Overview of Glucose-Dependent Insulinotropic Polypeptide Receptor
Introduction Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone released in response to the ingestion of glucose and fat. In addition to its well-described action on the incretin axis, 1 activation of the GIP receptor (GIPR) exerts pleiotropic metabolic benefits, which include improved lipid handling and storage, 2
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Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are incretin hormones secreted from enteroendocrine K and L cells, respectively, that potentiate insulin secretion from the pancreas (1). GLP-1 and GIP also act on the brain to reduce food intake and promote weight loss (2).
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Both agonism and antagonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) lead to weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical ...
The role of GIPR in food intake control
Abstract Glucose-dependent insulinotropic polypeptide (GIP) is one of two incretin hormones playing key roles in the control of food intake, nutrient assimilation, insulin secretion and whole-body metabolism. Recent pharmacological advances and clinical trials show that unimolecular co-agonists that target the receptors for the incretins - GIP and glucagon-like peptide 1 (GLP-1) - offer ...
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