ONHS Report: HT9427RFI2027TBIPHRP

Traumatic Brain Injury and Psychological Health Research Program Public Request for Information

Solicitation ID: HT9427RFI2027TBIPHRP

Agency: Congressionally Directed Medical Research Programs (CDMRP)/Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP)

Type: Sources Sought

Deadline: 2026-12-11T16:00:00 ET

Eligibility: Maybe (Topic Dependent)

Funding: Appropriations from FY21-24 and FY26 totaled $740.5 million.

Doc Type: RFI

Clearance: No

Program Manager: Patrick M. Younkins

Last Updated: 2026-10-27 16:03

Analyzed File: 2027 TBIPHRP RFI Questions.docx

Eligibility Reasoning

This RFI is issued solely for information and planning purposes and does not constitute a solicitation. ... At this time, questions concerning the composition and requirements for a future RFP will not be entertained.

Note: This is an AI-generated summary...

Summary

The Congressionally Directed Medical Research Programs (CDMRP) has issued a Request for Information (RFI) to gather stakeholder feedback for strategic planning of the Fiscal Year 2027 (FY27) Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP). The purpose is to inform future research focus areas and funding opportunities. This RFI is not a solicitation for proposals but a survey seeking input from a broad audience, including academia, industry, healthcare providers, and the public. The survey asks respondents to rate the urgency of funding specific research gaps categorized under three strategic goals: 'Understand' (etiology, predictive models), 'Prevent and Assess' (biomarkers, interventions, resilience), and 'Treat' (therapeutics, point-of-injury protocols, implementation science). It also seeks opinions on which stage of the research pipeline most needs funding and what critical research topics are currently overlooked.

Overall Technical Areas

Epidemiological & Etiological ModelingPredictive Health Trajectory ModelingRisk Prediction AlgorithmsGenetic and Endophenotype AnalysisCumulative Exposure Impact AnalysisBiomarker Development and ValidationMulti-Sensor Data FusionPharmacologic and Non-Pharmacologic InterventionsPsychological Resilience EnhancementPersonalized Preventive InterventionsMechanism-Based TherapeuticsCognitive and Functional RestorationRapid-Acting InterventionsMobile and Digital Health TechnologiesImplementation Science Research

Probable LBNL Areas

BSACSAEESAETALDOperationsPSA· Diagnostic Development

Focus Areas

Example Priorities:

Modeling and characterization of how genetics, endophenotypes, health demographics, pre-existing injuries, repetitive exposures, psychological health conditions, and environmental stressors interact to affect heterogeneous TBI outcomes
Translation and validation of predictive frameworks to understand how internal and external factors influence post-traumatic psychological health trajectories (e.g., acute stress, adjustment disorders, PTSD progression, and suicidality)
Translation and validation of risk-prediction algorithms (leveraging existing military/veteran cohorts) to map the synergistic, long-term impacts of cumulative blast exposures, repeated concussions, and/or chronic psychological stress on health outcomes
Identification of individuals that possess heightened biological vulnerability to acute stress disorder, PTSD, or prolonged post-concussive syndrome (PPCS)
Translation and validation of epidemiological indices and modeling tools to track and quantify the indirect, downstream impacts of parental TBI and/or PTSD on military Family stability and health

Specific Technical Skills:

EpidemiologyEtiology ResearchPredictive ModelingGenetics & EndophenotypingBiostatisticsData ScienceNeuroscienceLongitudinal Cohort AnalysisRisk Prediction AlgorithmsComputational Biology

Potential PIs for this Area:

Name	Score	Organization
Anna Giannakou	0.76	CSA \| SciData \| Data Science Applications · Data Science
Morgan Price	0.76	BSA \| Env. Genomics & Sys. Biology \| Comparative and Funct Genomics · Computational Biology
Satyarth Praveen	0.76	CSA \| SciData \| Data Science Applications · Risk Prediction Algorithms
Karthik Shekhar	0.75	BSA \| Biological Systems & Engineering \| Biodesign Dept · Neuroscience
Drew Paine	0.74	CSA \| SciData \| Data Science Applications · Longitudinal Cohort Analysis
Zixi Hu	0.74	CSA \| AMCR \| Mathematics · Biostatistics
Mark D. Risser	0.73	EESA \| CESD \| Earth System Sciences · Predictive Modeling
Justin Reese	0.73	BSA \| Env. Genomics & Sys. Biology \| BioSystems Data Science · Etiology Research
Fengchen Liu	0.72	Operations \| Information Technology \| IT Division Office · Epidemiology
Momoe Kato	0.72	BSA \| Env. Genomics & Sys. Biology \| Comparative and Funct Genomics · Genetics & Endophenotyping

Example Priorities:

Translation and validation of biomarkers or other objective methods for assessment, diagnosis, prognosis or real-time monitoring of psychological health conditions and/or TBI, including subclinical presentations, and associated sequelae of these conditions
Translation and clinical validation of multi-sensor data streams into actionable frameworks or tools to inform readiness or return-to-activity/duty decisions
Development and evaluation of pharmacologic and non-pharmacologic approaches, tools, and interventions designed to prevent or reduce the risk of psychological health conditions and/or TBI
Development and evaluation of crosscutting prevention approaches to address multiple adverse outcomes such as suicide, interpersonal violence (including intimate partner and family violence), and sexual assault by targeting upstream risk factors like compromised psychological health and/or TBI
Tailoring preventive interventions and neuroprotective thresholds to individual risk profiles

Specific Technical Skills:

Biomarker DiscoveryDiagnostic DevelopmentSensor Data FusionReal-time MonitoringClinical ValidationPharmacologyNeuroprotectionPreventive InterventionsPersonalized MedicinePsychological Resilience

Potential PIs for this Area:

Name	Score	Organization
Jian-Hua Mao	0.74	BSA \| Biological Systems & Engineering \| Department of BioEngineering and BioMedical Sciences · Biomarker Discovery
Georgios Pavlopoulos	0.73	BSA \| DOE Joint Genome Institute \| JGI Science Dept · Biomarker Discovery
Alexandre Bayen	0.73	ETA \| Energy Analysis \| Systems & Energy Tech Analysis · Real-time Monitoring
Victor Negut	0.72	PSA \| NSD \| ANP · Sensor Data Fusion
Jennifer Rosenbluth	0.72	· Diagnostic Development
Aris Polyzos	0.71	BSA \| Molecular Biophysics & Integrated Bioimaging \| Cellular & Tissue Image · Neuroprotection
Steffen Uhlemann	0.71	EESA \| EG \| Geophysics Dept · Psychological Resilience
Alan Meier	0.71	ETA \| Building & Industrial Energy Systems \| Bldg Technologies Dept · Preventive Interventions
Ehud Isacoff	0.71	BSA \| Molecular Biophysics & Integrated Bioimaging \| Cellular & Tissue Image · Pharmacology
Harry Caufield	0.71	BSA \| Env. Genomics & Sys. Biology \| BioSystems Data Science · Clinical Validation

Example Priorities:

Development and evaluation of mechanism-based therapeutic candidates—including personalized and endophenotype-tailored approaches—that target evolving pathophysiology, mitigate neurodegenerative processes, and alter the disease course of TBI and/or psychological health conditions
Interventions that can be administered across acute, post-acute, and chronic phases designed to restore cognitive reserve, repair sensory and motor deficits, and achieve sustained, long-term functional recovery following TBI
Rapid-acting interventions, non-pharmacologic symptom management solutions, and optimized clinical treatment strategies (including dosing, sequencing, and combination regimens) specifically structured to address co-occurring TBI and/or psychological health conditions
Acute interventions, point-of-injury protocols, and mobile health/digital technologies engineered for rapid deployment in rural, austere, or military environments, including delivery by non-clinicians (e.g., Emergency Medical Technicians, medics, corpsmen, peers, teams)
Health services and implementation research to accelerate the clinical adoption of evidence-based practices, and improve long-term treatment engagement, compliance, and recovery outcomes

Specific Technical Skills:

Therapeutic DevelopmentNeuropathophysiologyPersonalized MedicineCognitive RehabilitationMobile Health (mHealth)Digital TherapeuticsPoint-of-Injury CareImplementation ScienceHealth Services ResearchClinical Trial Design

Potential PIs for this Area:

Name	Score	Organization
Jian-Hua Mao	0.72	BSA \| Biological Systems & Engineering \| Department of BioEngineering and BioMedical Sciences · Personalized Medicine
Kevin Fan	0.71	LD \| LD \| Strategic Partnerships · Neuropathophysiology
Aris Polyzos	0.71	BSA \| Molecular Biophysics & Integrated Bioimaging \| Cellular & Tissue Image · Therapeutic Development
Karthik Shekhar	0.70	BSA \| Biological Systems & Engineering \| Biodesign Dept · Cognitive Rehabilitation
Dipak Ghosal	0.69	CSA \| ESNET \| Tech Adv and Engagement · Mobile Health (mHealth)
Eleanor Zizka	0.69	BSA \| Biological Systems & Engineering \| Department of BioEngineering and BioMedical Sciences · Clinical Trial Design
Rafael Zamora-Resendiz	0.69	CSA \| AMCR \| Computer Science · Health Services Research
Stephanie Holm	0.69	ETA \| Energy Analysis \| Systems & Energy Tech Analysis · Point-of-Injury Care
Michelle O'Malley	0.69	BSA \| Biological Systems & Engineering \| Biodesign Dept · Implementation Science
Seth Carbon	0.68	BSA \| Env. Genomics & Sys. Biology \| BioSystems Data Science · Digital Therapeutics

Potential LBNL PIs (Overall)

Note on PI Matching: These suggestions are generated through an AI-driven semantic analysis of LBNL staff profiles.

Name	Score	Organization
Thomas McKone	0.74	ETA \| Energy Analysis \| Systems & Energy Tech Analysis · Cumulative Exposure Impact Analysis
Victor Negut	0.73	PSA \| NSD \| ANP · Multi-Sensor Data Fusion
Jian-Hua Mao	0.73	BSA \| Biological Systems & Engineering \| Department of BioEngineering and BioMedical Sciences · Biomarker Development and Validation
Jovan Tadic	0.72	ETA \| Energy Analysis \| Systems & Energy Tech Analysis · Epidemiological & Etiological Modeling
Kevin Fan	0.72	LD \| LD \| Strategic Partnerships · Cognitive and Functional Restoration
Fengchen Liu	0.71	Operations \| Information Technology \| IT Division Office · Predictive Health Trajectory Modeling
Aris Polyzos	0.71	BSA \| Molecular Biophysics & Integrated Bioimaging \| Cellular & Tissue Image · Mechanism-Based Therapeutics
Satyarth Praveen	0.71	CSA \| SciData \| Data Science Applications · Risk Prediction Algorithms
Jennifer Rosenbluth	0.71	· Personalized Preventive Interventions
Jing Ke	0.71	ETA \| Energy Analysis \| Energy Efficiency Studies · Implementation Science Research

Fundamental Research Exemption (FRE)

Not Mentioned