Unlocking the Link: Serum FABP4’s Role in Islet Beta and Alpha Cell Function

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Relationships between serum FABP4 and islet

Relationships between serum FABP4 and islet β cell and α cell function
Relationships between serum FABP4 and islet β cell and α cell function

Recently, high levels of FABP4 were found linked with aand b-cell dysfunction in T2D (53) and work from 2 independent groups clarified mechanisms of b-cell dysfunction linked to FABP4 and fetuin-A ...

Example images of non diabetic control C T1D T2D and CF pancreata
Example images of non diabetic control C T1D T2D and CF pancreata

Abstract Background Serum fatty acid-binding protein 4 ( FABP4 ), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its association with pancreatic islet β- cell and α- cell functions has not been fully elucidated.

Serum fatty acid

Plasma exosomes from T2D subjects induce major features of tumor cell
Plasma exosomes from T2D subjects induce major features of tumor cell

Background Serum fatty acid-binding protein 4 ( FABP4 ), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its association with pancreatic islet β- cell and α- cell functions has not been fully elucidated. So the present study was to investigate the serum FABP4 levels and responses of islet β ...

Serum fatty acid-binding protein 4 ( FABP4 ), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its association with pancreatic islet β- cell and α- cell functions has not been fully elucidated.

3D chromatin maps of the human pancreas reveal lineage specific
3D chromatin maps of the human pancreas reveal lineage specific

PDF Serum fatty acid

Background Serum fatty acid-binding protein 4 ( FABP4 ), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its association with pancreatic islet β- cell and α- cell functions has not been fully elucidated.

So the present study was to investigate the serum FABP4 levels and responses of islet β- cells and α- cells in patients with T2D.

Pathophysiology of type 2 diabetes T2D Genetic and environmental
Pathophysiology of type 2 diabetes T2D Genetic and environmental

A hormone complex of FABP4 and nucleoside kinases regulates islet function

Hormonal FABP4 is discovered to be a pivotal regulator of an adipose-beta- cell endocrine axis that coordinates energy status and metabolic organ function , and targeting this axis improved ...

The increased islet mass and changes in islet insulin secretion that persisted ex vivo suggests a potential developmental role for endothelial FABP4 in β cell proliferation and function .

Efficient classifier for T2D single cells learnt by Vec2image
Efficient classifier for T2D single cells learnt by Vec2image

PDF A hormone complex of FABP4 and nucleoside kinases regulates islet function

Antibody-mediated targeting of this hormone complex improves metabolic outcomes, enhances beta- cell function and preserves beta- cell integrity to prevent both type 1 and type 2 diabetes.

3D chromatin maps of the human pancreas reveal lineage specific
3D chromatin maps of the human pancreas reveal lineage specific
SIX2 expression is reduced in β cells from T2D donors A Gene
SIX2 expression is reduced in β cells from T2D donors A Gene
Islet cell derived EVs promote the development of T1D T2D and diabetic
Islet cell derived EVs promote the development of T1D T2D and diabetic
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction
A Immunohistochemical quantification of Aβ 1 42 plaques
A Immunohistochemical quantification of Aβ 1 42 plaques

Our results identify augmented FABP4 expression in islet macrophages as an important mediator triggering the onset of β cell autoimmunity by enhancing inflammatory milieu in the islets , suggesting that pharmacological inhibition of FABP4 might be an effective approach for early therapeutic intervention of autoimmune diabetes.

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