Overview of Variation In Time-Of-Day Effects On Human Glp-1 Secretion
The circadian clock within intestinal L-cells governs time-of-day variation in GLP-1 secretion by directly regulating the exocytotic machinery required for hormone release.
The intestinal L cell is the principal source of glucagon-like peptide-1 ( GLP-1 ), a major determinant of insulin release. Because GLP-1 secretion is regulated in a circadian manner in rodents, we investigated whether the activity of the human L cell is also time sensitive. Rhythmic fluctuations in the mRNA levels of canonical clock genes were found in the human NCI-H716 L cell model, which ...
The incretin hormone glucagon-like peptide-1 ( GLP-1 ) is secreted from the intestinal L-cell in response to food intake ( 1 , 2). Due to its profound role in stimulating glucose-dependent insulin secretion , along with its beneficial effects to induce satiety and weight loss, long-acting GLP-1 receptor ( GLP -1R) agonists are now widely used in the treatment of type 2 diabetes (T2D) and obesity (3 ...
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