The Potential Role of Dopamine Pathways in the Pathophysiology of ...
This review focuses on four major dopamine (DA) circuits : the mesolimbic (MLP), mesocortical (MCP), nigrostriatal (NSP), and thalamic-tuberoinfundibular pathways (TTFP), and their roles in depression . The MLP, which is key to reward processing, is linked to anhedonia, a primary depression symptom.
Whereas basic and clinical studies demonstrate deficits of the dopaminergic system in depression , the origin of these deficits likely lies in dysregulation of its regulatory afferent circuits .
Dopamine Receptors
Based on the types of dopamine receptors and their distribution in different brain regions, this paper reviews the current research status of the molecular, cellular and circuit mechanisms of dopamine and its receptors involved in depression .
Advances in neurotransmitter
The prefrontal cortex (PFC), a core brain region governing emotional and cognitive regulation, exhibits dysfunctional neural circuitry that constitutes a key mechanism in the pathogenesis of depression . This article reviews neurotransmitter-mediated PFC-related neural circuits in depression .
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