Article Mitochondrial Bioenergetics

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Mitochondrial Bioenergetics in Different Pathophysiological Conditions ...

In the second volume of this Special Issue, three review papers and twelve original articles were published dealing with compelling topics related to mitochondrial bioenergetics and other related multifunctional roles of mitochondria in various pathophysiological contexts.

Mitochondrial function and phenotype are defined by bioenergetics Ryan J. Mailloux, Jason Treberg, Cathryn Grayson, Luis B. Agellon & Helmut Sies Nature Metabolism 5, 1641 (2023) Cite this article

Mitochondrial bioenergetics

In the fourth volume of this Special Issue, four review papers and two original articles were published, dealing with compelling topics related to mitochondrial bioenergetics in certain pathophysiological contexts.

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Article Mitochondrial Bioenergetics

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Mitochondrial Bioenergetics in Physiology

Acta Physiologica recently collated a special issue titled 'Mitochondrial Bioenergetics in Physiology', covering various aspects of mitochondrial adaptations in ectotherms, heat production in endotherms, the role of mitochondria in metabolic signaling during physiological challenges, and the function of mitochondrial transporters (Figure 1).

Mitochondria are the organelles that generate energy for the cells and act as biosynthetic and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial bioenergetics is considered an important measure to assess the pathogenesis of various diseases. Dysfunctional mitochondria affect or cause several conditions involving the most energy-intensive organs ...

From Mitochondria to Cells to Humans

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Article Mitochondrial Bioenergetics

These models can harness the power of cutting-edge technologies to inform mammalian in situ experiments to bridge the gap between isolated bioenergetics and human mitochondrial health. This gap must be bridged at the level of basic biology to effectively move laboratory interventions that target mitochondria to the clinic.

Given the pivotal role of mitochondrial bioenergetics for power-ing physiology, a very active research field currently seeks to de-cipher how mitochondrial functions are integrated into cellular and organismic physiology, and how mitochondria contribute to ecological adaptation and human diseases.

Mitochondrial bioenergetics and metabolism are fundamental to cellular function and organismal health. The intricate regulation of mitochondrial activities, particularly Ca 2+ homeostasis, MAMs, and the roles of mitochondria in inflammation and cell death, underscores their importance in health and disease.

In summary, this review examines the multidimensional role of mitochondria in diabetes, focusing on pancreatic β-cells and highlighting the significance of mitochondrial metabolism, bioenergetics , calcium, dynamics, and mitophagy in the pathophysiology of diabetes.

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