LBNL Logo ONHS Funding Opportunity Report

Participant Basic Agreement (PBA) Opportunity - Threat Agnostic Host-Directed Therapeutics

Solicitation ID: W911SR-26-R-HEAL

Agency: U.S. Army/CPE CBRND

Type: Special Notice
Deadline: N/A
Eligibility: Maybe (OTA/Consortium)
Funding: N/A
Doc Type: CSO
Clearance: No
Program Manager: Hunter Robinson
Last Updated: 2026-04-23 16:02
Analyzed File: Host Directed MCM PBA.pdf

Eligibility Reasoning

This announcement serves as an invitation to the full spectrum of drug development organizations... The HEALER portfolio will be executed under the terms of a Participant Basic Agreement (PBA)... Projects may be awarded under the authority of 10 U.S.C §4021, 10 U.S.C. §4022, and 10 U.S.C. §4023.

Note: This is an AI-generated summary...

Summary

The Capability Program Executive for Chemical, Biological, Radiological, and Nuclear Defense (CPE CBRND) seeks collaborators for its HEALER portfolio, a program to develop threat-agnostic, host-directed therapeutics. The initiative aims to create dual-use medical countermeasures that enhance the body's resilience to CBRN threats by targeting critical host systems such as neurological, respiratory, immune, hematologic/vascular, and cellular stress pathways. The program invites participation from both therapeutic developers and drug development support organizations (e.g., CROs, CDMOs). Interested entities must submit a five-page white paper outlining their product or service capabilities, including details on mechanism of action, efficacy data, regulatory status, and manufacturing. The program will be executed under a Participant Basic Agreement (PBA), and applicants must be willing to collaborate with other portfolio members.

Overall Technical Areas

Host-Directed TherapeuticsPharmacology and ToxicologyPreclinical Efficacy TestingIn Vivo / In Vitro AssaysValidated Animal Model DevelopmentPharmacokinetics / Pharmacodynamics (PK/PD)Clinical Trial ExecutioncGMP Pharmaceutical ManufacturingBiologic and Small Molecule DevelopmentNeurological Protection PathwaysImmune System ModulationCellular Stress and RepairRespiratory System StabilizationHematologic and Vascular Function

Probable LBNL Areas

BSAESAETAPSA

Focus Areas

Example Priorities:
  • Neurological Protection
  • Respiratory Stabilization
  • Immune Modulation
  • Hematologic & Vascular Function
  • Cellular Stress & Repair Pathways
Specific Technical Skills:
Neurological ProtectionRespiratory StabilizationImmune ModulationHematologic & Vascular FunctionCellular Stress & Repair Pathways
Potential PIs for this Area:
NameScoreOrganization
Gang Ren0.68ESA | MF | MF Image and Manipulation
Karthik Shekhar0.66BSA | Biological Systems & Engineering | Biodesign Dept
Aindrila Mukhopadhyay0.64BSA | Biological Systems & Engineering | Biodesign Dept
Grigory Tikhomirov0.64PSA | PHY | Detector Development
Seth Carbon0.64BSA | Env. Genomics & Sys. Biology | BioSystems Data Science
Chris Mungall0.64BSA | Env. Genomics & Sys. Biology | BioSystems Data Science
Rohan Adwankar0.64BSA | Biological Systems & Engineering | Process Engr & Analytics
Boxun Hu0.64ETA | ESDR | Energy Storage & Dist Dpt
Jayson Vavrek0.64PSA | NSD | ANP
Anandharaj Marimuthu0.64BSA | DOE Joint Genome Institute | JGI Technology Dept

Potential LBNL PIs (Overall)

Note on PI Matching: These suggestions are generated through an AI-driven semantic analysis of LBNL staff profiles.

NameScoreOrganization
Natalia Molchanova0.75ESA | MF | MF Biological Facility · Host-Directed Therapeutics
Priscilla Cooper0.74BSA | Biological Systems & Engineering | Department of BioEngineering and BioMedical Sciences · Cellular Stress and Repair
Deepika Awasthi0.74BSA | Biological Systems & Engineering | Biodesign Dept · Immune System Modulation
Claire Tomlin0.72BSA | Biological Systems & Engineering | Department of BioEngineering and BioMedical Sciences · Respiratory System Stabilization
Jennifer Rosenbluth0.72 · In Vivo / In Vitro Assays
Aris Polyzos0.72BSA | Molecular Biophysics & Integrated Bioimaging | Cellular & Tissue Image · Pharmacology and Toxicology
John Conboy0.72BSA | Biological Systems & Engineering | Department of BioEngineering and BioMedical Sciences · Hematologic and Vascular Function
Seth Carbon0.71BSA | Env. Genomics & Sys. Biology | BioSystems Data Science · Biologic and Small Molecule Development
Karthik Shekhar0.71BSA | Biological Systems & Engineering | Biodesign Dept · Neurological Protection Pathways
Jacob Hilzinger0.70BSA | Env. Genomics & Sys. Biology | Molecular Ecosystems Bio · cGMP Pharmaceutical Manufacturing

Fundamental Research Exemption (FRE)

Not Mentioned