Bdnf Enhancers

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Making of BDNF

A limited number of enhancer elements governing cell type-specific Bdnf expression have been identified, including a region ~840 kb upstream of exon I in astrocytes, a region ~4.8 kb upstream in hippocampal neurons, and regions ~3 kb and ~237 kb downstream in cortical neurons.

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Brain-derived neurotrophic factor ( BDNF ) is a neurotrophin with crucial roles in the developing and adult nervous system, contributing to neuronal survival, differentiation, and synaptic plasticity. The pleiotropic functions of BDNF require stringent spatiotemporal control of its expression, making BDNF one of the most thoroughly studied activity-regulated genes. Over the years, substantial ...

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Brain-derived neurotrophic factor ( BDNF ) promotes neuronal differentiation and survival and is implicated in the pathogenesis of many neurological disorders. Here, we identified a novel intergenic enhancer located 170 kb from the Bdnf gene, which promotes the expression of Bdnf transcript variants during mouse neuronal differentiation and activity.

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The deletion of the +3 kb enhancer region decreases the expression of. It gives the article a little more context before the image collection begins.

Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and. It gives the article a little more context before the image collection begins.

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