stoichiometric coefficient: 1.0

PKC dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R39 S10 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R39 S35 STOICHIOMETRY
right: S10
left: S35

Akt dephosphorylation in Tyr
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R38 S34 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R38 S15 STOICHIOMETRY
right: S15
left: S34

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

LEFT 0 conversion R74 S57 STOICHIOMETRY
type: Stoichiometry
physical entity: S57
stoichiometric coefficient: 1.0

RIGHT 0 conversion R1 S30 STOICHIOMETRY
type: Stoichiometry
physical entity: S30
stoichiometric coefficient: 1.0

LEFT 0 conversion R26 S23 STOICHIOMETRY
type: Stoichiometry
physical entity: S23
stoichiometric coefficient: 1.0

LEFT 0 conversion R14 S11 STOICHIOMETRY
type: Stoichiometry
physical entity: S11
stoichiometric coefficient: 1.0

S5
type: PhysicalEntity
member physical entity: PI3K(SH2)
cellular location: Vol_cell

PI3K_variant dephosphorylation by IRp
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R40 S36 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R40 S6 STOICHIOMETRY
right: S6
left: S36

P35568
type: UnificationXref
id: P35568
db: UniProt Knowledgebase

S33
type: PhysicalEntity
member physical entity: IRS1(S636~p,Y~u,Y896,YXXM)
cellular location: Vol_cell

Akt phosphorylation in Ser mediated by mTORC2_pS2481_2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R42 S34 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R42 S51 STOICHIOMETRY
right: S51
left: S34

AMPK_T172_dephosphorylation mediated by IRS1_pY
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R41 S14 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R41 S37 STOICHIOMETRY
right: S14
left: S37

LEFT 0 conversion R44 S39 STOICHIOMETRY
type: Stoichiometry
physical entity: S39
stoichiometric coefficient: 1.0

TSC1-TSC2 S1387_dephosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R44 S19 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R44 S39 STOICHIOMETRY
right: S19
left: S39

Akt dephosphorylation in Ser mediated by mTORC2_pS2481
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R43 S38 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R43 S15 STOICHIOMETRY
right: S15
left: S38

mTORC2 dephosphorylation mediated by phosphorylated PI3K_variant
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R46 S17 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R46 S41 STOICHIOMETRY
right: S17
left: S41

S52
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM)
cellular location: Vol_cell

mTORC1 dephosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R45 S40 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R45 S16 STOICHIOMETRY
right: S16
left: S40

Src module inactive
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R48 S43 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R48 S23 STOICHIOMETRY
right: S23
left: S43

p70S6K dephosphorylation mediated by mTORC1_pS2448
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R47 S42 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R47 S18 STOICHIOMETRY
right: S18
left: S42

IRS1-GS complex formation
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R49 S32 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R49 S20 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R49 S52 STOICHIOMETRY
right: S52
left: S32
left: S20

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R70 S22 STOICHIOMETRY
type: Stoichiometry
physical entity: S22
stoichiometric coefficient: 1.0

RIGHT 0 conversion R26 S43 STOICHIOMETRY
type: Stoichiometry
physical entity: S43
stoichiometric coefficient: 1.0

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

LEFT 0 conversion R50 S22 STOICHIOMETRY
type: Stoichiometry
physical entity: S22
stoichiometric coefficient: 1.0

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

RIGHT 0 conversion R61 S38 STOICHIOMETRY
type: Stoichiometry
physical entity: S38
stoichiometric coefficient: 1.0

Ras module GDP
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R51 S44 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R51 S24 STOICHIOMETRY
right: S24
left: S44

IRS1-SHP2 complex formation
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R50 S32 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R50 S53 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R50 S22 STOICHIOMETRY
right: S53
left: S22
left: S32

MEK dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R53 S26 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R53 S46 STOICHIOMETRY
right: S26
left: S46

RAF module active-active
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R52 S45 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R52 S54 STOICHIOMETRY
right: S54
left: S45

RIGHT 1 conversion R79 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

ERK module y204_y187 dephosphorylation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R55 S47 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R55 S55 STOICHIOMETRY
right: S55
left: S47

ERK module dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R54 S27 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R54 S47 STOICHIOMETRY
right: S27
left: S47

LEFT 0 conversion R56 S48 STOICHIOMETRY
type: Stoichiometry
physical entity: S48
stoichiometric coefficient: 1.0

Receptor binding 2nd insulin molecule
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R57 S49 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R57 S56 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R57 S1 STOICHIOMETRY
right: S56
left: S49
left: S1

LEFT 0 conversion R71 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

GS activation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R56 S48 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R56 S20 STOICHIOMETRY
right: S20
left: S48

Phosphorylated receptor internalization
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R59 S57 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R59 S49 STOICHIOMETRY
right: S57
left: S49

Receptor unbinding and dephosphorylation (on the cell membrane)
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R58 S2 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R58 S1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R58 S49 STOICHIOMETRY
right: S2
right: S1
left: S49

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

LEFT 0 conversion R17 S11 STOICHIOMETRY
type: Stoichiometry
physical entity: S11
stoichiometric coefficient: 1.0

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

RIGHT 0 conversion R73 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

S18
type: PhysicalEntity
member physical entity: p70S6K(T389~u)
cellular location: Vol_cell

S28
type: PhysicalEntity
member physical entity: SynthG4()
cellular location: Vol_cell

IRS-1_PI3-K complex dissociation (PI3-K inactivation)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R60 S50 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R60 S32 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R60 S5 STOICHIOMETRY
right: S32
right: S5
left: S50

S15
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~u)
cellular location: Vol_cell

Akt dephosphorylation in Tyr phosphorylated form
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R62 S34 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R62 S51 STOICHIOMETRY
right: S34
left: S51

Akt phosphorylation/dephosphorylation in Tyr
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R61 S51 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R61 S38 STOICHIOMETRY
right: S38
left: S51

IRS1-GS complex formation_2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R64 S20 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R64 S50 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R64 S59 STOICHIOMETRY
right: S59
left: S50
left: S20

RasGAP module_forward
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R63 S21 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R63 S58 STOICHIOMETRY
participant stoichiometry: LEFT 1 conversion R63 S49 STOICHIOMETRY
right: S58
left: S49
left: S21

Receptor binding to 1st insulin molecule
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R1 S2 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R1 S1 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R1 S30 STOICHIOMETRY
right: S30
left: S2
left: S1

IRS1-SHP2 complex dissociation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R66 S22 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R66 S53 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R66 S32 STOICHIOMETRY
right: S32
right: S22
left: S53

Free receptor internalization
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R2 S3 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R2 S2 STOICHIOMETRY
right: S3
left: S2

LEFT 0 conversion R27 S24 STOICHIOMETRY
type: Stoichiometry
physical entity: S24
stoichiometric coefficient: 1.0

IRS1-GS complex dissociation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R65 S20 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R65 S32 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R65 S52 STOICHIOMETRY
right: S20
right: S32
left: S52

Free receptor externalization
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R3 S3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R3 S2 STOICHIOMETRY
right: S2
left: S3

ERK module phosphorylated and Y187 dephosphorylated
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R68 S47 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R68 S55 STOICHIOMETRY
right: S47
left: S55

receptor synthesis
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R4 S29 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R4 S29 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R4 S3 STOICHIOMETRY
right: S29
right: S3
left: S29

RAF module inactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R67 S25 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R67 S54 STOICHIOMETRY
right: S25
left: S54

Receptor Degradation
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R5 S3 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R5 S31 STOICHIOMETRY
right: S31
left: S3

IRS-1 phosphorylation in Tyr
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R6 S4 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R6 S32 STOICHIOMETRY
right: S32
left: S4

IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R69 S20 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R69 S52 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R69 S32 STOICHIOMETRY
right: S20
right: S32
left: S52

IRS-1 phosphorylation in Ser
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R7 S33 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R7 S4 STOICHIOMETRY
right: S33
left: S4

RIGHT 0 conversion R77 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

Lipid formation 145
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R8 S7 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R8 S8 STOICHIOMETRY
right: S8
left: S7

PI45 formation
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R9 S7 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R9 S8 STOICHIOMETRY
right: S7
left: S8

S44
type: PhysicalEntity
member physical entity: Ras(state~GTP)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

S11
type: PhysicalEntity
member physical entity: GLUT4(loc~c)
cellular location: Vol_cell

S42
type: PhysicalEntity
member physical entity: p70S6K(T389~p)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

http://identifiers.org/pubmed/27245161
type: PublicationXref
id: 27245161
db: PubMed

S27
type: PhysicalEntity
member physical entity: Erk(T202_T185~u,Y204_Y187~u)
cellular location: Vol_cell

LEFT 1 conversion R50 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

S4
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~u,Y896,YXXM)
cellular location: Vol_cell

S4
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~u,Y896,YXXM)
cellular location: Vol_cell

RIGHT 1 conversion R71 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

RIGHT 1 conversion R82 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

P49815
type: UnificationXref
id: P49815
db: UniProt Knowledgebase

LEFT 0 conversion R49 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

LEFT 0 conversion R83 S61 STOICHIOMETRY
type: Stoichiometry
physical entity: S61
stoichiometric coefficient: 1.0

RIGHT 0 conversion R9 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

LEFT 0 conversion R3 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

S2
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~m)
cellular location: Vol_cell

S47
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~u)
cellular location: Vol_cell

RIGHT 0 conversion R52 S54 STOICHIOMETRY
type: Stoichiometry
physical entity: S54
stoichiometric coefficient: 1.0

LEFT 0 conversion R34 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S19
type: PhysicalEntity
member physical entity: TSC1_TSC2(S1387~u,T1462~p)
cellular location: Vol_cell

LEFT 0 conversion R40 S36 STOICHIOMETRY
type: Stoichiometry
physical entity: S36
stoichiometric coefficient: 1.0

RIGHT 0 conversion R62 S34 STOICHIOMETRY
type: Stoichiometry
physical entity: S34
stoichiometric coefficient: 1.0

LEFT 0 conversion R2 S2 STOICHIOMETRY
type: Stoichiometry
physical entity: S2
stoichiometric coefficient: 1.0

RIGHT 0 conversion R44 S19 STOICHIOMETRY
type: Stoichiometry
physical entity: S19
stoichiometric coefficient: 1.0

LEFT 1 conversion R49 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

S50
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
cellular location: Vol_cell

S53
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896!1,YXXM).SHP2(SH2!1)
cellular location: Vol_cell

LEFT 0 conversion R75 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

RIGHT 0 conversion R27 S44 STOICHIOMETRY
type: Stoichiometry
physical entity: S44
stoichiometric coefficient: 1.0

LEFT 0 conversion R67 S54 STOICHIOMETRY
type: Stoichiometry
physical entity: S54
stoichiometric coefficient: 1.0

LEFT 0 conversion R55 S47 STOICHIOMETRY
type: Stoichiometry
physical entity: S47
stoichiometric coefficient: 1.0

S43
type: PhysicalEntity
member physical entity: Src(state~a)
cellular location: Vol_cell

S38
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~u)
cellular location: Vol_cell

LEFT 0 conversion R79 S58 STOICHIOMETRY
type: Stoichiometry
physical entity: S58
stoichiometric coefficient: 1.0

RIGHT 0 conversion R38 S15 STOICHIOMETRY
type: Stoichiometry
physical entity: S15
stoichiometric coefficient: 1.0

S1
type: PhysicalEntity
member physical entity: I(bs)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

Vol_cell
type: CellularLocationVocabulary

S19
type: PhysicalEntity
member physical entity: TSC1_TSC2(S1387~u,T1462~p)
cellular location: Vol_cell

S11
type: PhysicalEntity
member physical entity: GLUT4(loc~c)
cellular location: Vol_cell

LEFT 1 conversion R57 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

RIGHT 0 conversion R72 S60 STOICHIOMETRY
type: Stoichiometry
physical entity: S60
stoichiometric coefficient: 1.0

RIGHT 0 conversion R76 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

RIGHT 0 conversion R83 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

LEFT 0 conversion R35 S33 STOICHIOMETRY
type: Stoichiometry
physical entity: S33
stoichiometric coefficient: 1.0

S31
type: PhysicalEntity
member physical entity: Degr()
cellular location: Vol_cell

S30
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~u,alpha!1,beta,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R74 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

LEFT 0 conversion R15 S12 STOICHIOMETRY
type: Stoichiometry
physical entity: S12
stoichiometric coefficient: 1.0

S6
type: PhysicalEntity
member physical entity: PI3K_variant(Y~u)
cellular location: Vol_cell

P01308
type: UnificationXref
id: P01308
db: UniProt Knowledgebase

LEFT 0 conversion R28 S25 STOICHIOMETRY
type: Stoichiometry
physical entity: S25
stoichiometric coefficient: 1.0

S41
type: PhysicalEntity
member physical entity: mTORC2(S2481~p)
cellular location: Vol_cell

S4
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~u,Y896,YXXM)
cellular location: Vol_cell

S2
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~m)
cellular location: Vol_cell

S57
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~c)
cellular location: Vol_cell

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

LEFT 0 conversion R45 S40 STOICHIOMETRY
type: Stoichiometry
physical entity: S40
stoichiometric coefficient: 1.0

S26
type: PhysicalEntity
member physical entity: Mek(S218_S222~u)
cellular location: Vol_cell

RIGHT 0 conversion R56 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

RIGHT 1 conversion R83 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

LEFT 0 conversion R24 S17 STOICHIOMETRY
type: Stoichiometry
physical entity: S17
stoichiometric coefficient: 1.0

S8
type: PhysicalEntity
member physical entity: PI345()
cellular location: Vol_cell

http://identifiers.org/taxonomy/9606
type: UnificationXref
id: 9606
db: Taxonomy

RIGHT 0 conversion R43 S15 STOICHIOMETRY
type: Stoichiometry
physical entity: S15
stoichiometric coefficient: 1.0

LEFT 0 conversion R18 S6 STOICHIOMETRY
type: Stoichiometry
physical entity: S6
stoichiometric coefficient: 1.0

LEFT 0 conversion R9 S8 STOICHIOMETRY
type: Stoichiometry
physical entity: S8
stoichiometric coefficient: 1.0

RIGHT 0 conversion R28 S45 STOICHIOMETRY
type: Stoichiometry
physical entity: S45
stoichiometric coefficient: 1.0

LEFT 0 conversion R41 S37 STOICHIOMETRY
type: Stoichiometry
physical entity: S37
stoichiometric coefficient: 1.0

S16
type: PhysicalEntity
member physical entity: mTORC1(S2448~u)
cellular location: Vol_cell

GLUT4(loc~c)
type: Protein
xref: P14672

PKC(T410~u)
type: Protein
xref: P17252

Amino_Acids()
type: PhysicalEntity

GLUT4(loc~m)
type: Protein
xref: P14672

Akt(S474~u,T309~u)
type: Protein
xref: P31748

AMPK(T172~u)
type: Protein
xref: Q13131

LEFT 0 conversion R66 S53 STOICHIOMETRY
type: Stoichiometry
physical entity: S53
stoichiometric coefficient: 1.0

mTORC2(S2481~u)
type: Protein
xref: P42345

mTORC1(S2448~u)
type: Protein
xref: P42345

TSC1_TSC2(S1387~u,T1462~p)
type: Protein
xref: P49815

p70S6K(T389~u)
type: PhysicalEntity

S7
type: PhysicalEntity
member physical entity: PI45()
cellular location: Vol_cell

RIGHT 0 conversion R81 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

S54
type: PhysicalEntity
member physical entity: Raf(state~aa)
cellular location: Vol_cell

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

Q13131
type: UnificationXref
id: Q13131
db: UniProt Knowledgebase

S16
type: PhysicalEntity
member physical entity: mTORC1(S2448~u)
cellular location: Vol_cell

LEFT 0 conversion R46 S41 STOICHIOMETRY
type: Stoichiometry
physical entity: S41
stoichiometric coefficient: 1.0

DiCamillo2016 Insulin signalling pathway Rule based model
type: Pathway
pathway component: Receptor dissociating 2nd insulin molecule
pathway component: IRS1-GS and IRS1-SHP2 complex formation and IRS1 phosphorylation
pathway component: Phosphorylated receptor externalization
pathway component: Phosphorylated receptor internalization_ 2
pathway component: GS inhibition
pathway component: RasGAP module activation
pathway component: ERK module phosphorylated 1
pathway component: Receptor unbinding and dephosphorylation (inside the cell)
pathway component: Receptor phosphorylation
pathway component: IRS1-GS complex formation_3
pathway component: Receptor releasing1st insulin molecule
pathway component: RasGAP module inactivation
pathway component: IRS-1 dephosphorylation in Ser
pathway component: SHP2 activity against RasGAP
pathway component: IRS-1 dephosphorylation in Tyr
pathway component: IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation _2
pathway component: Akt phosphorylation in Tyr
pathway component: IRS-1_PI3-K complex formation (PI3-K activation)
pathway component: PKC dephosphorylation
pathway component: Akt dephosphorylation in Tyr
pathway component: Phosphorylated receptor internalization_3
pathway component: RasGAP module _2
pathway component: Receptor unbinding and dephosphorylation (inside the cell) _2
pathway component: PI3K_variant dephosphorylation by IRp
pathway component: SHP2 activity against RasGAP_2
pathway component: Akt phosphorylation in Ser mediated by mTORC2_pS2481_2
pathway component: AMPK_T172_dephosphorylation mediated by IRS1_pY
pathway component: TSC1-TSC2 S1387_dephosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
pathway component: Akt dephosphorylation in Ser mediated by mTORC2_pS2481
pathway component: mTORC2 dephosphorylation mediated by phosphorylated PI3K_variant
pathway component: mTORC1 dephosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
pathway component: Src module inactive
pathway component: p70S6K dephosphorylation mediated by mTORC1_pS2448
pathway component: IRS1-GS complex formation
pathway component: Ras module GDP
pathway component: IRS1-SHP2 complex formation
pathway component: MEK dephosphorylation
pathway component: RAF module active-active
pathway component: Lipid formation rate
pathway component: ERK module y204_y187 dephosphorylation
pathway component: Lipids formation 134
pathway component: ERK module dephosphorylation
pathway component: PKC phosphorylation
pathway component: Receptor binding 2nd insulin molecule
pathway component: Akt phosphorylation
pathway component: GS activation
pathway component: GLUT4 translocation internalize
pathway component: Phosphorylated receptor internalization
pathway component: GLUT4 translocation externalize
pathway component: Receptor unbinding and dephosphorylation (on the cell membrane)
pathway component: GLUT4 degradation
pathway component: GLUT4 synthesis
pathway component: IRS1 phosphorylation by P70S6K
pathway component: PI3k variant phosphorylation
pathway component: IRS-1_PI3-K complex dissociation (PI3-K inactivation)
pathway component: Akt dephosphorylation in Tyr phosphorylated form
pathway component: Akt phosphorylation/dephosphorylation in Tyr
pathway component: AMPK_T172 phosphorylation
pathway component: IRS1-GS complex formation_2
pathway component: RasGAP module_forward
pathway component: Receptor binding to 1st insulin molecule
pathway component: TSC1-TSC2 S1387_phosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
pathway component: IRS1-SHP2 complex dissociation
pathway component: Free receptor internalization
pathway component: Akt phosphorylation in Ser mediated by mTORC2_pS2481
pathway component: IRS1-GS complex dissociation
pathway component: Free receptor externalization
pathway component: mTORC2 phosphorylation mediated by phosphorylated PI3K_variant
pathway component: ERK module phosphorylated and Y187 dephosphorylated
pathway component: receptor synthesis
pathway component: mTORC1 phosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
pathway component: RAF module inactivation
pathway component: Receptor Degradation
pathway component: Src module active
pathway component: IRS-1 phosphorylation in Tyr
pathway component: p70S6K phosphorylation mediated by mTORC1_pS2448
pathway component: IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation
pathway component: IRS-1 phosphorylation in Ser
pathway component: RAF module active

LEFT 0 conversion R65 S52 STOICHIOMETRY
type: Stoichiometry
physical entity: S52
stoichiometric coefficient: 1.0

GS(SH2,state~a)
type: PhysicalEntity

S22
type: PhysicalEntity
member physical entity: SHP2(SH2)
cellular location: Vol_cell

SHP2(SH2)
type: PhysicalEntity

S47
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~u)
cellular location: Vol_cell

RIGHT 0 conversion R71 S1 STOICHIOMETRY
type: Stoichiometry
physical entity: S1
stoichiometric coefficient: 1.0

RasGAP(bs)
type: PhysicalEntity

Ras(state~GDP)
type: PhysicalEntity

Src(state~i)
type: PhysicalEntity

Mek(S218_S222~u)
type: Protein
xref: Q02750

Raf(state~i)
type: Protein
xref: P04049

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

SynthG4()
type: PhysicalEntity

LEFT 0 conversion R54 S47 STOICHIOMETRY
type: Stoichiometry
physical entity: S47
stoichiometric coefficient: 1.0

Erk(T202_T185~u,Y204_Y187~u)
type: Protein
xref: P28482

S42
type: PhysicalEntity
member physical entity: p70S6K(T389~p)
cellular location: Vol_cell

SynthIR()
type: PhysicalEntity

S34
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~p)
cellular location: Vol_cell

BioModels Database
type: Provenance
xref: BIOMD0000000833

LEFT 0 conversion R29 S26 STOICHIOMETRY
type: Stoichiometry
physical entity: S26
stoichiometric coefficient: 1.0

S40
type: PhysicalEntity
member physical entity: mTORC1(S2448~p)
cellular location: Vol_cell

RIGHT 0 conversion R58 S1 STOICHIOMETRY
type: Stoichiometry
physical entity: S1
stoichiometric coefficient: 1.0

RIGHT 1 conversion R70 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S57
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~c)
cellular location: Vol_cell

LEFT 1 conversion R75 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

S10
type: PhysicalEntity
member physical entity: PKC(T410~u)
cellular location: Vol_cell

RIGHT 0 conversion R68 S47 STOICHIOMETRY
type: Stoichiometry
physical entity: S47
stoichiometric coefficient: 1.0

S36
type: PhysicalEntity
member physical entity: PI3K_variant(Y~p)
cellular location: Vol_cell

LEFT 1 conversion R63 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

LEFT 0 conversion R73 S57 STOICHIOMETRY
type: Stoichiometry
physical entity: S57
stoichiometric coefficient: 1.0

RIGHT 0 conversion R82 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

S25
type: PhysicalEntity
member physical entity: Raf(state~i)
cellular location: Vol_cell

BioModels Database
type: Provenance
xref: MODEL1604100005

LEFT 0 conversion R16 S28 STOICHIOMETRY
type: Stoichiometry
physical entity: S28
stoichiometric coefficient: 1.0

Degr()
type: PhysicalEntity

I(bs!1).IR(NPXY,Y999~u,alpha!1,beta,loc~m)
type: Protein
xref: P01308

LEFT 1 conversion R36 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

IRS1(S636~p,Y~u,Y896,YXXM)
type: Protein
xref: P35568

IRS1(S636~u,Y~p,Y896,YXXM)
type: Protein
xref: P35568

PKC(T410~p)
type: Protein
xref: P17252

LEFT 0 conversion R23 S16 STOICHIOMETRY
type: Stoichiometry
physical entity: S16
stoichiometric coefficient: 1.0

S48
type: PhysicalEntity
member physical entity: GS(SH2,state~i)
cellular location: Vol_cell

Akt(S474~u,T309~p)
type: Protein
xref: P31748

AMPK(T172~p)
type: Protein
xref: Q13131

PI3K_variant(Y~p)
type: PhysicalEntity

S1
type: PhysicalEntity
member physical entity: I(bs)
cellular location: Vol_cell

TSC1_TSC2(S1387~p,T1462~u)
type: Protein
xref: P49815

Akt(S474~p,T309~u)
type: Protein
xref: P31748

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

S44
type: PhysicalEntity
member physical entity: Ras(state~GTP)
cellular location: Vol_cell

RIGHT 0 conversion R80 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

LEFT 0 conversion R33 S30 STOICHIOMETRY
type: Stoichiometry
physical entity: S30
stoichiometric coefficient: 1.0

LEFT 0 conversion R64 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

S11
type: PhysicalEntity
member physical entity: GLUT4(loc~c)
cellular location: Vol_cell

S45
type: PhysicalEntity
member physical entity: Raf(state~a)
cellular location: Vol_cell

LEFT 0 conversion R25 S18 STOICHIOMETRY
type: Stoichiometry
physical entity: S18
stoichiometric coefficient: 1.0

mTORC1(S2448~p)
type: Protein
xref: P42345

S1
type: PhysicalEntity
member physical entity: I(bs)
cellular location: Vol_cell

RIGHT 0 conversion R49 S52 STOICHIOMETRY
type: Stoichiometry
physical entity: S52
stoichiometric coefficient: 1.0

GO:0008286
type: UnificationXref
id: GO:0008286
db: Gene Ontology

p70S6K(T389~p)
type: PhysicalEntity

mTORC2(S2481~p)
type: Protein
xref: P42345

S15
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~u)
cellular location: Vol_cell

S2
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~m)
cellular location: Vol_cell

Ras(state~GTP)
type: PhysicalEntity

Src(state~a)
type: PhysicalEntity

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

Mek(S218_S222~p)
type: Protein
xref: Q02750

Raf(state~a)
type: Protein
xref: P04049

S14
type: PhysicalEntity
member physical entity: AMPK(T172~u)
cellular location: Vol_cell

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

GS(SH2,state~i)
type: PhysicalEntity

Erk(T202_T185~p,Y204_Y187~u)
type: Protein
xref: P28482

I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
type: Protein
xref: P01308

S8
type: PhysicalEntity
member physical entity: PI345()
cellular location: Vol_cell

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

RIGHT 1 conversion R16 S28 STOICHIOMETRY
type: Stoichiometry
physical entity: S28
stoichiometric coefficient: 1.0

S50
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
cellular location: Vol_cell

S8
type: PhysicalEntity
member physical entity: PI345()
cellular location: Vol_cell

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

LEFT 0 conversion R6 S4 STOICHIOMETRY
type: Stoichiometry
physical entity: S4
stoichiometric coefficient: 1.0

RIGHT 0 conversion R22 S39 STOICHIOMETRY
type: Stoichiometry
physical entity: S39
stoichiometric coefficient: 1.0

RIGHT 1 conversion R4 S29 STOICHIOMETRY
type: Stoichiometry
physical entity: S29
stoichiometric coefficient: 1.0

S1
type: PhysicalEntity
member physical entity: I(bs)
cellular location: Vol_cell

LEFT 1 conversion R64 S50 STOICHIOMETRY
type: Stoichiometry
physical entity: S50
stoichiometric coefficient: 1.0

LEFT 0 conversion R32 S30 STOICHIOMETRY
type: Stoichiometry
physical entity: S30
stoichiometric coefficient: 1.0

Akt(S474~p,T309~p)
type: Protein
xref: P31748

S7
type: PhysicalEntity
member physical entity: PI45()
cellular location: Vol_cell

RIGHT 0 conversion R45 S16 STOICHIOMETRY
type: Stoichiometry
physical entity: S16
stoichiometric coefficient: 1.0

RIGHT 1 conversion R69 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
type: Protein
xref: P35568

RIGHT 0 conversion R29 S46 STOICHIOMETRY
type: Stoichiometry
physical entity: S46
stoichiometric coefficient: 1.0

S58
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY!2,Y999~p,alpha!1,beta,loc~m).RasGAP(bs!2)
cellular location: Vol_cell

IRS1(S636~u,Y~p,Y896!1,YXXM).SHP2(SH2!1)
type: Protein
xref: P35568

GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM)
type: PhysicalEntity

Erk(T202_T185~p,Y204_Y187~p)
type: Protein
xref: P28482

Raf(state~aa)
type: Protein
xref: P04049

I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~c)
type: Protein
xref: P01308

I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
type: Protein
xref: P01308

S41
type: PhysicalEntity
member physical entity: mTORC2(S2481~p)
cellular location: Vol_cell

GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM!2).PI3K(SH2!2)
type: PhysicalEntity

RIGHT 0 conversion R69 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

I(bs!1).IR(NPXY!2,Y999~p,alpha!1,beta,loc~m).RasGAP(bs!2)
type: Protein
xref: P01308

S17
type: PhysicalEntity
member physical entity: mTORC2(S2481~u)
cellular location: Vol_cell

S39
type: PhysicalEntity
member physical entity: TSC1_TSC2(S1387~p,T1462~u)
cellular location: Vol_cell

RIGHT 0 conversion R13 S35 STOICHIOMETRY
type: Stoichiometry
physical entity: S35
stoichiometric coefficient: 1.0

Q02750
type: UnificationXref
id: Q02750
db: UniProt Knowledgebase

I(bs)
type: Protein
xref: P01308

IR(NPXY,Y999~u,alpha,beta,loc~m)
type: Protein
xref: P06213

IR(NPXY,Y999~u,alpha,beta,loc~c)
type: Protein
xref: P06213

IRS1(S636~u,Y~u,Y896,YXXM)
type: Protein
xref: P35568

PI3K(SH2)
type: PhysicalEntity

PI3K_variant(Y~u)
type: PhysicalEntity

LEFT 0 conversion R42 S34 STOICHIOMETRY
type: Stoichiometry
physical entity: S34
stoichiometric coefficient: 1.0

PI45()
type: PhysicalEntity

PI345()
type: PhysicalEntity

PI34()
type: PhysicalEntity

S58
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY!2,Y999~p,alpha!1,beta,loc~m).RasGAP(bs!2)
cellular location: Vol_cell

I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~c)
type: Protein
xref: P01308

S4
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~u,Y896,YXXM)
cellular location: Vol_cell

LEFT 0 conversion R57 S1 STOICHIOMETRY
type: Stoichiometry
physical entity: S1
stoichiometric coefficient: 1.0

I(bs!1).I(bs!2).IR(NPXY!3,Y999~p,alpha!1,beta!2,loc~m).RasGAP(bs!3)
type: Protein
xref: P01308

LEFT 0 conversion R47 S42 STOICHIOMETRY
type: Stoichiometry
physical entity: S42
stoichiometric coefficient: 1.0

S55
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~p)
cellular location: Vol_cell

LEFT 0 conversion R53 S46 STOICHIOMETRY
type: Stoichiometry
physical entity: S46
stoichiometric coefficient: 1.0

LEFT 0 conversion R19 S4 STOICHIOMETRY
type: Stoichiometry
physical entity: S4
stoichiometric coefficient: 1.0

RIGHT 0 conversion R3 S2 STOICHIOMETRY
type: Stoichiometry
physical entity: S2
stoichiometric coefficient: 1.0

LEFT 0 conversion R36 S5 STOICHIOMETRY
type: Stoichiometry
physical entity: S5
stoichiometric coefficient: 1.0

S22
type: PhysicalEntity
member physical entity: SHP2(SH2)
cellular location: Vol_cell

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R6 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

RIGHT 0 conversion R19 S33 STOICHIOMETRY
type: Stoichiometry
physical entity: S33
stoichiometric coefficient: 1.0

RIGHT 1 conversion R66 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S33
type: PhysicalEntity
member physical entity: IRS1(S636~p,Y~u,Y896,YXXM)
cellular location: Vol_cell

S15
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~u)
cellular location: Vol_cell

LEFT 0 conversion R12 S15 STOICHIOMETRY
type: Stoichiometry
physical entity: S15
stoichiometric coefficient: 1.0

P42345
type: UnificationXref
id: P42345
db: UniProt Knowledgebase

RIGHT 0 conversion R11 S9 STOICHIOMETRY
type: Stoichiometry
physical entity: S9
stoichiometric coefficient: 1.0

S9
type: PhysicalEntity
member physical entity: PI34()
cellular location: Vol_cell

LEFT 0 conversion R70 S53 STOICHIOMETRY
type: Stoichiometry
physical entity: S53
stoichiometric coefficient: 1.0

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

P06213
type: UnificationXref
id: P06213
db: UniProt Knowledgebase

LEFT 0 conversion R37 S38 STOICHIOMETRY
type: Stoichiometry
physical entity: S38
stoichiometric coefficient: 1.0

RIGHT 0 conversion R48 S23 STOICHIOMETRY
type: Stoichiometry
physical entity: S23
stoichiometric coefficient: 1.0

LEFT 0 conversion R60 S50 STOICHIOMETRY
type: Stoichiometry
physical entity: S50
stoichiometric coefficient: 1.0

RIGHT 0 conversion R46 S17 STOICHIOMETRY
type: Stoichiometry
physical entity: S17
stoichiometric coefficient: 1.0

S15
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~u)
cellular location: Vol_cell

S46
type: PhysicalEntity
member physical entity: Mek(S218_S222~p)
cellular location: Vol_cell

P28482
type: UnificationXref
id: P28482
db: UniProt Knowledgebase

S40
type: PhysicalEntity
member physical entity: mTORC1(S2448~p)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

S50
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
cellular location: Vol_cell

S9
type: PhysicalEntity
member physical entity: PI34()
cellular location: Vol_cell

P04049
type: UnificationXref
id: P04049
db: UniProt Knowledgebase

S38
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~u)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

LEFT 0 conversion R78 S59 STOICHIOMETRY
type: Stoichiometry
physical entity: S59
stoichiometric coefficient: 1.0

S11
type: PhysicalEntity
member physical entity: GLUT4(loc~c)
cellular location: Vol_cell

S18
type: PhysicalEntity
member physical entity: p70S6K(T389~u)
cellular location: Vol_cell

RIGHT 0 conversion R21 S38 STOICHIOMETRY
type: Stoichiometry
physical entity: S38
stoichiometric coefficient: 1.0

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

S60
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~c)
cellular location: Vol_cell

S8
type: PhysicalEntity
member physical entity: PI345()
cellular location: Vol_cell

LEFT 0 conversion R68 S55 STOICHIOMETRY
type: Stoichiometry
physical entity: S55
stoichiometric coefficient: 1.0

S23
type: PhysicalEntity
member physical entity: Src(state~i)
cellular location: Vol_cell

LEFT 0 conversion R10 S9 STOICHIOMETRY
type: Stoichiometry
physical entity: S9
stoichiometric coefficient: 1.0

RIGHT 0 conversion R34 S4 STOICHIOMETRY
type: Stoichiometry
physical entity: S4
stoichiometric coefficient: 1.0

LEFT 0 conversion R52 S45 STOICHIOMETRY
type: Stoichiometry
physical entity: S45
stoichiometric coefficient: 1.0

P17252
type: UnificationXref
id: P17252
db: UniProt Knowledgebase

LEFT 0 conversion R48 S43 STOICHIOMETRY
type: Stoichiometry
physical entity: S43
stoichiometric coefficient: 1.0

LEFT 0 conversion R63 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

S49
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~p,alpha!1,beta,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R59 S57 STOICHIOMETRY
type: Stoichiometry
physical entity: S57
stoichiometric coefficient: 1.0

RIGHT 0 conversion R33 S49 STOICHIOMETRY
type: Stoichiometry
physical entity: S49
stoichiometric coefficient: 1.0

S50
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
cellular location: Vol_cell

RIGHT 0 conversion R55 S55 STOICHIOMETRY
type: Stoichiometry
physical entity: S55
stoichiometric coefficient: 1.0

S52
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM)
cellular location: Vol_cell

S55
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~p)
cellular location: Vol_cell

LEFT 0 conversion R8 S7 STOICHIOMETRY
type: Stoichiometry
physical entity: S7
stoichiometric coefficient: 1.0

LEFT 0 conversion R22 S19 STOICHIOMETRY
type: Stoichiometry
physical entity: S19
stoichiometric coefficient: 1.0

S27
type: PhysicalEntity
member physical entity: Erk(T202_T185~u,Y204_Y187~u)
cellular location: Vol_cell

S39
type: PhysicalEntity
member physical entity: TSC1_TSC2(S1387~p,T1462~u)
cellular location: Vol_cell

RIGHT 0 conversion R5 S31 STOICHIOMETRY
type: Stoichiometry
physical entity: S31
stoichiometric coefficient: 1.0

S4
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~u,Y896,YXXM)
cellular location: Vol_cell

MODEL1604100005
type: UnificationXref
id: MODEL1604100005
db: BioModels Database

RIGHT 1 conversion R65 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

Receptor dissociating 2nd insulin molecule
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R71 S1 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R71 S56 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R71 S49 STOICHIOMETRY
right: S49
right: S1
left: S56

S29
type: PhysicalEntity
member physical entity: SynthIR()
cellular location: Vol_cell

S53
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896!1,YXXM).SHP2(SH2!1)
cellular location: Vol_cell

IRS1-GS and IRS1-SHP2 complex formation and IRS1 phosphorylation
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R70 S32 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R70 S53 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R70 S22 STOICHIOMETRY
right: S22
right: S32
left: S53

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

Phosphorylated receptor externalization
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R73 S57 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R73 S49 STOICHIOMETRY
right: S49
left: S57

Phosphorylated receptor internalization_ 2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R72 S60 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R72 S56 STOICHIOMETRY
right: S60
left: S56

RasGAP module activation
type: BiochemicalReaction
participant stoichiometry: LEFT 1 conversion R75 S56 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R75 S61 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R75 S21 STOICHIOMETRY
right: S61
left: S56
left: S21

LEFT 0 conversion R76 S58 STOICHIOMETRY
type: Stoichiometry
physical entity: S58
stoichiometric coefficient: 1.0

Receptor unbinding and dephosphorylation (inside the cell)
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R74 S57 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R74 S3 STOICHIOMETRY
right: S3
left: S57

IRS1-GS complex formation_3
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R77 S50 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R77 S59 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R77 S20 STOICHIOMETRY
right: S20
right: S50
left: S59

RasGAP module inactivation
type: BiochemicalReaction
participant stoichiometry: RIGHT 1 conversion R76 S49 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R76 S58 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R76 S21 STOICHIOMETRY
right: S21
right: S49
left: S58

SHP2 activity against RasGAP
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R79 S58 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R79 S49 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R79 S21 STOICHIOMETRY
right: S21
right: S49
left: S58

S38
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~u)
cellular location: Vol_cell

IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation _2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R78 S20 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R78 S59 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R78 S50 STOICHIOMETRY
right: S20
right: S50
left: S59

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

RIGHT 0 conversion R41 S14 STOICHIOMETRY
type: Stoichiometry
physical entity: S14
stoichiometric coefficient: 1.0

S56
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY,Y999~p,alpha!1,beta!2,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R53 S26 STOICHIOMETRY
type: Stoichiometry
physical entity: S26
stoichiometric coefficient: 1.0

LEFT 0 conversion R61 S51 STOICHIOMETRY
type: Stoichiometry
physical entity: S51
stoichiometric coefficient: 1.0

S14
type: PhysicalEntity
member physical entity: AMPK(T172~u)
cellular location: Vol_cell

S34
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~p)
cellular location: Vol_cell

S46
type: PhysicalEntity
member physical entity: Mek(S218_S222~p)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

S52
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM)
cellular location: Vol_cell

RIGHT 0 conversion R79 S21 STOICHIOMETRY
type: Stoichiometry
physical entity: S21
stoichiometric coefficient: 1.0

RIGHT 0 conversion R23 S40 STOICHIOMETRY
type: Stoichiometry
physical entity: S40
stoichiometric coefficient: 1.0

RIGHT 0 conversion R32 S1 STOICHIOMETRY
type: Stoichiometry
physical entity: S1
stoichiometric coefficient: 1.0

RIGHT 0 conversion R47 S18 STOICHIOMETRY
type: Stoichiometry
physical entity: S18
stoichiometric coefficient: 1.0

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

S26
type: PhysicalEntity
member physical entity: Mek(S218_S222~u)
cellular location: Vol_cell

Phosphorylated receptor internalization_3
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R80 S60 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R80 S56 STOICHIOMETRY
right: S56
left: S60

S47
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~u)
cellular location: Vol_cell

RasGAP module _2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R82 S21 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R82 S56 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R82 S61 STOICHIOMETRY
right: S21
right: S56
left: S61

Receptor unbinding and dephosphorylation (inside the cell) _2
type: BiochemicalReaction
participant stoichiometry: LEFT 0 conversion R81 S60 STOICHIOMETRY
participant stoichiometry: RIGHT 0 conversion R81 S3 STOICHIOMETRY
right: S3
left: S60

SHP2 activity against RasGAP_2
type: BiochemicalReaction
participant stoichiometry: RIGHT 0 conversion R83 S21 STOICHIOMETRY
participant stoichiometry: LEFT 0 conversion R83 S61 STOICHIOMETRY
participant stoichiometry: RIGHT 1 conversion R83 S56 STOICHIOMETRY
right: S56
right: S21
left: S61

S53
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896!1,YXXM).SHP2(SH2!1)
cellular location: Vol_cell

RIGHT 0 conversion R20 S37 STOICHIOMETRY
type: Stoichiometry
physical entity: S37
stoichiometric coefficient: 1.0

LEFT 0 conversion R62 S51 STOICHIOMETRY
type: Stoichiometry
physical entity: S51
stoichiometric coefficient: 1.0

S61
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY!3,Y999~p,alpha!1,beta!2,loc~m).RasGAP(bs!3)
cellular location: Vol_cell

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

LEFT 0 conversion R51 S44 STOICHIOMETRY
type: Stoichiometry
physical entity: S44
stoichiometric coefficient: 1.0

RIGHT 0 conversion R42 S51 STOICHIOMETRY
type: Stoichiometry
physical entity: S51
stoichiometric coefficient: 1.0

LEFT 0 conversion R82 S61 STOICHIOMETRY
type: Stoichiometry
physical entity: S61
stoichiometric coefficient: 1.0

BIOMD0000000833
type: UnificationXref
id: BIOMD0000000833
db: BioModels Database

LEFT 1 conversion R1 S2 STOICHIOMETRY
type: Stoichiometry
physical entity: S2
stoichiometric coefficient: 1.0

RIGHT 0 conversion R37 S51 STOICHIOMETRY
type: Stoichiometry
physical entity: S51
stoichiometric coefficient: 1.0

RIGHT 0 conversion R35 S4 STOICHIOMETRY
type: Stoichiometry
physical entity: S4
stoichiometric coefficient: 1.0

RIGHT 0 conversion R18 S36 STOICHIOMETRY
type: Stoichiometry
physical entity: S36
stoichiometric coefficient: 1.0

S23
type: PhysicalEntity
member physical entity: Src(state~i)
cellular location: Vol_cell

RIGHT 0 conversion R39 S10 STOICHIOMETRY
type: Stoichiometry
physical entity: S10
stoichiometric coefficient: 1.0

S51
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~p)
cellular location: Vol_cell

P31748
type: UnificationXref
id: P31748
db: UniProt Knowledgebase

LEFT 0 conversion R11 S8 STOICHIOMETRY
type: Stoichiometry
physical entity: S8
stoichiometric coefficient: 1.0

S10
type: PhysicalEntity
member physical entity: PKC(T410~u)
cellular location: Vol_cell

S38
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~u)
cellular location: Vol_cell

RIGHT 0 conversion R63 S58 STOICHIOMETRY
type: Stoichiometry
physical entity: S58
stoichiometric coefficient: 1.0

RIGHT 0 conversion R54 S27 STOICHIOMETRY
type: Stoichiometry
physical entity: S27
stoichiometric coefficient: 1.0

LEFT 0 conversion R1 S1 STOICHIOMETRY
type: Stoichiometry
physical entity: S1
stoichiometric coefficient: 1.0

RIGHT 0 conversion R17 S31 STOICHIOMETRY
type: Stoichiometry
physical entity: S31
stoichiometric coefficient: 1.0

S21
type: PhysicalEntity
member physical entity: RasGAP(bs)
cellular location: Vol_cell

S6
type: PhysicalEntity
member physical entity: PI3K_variant(Y~u)
cellular location: Vol_cell

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

RIGHT 0 conversion R78 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

RIGHT 0 conversion R65 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

LEFT 0 conversion R31 S20 STOICHIOMETRY
type: Stoichiometry
physical entity: S20
stoichiometric coefficient: 1.0

S51
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~p)
cellular location: Vol_cell

S37
type: PhysicalEntity
member physical entity: AMPK(T172~p)
cellular location: Vol_cell

S30
type: PhysicalEntity
member physical entity: I(bs!1).IR(NPXY,Y999~u,alpha!1,beta,loc~m)
cellular location: Vol_cell

LEFT 0 conversion R77 S59 STOICHIOMETRY
type: Stoichiometry
physical entity: S59
stoichiometric coefficient: 1.0

RIGHT 0 conversion R24 S41 STOICHIOMETRY
type: Stoichiometry
physical entity: S41
stoichiometric coefficient: 1.0

S12
type: PhysicalEntity
member physical entity: GLUT4(loc~m)
cellular location: Vol_cell

S31
type: PhysicalEntity
member physical entity: Degr()
cellular location: Vol_cell

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

S34
type: PhysicalEntity
member physical entity: Akt(S474~u,T309~p)
cellular location: Vol_cell

S59
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM!2).PI3K(SH2!2)
cellular location: Vol_cell

RIGHT 0 conversion R66 S22 STOICHIOMETRY
type: Stoichiometry
physical entity: S22
stoichiometric coefficient: 1.0

S61
type: PhysicalEntity
member physical entity: I(bs!1).I(bs!2).IR(NPXY!3,Y999~p,alpha!1,beta!2,loc~m).RasGAP(bs!3)
cellular location: Vol_cell

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

RIGHT 0 conversion R50 S53 STOICHIOMETRY
type: Stoichiometry
physical entity: S53
stoichiometric coefficient: 1.0

LEFT 0 conversion R80 S60 STOICHIOMETRY
type: Stoichiometry
physical entity: S60
stoichiometric coefficient: 1.0

RIGHT 0 conversion R12 S34 STOICHIOMETRY
type: Stoichiometry
physical entity: S34
stoichiometric coefficient: 1.0

S35
type: PhysicalEntity
member physical entity: PKC(T410~p)
cellular location: Vol_cell

RIGHT 0 conversion R10 S8 STOICHIOMETRY
type: Stoichiometry
physical entity: S8
stoichiometric coefficient: 1.0

S25
type: PhysicalEntity
member physical entity: Raf(state~i)
cellular location: Vol_cell

S32
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM)
cellular location: Vol_cell

RIGHT 0 conversion R4 S3 STOICHIOMETRY
type: Stoichiometry
physical entity: S3
stoichiometric coefficient: 1.0

S47
type: PhysicalEntity
member physical entity: Erk(T202_T185~p,Y204_Y187~u)
cellular location: Vol_cell

LEFT 0 conversion R81 S60 STOICHIOMETRY
type: Stoichiometry
physical entity: S60
stoichiometric coefficient: 1.0

S59
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM!2).PI3K(SH2!2)
cellular location: Vol_cell

S50
type: PhysicalEntity
member physical entity: IRS1(S636~u,Y~p,Y896,YXXM!1).PI3K(SH2!1)
cellular location: Vol_cell

RIGHT 0 conversion R36 S50 STOICHIOMETRY
type: Stoichiometry
physical entity: S50
stoichiometric coefficient: 1.0

S5
type: PhysicalEntity
member physical entity: PI3K(SH2)
cellular location: Vol_cell

S48
type: PhysicalEntity
member physical entity: GS(SH2,state~i)
cellular location: Vol_cell

RIGHT 0 conversion R57 S56 STOICHIOMETRY
type: Stoichiometry
physical entity: S56
stoichiometric coefficient: 1.0

S3
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~c)
cellular location: Vol_cell

RIGHT 0 conversion R31 S48 STOICHIOMETRY
type: Stoichiometry
physical entity: S48
stoichiometric coefficient: 1.0

S59
type: PhysicalEntity
member physical entity: GS(SH2!1,state~a).IRS1(S636~u,Y~p,Y896!1,YXXM!2).PI3K(SH2!2)
cellular location: Vol_cell

S24
type: PhysicalEntity
member physical entity: Ras(state~GDP)
cellular location: Vol_cell

LEFT 0 conversion R69 S52 STOICHIOMETRY
type: Stoichiometry
physical entity: S52
stoichiometric coefficient: 1.0

S20
type: PhysicalEntity
member physical entity: GS(SH2,state~a)
cellular location: Vol_cell

LEFT 0 conversion R4 S29 STOICHIOMETRY
type: Stoichiometry
physical entity: S29
stoichiometric coefficient: 1.0

RIGHT 0 conversion R7 S33 STOICHIOMETRY
type: Stoichiometry
physical entity: S33
stoichiometric coefficient: 1.0

S51
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~p)
cellular location: Vol_cell

RIGHT 1 conversion R60 S32 STOICHIOMETRY
type: Stoichiometry
physical entity: S32
stoichiometric coefficient: 1.0

RIGHT 1 conversion R78 S50 STOICHIOMETRY
type: Stoichiometry
physical entity: S50
stoichiometric coefficient: 1.0

RIGHT 1 conversion R58 S2 STOICHIOMETRY
type: Stoichiometry
physical entity: S2
stoichiometric coefficient: 1.0

S37
type: PhysicalEntity
member physical entity: AMPK(T172~p)
cellular location: Vol_cell

RIGHT 0 conversion R75 S61 STOICHIOMETRY
type: Stoichiometry
physical entity: S61
stoichiometric coefficient: 1.0

S36
type: PhysicalEntity
member physical entity: PI3K_variant(Y~p)
cellular location: Vol_cell

LEFT 0 conversion R7 S4 STOICHIOMETRY
type: Stoichiometry
physical entity: S4
stoichiometric coefficient: 1.0

S51
type: PhysicalEntity
member physical entity: Akt(S474~p,T309~p)
cellular location: Vol_cell

S2
type: PhysicalEntity
member physical entity: IR(NPXY,Y999~u,alpha,beta,loc~m)
cellular location: Vol_cell

RIGHT 0 conversion R64 S59 STOICHIOMETRY
type: Stoichiometry
physical entity: S59
stoichiometric coefficient: 1.0