Achieving PeaK
Insulin secretion by the β-cell occurs in two distinct phases after an intravenous glucose load, with an acute phase occurring within minutes and a chronic phase persisting through the end of the glucose challenge.
Insulin secretion by the β-cell occurs in two distinct phases after an intravenous glucose load, with an acute phase occurring within minutes and a chronic phase persisting through the end of the glucose challenge.
(PDF) Achieving PeaK
Insulin secretion by the β-cell occurs in two distinct phases after an intravenous glucose load, with an acute phase occurring within minutes and a chronic phase persisting through the end of the ...
Achieving " PeaK-A " insulin secretion . Carmella Evans-Molina 1 Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 2 Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 3 Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 4 Herman B. Wells ...
Achieving PeaK
Home Open Access Faculty and Graduate Student Articles Open Access Policy Articles Achieving " PeaK-A " Insulin Secretion
Cite As Evans-Molina C, Mirmira RG. Achieving " PeaK-A " insulin secretion . Diabetes. 2013;62 (5):1389-1390. doi:10.2337/db13-0196
Achieving PeaK
The results of genome-wide association studies provide genetic credence to the notion that defects in insulin secretion may be primarily causative of disease, and two major classes of drugs used clinically in T2D are capable of enhancing insulin release: sulfonylureas and incretins. Glucose homeostasis reflects the integrated efficiencies of the islet β-cell to secrete insulin and of ...
by Evans-Molina, Carmella; Mirmira, Raghavendra G. Publication date 2013-04-16 Collection pubmed; journals Contributor American Diabetes Association Language English Volume 62 Item Size 5.7M This article is from Diabetes, volume 62.
Metabolic Cycles and Signals for Insulin Secretion
A decade later came key evidence for glucose-stimulated insulin secretion (GSIS) ex vivo. Anderson and Long (Anderson and Long, 1947) established a perfusion system that incorporated the stomach, duodenum and pancreas, and using a bioassay for insulin found that glucose promotes insulin release.
Insulin secretion from pancreatic β-cells is potently activated by an increase in glucose after feeding but other dietary components — amino acids, fatty acids, metabolites, α-cell-produced ...