Resurrecting the Beta Cell in Type 2 Diabetes
Resurrecting the Beta Cell in Type 2 Diabetes : Examining Tomorrow's Breakthroughs Today Explore the role of progressive beta-cell dysfunction in the development of type 2 diabetes and review data on currently available as well as therapies currently in development that address beta-cell function, preservation, and/or neogenesis.
The pancreatic beta cell plays a key role in the maintenance of glucose homeostasis by regulating insulin secretion in response to metabolic cues. In type 2 diabetes , beta cell dysfunction is a key early pathogenic event that contributes to disease onset and progression. Conversely, improvements in beta cell function are linked to type 2 diabetes remission, underscoring the critical role of ...
PDF The role of the beta cell in type 2 diabetes
Introduction The pancreatic beta cell plays a key role in the maintenance of glucose homeostasis by regulating insulin secretion in response to metabolic cues. In type 2 diabetes , beta cell dys-function is a key early pathogenic event that contributes to disease onset and progression. Conversely, improvements in beta cell function are linked to type 2 diabetes remission, underscoring the ...
Diabetes mellitus is marked by hyperglycemia due to insufficient insulin secretion or action. Insulin, produced by β- cells in the pancreatic islets of Langerhans, regulates glucose uptake by most cell types [1]. Type 1 diabetes (T1D) and type 2 diabetes (T2D) are the two primary forms of diabetes , with T1D involving autoimmune β- cell destruction (~5% of diabetes cases) [ 2 ] and T2D insulin ...
The Beta Cell in Type 2 Diabetes
In the setting of T2D, β- cells undergo changes in gene expression, reverting to a more immature state and in some cases transdifferentiating into other islet cell types . Alleviation of metabolic stress, ER stress, and maladaptive prostaglandin signaling could improve β- cell function and survival. Th …
Abstract Diminished functional beta-cell mass is a key pathogenic mechanism underlying both type 1 and type 2 diabetes (T1D and T2D), precipitated by the progressive impairment of insulin secretion, loss of cellular identity, and ultimately, beta-cell death. The replenishment of beta-cell deficit through the transplantation of pancreatic islets from cadaveric donors or beta-cells derived from ...
The role of the beta cell in type 2 diabetes
The authors discuss how these studies collectively support the notion that in type 2 diabetes , beta cell dysfunction is a key early pathogenic event and emphasise the role of intra-islet and inter-organ crosstalk, microRNA and beta cell heterogeneity in disease progression.
Beneficial effects of insulin on glycemic control and beta-cell function in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy
Reversing pancreatic
Therapies aimed at preventing or reversing the regression of pancreatic insulin-producing cells could restore healthy sugar metabolism in individuals with type 2 diabetes . Jinsook Son and Domenico ...
