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7786-30-3: Magnesium dichloride
Chemical details of Magnesium dichloride
Chemical Identity
- Preferred Name: Magnesium dichloride
CASRN: 7786-30-3
Substance Class(es) (from SciFinder): Small Molecule- E&H Chemical Class L1: Inorganic Chemicals ; L2: inorganic salt
Molecular Structure
HAZARD EVIDENCE
Hazard Tiers
Tier levels(1) Hazard classes(2)
-
Open-FF's Compiled Hazard Summary:
Tier 1: Authoritative GHS record of substantial hazard
Tier 2: Expanded perspective
Tier 3: Demonstrated Low Hazard
Tier 4: Data Deficient
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Hazard classes:
CMR: Carcinogen, Mutagen or Reproductive hazard
IHL: Inhalation hazards
ORL: Oral hazards
SKN: Dermal and eye hazards
OGN: Organ and systemic hazards
EDC: Endocrine disruption hazards (note that GHS does not yet have comprehensive classification of EDCs. Therefore, the strongest hazard level in this system is effectively level 2)
ENV: Environmental hazards
Our Tier Summary: Magnesium dichloride exhibits known hazards (Tier 1) for oral and dermal/eye exposure. An expanded perspective (Tier 2) suggests potential concerns for carcinogenicity/mutagenicity/reproductive hazards, endocrine disruption, and inhalation. However, data gaps (Tier 4) exist for environmental and organ/systemic hazards.
Evidence for Tier levels
(Select category below for more detail)
The overall tier level for Magnesium dichloride is based on its most severe hazard class(es): - Tier 1
Carcinogenic, Mutagenic, or Reproductive Toxicity - Tier 2
- Genotoxicity_Mutagenicity: Very High Hazard (ChemInfoHazard)
Endocrine Disruption - Tier 2
- Endocrine_Disruption: High Hazard (ChemInfoHazard)
Environmental Hazard - Tier 4
- no data found
Inhalation Hazard - Tier 2
- H335: May cause respiratory irritation (ChemInformatics; PubChem)
Oral Hazard - Tier 1
- H302: Harmful if swallowed (ChemInformatics; PubChem)
Dermal/Eye Hazard - Tier 1
- H318: Causes serious eye damage (ChemInformatics; PubChem)
Organ Hazard - Tier 4
- no data found
Lists of Concern and/or Low Hazard
While Magnesium dichloride is recognized on several "Low Hazard" lists, including FDA GRAS and EPA's Substances Added to Food, it also appears on the TEDX list of potential endocrine disruptors. Its presence on low hazard lists likely pertains to tightly regulated, low-quantity uses, and it may still pose hazards under other conditions.
List of Concerns: Details
TEDX list The Endocrine Disruption Exchange: This list of Potential Endocrine Disruptors identifies chemicals that have shown evidence of endocrine disruption in scientific research.- Link to resource
Evidence of Low Hazard: Details
SCIL Green Circle list From SCIL: "The chemical has been verified to be of low concern based on experimental and modeled data:"- Link to resource
Substances added to Food From EPA: The Substances Added to Food inventory replaces what was previously known as Everything Added to Foods in the United States (EAFUS). The Substances Added to Food inventory includes the following types of ingredients regulated by the U.S. Food and Drug Administration (FDA): -Food additives and color additives that are listed in FDA regulations (21 CFR Parts 172, 173 and Parts 73)"- Link to resource
FDA's GRAS list From FDA: "This database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances."- Link to resource
How complete is the understanding of this chemical?
With over 100,000 literature references and a well-defined molecular structure, magnesium dichloride is extensively characterized in scientific literature. It also has a reasonable number of toxicity records (45) in the EPA ToxValDB, though specific hazard areas remain data deficient and it has not undergone the rigorous IRIS or PPRTV evaluations.
Links to Profiles and Data Sheets
These badges connect you directly to original chemical profile sheets. Active resources are highlighted in green, while unassessed resources are greyed out and crossed out.
SOURCES
Chemical-specific data for tier generation
Authoritative indicators of hazards (GHS)
Expand for details
(ORL) H302: Harmful if swallowed
(SKN) H315: Causes skin irritation- (SKN) H318: Causes serious eye damage
- (SKN) H319: Causes serious eye irritation
- (IHL) H335: May cause respiratory irritation
Other indications of hazards
Expand for details
- (EDC) Endocrine_Disruption: high
- (SKN) Eye_Irritation: high
- (CMR) Genotoxicity_Mutagenicity: very high
Affirmative data showing low concern
Expand for details
- Oral
(ORL) : low - Dermal (SKN) : low
- Systemic_Toxicity:_Repeat_Exposure: low
- Acute_Aquatic_Toxicity (ENV) : low
- Bioaccumulation: low
