PLoS PathogplosplospathPLoS Pathogens1553-7374Public Library of ScienceSan Francisco, USA10.1371/image.ppat.v15.i03Issue ImageMedicine and health sciencesPathology and laboratory medicinePathogensIntracellular pathogensBiology and life sciencesCell biologyCellular typesAnimal cellsImmune cellsGranulomasBiology and life sciencesImmunologyImmune cellsGranulomasMedicine and health sciencesImmunologyImmune cellsGranulomasBiology and life sciencesOrganismsBacteriaActinobacteriaMycobacterium tuberculosisBiology and life sciencesCell biologyCellular typesAnimal cellsBlood cellsWhite blood cellsMacrophagesBiology and life sciencesCell biologyCellular typesAnimal cellsImmune cellsWhite blood cellsMacrophagesBiology and life sciencesImmunologyImmune cellsWhite blood cellsMacrophagesMedicine and health sciencesImmunologyImmune cellsWhite blood cellsMacrophagesBiology and life sciencesCell biologyCellular typesAnimal cellsBlood cellsWhite blood cellsLymphocytesBiology and life sciencesCell biologyCellular typesAnimal cellsImmune cellsWhite blood cellsLymphocytesBiology and life sciencesImmunologyImmune cellsWhite blood cellsLymphocytesMedicine and health sciencesImmunologyImmune cellsWhite blood cellsLymphocytesEngineering and technologySignal processingImage processingMedicine and health sciencesDiagnostic medicineDiagnostic radiologyPulmonary imagingResearch and analysis methodsImaging techniquesDiagnostic radiologyPulmonary imagingMedicine and health sciencesRadiology and imagingDiagnostic radiologyPulmonary imagingPLoS Pathogens Issue Image | Vol. 15(3) March 2019Issue Image320193132019153ev15.i032019Durbin, Verma and SalgameThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.<bold>Transmission phenotype of <italic>Mycobacterium tuberculosis</italic> strains is mechanistically linked to induction of distinct pulmonary pathology</bold>

Fig 5. Intracellular acid-fast bacteria within discrete granulomas in Mtb-HT infected mice.

In contrast to the diffuse lung pathology present in Mtb-LT infected mice, granulomas in Mtb-HT infected mice are compact aggregates of macrophages with few intracellular bacteria surrounded by lymphocytes. A fraction of these compact lesions expand and develop necrotic "caseous" centers in Mtb-HT infected mice which erode into the walls of adjacent intact airways, allowing high rates of transmission. Verma et al.

Image Credit: Durbin, J., Verma S. and Salgame, P. (2019)

<fig id="image-ppat-v15-i03-g001"><object-id pub-id-type="doi">10.1371/image.ppat.v15.i03.g001</object-id><caption><title><bold>Transmission phenotype of <italic>Mycobacterium tuberculosis</italic> strains is mechanistically linked to induction of distinct pulmonary pathology</bold>

Fig 5. Intracellular acid-fast bacteria within discrete granulomas in Mtb-HT infected mice.

In contrast to the diffuse lung pathology present in Mtb-LT infected mice, granulomas in Mtb-HT infected mice are compact aggregates of macrophages with few intracellular bacteria surrounded by lymphocytes. A fraction of these compact lesions expand and develop necrotic "caseous" centers in Mtb-HT infected mice which erode into the walls of adjacent intact airways, allowing high rates of transmission. Verma et al.

Image Credit: Durbin, J., Verma S. and Salgame, P. (2019)

2019Durbin, Verma and SalgameThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.