oxoglutarate carrier with - stunning roundup

(PDF) The mitochondrial oxoglutarate carrier

The 2-oxoglutarate carrier (OGC) belongs to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm ...

The 2-oxoglutarate carrier (OGC) belongs to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial matrix. Initially, OGC was characterized by determining substrate specificity, kinetic parameters of transport, inhibitors and molecular probes that form covalent bonds with specific ...

Key Details About Oxoglutarate Carrier With

Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate ) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed: 25637873, PubMed: 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs ...

Abstract The 2-oxoglutarate carrier (OGC) belongs to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial ma-trix. Initially, OGC was characterized by determining sub-strate specificity, kinetic parameters of transport, inhibitors and molecular probes that form covalent bonds ...

Targeting and assembly of the oxoglutarate carrier

We have studied the targeting and assembly of the 2-oxoglutarate carrier (OGC), an integral inner-membrane protein of mitochondria. The precursor of OGC, synthesized without a cleavable presequence, is transported into mitochondria in an ATP- and ...

Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate ) across the inner mitochondrial membrane in an electroneutral exchange for malate (By similarity). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity).

Mitochondrial 2

Mitochondrial 2- oxoglutarate /malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene. [5][6][7] Inactivating mutations in this gene predispose to metastasic paraganglioma.

The status of the mitochondrial GSH pool is reliant on transport from the cytosol through the 2-oxoglutarate carrier (OGC), an inner membrane anion carrier . We have previously reported that the outer mitochondrial membrane protein, Bcl-2, directly binds GSH and is a key regulator of OGC-dependent mitochondrial GSH transport.

The 2oxoglutaratemalate carrier extends the family of mitochondrial ...

The 2- oxoglutarate /malate carrier (OGC) aids this by transporting 2- oxoglutarate and malate across the mitochondrial membrane.2 Recent evidence shows that knockdown of OGC results in a 75% reduction in ATP production in non- small cell lung cancer.3 In addition, a heterozygous OGC knockout reduced the growth of spontaneous lung cancer in mice ...

The 2- oxoglutarate /malate carrier (OGC) aids this by transporting 2-oxoglutarate and malate across the mitochondrial membrane. 2 Recent evidence shows that knockdown of OGC results in a 75% reduction in ATP production in non-small cell lung cancer. 3 In addition, a heterozygous OGC knockout reduced the growth of spontaneous lung cancer in mice ...