In this review, we first discuss the roles ofm6Amodification in regulating RNA stability and splicing of DNA repair genes, as well as its roles in guiding DNA repair. We then discuss the crosstalk betweenm6A-modified RNA and DNA damage and repair, highlighting several outstanding questions.
Although the transcriptional and genomic landscapes of T-ALL are well described, posttranscriptional mechanisms, particularly RNA modifications, have remained poorly understood.Amongthese,m6Ais the most abundant internal RNA modification in eukaryotic mRNA, regulating RNA stability, splicing, and translation in a context-dependent manner.
N6 -Methyladenosine (m6A) is a modified nucleotide in mRNAs and non-coding RNAs that influences gene expression, primarily by promoting the degradation of specific transcripts. Recent studies ...
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Amongthese, the most prevalent RNA modification in eukaryotes is adenosine methylation, which formsm6Athrough the addition of a methyl group at the nitrogen-6 position of adenosine [4].m6Amethylation is the most common modification in most mRNAs and plays a multifaceted role throughout various stages of the RNA life cycle, such as ...
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WeiH LiW YangM FangQ NianJ HuangY et al. METTL3/16-mediatedm(6)Amodification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells.
