# signf corr. p-value T Q Q&T Q&T/Q Q&T/T term ID t type t group t name and depth in group Q&T list # 1 ! 1.87e-12 776 62 22 0.355 0.028 GO:1903047 BP 1 mitotic cell cycle process 1 HMMR,MCM2,MCM6,APEX1,CCND1,KIF20A,GADD45A,CDC20,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,KIF11,CCNA2,MKI67,SPC25,CDK2AP2,CDK1,UBE2C,PRC1 1 ! 9.38e-12 946 62 23 0.371 0.024 GO:0000278 BP 1 mitotic cell cycle 1 HMMR,MCM2,MCM6,APEX1,CCND1,KIF20A,GADD45A,CDC20,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,KIF11,CCNA2,MKI67,SPC25,CDK2AP2,PBK,CDK1,UBE2C,PRC1 1 ! 2.84e-11 6 89 6 0.067 1.000 CORUM:310 cor 1 Cell cycle kinase complex CDC2 1 CCND1,CDKN1A,PCNA,CCNB1,CCNB2,CDK1 1 ! 1.07e-09 124 62 11 0.177 0.089 KEGG:04110 keg 1 Cell cycle 1 MCM2,MCM6,CCND1,GADD45A,CDC20,CDKN1A,PCNA,CCNB1,MDM2,CCNA2,CDK1 1 ! 1.72e-08 513 65 16 0.246 0.031 GO:0009636 BP 1 response to toxic substance 1 ABCC2,DPYSL2,HMOX1,APEX1,CCND1,CHKA,CDKN1A,CDO1,RGN,PCNA,CCNB1,MDM2,EPHX1,CDK1,TXNRD1,SRXN1 1 ! 2.11e-08 1249 67 23 0.343 0.018 GO:0022402 BP 1 cell cycle process 1 HMMR,MCM2,MCM6,APEX1,CCND1,KIF20A,GADD45A,CDC20,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,KIF11,CCNA2,MKI67,SPC25,CDK2AP2,CDK1,SLC25A33,UBE2C,PRC1 1 ! 3.42e-08 706 67 18 0.269 0.025 GO:0010564 BP 1 regulation of cell cycle process 1 HMMR,APEX1,CCND1,KIF20A,GADD45A,CDC20,CDKN1A,PCNA,CCNB1,MDM2,KIF23,KIF11,MKI67,CDK2AP2,CDK1,SLC25A33,UBE2C,PRC1 1 ! 4.46e-08 950 88 23 0.261 0.024 GO:0014070 BP 1 response to organic cyclic compound 1 ABCC2,SREBF1,DPYSL2,APEX1,RIOK3,CPT1A,CCND1,CHKA,KLF9,GOT1,PCK1,CDKN1A,CDO1,PCNA,CCNB1,MDM2,AGT,EPHX1,CCNA2,ACSL1,CDK1,NR1D2,GLDC 1 ! 4.57e-08 1766 70 27 0.386 0.015 GO:0007049 BP 1 cell cycle 1 HMMR,MCM2,MCM6,APEX1,CCND1,KRT18,KIF20A,CCNG1,GADD45A,CDC20,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,KIF11,CCNA2,MKI67,SPC25,PELO,CDK2AP2,PBK,CDK1,SLC25A33,UBE2C,PRC1 1 ! 1.00e-07 4 53 4 0.075 1.000 CORUM:5544 cor 1 CDC2-PCNA-CCNB1-GADD45A complex 1 GADD45A,PCNA,CCNB1,CDK1 1 ! 1.22e-07 996 96 24 0.250 0.024 GO:0055114 BP 1 oxidation-reduction process 1 FMO3,HMOX1,APEX1,ECH1,PTGR1,PHYH,UGDH,CPT1A,HMGCR,COQ10B,CDO1,CCNB1,PGD,SELENBP1,PDIA6,PDIA4,CPT2,DHRS3,CYB5A,CDK1,IMPDH2,GLDC,TXNRD1,SRXN1 1 ! 1.24e-07 628 46 15 0.326 0.024 REAC:R-HSA-1640170 rea 1 Cell Cycle 1 HMMR,MCM2,MCM6,CCND1,KIF20A,CDC20,TOP2A,PCNA,CCNB1,MDM2,KIF23,CCNA2,SPC25,CDK1,UBE2C 1 ! 1.29e-07 522 46 14 0.304 0.027 REAC:R-HSA-69278 rea 1 Cell Cycle, Mitotic 1 HMMR,MCM2,MCM6,CCND1,KIF20A,CDC20,TOP2A,PCNA,CCNB1,KIF23,CCNA2,SPC25,CDK1,UBE2C 1 ! 1.41e-07 3116 88 40 0.455 0.013 GO:0070887 BP 1 cellular response to chemical stimulus 1 TNFRSF12A,FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,MCM2,HMOX1,APEX1,RIOK3,CPT1A,CCND1,KRT18,HMGCR,KLF9,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,PCNA,CCNB1,MDM2,AGT,EPHX1,PDIA6,CCNA2,ACSL1,PELO,CDK1,SHCBP1,SLC25A33,NR1D2,IMPDH2,ZFAND2A,GLDC,TXNRD1,SRXN1 1 ! 1.63e-07 283 62 12 0.194 0.042 GO:0044843 BP 1 cell cycle G1/S phase transition 1 MCM2,MCM6,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CCNA2,CDK2AP2,CDK1 1 ! 2.59e-07 1151 67 21 0.313 0.018 GO:0051726 BP 1 regulation of cell cycle 1 HMMR,APEX1,CCND1,KIF20A,CCNG1,GADD45A,CDC20,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,KIF11,CCNA2,MKI67,CDK2AP2,CDK1,SLC25A33,UBE2C,PRC1 1 ! 5.21e-07 1987 98 33 0.337 0.017 GO:0044281 BP 1 small molecule metabolic process 1 ABCC2,SREBF1,HMMR,TRIB3,ECH1,PTGR1,PHYH,UGDH,CPT1A,CHKA,ACOT13,HMGCR,COQ10B,GOT1,PCK1,SLC17A3,CDO1,RGN,CCNB1,HMGCS2,YARS,PGD,EPHX1,ACSL1,CPT2,FDPS,DHRS3,CYB5A,CDK1,SLC25A33,IMPDH2,GLDC,TXNRD1 1 ! 6.78e-07 975 46 16 0.348 0.016 GO:0042493 BP 1 response to drug 1 ABCC2,DPYSL2,HMOX1,PTGR1,CPT1A,CCND1,CHKA,KLF9,SLC17A3,CDO1,PCNA,CCNB1,MDM2,CCNA2,ACSL1,CDK1 1 ! 9.31e-07 591 63 15 0.238 0.025 GO:0051301 BP 1 cell division 1 CCND1,KIF20A,CCNG1,CDC20,TOP2A,CCNB1,KIF23,KIF11,CCNA2,SPC25,PELO,CDK2AP2,CDK1,UBE2C,PRC1 1 ! 1.16e-06 511 62 14 0.226 0.027 GO:0044772 BP 1 mitotic cell cycle phase transition 1 HMMR,MCM2,MCM6,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CCNA2,CDK2AP2,CDK1,UBE2C 1 ! 1.31e-06 264 62 11 0.177 0.042 GO:0000082 BP 1 G1/S transition of mitotic cell cycle 1 MCM2,MCM6,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 2.86e-06 117 98 10 0.102 0.085 REAC:R-HSA-1989781 rea 1 PPARA activates gene expression 1 SREBF1,TRIB3,CPT1A,HMGCR,HMGCS2,AGT,ACSL1,CPT2,NPAS2,TXNRD1 1 ! 2.91e-06 65 62 7 0.113 0.108 GO:0031571 BP 1 mitotic G1 DNA damage checkpoint 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 2.91e-06 65 62 7 0.113 0.108 GO:0044819 BP 1 mitotic G1/S transition checkpoint 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 3.21e-06 553 62 14 0.226 0.025 GO:0044770 BP 1 cell cycle phase transition 1 HMMR,MCM2,MCM6,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CCNA2,CDK2AP2,CDK1,UBE2C 1 ! 3.25e-06 66 62 7 0.113 0.106 GO:0044783 BP 1 G1 DNA damage checkpoint 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 3.38e-06 119 98 10 0.102 0.084 REAC:R-HSA-400206 rea 1 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 1 SREBF1,TRIB3,CPT1A,HMGCR,HMGCS2,AGT,ACSL1,CPT2,NPAS2,TXNRD1 1 ! 3.48e-06 107 62 8 0.129 0.075 GO:0044774 BP 1 mitotic DNA integrity checkpoint 1 CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,CDK1 1 ! 3.88e-06 148 62 9 0.145 0.061 REAC:R-HSA-453279 rea 1 Mitotic G1-G1/S phases 1 MCM2,MCM6,CCND1,CDKN1A,TOP2A,PCNA,CCNB1,CCNA2,CDK1 1 ! 4.41e-06 72 62 7 0.113 0.097 KEGG:04115 keg 1 p53 signaling pathway 1 CCND1,CCNG1,GADD45A,CDKN1A,CCNB1,MDM2,CDK1 1 ! 4.66e-06 111 62 8 0.129 0.072 GO:2000134 BP 1 negative regulation of G1/S transition of mitotic cell cycle 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 4.68e-06 3180 88 38 0.432 0.012 GO:0010033 BP 1 response to organic substance 1 TNFRSF12A,ABCC2,HERPUD1,CREB3L3,SREBF1,MCM2,DPYSL2,HMOX1,APEX1,RIOK3,CPT1A,CCND1,CHKA,KRT18,HMGCR,KLF9,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CDO1,PCNA,CCNB1,MDM2,AGT,EPHX1,PDIA6,CCNA2,SERPINH1,ACSL1,PELO,CDK1,SHCBP1,SLC25A33,NR1D2,IMPDH2,GLDC 1 ! 5.69e-06 4559 90 47 0.522 0.010 GO:0042221 BP 1 response to chemical 1 TNFRSF12A,FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,MCM2,DPYSL2,HMOX1,APEX1,RIOK3,PTGR1,CPT1A,CCND1,CHKA,KRT18,HMGCR,KLF9,GOT1,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,PCNA,CCNB1,MDM2,AGT,EPHX1,PDIA6,CCNA2,SERPINH1,ACSL1,PELO,CYB5A,CDK1,SHCBP1,FGA,SLC25A33,NR1D2,IMPDH2,ZFAND2A,GLDC,TXNRD1,SRXN1 1 ! 5.72e-06 167 62 9 0.145 0.054 GO:2000045 BP 1 regulation of G1/S transition of mitotic cell cycle 1 APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 6.56e-06 107 67 8 0.119 0.075 GO:0071156 BP 1 regulation of cell cycle arrest 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1,SLC25A33 1 ! 7.59e-06 118 62 8 0.129 0.068 GO:1902807 BP 1 negative regulation of cell cycle G1/S phase transition 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 1.37e-05 77 65 7 0.108 0.091 GO:0031100 BP 1 animal organ regeneration 1 HMOX1,CCND1,CDKN1A,RGN,PCNA,CCNA2,CDK1 1 ! 1.41e-05 185 62 9 0.145 0.049 GO:1902806 BP 1 regulation of cell cycle G1/S phase transition 1 APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 1.59e-05 33 89 6 0.067 0.182 GO:0097472 MF 1 cyclin-dependent protein kinase activity 1 CCND1,CDKN1A,CCNB1,CCNA2,CCNB2,CDK1 1 ! 1.63e-05 628 62 14 0.226 0.022 GO:0007346 BP 1 regulation of mitotic cell cycle 1 HMMR,APEX1,CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF11,MKI67,CDK2AP2,CDK1,UBE2C 1 ! 1.92e-05 11390 77 68 0.883 0.006 GO:0005737 CC 1 cytoplasm 1 IFRD1,FMO3,HERPUD1,CREB3L3,HMMR,MCM2,DPYSL2,HMOX1,APEX1,RIOK3,PTGR1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,POLR3G,COQ10B,GADD45A,CDC20,KLF9,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,CCNB1,HMGCS2,YARS,MDM2,AGT,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,DEPTOR,CPT2,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,CDK1,SHCBP1,SLC25A33,UBE2C,ZFAND2A,GLDC,CRELD2,MAFF,TXNRD1,PRC1,SRXN1 1 ! 1.99e-05 49 62 6 0.097 0.122 REAC:R-HSA-6791312 rea 1 TP53 Regulates Transcription of Cell Cycle Genes 1 GADD45A,CDKN1A,PCNA,CCNB1,CCNA2,CDK1 1 ! 2.25e-05 14266 78 76 0.974 0.005 GO:0044424 CC 1 intracellular part 1 IFRD1,FMO3,HERPUD1,CREB3L3,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,RIOK3,PTGR1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,DEPTOR,CPT2,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,PBK,CDK1,SHCBP1,SLC25A33,NR1D2,UBE2C,ZFAND2A,GLDC,CRELD2,MAFF,TXNRD1,PRC1,TCEA3,SRXN1 1 ! 2.51e-05 130 62 8 0.129 0.062 REAC:R-HSA-69206 rea 1 G1/S Transition 1 MCM2,MCM6,CCND1,CDKN1A,PCNA,CCNB1,CCNA2,CDK1 1 ! 2.85e-05 191 65 9 0.138 0.047 GO:0031099 BP 1 regeneration 1 IFRD1,HMOX1,CCND1,CDKN1A,RGN,PCNA,CCNB1,CCNA2,CDK1 1 ! 3.00e-05 274 62 10 0.161 0.036 GO:0090068 BP 1 positive regulation of cell cycle process 1 APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,KIF23,CDK1,UBE2C 1 ! 3.91e-05 418 43 10 0.233 0.024 GO:0010498 BP 1 proteasomal protein catabolic process 1 HERPUD1,CDC20,SDF2L1,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 4.12e-05 23 32 4 0.125 0.174 REAC:R-HSA-174048 rea 1 APC/C:Cdc20 mediated degradation of Cyclin B 1 CDC20,CCNB1,CDK1,UBE2C 1 ! 4.36e-05 291 43 9 0.209 0.031 REAC:R-HSA-69620 rea 1 Cell Cycle Checkpoints 1 MCM2,MCM6,CDC20,CCNB1,MDM2,CCNA2,SPC25,CDK1,UBE2C 1 ! 4.54e-05 371 62 11 0.177 0.030 GO:1901990 BP 1 regulation of mitotic cell cycle phase transition 1 HMMR,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1,UBE2C 1 ! 4.55e-05 748 96 18 0.188 0.024 GO:0016491 MF 1 oxidoreductase activity 1 FMO3,HMOX1,APEX1,PTGR1,PHYH,UGDH,HMGCR,CDO1,PGD,SELENBP1,PDIA6,PDIA4,DHRS3,CYB5A,IMPDH2,GLDC,TXNRD1,SRXN1 1 ! 4.82e-05 56 62 6 0.097 0.107 GO:0006977 BP 1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 4.90e-05 6043 89 53 0.596 0.009 GO:0003824 MF 1 catalytic activity 1 FMO3,ABCC2,MCM2,MCM6,DPYSL2,HMOX1,APEX1,RIOK3,ECH1,PTGR1,PHYH,CPT1A,CCND1,CHKA,ACOT13,KIF20A,HMGCR,POLR3G,GOT1,PCK1,CDKN1A,SDF2L1,CDO1,RGN,TOP2A,PCNA,CCNB1,HMGCS2,YARS,MDM2,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,ACSL1,PELO,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,PBK,CDK1,UBE2C,IMPDH2,GLDC,TXNRD1,SRXN1 1 ! 5.06e-05 13 20 3 0.150 0.231 CORUM:1005 cor 1 RC complex during G2/M-phase of cell cycle 1 CCNB1,CCNA2,CDK1 1 ! 5.29e-05 6 32 3 0.094 0.500 REAC:R-HSA-176417 rea 1 Phosphorylation of Emi1 1 CDC20,CCNB1,CDK1 1 ! 5.37e-05 57 62 6 0.097 0.105 GO:0072431 BP 1 signal transduction involved in mitotic G1 DNA damage checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 5.37e-05 57 62 6 0.097 0.105 GO:1902400 BP 1 intracellular signal transduction involved in G1 DNA damage checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 6.58e-05 101 62 7 0.113 0.069 GO:0044773 BP 1 mitotic DNA damage checkpoint 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 6.64e-05 59 62 6 0.097 0.102 GO:0072413 BP 1 signal transduction involved in mitotic cell cycle checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 6.64e-05 59 62 6 0.097 0.102 GO:1902402 BP 1 signal transduction involved in mitotic DNA damage checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 6.64e-05 59 62 6 0.097 0.102 GO:1902403 BP 1 signal transduction involved in mitotic DNA integrity checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 6.76e-05 9038 91 68 0.747 0.008 GO:0044446 CC 1 intracellular organelle part 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,ECH1,PHYH,CPT1A,CCND1,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,NDUFAF4,SLC17A3,CDKN1A,SDF2L1,DNAJB9,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,NUSAP1,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,NIFK,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,CDK1,SHCBP1,FGA,SLC25A33,NR1D2,UBE2C,IMPDH2,GLDC,MAFF,TXNRD1,PRC1 1 ! 6.85e-05 945 88 19 0.216 0.020 GO:0010243 BP 1 response to organonitrogen compound 1 ABCC2,HERPUD1,SREBF1,DPYSL2,APEX1,CCND1,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CDO1,PCNA,MDM2,AGT,CCNA2,CDK1,SLC25A33,GLDC 1 ! 7.20e-05 157 62 8 0.129 0.051 GO:0031570 BP 1 DNA integrity checkpoint 1 CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,CDK1 1 ! 8.05e-05 4 46 3 0.065 0.750 CORUM:5546 cor 1 CDC2-PCNA-CCNB1-GADD45G complex 1 PCNA,CCNB1,CDK1 1 ! 8.05e-05 4 46 3 0.065 0.750 CORUM:5545 cor 1 CDC2-PCNA-CCNB1-GADD45B complex 1 PCNA,CCNB1,CDK1 1 ! 9.17e-05 1069 88 20 0.227 0.019 GO:1901698 BP 1 response to nitrogen compound 1 ABCC2,HERPUD1,SREBF1,DPYSL2,APEX1,RIOK3,CCND1,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CDO1,PCNA,MDM2,AGT,CCNA2,CDK1,SLC25A33,GLDC 1 ! 9.34e-05 372 98 13 0.133 0.035 GO:0019216 BP 1 regulation of lipid metabolic process 1 SREBF1,TRIB3,CPT1A,HMGCR,RGN,HMGCS2,AGT,ACSL1,CPT2,FDPS,NPAS2,NR1D2,TXNRD1 1 ! 9.59e-05 72 54 6 0.111 0.083 GO:1901992 BP 1 positive regulation of mitotic cell cycle phase transition 1 APEX1,CCND1,CCNB1,MDM2,CDK1,UBE2C 1 ! 9.64e-05 163 62 8 0.129 0.049 GO:0007093 BP 1 mitotic cell cycle checkpoint 1 CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,CDK1 1 ! 1.09e-04 3 6 2 0.333 0.667 REAC:R-HSA-170145 rea 1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes 1 CCNA2,CDK1 1 ! 1.19e-04 14606 78 76 0.974 0.005 GO:0005622 CC 1 intracellular 1 IFRD1,FMO3,HERPUD1,CREB3L3,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,RIOK3,PTGR1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,DEPTOR,CPT2,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,PBK,CDK1,SHCBP1,SLC25A33,NR1D2,UBE2C,ZFAND2A,GLDC,CRELD2,MAFF,TXNRD1,PRC1,TCEA3,SRXN1 1 ! 1.20e-04 408 62 11 0.177 0.027 GO:1901987 BP 1 regulation of cell cycle phase transition 1 HMMR,APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1,UBE2C 1 ! 1.28e-04 75 32 5 0.156 0.067 REAC:R-HSA-176409 rea 1 APC/C:Cdc20 mediated degradation of mitotic proteins 1 CDC20,CCNB1,CCNA2,CDK1,UBE2C 1 ! 1.36e-04 76 32 5 0.156 0.066 REAC:R-HSA-176814 rea 1 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1 CDC20,CCNB1,CCNA2,CDK1,UBE2C 1 ! 1.43e-04 2 6 2 0.333 1.000 CORUM:5557 cor 1 CDC2-CCNA2 complex 1 CCNA2,CDK1 1 ! 1.48e-04 1571 88 24 0.273 0.015 GO:1901700 BP 1 response to oxygen-containing compound 1 ABCC2,SREBF1,DPYSL2,HMOX1,APEX1,CPT1A,CCND1,HMGCR,KLF9,GOT1,PCK1,CDKN1A,CDO1,RGN,PCNA,CCNB1,MDM2,AGT,CCNA2,ACSL1,CDK1,SLC25A33,GLDC,TXNRD1 1 ! 1.58e-04 18 53 4 0.075 0.222 REAC:R-HSA-6804114 rea 1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 1 GADD45A,PCNA,CCNB1,CDK1 1 ! 1.60e-04 362 43 9 0.209 0.025 GO:0043161 BP 1 proteasome-mediated ubiquitin-dependent protein catabolic process 1 HERPUD1,CDC20,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 1.77e-04 80 32 5 0.156 0.062 REAC:R-HSA-176408 rea 1 Regulation of APC/C activators between G1/S and early anaphase 1 CDC20,CCNB1,CCNA2,CDK1,UBE2C 1 ! 2.13e-04 9254 91 68 0.747 0.007 GO:0044422 CC 1 organelle part 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,ECH1,PHYH,CPT1A,CCND1,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,NDUFAF4,SLC17A3,CDKN1A,SDF2L1,DNAJB9,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,NUSAP1,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,NIFK,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,CDK1,SHCBP1,FGA,SLC25A33,NR1D2,UBE2C,IMPDH2,GLDC,MAFF,TXNRD1,PRC1 1 ! 2.23e-04 72 62 6 0.097 0.083 GO:0072401 BP 1 signal transduction involved in DNA integrity checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 2.23e-04 72 62 6 0.097 0.083 GO:0072422 BP 1 signal transduction involved in DNA damage checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 2.35e-04 4 62 3 0.048 0.750 CORUM:311 cor 1 Cell cycle kinase complex CDK2 1 CCND1,CDKN1A,PCNA 1 ! 2.35e-04 4 62 3 0.048 0.750 CORUM:312 cor 1 Cell cycle kinase complex CDK4 1 CCND1,CDKN1A,PCNA 1 ! 2.42e-04 73 62 6 0.097 0.082 GO:0072395 BP 1 signal transduction involved in cell cycle checkpoint 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 2.54e-04 86 32 5 0.156 0.058 REAC:R-HSA-174143 rea 1 APC/C-mediated degradation of cell cycle proteins 1 CDC20,CCNB1,CCNA2,CDK1,UBE2C 1 ! 2.54e-04 86 32 5 0.156 0.058 REAC:R-HSA-453276 rea 1 Regulation of mitotic cell cycle 1 CDC20,CCNB1,CCNA2,CDK1,UBE2C 1 ! 2.83e-04 311 87 11 0.126 0.035 GO:0007059 BP 1 chromosome segregation 1 RIOK3,CDC20,TOP2A,CCNB1,NUSAP1,KIF23,KIF11,MKI67,SPC25,UBE2C,PRC1 1 ! 2.85e-04 2 20 2 0.100 1.000 CORUM:5543 cor 1 CCNB1-CDC2 complex 1 CCNB1,CDK1 1 ! 2.91e-04 188 62 8 0.129 0.043 GO:1901991 BP 1 negative regulation of mitotic cell cycle phase transition 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 3.00e-04 87 54 6 0.111 0.069 GO:1901989 BP 1 positive regulation of cell cycle phase transition 1 APEX1,CCND1,CCNB1,MDM2,CDK1,UBE2C 1 ! 3.23e-04 2603 88 31 0.352 0.012 GO:0071310 BP 1 cellular response to organic substance 1 TNFRSF12A,ABCC2,HERPUD1,CREB3L3,SREBF1,MCM2,HMOX1,APEX1,RIOK3,CPT1A,CCND1,KRT18,HMGCR,KLF9,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CCNB1,MDM2,AGT,PDIA6,CCNA2,ACSL1,PELO,SHCBP1,SLC25A33,NR1D2,IMPDH2,GLDC 1 ! 3.47e-04 40 62 5 0.081 0.125 GO:0000307 CC 1 cyclin-dependent protein kinase holoenzyme complex 1 CCND1,CDKN1A,CCNB1,CCNA2,CDK1 1 ! 3.65e-04 270 62 9 0.145 0.033 GO:0045930 BP 1 negative regulation of mitotic cell cycle 1 CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 3.77e-04 542 90 14 0.156 0.026 GO:0010035 BP 1 response to inorganic substance 1 ABCC2,HMOX1,APEX1,CCND1,GOT1,RGN,PCNA,CCNB1,MDM2,CCNA2,CYB5A,CDK1,FGA,TXNRD1 1 ! 3.81e-04 1870 68 22 0.324 0.012 GO:0033554 BP 1 cellular response to stress 1 HERPUD1,CREB3L3,HMOX1,APEX1,CCND1,GADD45A,PCK1,CDKN1A,SDF2L1,DNAJB9,RGN,TOP2A,PCNA,CCNB1,MDM2,PDIA6,CCNA2,PDIA4,PBK,CDK1,TXNRD1,SRXN1 1 ! 3.89e-04 5205 62 36 0.581 0.007 GO:0043233 CC 1 organelle lumen 1 CREB3L3,MCM2,MCM6,HMOX1,APEX1,PHYH,CCND1,KIF20A,CCNG1,POLR3G,GADD45A,CDC20,KLF9,CDKN1A,SDF2L1,DNAJB9,TOP2A,PCNA,CCNB1,HMGCS2,MDM2,KIF23,SELENBP1,PDIA6,CCNA2,MKI67,SERPINH1,NIFK,PDIA4,CPT2,CDK1,NR1D2,UBE2C,GLDC,MAFF,TXNRD1 1 ! 3.89e-04 5205 62 36 0.581 0.007 GO:0031974 CC 1 membrane-enclosed lumen 1 CREB3L3,MCM2,MCM6,HMOX1,APEX1,PHYH,CCND1,KIF20A,CCNG1,POLR3G,GADD45A,CDC20,KLF9,CDKN1A,SDF2L1,DNAJB9,TOP2A,PCNA,CCNB1,HMGCS2,MDM2,KIF23,SELENBP1,PDIA6,CCNA2,MKI67,SERPINH1,NIFK,PDIA4,CPT2,CDK1,NR1D2,UBE2C,GLDC,MAFF,TXNRD1 1 ! 3.89e-04 5205 62 36 0.581 0.007 GO:0070013 CC 1 intracellular organelle lumen 1 CREB3L3,MCM2,MCM6,HMOX1,APEX1,PHYH,CCND1,KIF20A,CCNG1,POLR3G,GADD45A,CDC20,KLF9,CDKN1A,SDF2L1,DNAJB9,TOP2A,PCNA,CCNB1,HMGCS2,MDM2,KIF23,SELENBP1,PDIA6,CCNA2,MKI67,SERPINH1,NIFK,PDIA4,CPT2,CDK1,NR1D2,UBE2C,GLDC,MAFF,TXNRD1 1 ! 4.28e-04 3 6 2 0.333 0.667 CORUM:5559 cor 1 CDC2-CCNA2-CDK2 complex 1 CCNA2,CDK1 1 ! 4.29e-04 1231 43 14 0.326 0.011 GO:1901565 BP 1 organonitrogen compound catabolic process 1 HERPUD1,HMMR,HMOX1,CDC20,SDF2L1,DNAJB9,CDO1,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A,GLDC 1 ! 4.37e-04 2162 65 23 0.354 0.011 GO:0044248 BP 1 cellular catabolic process 1 HERPUD1,HMMR,HMOX1,APEX1,PHYH,CPT1A,CDC20,ETF1,SDF2L1,DNAJB9,CDO1,RGN,CCNB1,MDM2,EPHX1,ACSL1,PELO,CPT2,PBK,CDK1,UBE2C,ZFAND2A,GLDC 1 ! 4.88e-04 82 62 6 0.097 0.073 GO:0071158 BP 1 positive regulation of cell cycle arrest 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 5.40e-04 279 46 8 0.174 0.029 GO:0009410 BP 1 response to xenobiotic stimulus 1 ABCC2,DPYSL2,CDO1,PCNA,MDM2,EPHX1,CCNA2,ACSL1 1 ! 5.52e-04 374 62 10 0.161 0.027 GO:0045787 BP 1 positive regulation of cell cycle 1 APEX1,CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,KIF23,CDK1,UBE2C 1 ! 5.68e-04 27 46 4 0.087 0.148 REAC:R-HSA-1538133 rea 1 G0 and Early G1 1 TOP2A,PCNA,CCNA2,CDK1 1 ! 5.85e-04 5 62 3 0.048 0.600 CORUM:313 cor 1 Cell cycle kinase complex CDK5 1 CCND1,CDKN1A,PCNA 1 ! 6.01e-04 19 20 3 0.150 0.158 REAC:R-HSA-176412 rea 1 Phosphorylation of the APC/C 1 CCNB1,CDK1,UBE2C 1 ! 6.19e-04 969 98 19 0.194 0.020 GO:0019752 BP 1 carboxylic acid metabolic process 1 ABCC2,SREBF1,HMMR,TRIB3,ECH1,PTGR1,PHYH,UGDH,CPT1A,GOT1,PCK1,CDO1,RGN,YARS,PGD,ACSL1,CPT2,CYB5A,GLDC 1 ! 6.29e-04 35 32 4 0.125 0.114 GO:0031145 BP 1 anaphase-promoting complex-dependent catabolic process 1 CDC20,CCNB1,CDK1,UBE2C 1 ! 6.30e-04 208 62 8 0.129 0.038 GO:1901988 BP 1 negative regulation of cell cycle phase transition 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 6.43e-04 1073 98 20 0.204 0.019 GO:0006082 BP 1 organic acid metabolic process 1 ABCC2,SREBF1,HMMR,TRIB3,ECH1,PTGR1,PHYH,UGDH,CPT1A,GOT1,PCK1,SLC17A3,CDO1,RGN,YARS,PGD,ACSL1,CPT2,CYB5A,GLDC 1 ! 6.73e-04 32 89 5 0.056 0.156 GO:0004693 MF 1 cyclin-dependent protein serine/threonine kinase activity 1 CCND1,CDKN1A,CCNB1,CCNB2,CDK1 1 ! 7.55e-04 213 62 8 0.129 0.038 GO:0000075 BP 1 cell cycle checkpoint 1 CCND1,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,CDK1 1 ! 8.56e-04 3 20 2 0.100 0.667 CORUM:5551 cor 1 CDC2-CCNB1-PTCH1 complex 1 CCNB1,CDK1 1 ! 8.56e-04 3 20 2 0.100 0.667 CORUM:5550 cor 1 CDC2-CCNB1-CCNF complex 1 CCNB1,CDK1 1 ! 8.56e-04 3 20 2 0.100 0.667 CORUM:243 cor 1 RalBP1-CDC2-CCNB1 complex 1 CCNB1,CDK1 1 ! 8.56e-04 5 89 3 0.034 0.600 REAC:R-HSA-69478 rea 1 G2/M DNA replication checkpoint 1 CCNB1,CCNB2,CDK1 1 ! 9.10e-04 148 62 7 0.113 0.047 GO:0000077 BP 1 DNA damage checkpoint 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 9.26e-04 287 65 9 0.138 0.031 GO:0034599 BP 1 cellular response to oxidative stress 1 HMOX1,APEX1,RGN,PCNA,MDM2,CCNA2,CDK1,TXNRD1,SRXN1 1 ! 9.30e-04 158 62 7 0.113 0.044 KEGG:04218 keg 1 Cellular senescence 1 CCND1,GADD45A,CDKN1A,CCNB1,MDM2,CCNA2,CDK1 1 ! 1.02e-03 72 7 3 0.429 0.042 REAC:R-HSA-174184 rea 1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 1 CCNA2,CDK1,UBE2C 1 ! 1.06e-03 73 7 3 0.429 0.041 REAC:R-HSA-179419 rea 1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 1 CCNA2,CDK1,UBE2C 1 ! 1.14e-03 910 88 17 0.193 0.019 GO:0033993 BP 1 response to lipid 1 ABCC2,SREBF1,CPT1A,CCND1,KLF9,GOT1,PCK1,CDKN1A,CDO1,PCNA,CCNB1,MDM2,AGT,CCNA2,ACSL1,NR1D2,GLDC 1 ! 1.23e-03 855 46 12 0.261 0.014 MIRNA:hsa-miR-193b-3p mir 1 hsa-miR-193b-3p 1 MCM6,CCND1,CDC20,DNAJB9,TOP2A,PCNA,EPHX1,CCNA2,SPC25,CDK1,SHCBP1,UBE2C 1 ! 1.31e-03 38 85 5 0.059 0.132 GO:0033762 BP 1 response to glucagon 1 ABCC2,SREBF1,PCK1,CDO1,CCNA2 1 ! 1.32e-03 16 2 2 1.000 0.125 GO:0071243 BP 1 cellular response to arsenic-containing substance 1 HMOX1,ZFAND2A 1 ! 1.32e-03 102 59 6 0.102 0.059 GO:0007052 BP 1 mitotic spindle organization 1 CDC20,CCNB1,KIF23,KIF11,SPC25,PRC1 1 ! 1.42e-03 25 20 3 0.150 0.120 REAC:R-HSA-69273 rea 1 Cyclin A/B1/B2 associated events during G2/M transition 1 CCNB1,CCNA2,CDK1 1 ! 1.56e-03 1142 89 19 0.213 0.017 GO:0015630 CC 1 microtubule cytoskeleton 1 HMMR,MCM2,DPYSL2,APEX1,KRT18,ACOT13,KIF20A,CDC20,TOP2A,PCNA,CCNB1,NUSAP1,KIF23,KIF11,CCNB2,CDK2AP2,CDK1,SHCBP1,PRC1 1 ! 1.67e-03 33 43 4 0.093 0.121 GO:0010039 BP 1 response to iron ion 1 HMOX1,CCND1,CCNB1,MDM2 1 ! 1.76e-03 160 62 7 0.113 0.044 REAC:R-HSA-69242 rea 1 S Phase 1 MCM2,MCM6,CCND1,CDKN1A,PCNA,CCNA2,UBE2C 1 ! 1.86e-03 10713 98 77 0.786 0.007 GO:0044237 BP 1 cellular metabolic process 1 FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,TRIB3,RIOK3,ECH1,PTGR1,PHYH,UGDH,CPT1A,CCND1,CHKA,ACOT13,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,ETF1,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,PGD,EPHX1,PDIA6,SLC20A1,CCNA2,SERPINH1,ACSL1,PELO,NIFK,DEPTOR,CPT2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,PBK,CDK1,NPAS2,FGA,SLC25A33,NR1D2,UBE2C,EIF1AD,IMPDH2,ZFAND2A,GLDC,MAFF,SLC39A10,TXNRD1,TCEA3 1 ! 1.96e-03 230 65 8 0.123 0.035 GO:0000302 BP 1 response to reactive oxygen species 1 HMOX1,APEX1,RGN,PCNA,MDM2,CCNA2,CDK1,TXNRD1 1 ! 2.02e-03 185 56 7 0.125 0.038 GO:0035966 BP 1 response to topologically incorrect protein 1 HERPUD1,CREB3L3,CCND1,SDF2L1,DNAJB9,PDIA6,SERPINH1 1 ! 2.02e-03 231 65 8 0.123 0.035 GO:0097237 BP 1 cellular response to toxic substance 1 HMOX1,APEX1,RGN,PCNA,MDM2,CDK1,TXNRD1,SRXN1 1 ! 2.08e-03 10736 98 77 0.786 0.007 GO:0043231 CC 1 intracellular membrane-bounded organelle 1 IFRD1,FMO3,HERPUD1,CREB3L3,SREBF1,MCM2,MCM6,HMOX1,APEX1,TRIB3,ECH1,PHYH,UGDH,CPT1A,CCND1,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,NDUFAF4,SLC17A3,CDKN1A,SDF2L1,DNAJB9,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,TCF19,NUSAP1,KIF23,PGD,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,PBK,CDK1,NPAS2,FGA,SLC25A33,NR1D2,UBE2C,EIF1AD,IMPDH2,ZFAND2A,GLDC,CRELD2,MAFF,TXNRD1,PRC1,TCEA3 1 ! 2.08e-03 2 20 2 0.100 1.000 GO:0097125 CC 1 cyclin B1-CDK1 complex 1 CCNB1,CDK1 1 ! 2.12e-03 105 62 6 0.097 0.057 GO:0030330 BP 1 DNA damage response, signal transduction by p53 class mediator 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 2.15e-03 121 85 7 0.082 0.058 KEGG:04152 keg 1 AMPK signaling pathway 1 CREB3L3,SREBF1,CPT1A,CCND1,HMGCR,PCK1,CCNA2 1 ! 2.16e-03 11679 98 81 0.827 0.007 GO:0008152 BP 1 metabolic process 1 FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,APEX1,TRIB3,RIOK3,ECH1,PTGR1,PHYH,UGDH,CPT1A,CCND1,CHKA,ACOT13,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,ETF1,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,PGD,SELENBP1,EPHX1,PDIA6,SLC20A1,CCNA2,SERPINH1,ACSL1,PELO,NIFK,PDIA4,DEPTOR,CPT2,FDPS,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,PBK,CDK1,NPAS2,FGA,SLC25A33,NR1D2,UBE2C,EIF1AD,IMPDH2,ZFAND2A,GLDC,MAFF,SLC39A10,TXNRD1,TCEA3,SRXN1 1 ! 2.34e-03 1058 98 19 0.194 0.018 GO:0043436 BP 1 oxoacid metabolic process 1 ABCC2,SREBF1,HMMR,TRIB3,ECH1,PTGR1,PHYH,UGDH,CPT1A,GOT1,PCK1,CDO1,RGN,YARS,PGD,ACSL1,CPT2,CYB5A,GLDC 1 ! 2.61e-03 36 52 4 0.077 0.111 REAC:R-HSA-6804757 rea 1 Regulation of TP53 Degradation 1 CCNG1,MDM2,CCNA2,CDK1 1 ! 2.68e-03 123 87 7 0.080 0.057 GO:1902850 BP 1 microtubule cytoskeleton organization involved in mitosis 1 CDC20,CCNB1,NUSAP1,KIF23,KIF11,SPC25,PRC1 1 ! 2.85e-03 2029 65 21 0.323 0.010 GO:1901575 BP 1 organic substance catabolic process 1 HERPUD1,HMMR,HMOX1,APEX1,PHYH,CPT1A,CDC20,ETF1,SDF2L1,DNAJB9,CDO1,RGN,CCNB1,MDM2,PELO,CPT2,PBK,CDK1,UBE2C,ZFAND2A,GLDC 1 ! 2.92e-03 2435 43 18 0.419 0.007 GO:0009056 BP 1 catabolic process 1 HERPUD1,HMMR,HMOX1,CPT1A,CDC20,SDF2L1,DNAJB9,CDO1,CCNB1,MDM2,EPHX1,ACSL1,CPT2,PBK,CDK1,UBE2C,ZFAND2A,GLDC 1 ! 2.92e-03 37 52 4 0.077 0.108 REAC:R-HSA-6806003 rea 1 Regulation of TP53 Expression and Degradation 1 CCNG1,MDM2,CCNA2,CDK1 1 ! 2.97e-03 7 89 3 0.034 0.429 REAC:R-HSA-2980767 rea 1 Activation of NIMA Kinases NEK9, NEK6, NEK7 1 CCNB1,CCNB2,CDK1 1 ! 2.98e-03 62 61 5 0.082 0.081 GO:0016667 MF 1 oxidoreductase activity, acting on a sulfur group of donors 1 SELENBP1,PDIA6,PDIA4,TXNRD1,SRXN1 1 ! 3.41e-03 240 67 8 0.119 0.033 GO:0007050 BP 1 cell cycle arrest 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1,SLC25A33 1 ! 3.42e-03 678 43 10 0.233 0.015 GO:0051603 BP 1 proteolysis involved in cellular protein catabolic process 1 HERPUD1,CDC20,SDF2L1,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 3.46e-03 175 41 6 0.146 0.034 GO:0000819 BP 1 sister chromatid segregation 1 CDC20,TOP2A,CCNB1,KIF23,UBE2C,PRC1 1 ! 3.80e-03 440 65 10 0.154 0.023 GO:0006979 BP 1 response to oxidative stress 1 ABCC2,HMOX1,APEX1,RGN,PCNA,MDM2,CCNA2,CDK1,TXNRD1,SRXN1 1 ! 3.99e-03 74 34 4 0.118 0.054 KEGG:03320 keg 1 PPAR signaling pathway 1 CPT1A,HMGCS2,ACSL1,CPT2 1 ! 4.05e-03 491 59 10 0.169 0.020 GO:0000226 BP 1 microtubule cytoskeleton organization 1 KIF20A,GADD45A,CDC20,CCNB1,KIF23,KIF11,SPC25,CDK2AP2,CDK1,PRC1 1 ! 4.27e-03 200 62 7 0.113 0.035 KEGG:05203 keg 1 Viral carcinogenesis 1 CREB3L3,CCND1,CDC20,CDKN1A,MDM2,CCNA2,CDK1 1 ! 4.37e-03 16 6 2 0.333 0.125 REAC:R-HSA-1362300 rea 1 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 1 CCNA2,CDK1 1 ! 4.43e-03 120 96 7 0.073 0.058 GO:0016616 MF 1 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 PTGR1,UGDH,HMGCR,PGD,DHRS3,CYB5A,IMPDH2 1 ! 4.55e-03 331 87 10 0.115 0.030 GO:0005819 CC 1 spindle 1 ACOT13,KIF20A,CDC20,CCNB1,NUSAP1,KIF23,KIF11,CDK1,SHCBP1,PRC1 1 ! 4.74e-03 2087 98 31 0.316 0.015 REAC:R-HSA-1430728 rea 1 Metabolism 1 FMO3,SREBF1,HMMR,HMOX1,SLC10A1,TRIB3,PTGR1,PHYH,UGDH,CPT1A,CHKA,ACOT13,HMGCR,COQ10B,GOT1,NDUFAF4,PCK1,CDO1,HMGCS2,AGT,PGD,EPHX1,ACSL1,CPT2,FDPS,SLC2A2,CYB5A,NPAS2,IMPDH2,GLDC,TXNRD1 1 ! 4.77e-03 30 2 2 1.000 0.067 GO:0046685 BP 1 response to arsenic-containing substance 1 HMOX1,ZFAND2A 1 ! 5.63e-03 133 89 7 0.079 0.053 KEGG:04068 keg 1 FoxO signaling pathway 1 CCND1,GADD45A,PCK1,CDKN1A,CCNB1,MDM2,CCNB2 1 ! 6.87e-03 733 43 10 0.233 0.014 GO:0044257 BP 1 cellular protein catabolic process 1 HERPUD1,CDC20,SDF2L1,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 7.06e-03 129 62 6 0.097 0.047 GO:0042770 BP 1 signal transduction in response to DNA damage 1 GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK1 1 ! 7.23e-03 141 88 7 0.080 0.050 GO:0051384 BP 1 response to glucocorticoid 1 ABCC2,CCND1,KLF9,GOT1,CDKN1A,CDO1,PCNA 1 ! 7.42e-03 150 62 6 0.097 0.040 KEGG:05206 keg 1 MicroRNAs in cancer 1 HMOX1,CCND1,CCNG1,CDKN1A,MDM2,KIF23 1 ! 7.44e-03 150 54 6 0.111 0.040 GO:0045931 BP 1 positive regulation of mitotic cell cycle 1 APEX1,CCND1,CCNB1,MDM2,CDK1,UBE2C 1 ! 7.60e-03 365 62 9 0.145 0.025 REAC:R-HSA-3700989 rea 1 Transcriptional Regulation by TP53 1 CCNG1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CCNA2,CDK1,TXNRD1 1 ! 7.93e-03 578 43 9 0.209 0.016 GO:0006511 BP 1 ubiquitin-dependent protein catabolic process 1 HERPUD1,CDC20,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 8.22e-03 147 56 6 0.107 0.041 GO:0035967 BP 1 cellular response to topologically incorrect protein 1 HERPUD1,CREB3L3,CCND1,SDF2L1,DNAJB9,PDIA6 1 ! 8.63e-03 584 43 9 0.209 0.015 GO:0019941 BP 1 modification-dependent protein catabolic process 1 HERPUD1,CDC20,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 9.44e-03 2 42 2 0.048 1.000 GO:1905463 BP 1 negative regulation of DNA duplex unwinding 1 MCM2,TOP2A 1 ! 9.65e-03 949 98 17 0.173 0.018 GO:0009725 BP 1 response to hormone 1 ABCC2,SREBF1,APEX1,TRIB3,CCND1,KLF9,GOT1,PCK1,CDKN1A,CDO1,PCNA,MDM2,AGT,CCNA2,ACSL1,SLC25A33,NR1D2 1 ! 9.77e-03 4078 62 29 0.468 0.007 GO:0031981 CC 1 nuclear lumen 1 CREB3L3,MCM2,MCM6,HMOX1,APEX1,CCND1,KIF20A,CCNG1,POLR3G,GADD45A,CDC20,KLF9,CDKN1A,DNAJB9,TOP2A,PCNA,CCNB1,MDM2,KIF23,SELENBP1,CCNA2,MKI67,NIFK,CPT2,CDK1,NR1D2,UBE2C,MAFF,TXNRD1 1 ! 9.99e-03 2 62 2 0.032 1.000 CORUM:314 cor 1 PCNA-p21 complex 1 CDKN1A,PCNA 1 ! 1.00e-02 595 43 9 0.209 0.015 GO:0043632 BP 1 modification-dependent macromolecule catabolic process 1 HERPUD1,CDC20,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 1.02e-02 165 30 5 0.167 0.030 GO:0071466 BP 1 cellular response to xenobiotic stimulus 1 ABCC2,CDO1,EPHX1,CCNA2,ACSL1 1 ! 1.03e-02 349 54 8 0.148 0.023 GO:0035690 BP 1 cellular response to drug 1 ABCC2,HMOX1,APEX1,KLF9,PCNA,MDM2,CCNA2,CDK1 1 ! 1.05e-02 303 62 8 0.129 0.026 GO:0010948 BP 1 negative regulation of cell cycle process 1 CCND1,GADD45A,CDKN1A,PCNA,CCNB1,MDM2,CDK2AP2,CDK1 1 ! 1.07e-02 23 29 3 0.103 0.130 GO:0010971 BP 1 positive regulation of G2/M transition of mitotic cell cycle 1 CCND1,CCNB1,CDK1 1 ! 1.10e-02 9521 90 65 0.722 0.007 GO:0044444 CC 1 cytoplasmic part 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMMR,DPYSL2,HMOX1,APEX1,RIOK3,ECH1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,HMGCR,POLR3G,COQ10B,CDC20,KLF9,GOT1,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,CCNB1,HMGCS2,YARS,MDM2,AGT,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,CCNA2,SERPINH1,ACSL1,SPC25,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK1,FGA,SLC25A33,UBE2C,IMPDH2,GLDC,CRELD2,MAFF,TXNRD1,PRC1,SRXN1 1 ! 1.11e-02 3 42 2 0.048 0.667 CORUM:1452 cor 1 MCM2-MCM6-MCM7 complex 1 MCM2,MCM6 1 ! 1.12e-02 138 96 7 0.073 0.051 GO:0016614 MF 1 oxidoreductase activity, acting on CH-OH group of donors 1 PTGR1,UGDH,HMGCR,PGD,DHRS3,CYB5A,IMPDH2 1 ! 1.13e-02 354 90 10 0.111 0.028 GO:0010038 BP 1 response to metal ion 1 ABCC2,HMOX1,CCND1,GOT1,PCNA,CCNB1,MDM2,CYB5A,CDK1,FGA 1 ! 1.14e-02 35 65 4 0.062 0.114 GO:0097421 BP 1 liver regeneration 1 HMOX1,CCND1,RGN,PCNA 1 ! 1.16e-02 379 37 7 0.189 0.018 REAC:R-HSA-68886 rea 1 M Phase 1 KIF20A,CDC20,CCNB1,KIF23,SPC25,CDK1,UBE2C 1 ! 1.25e-02 4 20 2 0.100 0.500 GO:1905448 BP 1 positive regulation of mitochondrial ATP synthesis coupled electron transport 1 CCNB1,CDK1 1 ! 1.28e-02 1302 90 19 0.211 0.015 GO:0044432 CC 1 endoplasmic reticulum part 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMOX1,HMGCR,SLC17A3,SDF2L1,DNAJB9,EPHX1,PDIA6,SERPINH1,ACSL1,PDIA4,DHRS3,RPN1,CYB5A,CDK1,FGA 1 ! 1.32e-02 58 88 5 0.057 0.086 GO:0046686 BP 1 response to cadmium ion 1 HMOX1,GOT1,PCNA,CYB5A,CDK1 1 ! 1.34e-02 3656 90 35 0.389 0.010 GO:0065008 BP 1 regulation of biological quality 1 TNFRSF12A,IFRD1,ABCC2,HERPUD1,SREBF1,DPYSL2,HMOX1,APEX1,CPT1A,CCND1,CHKA,HMGCR,CDC20,GOT1,PCK1,CDKN1A,CDO1,RGN,PCNA,MDM2,AGT,PDIA6,PDIA4,DEPTOR,CCNB2,DHRS3,SLC2A2,FGA,SLC25A33,NR1D2,UBE2C,GLDC,MAFF,SLC39A10,TXNRD1 1 ! 1.37e-02 11 89 3 0.034 0.273 REAC:R-HSA-2514853 rea 1 Condensation of Prometaphase Chromosomes 1 CCNB1,CCNB2,CDK1 1 ! 1.40e-02 119 46 5 0.109 0.042 REAC:R-HSA-69239 rea 1 Synthesis of DNA 1 MCM2,MCM6,PCNA,CCNA2,UBE2C 1 ! 1.41e-02 410 98 11 0.112 0.027 GO:0043434 BP 1 response to peptide hormone 1 ABCC2,SREBF1,APEX1,TRIB3,GOT1,PCK1,CDO1,MDM2,AGT,CCNA2,SLC25A33 1 ! 1.41e-02 156 88 7 0.080 0.045 GO:0031960 BP 1 response to corticosteroid 1 ABCC2,CCND1,KLF9,GOT1,CDKN1A,CDO1,PCNA 1 ! 1.43e-02 2 89 2 0.022 1.000 CORUM:5542 cor 1 CCNB2-CDC2 complex 1 CCNB2,CDK1 1 ! 1.46e-02 37 20 3 0.150 0.081 GO:0016572 BP 1 histone phosphorylation 1 CCNB1,CCNA2,CDK1 1 ! 1.51e-02 735 98 16 0.163 0.022 REAC:R-HSA-556833 rea 1 Metabolism of lipids 1 SREBF1,SLC10A1,TRIB3,PTGR1,PHYH,CPT1A,CHKA,ACOT13,HMGCR,HMGCS2,AGT,ACSL1,CPT2,FDPS,NPAS2,TXNRD1 1 ! 1.55e-02 85 62 5 0.081 0.059 GO:0000079 BP 1 regulation of cyclin-dependent protein serine/threonine kinase activity 1 CCND1,CCNG1,GADD45A,CDKN1A,CCNB1 1 ! 1.60e-02 86 29 4 0.138 0.047 GO:1902554 CC 1 serine/threonine protein kinase complex 1 CCND1,CCNB1,CCNA2,CDK1 1 ! 1.65e-02 166 56 6 0.107 0.036 GO:0006986 BP 1 response to unfolded protein 1 HERPUD1,CREB3L3,CCND1,DNAJB9,PDIA6,SERPINH1 1 ! 1.66e-02 3473 62 26 0.419 0.007 GO:0005654 CC 1 nucleoplasm 1 CREB3L3,MCM2,MCM6,APEX1,CCND1,KIF20A,CCNG1,POLR3G,GADD45A,CDC20,KLF9,CDKN1A,TOP2A,PCNA,CCNB1,MDM2,KIF23,CCNA2,MKI67,NIFK,CPT2,CDK1,NR1D2,UBE2C,MAFF,TXNRD1 1 ! 1.70e-02 1029 85 16 0.188 0.016 GO:0005789 CC 1 endoplasmic reticulum membrane 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMOX1,HMGCR,SLC17A3,SDF2L1,DNAJB9,EPHX1,PDIA6,ACSL1,DHRS3,RPN1,CYB5A,CDK1 1 ! 1.70e-02 147 37 5 0.135 0.034 GO:0000070 BP 1 mitotic sister chromatid segregation 1 CDC20,CCNB1,KIF23,UBE2C,PRC1 1 ! 1.70e-02 3862 90 36 0.400 0.009 GO:0006950 BP 1 response to stress 1 TNFRSF12A,IFRD1,ABCC2,HERPUD1,CREB3L3,SREBF1,HMOX1,APEX1,RIOK3,CCND1,HMGCR,POLR3G,GADD45A,GOT1,PCK1,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,PCNA,CCNB1,MDM2,AGT,PDIA6,CCNA2,SERPINH1,PDIA4,PBK,CDK1,FGA,NR1D2,MAFF,TXNRD1,SRXN1 1 ! 1.76e-02 159 59 6 0.102 0.038 GO:0007051 BP 1 spindle organization 1 CDC20,CCNB1,KIF23,KIF11,SPC25,PRC1 1 ! 1.76e-02 27 29 3 0.103 0.111 GO:1902751 BP 1 positive regulation of cell cycle G2/M phase transition 1 CCND1,CCNB1,CDK1 1 ! 1.78e-02 1033 85 16 0.188 0.015 GO:0098827 CC 1 endoplasmic reticulum subcompartment 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMOX1,HMGCR,SLC17A3,SDF2L1,DNAJB9,EPHX1,PDIA6,ACSL1,DHRS3,RPN1,CYB5A,CDK1 1 ! 1.79e-02 680 62 11 0.177 0.016 GO:0019900 MF 1 kinase binding 1 DPYSL2,CCND1,KIF20A,GADD45A,CDKN1A,TOP2A,PCNA,CCNB1,KIF11,CCNA2,PRC1 1 ! 1.91e-02 127 46 5 0.109 0.039 REAC:R-HSA-69306 rea 1 DNA Replication 1 MCM2,MCM6,PCNA,CCNA2,UBE2C 1 ! 1.93e-02 87 30 4 0.133 0.046 GO:0070542 BP 1 response to fatty acid 1 CPT1A,CCNB1,ACSL1,GLDC 1 ! 1.95e-02 44 34 3 0.088 0.068 KEGG:00071 keg 1 Fatty acid degradation 1 CPT1A,ACSL1,CPT2 1 ! 1.96e-02 386 88 10 0.114 0.026 GO:0048545 BP 1 response to steroid hormone 1 ABCC2,SREBF1,CCND1,KLF9,GOT1,CDKN1A,CDO1,PCNA,MDM2,NR1D2 1 ! 1.98e-02 9 20 2 0.100 0.222 REAC:R-HSA-113507 rea 1 E2F-enabled inhibition of pre-replication complex formation 1 CCNB1,CDK1 1 ! 2.05e-02 82 34 4 0.118 0.049 HP:0002157 hp 1 Azotemia 1 CPT1A,CCND1,CPT2,SLC2A2 1 ! 2.07e-02 2 62 2 0.032 1.000 GO:0070557 CC 1 PCNA-p21 complex 1 CDKN1A,PCNA 1 ! 2.14e-02 107 32 4 0.125 0.037 REAC:R-HSA-2500257 rea 1 Resolution of Sister Chromatid Cohesion 1 CDC20,CCNB1,SPC25,CDK1 1 ! 2.15e-02 335 30 6 0.200 0.018 GO:0001101 BP 1 response to acid chemical 1 ABCC2,CPT1A,CDO1,CCNB1,ACSL1,GLDC 1 ! 2.16e-02 107 98 6 0.061 0.056 KEGG:04931 keg 1 Insulin resistance 1 CREB3L3,SREBF1,TRIB3,CPT1A,PCK1,SLC2A2 1 ! 2.17e-02 91 62 5 0.081 0.055 GO:1904029 BP 1 regulation of cyclin-dependent protein kinase activity 1 CCND1,CCNG1,GADD45A,CDKN1A,CCNB1 1 ! 2.21e-02 1051 85 16 0.188 0.015 GO:0042175 CC 1 nuclear outer membrane-endoplasmic reticulum membrane network 1 FMO3,HERPUD1,CREB3L3,SREBF1,HMOX1,HMGCR,SLC17A3,SDF2L1,DNAJB9,EPHX1,PDIA6,ACSL1,DHRS3,RPN1,CYB5A,CDK1 1 ! 2.22e-02 4 42 2 0.048 0.500 CORUM:2792 cor 1 MCM2-MCM4-MCM6-MCM7 complex 1 MCM2,MCM6 1 ! 2.27e-02 267 56 7 0.125 0.026 GO:0034976 BP 1 response to endoplasmic reticulum stress 1 HERPUD1,CREB3L3,CCND1,SDF2L1,DNAJB9,PDIA6,PDIA4 1 ! 2.33e-02 5004 98 45 0.459 0.009 GO:0005829 CC 1 cytosol 1 CREB3L3,SREBF1,HMMR,DPYSL2,HMOX1,TRIB3,RIOK3,ECH1,PHYH,UGDH,CCND1,CHKA,KRT18,ACOT13,POLR3G,CDC20,KLF9,GOT1,ETF1,PCK1,CDKN1A,CDO1,RGN,CCNB1,YARS,MDM2,AGT,KIF23,KIF11,PGD,SELENBP1,PDIA6,CCNA2,SPC25,CCNB2,FDPS,RPN1,CYB5A,CDK1,NPAS2,UBE2C,IMPDH2,TXNRD1,PRC1,SRXN1 1 ! 2.37e-02 85 34 4 0.118 0.047 HP:0004364 hp 1 Abnormality of nitrogen compound homeostasis 1 CPT1A,CCND1,CPT2,SLC2A2 1 ! 2.47e-02 10 20 2 0.100 0.200 REAC:R-HSA-2465910 rea 1 MASTL Facilitates Mitotic Progression 1 CCNB1,CDK1 1 ! 2.52e-02 32 87 4 0.046 0.125 GO:0030261 BP 1 chromosome condensation 1 TOP2A,CCNB1,NUSAP1,CDK1 1 ! 2.53e-02 48 34 3 0.088 0.062 KEGG:01212 keg 1 Fatty acid metabolism 1 CPT1A,ACSL1,CPT2 1 ! 2.65e-02 259 59 7 0.119 0.027 GO:0140014 BP 1 mitotic nuclear division 1 CDC20,CCNB1,KIF23,KIF11,MKI67,UBE2C,PRC1 1 ! 2.73e-02 1105 65 14 0.215 0.013 GO:0044265 BP 1 cellular macromolecule catabolic process 1 HERPUD1,APEX1,CDC20,ETF1,SDF2L1,DNAJB9,RGN,CCNB1,MDM2,PELO,PBK,CDK1,UBE2C,ZFAND2A 1 ! 2.73e-02 1167 54 13 0.241 0.011 GO:0051276 BP 1 chromosome organization 1 MCM2,MCM6,APEX1,CDC20,TOP2A,PCNA,CCNB1,KIF23,CCNA2,MKI67,CDK1,UBE2C,PRC1 1 ! 2.75e-02 251 41 6 0.146 0.024 GO:0098813 BP 1 nuclear chromosome segregation 1 CDC20,TOP2A,CCNB1,KIF23,UBE2C,PRC1 1 ! 2.81e-02 12266 91 76 0.835 0.006 GO:0043227 CC 1 membrane-bounded organelle 1 IFRD1,FMO3,HERPUD1,CREB3L3,SREBF1,MCM2,MCM6,DPYSL2,HMOX1,APEX1,ECH1,PTGR1,PHYH,CPT1A,CCND1,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,NUSAP1,KIF23,SELENBP1,EPHX1,PDIA6,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,CPT2,CCNB2,FDPS,DHRS3,RPN1,CYB5A,CDK2AP2,PBK,CDK1,FGA,SLC25A33,NR1D2,UBE2C,IMPDH2,ZFAND2A,GLDC,CRELD2,MAFF,TXNRD1,PRC1,TCEA3 1 ! 2.83e-02 3 42 2 0.048 0.667 GO:1905462 BP 1 regulation of DNA duplex unwinding 1 MCM2,TOP2A 1 ! 2.92e-02 100 29 4 0.138 0.040 GO:1902911 CC 1 protein kinase complex 1 CCND1,CCNB1,CCNA2,CDK1 1 ! 2.98e-02 3 62 2 0.032 0.667 CORUM:6300 cor 1 CDKN1A-TP53-CDK1-PCNA complex 1 CDKN1A,CDK1 1 ! 2.99e-02 14 89 3 0.034 0.214 REAC:R-HSA-162658 rea 1 Golgi Cisternae Pericentriolar Stack Reorganization 1 CCNB1,CCNB2,CDK1 1 ! 3.07e-02 460 35 7 0.200 0.015 GO:0015711 BP 1 organic anion transport 1 ABCC2,DPYSL2,CPT1A,SLC17A3,ACSL1,CPT2,SLC2A2 1 ! 3.12e-02 6 20 2 0.100 0.333 GO:1903862 BP 1 positive regulation of oxidative phosphorylation 1 CCNB1,CDK1 1 ! 3.12e-02 6 20 2 0.100 0.333 GO:1901857 BP 1 positive regulation of cellular respiration 1 CCNB1,CDK1 1 ! 3.12e-02 6 20 2 0.100 0.333 GO:1905446 BP 1 regulation of mitochondrial ATP synthesis coupled electron transport 1 CCNB1,CDK1 1 ! 3.16e-02 36 46 3 0.065 0.083 KEGG:03030 keg 1 DNA replication 1 MCM2,MCM6,PCNA 1 ! 3.32e-02 71 62 4 0.065 0.056 KEGG:05214 keg 1 Glioma 1 CCND1,GADD45A,CDKN1A,MDM2 1 ! 3.34e-02 1047 88 16 0.182 0.015 GO:1901701 BP 1 cellular response to oxygen-containing compound 1 ABCC2,SREBF1,APEX1,CPT1A,HMGCR,KLF9,GOT1,PCK1,RGN,PCNA,CCNB1,MDM2,AGT,CCNA2,CDK1,SLC25A33 1 ! 3.34e-02 169 37 5 0.135 0.030 GO:0030496 CC 1 midbody 1 KIF20A,KIF23,CDK1,SHCBP1,PRC1 1 ! 3.39e-02 53 64 4 0.062 0.075 MIRNA:hsa-miR-1298-5p mir 1 hsa-miR-1298-5p 1 CPT1A,ETF1,MKI67,TXNRD1 1 ! 3.41e-02 16791 92 91 0.989 0.005 GO:0044464 CC 1 cell part 1 TNFRSF12A,IFRD1,FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,SLC10A1,APEX1,RIOK3,ECH1,PTGR1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,NUSAP1,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,SLC20A1,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,DEPTOR,CPT2,CCNB2,FDPS,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,PBK,CDK1,SHCBP1,FGA,SLC25A33,NR1D2,UBE2C,IMPDH2,ZFAND2A,GLDC,CRELD2,MAFF,SLC39A10,TXNRD1,PRC1,TCEA3,SRXN1 1 ! 3.49e-02 882 43 10 0.233 0.011 GO:0030163 BP 1 protein catabolic process 1 HERPUD1,CDC20,SDF2L1,DNAJB9,CCNB1,MDM2,PBK,CDK1,UBE2C,ZFAND2A 1 ! 3.50e-02 72 62 4 0.065 0.056 KEGG:05218 keg 1 Melanoma 1 CCND1,GADD45A,CDKN1A,MDM2 1 ! 3.50e-02 72 62 4 0.065 0.056 KEGG:01524 keg 1 Platinum drug resistance 1 ABCC2,CDKN1A,TOP2A,MDM2 1 ! 3.58e-02 2121 83 23 0.277 0.011 GO:0008283 BP 1 cell proliferation 1 HMOX1,CCND1,HMGCR,POLR3G,CDC20,KLF9,CDKN1A,RGN,PCNA,CCNB1,MDM2,AGT,TCF19,CCNA2,MKI67,PELO,CDK1,SHCBP1,SLC25A33,IMPDH2,SLC39A10,TXNRD1,PRC1 1 ! 3.68e-02 4 34 2 0.059 0.500 GO:0004095 MF 1 carnitine O-palmitoyltransferase activity 1 CPT1A,CPT2 1 ! 3.69e-02 164 65 6 0.092 0.037 GO:0034614 BP 1 cellular response to reactive oxygen species 1 APEX1,RGN,PCNA,MDM2,CCNA2,CDK1 1 ! 3.69e-02 22 83 3 0.036 0.136 KEGG:00900 keg 1 Terpenoid backbone biosynthesis 1 HMGCR,HMGCS2,FDPS 1 ! 3.74e-02 600 62 10 0.161 0.017 GO:0019901 MF 1 protein kinase binding 1 DPYSL2,CCND1,KIF20A,CDKN1A,TOP2A,PCNA,CCNB1,KIF11,CCNA2,PRC1 1 ! 3.77e-02 99 20 3 0.150 0.030 KEGG:04914 keg 1 Progesterone-mediated oocyte maturation 1 CCNB1,CCNA2,CDK1 1 ! 4.00e-02 16822 92 91 0.989 0.005 GO:0005623 CC 1 cell 1 TNFRSF12A,IFRD1,FMO3,ABCC2,HERPUD1,CREB3L3,SREBF1,HMMR,MCM2,MCM6,DPYSL2,HMOX1,SLC10A1,APEX1,RIOK3,ECH1,PTGR1,PHYH,CPT1A,CCND1,CHKA,KRT18,ACOT13,KIF20A,HMGCR,CCNG1,POLR3G,COQ10B,GADD45A,CDC20,KLF9,GOT1,ETF1,NDUFAF4,PCK1,SLC17A3,CDKN1A,SDF2L1,DNAJB9,CDO1,RGN,TOP2A,UTP3,PCNA,CCNB1,HMGCS2,YARS,MDM2,AGT,TCF19,NUSAP1,KIF23,KIF11,SELENBP1,EPHX1,PDIA6,SLC20A1,CCNA2,MKI67,SERPINH1,ACSL1,SPC25,PELO,NIFK,PDIA4,DEPTOR,CPT2,CCNB2,FDPS,DHRS3,SLC2A2,RPN1,CYB5A,CDK2AP2,PBK,CDK1,SHCBP1,FGA,SLC25A33,NR1D2,UBE2C,IMPDH2,ZFAND2A,GLDC,CRELD2,MAFF,SLC39A10,TXNRD1,PRC1,TCEA3,SRXN1 1 ! 4.02e-02 92 34 4 0.118 0.043 GO:0015908 BP 1 fatty acid transport 1 ABCC2,CPT1A,ACSL1,CPT2 1 ! 4.09e-02 12 89 3 0.034 0.250 GO:0007077 BP 1 mitotic nuclear envelope disassembly 1 CCNB1,CCNB2,CDK1 1 ! 4.15e-02 37 85 4 0.047 0.108 GO:0019432 BP 1 triglyceride biosynthetic process 1 SREBF1,PCK1,RGN,ACSL1 1 ! 4.24e-02 300 98 9 0.092 0.030 GO:0071375 BP 1 cellular response to peptide hormone stimulus 1 SREBF1,APEX1,TRIB3,GOT1,PCK1,MDM2,AGT,CCNA2,SLC25A33 1 ! 4.28e-02 13 20 2 0.100 0.154 REAC:R-HSA-75035 rea 1 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 1 CCNB1,CDK1 1 ! 4.29e-02 339 4 3 0.750 0.009 GO:0031331 BP 1 positive regulation of cellular catabolic process 1 HERPUD1,HMOX1,ZFAND2A 1 ! 4.31e-02 76 62 4 0.065 0.053 KEGG:05220 keg 1 Chronic myeloid leukemia 1 CCND1,GADD45A,CDKN1A,MDM2 1 ! 4.40e-02 90 42 4 0.095 0.044 REAC:R-HSA-69052 rea 1 Switching of origins to a post-replicative state 1 MCM2,MCM6,CCNA2,UBE2C 1 ! 4.53e-02 258 88 8 0.091 0.031 GO:0016054 BP 1 organic acid catabolic process 1 HMMR,ECH1,PHYH,CPT1A,GOT1,CDO1,CPT2,GLDC 1 ! 4.53e-02 258 88 8 0.091 0.031 GO:0046395 BP 1 carboxylic acid catabolic process 1 HMMR,ECH1,PHYH,CPT1A,GOT1,CDO1,CPT2,GLDC 1 ! 4.55e-02 122 54 5 0.093 0.041 GO:0000784 CC 1 nuclear chromosome, telomeric region 1 MCM2,MCM6,APEX1,PCNA,CDK1 1 ! 4.88e-02 76 43 4 0.093 0.053 GO:0043627 BP 1 response to estrogen 1 ABCC2,HMOX1,CCND1,MDM2 #INFO: PARAMETERS: ordered_queries = 1 #INFO: PARAMETERS: organism = hsapiens #INFO: PARAMETERS: user_thr = 1.00 #INFO: PARAMETERS: significant = 1 #INFO: PARAMETERS: analytical = 1 #INFO: User: http #INFO: Host: arak-prod #INFO: Time: 2018-9-26 18:20:8 #INFO: Version: beta #WARNING: Gene KIAA0101 in query [1/3] is not recognized, skipping! #WARNING: Gene VIMP in query [1/66] is not recognized, skipping! #INFO: Effective domain size for CORUM: 3219, threshold 0.000203 #INFO: Effective domain size for GO: 19498, threshold 2.4e-05 #INFO: Effective domain size for HP: 3799, threshold 5.7e-05 #INFO: Effective domain size for KEGG: 7229, threshold 0.000665 #INFO: Effective domain size for MIRNA: 14844, threshold 8.4e-05 #INFO: Effective domain size for REAC: 10578, threshold 0.000147