LIfT BioSciences Presents Preclinical Data on Immunomodulatory Alpha Neutrophils (IMANs) for Solid Tumors

Analysis reveals significant industry trends and economic implications

Release Date

2025-05-19

Category

Clinical Trial Event

Reference

Source

Breakthrough Clinical Results

LIfT BioSciences announced the presentation of preclinical data on its first-in-class Immunomodulatory Alpha Neutrophils (IMANs) at the ISCT 2025 Annual Meeting. The data highlighted IMANs' dual mechanism of action: direct tumor cytotoxicity and potent immunomodulatory effects. IMANs demonstrated superior tumor penetration and killing capabilities across multiple solid tumor types, effectively converting 'cold' tumors into immune-responsive 'hot' tumors. This dual action rejuvenates the innate immune system and drives a durable immune response, offering a potential new approach for treating solid tumors where current therapies fall short. The company is preparing to advance IMANs toward clinical trials.

Key Highlights

  • IMANs demonstrate superior tumor penetration and direct cancer cell killing across multiple solid tumor types.
  • IMANs possess a dual mechanism of action, converting 'cold' tumors into 'hot' tumors and activating systemic anti-cancer immunity.
  • Preclinical data showed persistent tumor infiltration and NK cell recruitment for over 21 days in humanized models.
  • LIfT BioSciences is preparing to advance IMANs toward clinical trials.

Emerging Mechanism of Action

CAR T-cell therapy has shown remarkable success in treating hematological malignancies, but its efficacy in solid tumors has been limited. Several key mechanisms of action (MoAs) and strategies are emerging to address these limitations:

In addition to CAR T-cell therapy, other MoAs are being investigated for solid tumors, including:

Overall, the field of solid tumor therapy is rapidly evolving, with multiple promising MoAs and strategies emerging. Further research is needed to optimize these approaches and translate them into effective clinical therapies.

Drug used in other indications

Immunomodulatory alpha neutrophils (IMANs) are not explicitly mentioned in the provided text. However, the provided research papers discuss various immunomodulatory agents and their applications in different diseases, including those affecting neutrophils. While solid tumors are a significant area of research for immunomodulatory therapies, other indications are also being explored. Based on the provided text, these include:

Intervention models for these trials vary depending on the specific disease and agent being investigated. Common models include:

It is important to note that the specific intervention models used vary depending on the research question being addressed and the stage of drug development. For example, early-stage research often relies on in vitro and in vivo studies, while later-stage research typically involves RCTs.

This information is based on the provided text and may not represent the full spectrum of ongoing research on immunomodulatory therapies.

Company Mechanism of Action

The provided text does not contain information about the specific mechanisms of action used by drugs from LIfT BioSciences. Therefore, I cannot answer your question using the provided context.

It's important to note that accessing external websites or specific files online is beyond my capabilities as a large language model.

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