Chapter 1 : Introduction



Introduction arrow_upward


  • Biochemistry is the science in which chemistry is applied to the study of living organisms or it is the chemical study of atoms and molecules which comprise living organisms.

  • What is Biochemistry? arrow_upward


  • Biochemistry is the study of structure, composition, constituents, and chemical reactions of substances found in living systems.
  • Biochemistry governs all living organisms and living processes.
  • Biochemistry is a separate branch of science which combines biology with physical, organic and inorganic chemistry.
  • Living organisms should be able:
    • To transform matter and energy into different forms.
    • To show response to changes in their environment.
    • To show growth and reproduction.
  • All living organisms undergo changes due to large organic compounds, such compounds are called macromolecules.

  • History of Biochemistry arrow_upward


  • The history of biochemistry spans approximately 400 years.
  • Although the term “biochemistry” seems to have been first used in 1882, it is generally accepted that the word "biochemistry" was first proposed in 1903 by Carl Neuberg, a German chemist.
  • The first application of biochemistry was probably the making of bread using yeast, about 500 years ago.
  • Biochemistry is applied to medicine, dentistry, veterinary medicine, food technology, agriculture, physiology, pharmacology, microbiology, clinical chemistry and many more.
  • Biochemistry is linked with every way of human life.

  • What types of molecules do biochemists study? arrow_upward


  • The principal types of biological molecules or biomolecules are:
    • Proteins
    • Carbohydrates
    • Nucleic acids
    • Lipids
  • Most of these biomolecules are basically polymers which consist of repeating structural units called monomers.

  • Discipline related to Biochemistry arrow_upward


  • Biochemistry is closely related to other biological sciences that deal with molecules.
  • There is considerable overlap between these disciplines:
    • Molecular Genetics
    • Pharmacology
    • Molecular Biology
    • Chemical Biology
  • Genetic research is a field in which many experts in biochemistry take part.
    • The current research regarding stem cells has led to very important information about chemical processes that essentially cause cell death called apoptosis.
  • Biotechnology, the use of living things to make products, is another field in which the biochemistry expert thrives.
  • The food industry also attracts biochemists.
  • In studies regarding food, biochemists might work in a number of practical ways, such as:
    • Development of food products that are least likely to cause weight gain
    • Developing foods that have highly beneficial qualities.
    • Most wineries and breweries use biochemistry frequently to evaluate yeasts and acids used to make alcohol.
  • Experts in biochemistry might also use their skills to make chemical products like herbicides or pesticides.
  • Many work in small research labs that may study specific things or analyze materials for contaminants.
    • For example: Testing water and food for live parasitic agents is a valued act of biochemistry.
  • Biochemists have a wide choice of fields that include:
    • Applications in medicine
    • Genetics
    • Food science
    • Biotechnology
    • Pharmaceuticals

    Biochemical Reactions arrow_upward


  • Biochemical reactions are chemical reactions that take place inside the cells of living things.
  • The sum of all the biochemical reactions in an organism is called metabolism.

  • Major types of Biochemical Reactions arrow_upward


  • Oxidation:
    • Oxidation is the loss of electrons.
  • Reduction:
    • Reduction is the gain of electrons.
  • Hydrolysis:
    • Hydrolysis is the chemical process in which a molecule is cleaved into two parts by the addition of a water molecule.
  • Phosphorolysis:
    • Phosphorolysis is the splitting of a bond by the addition of phosphoric acid to a compound.
  • Decarboxylation:
    • Decarboxylation is the loss of carbon dioxide.
  • Deamination:
    • Deamination is the removal of amino group.
  • Transamination:
    • Transamination is the transfer of amino group from one molecule to another.


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