SGLT2 Inhibitors Confer Cardiovascular Protection via the Gut
In this context, SGLT2 inhibitors improve gut microbiota composition by suppressing TMA-producing bacteria such as Klebsiella and Shigella. At the same time, they increase the abundance of short-chain fatty acid (SCFA)-producing probiotics like Butyricicoccus and Bifidobacterium, thereby reducing TMAO production [42].
Recent approaches to slowing CKD progression include therapy with sodium-glucose cotransporter 2 inhibitor ( SGLT2 ) and gut microbiome modulation with probiotics , based on beneficial clinical outcomes of metabolic, immunological, inflammatory, and hemodynamic changes associated with CKD progression.
Therapeutic potential of prebiotics in modulating postprandial GLP
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A part of the metabolic effect of SGLT2 inhibitors may be microbiota-mediated and glucose-independent, since new research indicates that they also interact with the gut microbiota, increasing SCFA-producing taxa, enhancing intestinal barrier integrity, and lowering low-grade inflammation.
SGLT2 inhibitors, including dapagliflozin, reduce HbA1c and promote weight loss by preventing renal glucose reabsorption, with benefits in CKD and cardiovascular risk.
Useful Notes on Sglt2 Inhibition Probiotics
The aim of this systematic review and meta-analysis was to evaluate the effects of probiotics and glucose-lowering drugs (thiazolidinedione [TZD], glucagon-like pep-tide-1 receptor agonists [GLP-1 RA], dipeptidyl peptidase IV inhibitors, and sodium glucose co-transporter 2 inhibitors [SGLT-2i]) in patients with type 2 diabetes from randomized ...
SGLT2 Inhibitors
SGLT2 inhibitors are a type of medication used to treat type 2 diabetes. They are also known as gliflozins.
This review explores the relationship between gut microbiota, diabetes, and the potential of SGLT2 inhibitor drugs (gliflozins) in improving gut health and overall metabolic status. Gut microbiota plays a crucial role in regulating processes such as digestion, immunity, and homeostasis. Disruptions in the balance of this microbial community can lead to various health issues, including diabetes ...
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