Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated significant cardiovascular (CV) benefits, particularly in patients with diabetes mellitus, but the safety and efficacy of differentGLP-1RAs across diverse populations remain insufficiently defined.
Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have a reliable hypoglycaemic and weight-losseffectthat can intervene in obesity, which is the basis of type 2 diabetes pathology.GLP-1RA therapy has shown potential benefits in reducing the risk of major adverse cardiovascular events and improving kidney outcomes in patients with diabetes at high risk for cardiovascular disease ...
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Beyond the impressiveeffectsofGLP-1receptor agonists on blood glucose levels and body weight, large-scale randomized, controlled trials have shown thatGLP-1receptor agonists reduce ...
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GLP-1receptor agonists were initially developed to treat type 2 diabetes and have had a transformativeeffectonits therapy, and are highly effective for glycaemic control, with the added benefit of bodyweight reduction and a low risk of causing hypoglycaemia.GLP-1receptor agonists reduce risks for major adverse cardiovascular events (eg, non-fatal myocardial infarction, stroke, and ...
Thefunctionof GIP andGLP-1to reduce glycemia through glucose-dependent potentiation of insulin secretion provided the initial rationale for exploring the feasibility ofGLP-1R agonist (GLP-1RA)-based peptide therapies for the management of type 2 diabetes mellitus (T2DM).GLP-1RAs are a class of drugs resistant to degradation by the ubiquitous protease dipeptidyl peptidase-4 (DPP4), known ...
This umbrella review synthesizes the evidence for safety and efficacyGLP-1receptor agonists on multiple outcomes including but not limited to metabolic, cardiovascular and renal outcomes.
TheGLP-1receptor agonist liraglutide inhibits progression ofvasculardisease viaeffectsonatherogenesis, plaque stability and endothelialfunctionin an ApoE (-/-) mouse model
