A mathematical model for cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes defines survival threshold in erythroid progenitor cells

 init_EpoRJAK2 0 0 0 0 init_SHP1 0 init_STAT5 0 0 0 0 0 0 0 epo_level cyt Epo EpoRJAK2 JAK2ActEpo SOCS3 SOCS3Inh SOCS3Eqc 1 cyt DeaEpoRJAKActSHP1 EpoRpJAK2 SHP1Act SHP1ActEpoR cyt EpoRpJAK2 EpoRActJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 cyt 3 EpoRpJAK2 EpoRActJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 cyt 3 EpoRActJAK2 p1EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 cyt EpoRActJAK2 p2EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 cyt DeaEpoRJAKActSHP1 SHP1Act p1EpoRpJAK2 SHP1ActEpoR cyt DeaEpoRJAKActSHP1 SHP1Act p2EpoRpJAK2 SHP1ActEpoR cyt DeaEpoRJAKActSHP1 SHP1Act p12EpoRpJAK2 SHP1ActEpoR cyt SHP1 SHP1ActEpoR EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 cyt SHP1Dea SHP1Act cyt STAT5 STAT5ActJAK2 EpoRpJAK2 p12EpoRpJAK2 p1EpoRpJAK2 p2EpoRpJAK2 SOCS3 SOCS3Inh SOCS3Eqc 1 cyt STAT5 STAT5ActEpoR p12EpoRpJAK2 p1EpoRpJAK2 2 SOCS3 SOCS3Inh SOCS3Eqc 1 CIS CISInh CISEqc 1 cyt STAT5Imp pSTAT5 nuc STAT5Exp npSTAT5 nuc CISRNAEqc CISRNATurn npSTAT5 ActD 1 nuc CISnRNA1 CISRNADelay nuc CISnRNA2 CISRNADelay cyt CISRNA CISRNATurn cyt CISRNA CISEqc CISTurn cyt CIS CISTurn cyt SOCS3Eqc SOCS3Turn npSTAT5 ActD 1 cyt SOCS3 SOCS3Turn cyt SOCS3oe SOCS3Eqc SOCS3Turn SOCS3EqcOE