Glp1 Therapy And Cold Stress

Intestinal adaptation to cold

Normalising the Experience Feeling colder during GLP-1 therapy is a normal and expected sign that your body is adapting to weight loss and metabolic changes. Clinical studies, including the STEP and SURMOUNT trials, document that cold sensitivity is a common side effect as fat mass decreases and metabolism adjusts.

Why GLP

GLP-1 receptors exist inside the hypothalamus, the brain's control center for hunger, metabolism, and body temperature. When GLP-1 medications activate these receptors, they can shift the system toward conserving energy rather than producing heat. This helps explain why even people with adequate calorie intake still feel cold .