Regulation of iron metabolism in ferroptosis
A study by Song et al. [72] found that knockdown of DMT1 in glioblastoma cells significantly attenuated ferroptosis and demonstrated that temozolomide induced ferroptosis by targeting DMT1 to inhibit tumor growth.
The mechanism of HSV- induced ferroptosis . HSV infection induced LPO which down -regulated the STING DNA-sensing pathway. The down -regulation of STING DNA-sensing pathway inhibited the innate cell damage pathway and suppressed the innate antiviral immune response against HSV, thereby promoting HSV replication.
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation- induced damage. This mode of cell death differentiates from ...
Insight into the Double
Mechanism of DOX- induced ferroptosis in cardiomyocytes. After DOX enters the mitochondria, it combines with Fe 3+ and is reduced to DOX-Fe 2+ to produce lipid peroxides. Meanwhile, DOX can also coordinate the level of GPX4 to promote cell ferroptosis . Fe 3+ sequesters DXZ and DFO reduce the iron content in mitochondria. The Fe 2+ -specific chelating agent MFG blocks DOX- induced LPS and Fer-1 ...
The mechanism of drug- induced iron-dependent cell death in RAS-driven cancers relies on cystine/glutamate antiport and the accumulation of hydroxylated lipids. This type of death is similar to glutamate- induced excitotoxicity in neurons, and both types of cell death can be blocked with a specific small-molecule inhibitor called ferrostatin-1.
Iron metabolism and ferroptosis in human health and disease
The primary metabolic pathways involved in iron- induced ferroptosis encompass iron metabolism, amino acid metabolism, and lipid peroxidation metabolism. In the context of iron metabolism, processes such as ferritinophagy and the import/export of iron can initiate lipid peroxidation and ferroptosis through the Fenton reaction or ...
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of ...
Ferroptosis, a Distinct Form of Cell Death, and Research ...
Ferroptosis , an iron-dependent and lipid peroxidation-driven mode of regulated cell death, holds significant pathological significance. Its dysregulation manifests in dual facets: inhibition promotes tumorigenesis, whereas overactivation aggravates neurological disorders and organ injury. This paper systematically reviews the core molecular mechanisms of ferroptosis and provides a ...
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in ...
