Overview of Type Ca V 3
As a member of the Ca v 3 subfamily of voltage-gated calcium channels, the function of the T-type channel is important for the repetitive firing of action potentials in cells with rhythmic firing patterns such as cardiac muscle cells and neurons in the thalamus of the brain. [1]
In HEK-293 cells, T-type whole-cell patch clamp recordings were performed 2-3 days after transfection. T-type currents were recorded using a test pulse from a holding potential at (-100mV) to (-30 mV) and using 2 mM Ca 2+ at room temperature. The current density was calculated according to the capacitance of the cell and expressed in pA/picofarad.
Recent studies have demonstrated that the T-type Ca 2+ channel Ca v 3.2 is required for pressure overload-induced cardiac hypertrophy (Chianget al., 2009) and serum-induced hypertrophy in cultured neonatal mouse ventricular myocytes (Horibaet al., 2008). However, whether calcineurin also plays a role in regulating T-type calcium channels is ...
Ca V 3.3 contains a long bended S6 helix from domain III, with a positive charged region protruding into the cytosol, which is critical for T-type Ca V channel activation at low voltage.
As we can see from the illustration, Type Ca V 3 has many fascinating aspects to explore.
CaV3.x Channels (T
Ca V 3.x Channels (T-type) Ca V 3.x channels (T-type) are low-voltage activated channels with low single channel conductance. These channels are found in cells with rhythmic firing patterns where repetitive firing of action potentials is required. For example, they contribute the pacemaker potential of sinoatrial node cells in the heart, and also to the spontaneous spiking of neurons in the ...
Talavera K, Staes M, Janssens A, Klugbauer N, Droogmans G, Hofmann F, Nilius B (2001) Aspartate residues of the Glu-Glu-Asp-Asp (EEDD) pore locus control selectivity and permeation of the T-type Ca 2+ channel α 1G.
