Clonal evolution of chronic lymphocytic leukemia to acute lymphoblastic ...
Cytogenetic studies revealed that the lymphoblastic transformation arose as a clonal evolution from the initial stemline seen at the chronic phase. CASE REPORT A 38-year-old cross-addicted white male patient presented in December 1991 with progressive symptoms of diarrhea, abdominal cramping associated with weight loss, fever, and night sweats.
These results indicate that the lymphoblastic transformation in our case emerged from the pre-existing B-lymphocytic clone.
Clonal evolution of chronic lymphocytic leukemia to acute lymphoblastic ...
The pattern of marrow involvement was interstitial or diffuse, with cells showing immature nuclear features resembling acute leukemia or blastic lymphoma. All tumors demonstrated a consistent immunophenotype of B-cell lineage, surface immunoglobulin positivity, and CD5 antigen expression.
Cytogenetic studies revealed that the lymphoblastic plasms occurring in the same patient is the presence of transformation arose as a clonal evolution from the initial identical immunoglobulin gene (Ig) rearrangement and stemline seen at the chronic phase. expression [1,2].
The landscape and evolution of clonal hematopoiesis in chronic ...
Chronic lymphocytic leukemia (CLL) and clonal hematopoiesis (CH) both have high prevalences in older people. 12 Although CLL is a malignant condition characterized by the monoclonal expansion of B cells, CH is driven by somatic mutations that can alter the function of differentiated blood cells. CH of indeterminate potential (CHIP) is a subtype of CH with a variant allele frequency (VAF) of ...
A byproduct of evolution is the presence of numerous subpopulations within a tumor that can be unique in their molecular characteristics, growth kinetics, and response to therapy. 1,2 This process has notably been observed in chronic lymphocytic leukemia (CLL), a B-cell malignancy thought to originate from monoclonal B-cell lymphocytosis that ...
Clonal Evolution of High
Abstract Clonal evolution represents the natural process through which cancer cells continuously search for phenotypic advantages that enable them to develop and expand within microenvironmental constraints. In chronic lymphocytic leukemia (CLL), clonal evolution underpins leukemic progression and therapeutic resistance, with differences in clonal evolutionary dynamics accounting for its ...
A byproduct of evolution is the presence of numerous subpopulations within a tumor that can be unique in their molecular characteristics, growth kinetics, and response to therapy. 1,2 This process has notably been observed in chronic lymphocytic leukemia (CLL), a B-cell malignancy thought to originate from monoclonal B-cell lymphocytosis that ...
Clonal dynamics monitoring during clinical evolution in chronic ...
Chronic lymphocytic leukaemia is an ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because the disease usually develops ...
Leukemia is a polyclonal and progressive disease with drastic intra-clone heterogeneity. During the early stages of disease development, it is mostly shaped by the deterministic effects of key initiating events, which could establish the roles of genomic instability and cell plasticity in clonal evolution . Later, preleukemic cells acquire successive genetic mutations, undergoing distinct ...