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FY2025-2034 DTRA Chemical and Biological Technologies Fundamental Research Broad Agency Announcement

Solicitation ID: HDTRA125S0001

Agency: DTRA

Type: Combined Synopsis/Solicitation
Deadline: 2034-09-30T17:00:00 ET
Eligibility: Yes (Team Member)
Funding: Grants may range from $25K up to $1M annually. Topic A1: $400,000-$700,000 per year. Topic A2: $750,000 per year for base period. Topic A3: Up to $500,000 per year. Topic A4: Up to $500,000 per year. Topic A5: Up to $200,000 for a base year with a potential option year. Topics A6 & A7: $350,000-$500,000 per year.
Doc Type: BAA
Clearance: No
Program Manager: dtra.belvoir.rd.mbx.rd-cb-frbaa25-34-a@mail.mil
Last Updated: 2026-01-16 17:03
Analyzed File: HDTRA1-25-S-0001 FRCWMD - Amendment_1- Topics A1-A7 (December 2024).pdf

Eligibility Reasoning

The following entities may not participate as prime awardees nor furnish Principal Investigators (PIs) in awards made under this BAA but may act as collaborators, including as Co-PIs, and/or subawardees: ... Federal laboratories (including DoD and Department of Energy (DOE)). ... DOE-sponsored FFRDCs.

Note: This is an AI-generated summary...

Summary

The Defense Threat Reduction Agency (DTRA) has released a long-term Broad Agency Announcement (BAA), HDTRA1-25-S-0001, effective from FY2025 through FY2034, to fund fundamental (basic and applied) research aimed at countering chemical and biological (CB) Weapons of Mass Destruction (WMD). The primary focus is 'Fundamental Science for Chemical and Biological Defense' (Thrust Area 1), seeking to advance capabilities in detection, diagnostics, medical and material countermeasures, protection, and decontamination. This amendment introduces seven specific basic research topics (A1-A7) which include: drug-targeted delivery systems with monitoring; quantum computing for medical countermeasure development; oral microbiome analysis for presymptomatic diagnostics; threat-agnostic host response mechanisms; advanced materials for CB defense; quantum sensors; and triggered upconverting nanoparticles for detection. The submission process is two-phased, requiring a pre-application white paper (with pre-coordination generally required but waived for topics A1-A7) followed by an invited full proposal. DTRA anticipates awarding primarily grants of up to five years, with annual funding ranging from $25K to $1M, to a wide range of U.S. and foreign academic, industrial, and non-profit entities.

Overall Technical Areas

Targeted Delivery & Monitoring SystemsQuantum Biological SimulationComputational Drug DiscoveryMulti-Omic Host & Microbiome AnalysisThreat-Agnostic CountermeasuresAdvanced Protective MaterialsCatalytic & Reactive MaterialsInterface and Colloid ScienceQuantum Sensing TechnologiesTriggered Upconverting NanoparticlesOptical Signal Amplification

Probable LBNL Areas

N/A

Focus Areas

N/A

Potential LBNL PIs (Overall)

Note on PI Matching: These suggestions are generated through an AI-driven semantic analysis of LBNL staff profiles.

NameScoreOrganization
Andrew Doran0.76ESA | ALS | Photon Science Development · Catalytic & Reactive Materials
Ashok Ajoy0.76ESA | CSD | Condensed Phase - CPIMS · Quantum Sensing Technologies
Sharon Greenblum0.75BSA | DOE Joint Genome Institute | JGI Technology Dept · Multi-Omic Host & Microbiome Analysis
Gerard Marriott0.75BSA | Molecular Biophysics & Integrated Bioimaging | Cellular & Tissue Image · Targeted Delivery & Monitoring Systems
Zachary Jones0.75BSA | Biological Systems & Engineering | Process Engr & Analytics · Quantum Biological Simulation
Ahmad Omar0.75ESA | MSD | Material Physics · Interface and Colloid Science
Qin Yu0.74ESA | MSD | Material Physics · Advanced Protective Materials
Maciej Haranczyk0.74CSA | AMCR | Computer Science · Computational Drug Discovery
Armand Alivisatos0.73ESA | MSD | Material Physics · Triggered Upconverting Nanoparticles
Siyun Chen0.73PSA | ATAP | BELLA Center · Optical Signal Amplification

Fundamental Research Exemption (FRE)

Per DoD policy1, ‘…products of fundamental research are to remain unrestricted to the maximum extent possible.’ Furthermore, ‘The DoD will place no other restrictions on the conduct or reporting of unclassified fundamental research, except as otherwise required by statue [sic], regulation, or Executive Order.’ As such, fundamental research is normally exempt from controls under the International Traffic in Arms Regulation (ITAR) (22 CFR Parts 120-130) and/or the Department of Commerce regarding the Export Administration Regulations (15 CFR Parts 730-774), but the DoD rule recognizes that there are “rare” situations where export-controlled information or technology may be used in fundamental research that may require a license(s) or restrictions on products.