TSC1-TSC2 S1387_phosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
Akt phosphorylation in Ser mediated by mTORC2_pS2481
mTORC2 phosphorylation mediated by phosphorylated PI3K_variant
mTORC1 phosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
p70S6K phosphorylation mediated by mTORC1_pS2448
IRS-1_PI3-K complex formation (PI3-K activation)
Akt phosphorylation in Ser mediated by mTORC2_pS2481_2
AMPK_T172_dephosphorylation mediated by IRS1_pY
TSC1-TSC2 S1387_dephosphorylation_by_AMPK_pT172 and T1462_phosphorylation_by_Akt_pT308
Akt dephosphorylation in Ser mediated by mTORC2_pS2481
mTORC2 dephosphorylation mediated by phosphorylated PI3K_variant
mTORC1 dephosphorylation mediated by TSC1_TSC2_pS1387 and Aminoacids
p70S6K dephosphorylation mediated by mTORC1_pS2448
Receptor unbinding and dephosphorylation (on the cell membrane)
IRS-1_PI3-K complex dissociation (PI3-K inactivation)
Akt dephosphorylation in Tyr phosphorylated form
Akt phosphorylation/dephosphorylation in Tyr
Receptor binding to 1st insulin molecule
ERK module phosphorylated and Y187 dephosphorylated
IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation
This BioPAX Level3 file was automatically generated on Apr 8, 2022 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI.
The original model, 'DiCamillo2016___Insulin_signalling_pathway___Rule_based_model', was published in BioModels Database (http://www.ebi.ac.uk/biomodels/).
Receptor dissociating 2nd insulin molecule
IRS1-GS and IRS1-SHP2 complex formation and IRS1 phosphorylation
Phosphorylated receptor internalization_ 2
Receptor unbinding and dephosphorylation (inside the cell)
IRS1-GS and IRS1-SHP2 complex disruption and IRS1 dephosphorylation _2
Phosphorylated receptor internalization_3
Receptor unbinding and dephosphorylation (inside the cell) _2