ONHS Report: HT942526PRPIIRA

DoW Parkinson’s, Investigator-Initiated Research Award

Solicitation ID: HT942526PRPIIRA

Agency: DHA

Type: Grant

Deadline: 2026-11-06T00:00:00 ET

Eligibility: Yes (Unrestricted)

Funding: Approximately $10M to fund five awards, with a total cost cap of $2M per award.

Doc Type: BAA

Clearance: No

Program Manager: N/A

Last Updated: 2026-08-19 14:43

Analyzed File: HT942526PRPIIRA_GG.pdf

Eligibility Reasoning

Extramural and intramural U.S. Department of War (DOW) organizations are eligible to apply, including foreign and domestic organizations, for-profit and nonprofit organizations, and public or private entities. ... Applications from investigators within the DOW and applications involving multidisciplinary collaborations among academia, industry, the DOW, the U.S. Department of Veterans Affairs (VA) and other federal government agencies are highly encouraged.

Note: This is an AI-generated summary...

Summary

The Fiscal Year 2026 (FY26) Parkinson’s Research Program (PRP) Investigator-Initiated Research Award (IIRA) is a grant or cooperative agreement supporting rigorous, multidisciplinary, high-impact research projects with the potential to significantly contribute to Parkinson's disease (PD) research. The program, with a total allotment of approximately $10 million, expects to fund around five awards, each with a total cost cap of $2 million for a maximum performance period of three years. Research projects, which can span from basic science to clinical trials, must address at least one of four specified FY26 PRP Focus Areas: disease heterogeneity, in vitro model development, biological mechanisms or biomarkers for unmet medical needs, and interventions for unmet medical needs. Key features of this award include a Partnering Principal Investigator (PI) option, a requirement for preliminary data, and a minimum 15% effort commitment from the Initiating PI. All applications must demonstrate how the research will benefit Service Members, Veterans, and their families.

Overall Technical Areas

Parkinson's Disease HeterogeneityTherapeutic Outcome ResearchIn Vitro Model DevelopmentBiological Mechanisms ResearchBiomarker DiscoveryClinical Biomarker AnalysisNeuroimaging TechniquesPharmacological InterventionsNon-Pharmacological InterventionsNon-Invasive CNS StimulationClinical Trial DesignPreclinical Animal ModelsMotor Symptom ResearchNon-Motor Symptom ResearchBioinformatics and Statistical Analysis

Probable LBNL Areas

N/A

Focus Areas

Example Priorities:

Understanding how Parkinson’s disease biological and clinical heterogeneity impacts disease presentation, clinical course and therapeutic outcomes, from prodromal to late-stage Parkinson’s disease.

Specific Technical Skills:

Clinical NeurologyEpidemiologyLongitudinal StudiesBiomarker AnalysisStatistical ModelingGenomicsProteomicsProdromal Disease ResearchClinical Outcome AssessmentDisease Progression Modeling

Potential PIs for this Area:

Name	Score	Organization

Example Priorities:

Development and characterization of in vitro model systems that approximate in vivo cellular and system complexity.

Specific Technical Skills:

Cell CultureOrganoid DevelopmentMicrofluidicsStem Cell BiologyiPSC TechnologyHigh-Content ImagingSystems BiologyBioengineeringCellular AssaysMolecular Biology

Potential PIs for this Area:

Name	Score	Organization

Example Priorities:

Biological mechanisms or biomarkers, such as clinical, fluid, imaging, tissue, and devices, of unmet medical needs that could lead to the development of treatments for PD.
Applications can utilize laboratory models through to human participants.
Non-motor symptoms: Autonomic, Cognitive, Fatigue, Olfaction, Pain, Psychiatric, Sensory, Sleep and circadian rhythm disruptions
Motor symptoms: Dyskinesia, Dystonia, Gait and balance, Tremor

Specific Technical Skills:

Biomarker DiscoveryNeuroimagingFluid BiomarkersTissue AnalysisMedical Device DevelopmentAssay DevelopmentProteomicsGenomicsPathophysiologyClinical Assessment

Potential PIs for this Area:

Name	Score	Organization

Example Priorities:

Interventions that address unmet medical needs of PD that include both clinical and preclinical models.
Examples of interventions of interest include, but are not limited to: Biologicals, Pharmacological, Non-pharmacological, Surgical, Non-surgical devices, Non-invasive central nervous system stimulation

Specific Technical Skills:

PharmacologyDrug DevelopmentPreclinical ModelingClinical Trial DesignBiologicsNeurosurgeryMedical Device EngineeringNeuromodulationCNS StimulationRehabilitation Science

Potential PIs for this Area:

Name	Score	Organization

Potential LBNL PIs (Overall)

Note on PI Matching: These suggestions are generated through an AI-driven semantic analysis of LBNL staff profiles.

Name	Score	Organization
Georgios Pavlopoulos	0.76	BSA \| DOE Joint Genome Institute \| JGI Science Dept · Bioinformatics and Statistical Analysis
Zhong Wang	0.76	BSA \| DOE Joint Genome Institute \| Data Science & Informatics · Bioinformatics and Statistical Analysis
Jian-Hua Mao	0.74	BSA \| Biological Systems & Engineering \| Department of BioEngineering and BioMedical Sciences · Biomarker Discovery
Kevin Fan	0.74	LD \| LD \| Strategic Partnerships · Neuroimaging Techniques
Benjamin Cole	0.73	BSA \| DOE Joint Genome Institute \| JGI Science Dept · Biological Mechanisms Research
Jennifer Rosenbluth	0.73	· In Vitro Model Development
Karthik Shekhar	0.72	BSA \| Biological Systems & Engineering \| Biodesign Dept · Parkinson's Disease Heterogeneity
Amy Kronenberg	0.71	BSA \| Biological Systems & Engineering \| Biodesign Dept · Therapeutic Outcome Research
Ehud Isacoff	0.71	BSA \| Molecular Biophysics & Integrated Bioimaging \| Cellular & Tissue Image · Pharmacological Interventions
Tamas Torok	0.71	EESA \| CESD \| Molecular Ecology & Biogeochem · Non-Pharmacological Interventions

Fundamental Research Exemption (FRE)

In accordance with National Security Presidential Memorandum-33 and all associated laws, all fundamental research funded by the DOW must be evaluated for affiliations with foreign entities.