A report published in JAMA Internal Medicine several years ago highlighted a link between long-term use of anticholinergic medications likeBenadryland dementia. While this study and other observational studies have also found this association, it doesn't prove that these drugs cause dementia. But we do know that anticholinergic drugs can cause confusion and increase fall risk in older people ...
Summary:Jointpain is reported as a side effect among people who takeBenadryl(diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tylenol, and have Rheumatoid arthritis. The phase IV clinical study analyzes which people haveJointpain when takingBenadryl.
Diphenhydramine is also used for motion sickness and extrapyramidal symptoms in Parkinson'sdiseasepatients. Potential harm to the brain: Long-term anticholinergic use has been associated with increased dementia risk; diphenhydramine can impair many cognitive functions including memory.
Researchers say regularBenadryluse can weaken mobility and grip strength as you get older, making it a dangerous long-term choice.
Indications for diphenhydramine use include sedation, treatment of allergic reactions and vertigo, and prophylaxis for patients with prior transfusion reactions. Its potential adverse effects include those of the anticholinergic medications as noted above.
Diphenhydramine, once a pioneering antihistamine, is now overshadowed by second-generation antihistamines with similar efficacy and fewer adverse effects. Current data suggest that the adverse side-effect pro le of diphenhydramine is higher among children and older adults.
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