Leukemia Treatment Modification - Pictures, Info & More

Treatment Modifications Due to Toxicities During Chemotherapy in Leukemia

Here, we provide an overview of treatment modifications due to chemotherapy-induced toxicities in leukemia . Literature on PubMed and Google Scholar was searched using relevant keywords up to March 2025.

Starting with imatinib, successive generations of increasingly effective tyrosine kinase inhibitors (TKIs) have turned chronic phase chronic myeloid leukemia (CP-CML) from a lethal disease into a chronic condition compatible with almost normal life expectancy. 1 Asciminib, the first approved allosteric TKI and latest addition to the CML armamentarium, has set a new tolerability standard. 2 ...

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This article provides a comprehensive overview of targeted and epigenetic therapies for acute myeloid leukemia (AML), highlighting their role in advancing treatment strategies. Recognizing that AML arises from complex genetic and epigenetic alterations, a deeper understanding of its pathogenesis has paved the way for precision medicine. The article reviews key targeted therapies, including IDH ...

Epigenetic therapy for leukemias

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Leukemia comprises a group of malignant clonal hematopoietic stem cell disorders where epigenetic abnormalities significantly contribute to its pathogenesis and progression. Epigenetic alterations, such as DNA methylation, histone modifications , and non-coding RNA dysregulation, affect gene expression and cellular function, driving leukemia development. In recent years, therapeutic strategies ...

The development of CAR-T cell treatment has significantly improved our therapeutic armamentarium for pretreated patients with diffuse large B cell lymphoma (DLBCL), mantle cell lymphoma (MCL), or acute B-lymphoblastic leukemia , and will also be implemented in treatment algorithms for follicular lymphoma and multiple myeloma [176].

Additional Notes on Leukemia Treatment Modification

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📁 Category: Modification

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