Beta Cell Specific Probing With Fluorescent Exendin 4 Is Progressively

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Beta cell specific probing with fluorescent exendin

Probes based on GLP-1R agonist exendin-4 have shown promise as in vivo β cell tracers. However, questions remain regarding the β cell specificity of exendin-4 probes, and it is unclear if the expression levels of the GLP-1R are affected in a type 2 diabetic state.

Probes based on GLP-1R agonist exendin-4 have shown promise as in vivo β cell tracers. However, questions remain regarding the β cell specificity of exendin-4 probes, and it is unclear if the expression levels of the GLP-1R are affected in a type 2 diabetic state.

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Beta Cell Specific Probing With Fluorescent Exendin 4 Is Progressively

Beta cell specific probing with fluorescent exendin

Probes based on GLP-1R agonist exendin-4 have shown promise as in vivo β cell tracers. However, questions remain regarding the β cell specificity of exendin-4 probes, and it is unclear if the expression levels of the GLP-1R are affected in a type 2 diabetic state.

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Beta Cell Specific Probing With Fluorescent Exendin 4 Is Progressively

Using in vivo probing followed by ex vivo imaging we found fluorescent exendin-4 probes to distinctly label the pancreatic islets in mice in a Glp-1r dependent manner.

Beta cell specific probing with fluorescent exendin

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Beta Cell Specific Probing With Fluorescent Exendin 4 Is Progressively

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β cell specificity for exendin-4 based probes in mice is confirmed and it is suggested that GLP-1R targeting probes may provide a tool to monitor β cell function rather than mass in type 2 diabetic mouse models.

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Exendin-4 Stimulation of Cyclin A2 in B-Cell Proliferation - Page 3. It works as a short bridge between the article summary and the gallery section.

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