Figure 2 from Mutational landscape and patterns of clonal evolution in ...
Figure 2 . Patterns of relapse in ALL. A, Schematic overview of mechanisms of clonal evolution . Three patients developed a second primary tumor that was not clonally related to the previous tumor occurrence. Two patients developed a tumor that shared only one founding fusion between diagnosis and relapse, indicating the disease relapsed from a preleukemic cell. Further relapses arose through ...
The landscape of mutations and clonal evolution trajectories in pediatric ALL reveal relapse-fated, drug-resistant subclones present at diagnosis and expanded by therapy.
Mutational landscape, clonal evolution patterns, and role of RAS ...
Here we have dissected the mutational landscape of relapsed ALL, analyzed the pattern of clonal evolution associated with relapse in this disease, and explored the mechanisms underlying the mixed pattern of positive and negative selection of RAS mutations associated with leukemia progression.
Here we have dissected the mutational landscape of relapsed ALL, analyzed the pattern of clonal evolution associated with relapse in this disease, and explored the mechanisms underlying the mixed pattern of positive and negative selection of RAS mutations associated with leukemia progression.
Data from Mutational Landscape and Patterns of Clonal Evolution in ...
AbstractRelapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood cancer-related death. Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. However, the genomic landscape , evolutionary trajectories, and mutational mechanisms driving relapse are incompletely understood. In an analysis of 92 cases of ...
Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. However, the genomic landscape , evolutionary trajectories, and mutational mechanisms driving relapse are incompletely understood.
Mutational Landscape, Clonal Evolution Patterns and Role of RAS ...
A branched pattern of genetic evolution and the presence of recurrent mutations selected at relapse support that chemotherapy imposes a strong Darwinian genetic selection in leukemic cell populations.
In an analysis of 92 cases of relapsed childhood ALL incorporating multimodal DNA and RNA sequencing, deep digital mutational tracking, and xenografting to formally define clonal structure, we ...
Mutational patterns and clonal evolution from diagnosis to ...
To determine the mutational patterns leading to relapse and to delineate the clonal evolution of the ALL cells due to somatic point mutations and structural aberrations, we sequenced 96 genomes ...
Results To determine the mutational patterns leading to relapse and to delineate the clonal evolution of the ALL cells due to somatic point mutations and structural aberrations, we sequenced 96 genomes from matched diagnostic, relapse and remission samples from 29 Nordic patients with pediatric ALL (Table 1).