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<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group>
<journal-title>PLOS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher>
<publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1371/journal.pone.0305140</article-id>
<article-id pub-id-type="publisher-id">PONE-D-23-43053</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3">
<subject>Biology and life sciences</subject><subj-group><subject>Ecology</subject><subj-group><subject>Ecosystems</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Ecology and environmental sciences</subject><subj-group><subject>Ecology</subject><subj-group><subject>Ecosystems</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Science policy</subject><subj-group><subject>Research funding</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Science policy</subject><subj-group><subject>Research funding</subject><subj-group><subject>Institutional funding of science</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Science policy</subject><subj-group><subject>Research funding</subject><subj-group><subject>Government funding of science</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Computer and information sciences</subject><subj-group><subject>Network analysis</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>People and places</subject><subj-group><subject>Geographical locations</subject><subj-group><subject>Europe</subject><subj-group><subject>European Union</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>People and places</subject><subj-group><subject>Geographical locations</subject><subj-group><subject>Europe</subject><subj-group><subject>European Union</subject><subj-group><subject>Spain</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3">
<subject>Computer and information sciences</subject><subj-group><subject>Computing systems</subject><subj-group><subject>Quantum computing</subject></subj-group></subj-group></subj-group></article-categories>
<title-group>
<article-title>Visualising quantum innovation: A regional case study</article-title>
<alt-title alt-title-type="running-head">Visualising quantum innovation</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes" equal-contrib="yes" xlink:type="simple">
<contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0002-9075-0678</contrib-id>
<name name-style="western">
<surname>Jiménez Farías</surname>
<given-names>O.</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role content-type="http://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role content-type="http://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role content-type="http://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-original-draft/">Writing – original draft</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
<xref ref-type="aff" rid="aff001"/>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" xlink:type="simple">
<name name-style="western">
<surname>Demergasso</surname>
<given-names>Arnau</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role content-type="http://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role content-type="http://credit.niso.org/contributor-roles/validation/">Validation</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-original-draft/">Writing – original draft</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
<xref ref-type="aff" rid="aff001"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" xlink:type="simple">
<name name-style="western">
<surname>Vaziri</surname>
<given-names>Maryam</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role content-type="http://credit.niso.org/contributor-roles/methodology/">Methodology</role>
<role content-type="http://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<xref ref-type="aff" rid="aff001"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" xlink:type="simple">
<name name-style="western">
<surname>Vives Rodón</surname>
<given-names>Sergi</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role content-type="http://credit.niso.org/contributor-roles/software/">Software</role>
<role content-type="http://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<xref ref-type="aff" rid="aff001"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes" xlink:type="simple">
<name name-style="western">
<surname>Canessa</surname>
<given-names>Nelly</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<xref ref-type="aff" rid="aff001"/>
</contrib>
<contrib contrib-type="author" corresp="yes" equal-contrib="yes" xlink:type="simple">
<contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0001-9521-632X</contrib-id>
<name name-style="western">
<surname>Phillips</surname>
<given-names>Eoín</given-names>
</name>
<role content-type="http://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role content-type="http://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
<role content-type="http://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role content-type="http://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
<role content-type="http://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-original-draft/">Writing – original draft</role>
<role content-type="http://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
<xref ref-type="aff" rid="aff001"/>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><addr-line>Smart Society Research Group, La Salle-Ramon Llull University, Barcelona, Spain</addr-line></aff>
<contrib-group>
<contrib contrib-type="editor" xlink:type="simple">
<name name-style="western">
<surname>Khan</surname>
<given-names>Mudassir</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"/>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>King Khalid University, SAUDI ARABIA</addr-line></aff>
<author-notes>
<fn fn-type="conflict" id="coi001">
<p>The authors have declared that no competing interests exist.</p>
</fn>
<corresp id="cor001">* E-mail: <email xlink:type="simple">osvaldo.jimenez@salle.url.edu</email> (OJF); <email xlink:type="simple">eoinedward.phillips@salle.url.edu</email> (EP)</corresp>
</author-notes>
<pub-date pub-type="epub">
<day>24</day>
<month>6</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>19</volume>
<issue>6</issue>
<elocation-id>e0305140</elocation-id>
<history>
<date date-type="received">
<day>21</day>
<month>12</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>5</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-year>2024</copyright-year>
<copyright-holder>Jiménez Farías et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">
<license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="info:doi/10.1371/journal.pone.0305140"/>
<abstract>
<p>At the beginning of this century, the advent of a second generation of ‘quantum technologies’ was announced together with its revolutionary potential to change existing information technologies. Despite the rapidly increasing paid to quantum technological development, there has been little attention paid to the specific characteristics or relationships within emerging quantum ecosystems. The aim of this study is to visualize the innovation structures and relationships that are emerging to shape these technological developments. As these structures typically depend on specific regional features, we have specifically focused on the Spanish case, as it is potentially indicative of the differences between European innovation models and other regional patterns. This objective was achieved by researching the funding network of the ecosystem, collected from a systematic review of various official sources and relevant previous literature. The resulting dataset was framed using the Innovation Ecosystem model and broken down through network analysis theory, as well as characterized through descriptive statistics. This framework identified the significant role that projects play in European scientific and technological innovation, which work as hubs to concentrate resources and incentive cooperation between actors. This is relevant because current work on quantum technologies neglects their importance, as their analysis focuses on the quantity of institutions rather than their relations. Moreover, this paper points out the prominence of public funding to drive quantum innovation, largely stemming from the European Commission. This is another key mechanism that is missed by the existing literature. Finally, it also sheds light on the recipients of this funding, who are mostly research centres. These results allow us to conceptualize the Spanish quantum ecosystem and offer the opportunity for comparative studies with other quantum technologies ecosystems.</p>
</abstract>
<funding-group>
<award-group id="award001">
<funding-source>
<institution-wrap>
<institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100008332</institution-id>
<institution>Universitat Ramon Llull</institution>
</institution-wrap>
</funding-source>
<award-id>2023-URL-Proj-078</award-id>
<principal-award-recipient>
<contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0002-9075-0678</contrib-id>
<name name-style="western">
<surname>Farías</surname>
<given-names>O. Jiménez</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award002">
<funding-source>
<institution-wrap>
<institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100004837</institution-id>
<institution>Ministerio de Ciencia e Innovación</institution>
</institution-wrap>
</funding-source>
<award-id>PID2019-105131GB-I00</award-id>
<principal-award-recipient>
<contrib-id authenticated="true" contrib-id-type="orcid">https://orcid.org/0000-0001-9521-632X</contrib-id>
<name name-style="western">
<surname>Phillips</surname>
<given-names>Eoín</given-names>
</name>
</principal-award-recipient>
</award-group>
<funding-statement>O.Jiménez Farías (Recipient).: Ajuts a l’activitat de recerca del personla docent i investigador de la Universitat Ramon Llull, 2023-URL-Proj-078 Eoin Phillips (Recipient): Grant PID2019-105131GB-I00 from the Spanish Ministry of Science and Innovation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts>
<fig-count count="11"/>
<table-count count="2"/>
<page-count count="18"/>
</counts>
<custom-meta-group>
<custom-meta id="data-availability">
<meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the manuscript and its <xref ref-type="sec" rid="sec016">Supporting Information</xref> files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec id="sec001" sec-type="intro">
<title>Section I: Introduction</title>
<sec id="sec002">
<title>Historical background</title>
<p>Quantum technology stands for the set of artifacts and techniques designed to complement or supplement existing information and communication technology based on unprecedented control of microscopic systems [<xref ref-type="bibr" rid="pone.0305140.ref001">1</xref>]. In 2016, the Chinese space agency launched the satellite Micius devoted solely to quantum communications purposes [<xref ref-type="bibr" rid="pone.0305140.ref002">2</xref>]. Inside the satellite, a source of quantum light sends beams of entangled photons to two distant locations on Earth with the aim to provide communications channels secure from hacking attempts at distances longer than any existing system on Earth. In 2019, Google announced the first ‘speedup’ achieved by a quantum computer over any other existing computer system [<xref ref-type="bibr" rid="pone.0305140.ref003">3</xref>]. These two milestones in the field of quantum technology attracted the interest of most and announced an era of intense technological development that extends around the globe [<xref ref-type="bibr" rid="pone.0305140.ref004">4</xref>]. Potential applications of quantum technology include drug discovery [<xref ref-type="bibr" rid="pone.0305140.ref005">5</xref>], financial modelling [<xref ref-type="bibr" rid="pone.0305140.ref006">6</xref>], weather forecasting [<xref ref-type="bibr" rid="pone.0305140.ref007">7</xref>], cybersecurity [<xref ref-type="bibr" rid="pone.0305140.ref008">8</xref>], machine learning algorithms [<xref ref-type="bibr" rid="pone.0305140.ref009">9</xref>], and blockchain [<xref ref-type="bibr" rid="pone.0305140.ref010">10</xref>].</p>
<p>In the European context, Spain is one of the six nations that will allocate a quantum computer as part of the program EuroHPC JU together with Germany, Poland, Italy, Czech Republic, and France [<xref ref-type="bibr" rid="pone.0305140.ref011">11</xref>]. A conglomerate of start-ups purely focused on developing or applying quantum technologies have emerged, and these have been joined by existing companies, research institutes, and universities who are taking position and declaring themselves part of the Spanish quantum ecosystem.</p>
</sec>
<sec id="sec003">
<title>Objective of the study</title>
<p>Despite the longstanding conceptualization of quantum technologies as a distinct technological aim (and therefore as a distinct innovation process), the specific institutional structures and relations that have either given rise to the development of quantum technologies or which are emerging in the pursuit of these innovations have received very little scholarly attention. It has been shown in literature of technological innovations and scientific practice that the institutional structures that give rise to innovations are rarely universal. Rather, the specific structural organization of innovation institutions may depend upon specific social, economic, and political features of the region in question [<xref ref-type="bibr" rid="pone.0305140.ref012">12</xref>].</p>
<p>To put it another way, there are a range of ways in which the development of technologies may come about amongst which it is common to identify vertical, horizontal, triple helix [<xref ref-type="bibr" rid="pone.0305140.ref013">13</xref>] or ecosystem types of institutional arrangements [<xref ref-type="bibr" rid="pone.0305140.ref014">14</xref>]. It is the assumption of this article that the same must be true of the emergence of quantum technologies and quantum computers; meaning that it may be possible that quantum technologies in different regions may be brought about through different institutional/organizational arrangements.</p>
<p>As the perspectives of technological change are big, we recognize the relevance of consistently considering the characteristics of the actors, their origins, the role they aim to play, and how they relate to the other actors in the network. To our knowledge, this work represents the first academic work that attempts to capture the mechanisms that drive such a quantum ecosystem. By a systematic collection of data available in official channels and declarations, we have recreated the funding network of the Spanish ecosystem. The relation ‘funding’ is just one aspect of the ecosystem but it is a necessary one if we accept the fact that the state of the innovation ecosystem in Spain is primal. Given the complexity of the ecosystem even in this early state, we assume our description cannot be exhaustive but we argue it is sufficient to describe basic properties inherent to its emergence that will impact its evolution.</p>
</sec>
<sec id="sec004">
<title>Structure of the study</title>
<p>In Section I, we present a literature review that considers a set of reports by several organizations like the World Economic Forum, Ametic, McKinsey, Quantum Flagship, IBM, IQM, among others whose purpose is to promote awareness of the state of the art in the development of quantum technology. Interestingly, most of the reports number a set of institutions or collaborators that could be considered ‘self-named’ players in the quantum ecosystems—though the type of collaboration that links institutions within these ecosystems are not always evident. We complement this review with state-of-the-art literature on innovation ecosystems from where we conclude an important kind of actor must be considered in the description of the network: the European projects.</p>
<p>Section II describes our method of data collection that is based on the information that the actors make available. Different attributes such as kind of institution and the type of technology they are concerned with are recorded. We observe that the market relation producer-user is not well determined at this stage of the ecosystem but funding relation between among actors is more commonly declared. In some cases it is possible to track the exact amount of money that is involved in the relation but as it is not always the case, we restrict our analysis to the relation receiver-provider between them.</p>
<p>Network analysis is shown to be a useful description of the ecosystem revealing a rich structure of interactions as well as the most prominent actors within it. Visualization of the funding network as well as the most common measures in networks theory are presented in section III following descriptive statistics from the gathered data.</p>
<p>A discussion of our methods and data base is presented in Section IV where we discourse on possible ways in which our analysis can be extrapolated to the European region and is not exclusive to the Spanish case.</p>
<p>Finally in section V we present our concluding remarks.</p>
<sec id="sec005">
<title>### Literature review and limitations of current studies</title>
<p>Over the past twenty years, we have been told that we have experienced one, two or even three quantum revolutions [<xref ref-type="bibr" rid="pone.0305140.ref015">15</xref>]. Whilst this temporal dimension of technical change has been stated—and the possibility of debate of the extend of this change has been opened up—rather less has been said about the spatial dimensions of such change; that is what is the relationship between the character of quantum technological development and the places in which such development is said to be taking place.</p>
<p>Existing literature on the state of quantum technologies in Spain may be understood as falling under two types of publications. On the one hand, we have state-of-the-art reports produced in large by private consulting companies [<xref ref-type="bibr" rid="pone.0305140.ref016">16</xref>–<xref ref-type="bibr" rid="pone.0305140.ref019">19</xref>]. On the other hand, we have several academic articles [<xref ref-type="bibr" rid="pone.0305140.ref001">1</xref>, <xref ref-type="bibr" rid="pone.0305140.ref020">20</xref>]. In this section, we will detail the different approaches taken by the two strands of literature, offering a non-exhaustive sample of the most relevant reports and papers, as well as detailing the gaps and limitations of their methodology (see <xref ref-type="supplementary-material" rid="pone.0305140.s001">S1 Table</xref>).</p>
<p>Over the past 3 years, 15 reports have been published related seeking to describe the level of activity related to quantum technological innovation. In general, the regional focus of such reports is extremely broad. Aside from those that focus on the EU or the US in general [<xref ref-type="bibr" rid="pone.0305140.ref004">4</xref>, <xref ref-type="bibr" rid="pone.0305140.ref021">21</xref>], most of them try to describe the industry on a global scale [<xref ref-type="bibr" rid="pone.0305140.ref017">17</xref>–<xref ref-type="bibr" rid="pone.0305140.ref019">19</xref>]. Only one report [<xref ref-type="bibr" rid="pone.0305140.ref016">16</xref>] has focused on the Spanish case (made by the Spanish consulting agency AMETIC), thus making any cross-referencing and comparison impossible.</p>
<p>According to AMETIC as of 2023, there were 67 institutions or firms that should be regarded as being included in the Spanish quantum technological development. The criterion for inclusion is based on ‘own wording’ [<xref ref-type="bibr" rid="pone.0305140.ref016">16</xref>] and includes companies, R&amp;D centers, national projects/initiatives, and regional partnerships/ecosystems. However, in its report, each institution is listed sequentially with no sense of relation between them (see <xref ref-type="fig" rid="pone.0305140.g001">Fig 1</xref>).</p>
<fig id="pone.0305140.g001" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g001</object-id>
<label>Fig 1</label>
<caption>
<title>Extract from AMETIC’s report listing companies in the Spanish quantum ecosystem.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g001" xlink:type="simple"/>
</fig>
<p>Like AMETIC’s Spanish report, the other industry reports also represent quantum technological activity with regards to particular kinds of output: patents, peer-reviewed articles, total funding allocated or total number of players. However, they also follow AMETIC’s logic in representing their chosen institutions sequentially rather than relationally. As such, the reports give little indication of the ways in which institutions connect to each other except presumably as individual agents competing against each other across large regional areas for similar ends.</p>
<p>Unfortunately, the academic literature also does little to shed light on the quantum industry in Spain. This is because there is no academic paper that focuses on the region. Moreover, the existing literature tends to focus on specific aspects of the industry—such as the number of start-ups, patents, or job expectations—and does not help to comprehend the structures of quantum technological development [<xref ref-type="bibr" rid="pone.0305140.ref020">20</xref>, <xref ref-type="bibr" rid="pone.0305140.ref022">22</xref>].</p>
<p>Nevertheless, there is a common thread between the existing literature which is their rhetorical approach to the quantum technologies industry. The reports talk about an ‘industrial ecosystem of quantum technologies’ [<xref ref-type="bibr" rid="pone.0305140.ref016">16</xref>], a ‘new computation quantum ecosystem’ [<xref ref-type="bibr" rid="pone.0305140.ref023">23</xref>], a ‘national quantum ecosystem’ [<xref ref-type="bibr" rid="pone.0305140.ref018">18</xref>], a ‘QC ecosystem’ [<xref ref-type="bibr" rid="pone.0305140.ref019">19</xref>], or a ‘quantum communications ecosystem’ [<xref ref-type="bibr" rid="pone.0305140.ref017">17</xref>]. The academic articles also follow this rhetoric exemplified by formulations such as ‘the landscape of the quantum start-up ecosystem’ [<xref ref-type="bibr" rid="pone.0305140.ref022">22</xref>].</p>
<p>Despite the rather loose use of the term ecosystem in these articles and reports—it is unclear in these accounts what precisely accounts for an ecosystem rather than any other form of relation between institutions, companies, and universities—the rhetorical use of the term is clearly doing a degree of work to make sense of the range of institutions involved in the development and deployment of quantum technologies.</p>
</sec>
</sec>
<sec id="sec006">
<title>Conceptual framework</title>
<p>To further understand the use of the term ecosystem to describe the character of quantum technological development in Spain and to better analyze the forms of relations between the institutions involved in its development, this article suggests following an ‘innovation ecosystem’ perspective. This perspective not only looks ‘at the type and number of actors but focuses on the types of relationships between them’ [<xref ref-type="bibr" rid="pone.0305140.ref014">14</xref>]. In other words, the ecosystem approach focuses on the ‘network of interdependent actors who combine specialized yet complementary resources and/or capabilities’ [<xref ref-type="bibr" rid="pone.0305140.ref024">24</xref>] to produce any technological innovation.</p>
<p>Additionally, this technique of mapping out the ‘collaborative arrangements’ [<xref ref-type="bibr" rid="pone.0305140.ref025">25</xref>] captures the set of shared assets, standards, and interfaces that underpins an activity system around any technological innovation [<xref ref-type="bibr" rid="pone.0305140.ref026">26</xref>] and stresses its ‘multilayer’ nature [<xref ref-type="bibr" rid="pone.0305140.ref027">27</xref>]. In this sense, the ecosystem’s approach takes the individual firms as intrinsically part of a network of cooperation and competition with other firms [<xref ref-type="bibr" rid="pone.0305140.ref028">28</xref>], thus making the network the principal unit of analysis [<xref ref-type="bibr" rid="pone.0305140.ref029">29</xref>]. Moreover, it allows for an examination of both the macro level of national policy and the micro-level of individual firm activities [<xref ref-type="bibr" rid="pone.0305140.ref014">14</xref>]. In summary, this approach understands that the performance of one actor influences the performance of others and that of the entire innovation ecosystem [<xref ref-type="bibr" rid="pone.0305140.ref025">25</xref>].</p>
<p>This has a clear implication for the literature behind quantum technologies. On one hand, the relevant reports and articles declare the quantum technologies industry as an ecosystem. However, they do not demonstrate any structural network behind the activities, actors, and locations. In short, the existing literature uses a certain rhetoric with a clear theoretical background without actually employing it.</p>
<p>In contrast to existing literature on quantum technological development, the approach taken by this article allows us to specifically characterize the type of network that is shaping quantum innovation, giving a holistic picture of its wider mechanisms and general trends. This approach will permit a specific analysis of the Spanish case and its geographical particularities, which will be indicative of the innovation patterns used in the European Union (and warrant further comparison with other regions). Finally, by establishing concrete links between actors, we will assess the issue in an unbiased manner rather than trusting internal sources.</p>
<p>It’s important to highlight the concept of ‘actors’ as they represent the individual units connected by the links within the network. This concept is loosely defined by the ecosystem literature as exemplified by Adner’s [<xref ref-type="bibr" rid="pone.0305140.ref025">25</xref>] definition of actors being the ‘entities that undertake the activities’ in the ecosystem. Consequently, actors will be considered as organizations who possess agency within the ecosystem to in some way affect or contribute to its growth as opposed to ‘factors’ (such as public policy) which refer to wider social and economic structures [<xref ref-type="bibr" rid="pone.0305140.ref030">30</xref>].</p>
<p>This is relevant because one of the key actors found by our study are the European (and to a less extent national) projects which are neglected by the rest of the academic literature and private sector reports. For instance, AMETIC only names 9 projects while we found 54 of them (see Section III). This oversight may be caused by the ‘untraditional’ nature of the projects as they are not firms, governmental organizations, research centres, or other more established types of institutions. Nevertheless, they are actors precisely because they possess a particular agenda (both in terms of time and objectives) that is aimed at creating quantum technological innovation and thus affects the growth of the wider ecosystem.</p>
</sec>
</sec>
<sec id="sec007">
<title>Section II: Research design (approach)</title>
<sec id="sec008">
<title>Data collection and sample</title>
<p>To carry out our research objective of understanding the mechanisms driving quantum technological innovation in Spain, we have collected a broad sample of the actors in the Spanish quantum ecosystem. This will allow for comprehension of each actor’s characteristics, origins, the role they play, and connections with the other actors in the network, thus allowing for an analysis of the mechanisms behind quantum innovation.</p>
<p>This sample was collected through two types of secondary sources: (1) all the projects, ecosystems, companies, and research centres declared by AMETIC in their 2023 report presenting the state of the quantum industry in Spain [<xref ref-type="bibr" rid="pone.0305140.ref016">16</xref>]. (2) All the entities disclosing on the Internet that they receive and/or provide funding for working with quantum technologies in Spain. In other words, all the entities that fall under one or both these categories are declared as potential actors in the Spanish quantum ecosystem and are included in our sample. We have identified 67 actors with the first source and 154 with the second one making up 221 actors in total (see <xref ref-type="table" rid="pone.0305140.t001">Table 1</xref>). For a comprehensive breakdown of all the actors’ names and their sources, consult <xref ref-type="supplementary-material" rid="pone.0305140.s002">S2 Table</xref>.</p>
<table-wrap id="pone.0305140.t001" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.t001</object-id>
<label>Table 1</label> <caption><title>Total actors.</title></caption>
<alternatives>
<graphic id="pone.0305140.t001g" mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.t001" xlink:type="simple"/>
<table>
<colgroup>
<col align="left" valign="middle"/>
<col align="left" valign="middle"/>
</colgroup>
<thead>
<tr>
<th align="center" colspan="2">Sample Size based on the research criteria</th>
</tr>
</thead>
<tbody>
<tr>
<td align="justify">Actors declared by Internet searches</td>
<td align="justify">154</td>
</tr>
<tr>
<td align="justify">Actors declared by Ametic’s report</td>
<td align="justify">67</td>
</tr>
<tr>
<td align="justify"><bold>Total number of actors</bold></td>
<td align="justify"><bold>221</bold></td>
</tr>
</tbody>
</table>
</alternatives>
</table-wrap>
<p>Identifying the actors according to the first criterion was simple since AMETIC’s report provides a comprehensive list of these companies, research centres, projects, and ecosystems. We have taken it exactly as it is presented. However, the second criterion is more complex since there are several sources through which we have accessed the funding schemes of the actors. In other words, there is no unified source that provides all the entities receiving or providing funding for quantum innovation in Spain.</p>
<p>Consequently, this information was tracked though internet searches which has led us to several more sources as shown in <xref ref-type="table" rid="pone.0305140.t002">Table 2</xref>. First, the European Commission has the CORDIS database which declares every project under their funding schemes. Therefore, we have selected the projects that work on quantum technologies while containing one or more Spanish institutions and added them to our sample. The total number of actors found in this database is 48. Second, some actors come from official documents from the Spanish Government or related agencies detailing their funding schemes. These make up 45 of the total number of actors. Third, 51 actors declare their funding sources on their own webpages. Finally, a few outliers have been tracked through news sources or other European agencies which account for the remaining 7 and 3 actors respectively.</p>
<table-wrap id="pone.0305140.t002" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.t002</object-id>
<label>Table 2</label> <caption><title>Actors found through Internet searches.</title></caption>
<alternatives>
<graphic id="pone.0305140.t002g" mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.t002" xlink:type="simple"/>
<table>
<colgroup>
<col align="left" valign="middle"/>
<col align="left" valign="middle"/>
</colgroup>
<thead>
<tr>
<th align="center" colspan="2">Sample Size based on the research criteria</th>
</tr>
</thead>
<tbody>
<tr>
<td align="justify">Actors declared by the CORDIS database (either as projects or participant entities)</td>
<td align="justify">48</td>
</tr>
<tr>
<td align="justify">Actors declared by the Spanish government or related agencies</td>
<td align="justify">45</td>
</tr>
<tr>
<td align="justify">Actors declared on webpages</td>
<td align="justify">51</td>
</tr>
<tr>
<td align="justify">Actors declared on news sources</td>
<td align="justify">7</td>
</tr>
<tr>
<td align="justify">Actors declared by the EDF</td>
<td align="left">3</td>
</tr>
<tr>
<td align="justify"><bold>Total number of actors</bold></td>
<td align="justify"><bold>154</bold></td>
</tr>
</tbody>
</table>
</alternatives>
</table-wrap>
<p>In summary, we have used these two sources (AMETIC and Internet searches) to compile a database of every actor participating in the Spanish quantum ecosystem. For the second source, further tracking through European databases, official government documents, webpages, and news sources was warranted. However, compiling the sample was only the first part of our methodology. Once the raw data was gathered, we allocated three different variables to each actor which helps in understanding their relationships, roles, and activities in the ecosystem.</p>
</sec>
<sec id="sec009">
<title>Studied variables</title>
<p>While there are many potential relationships that may be explored, this paper has focused on the stated financial relationship between actors referred to as ‘funding role’. Consequently, by establishing their funding schemes, a certain type of relationship between actors will be defined which can be used to infer some properties of the ecosystem (see Section IV).</p>
<p>Therefore, we have classified every actor under the following criteria: (1) Providers (2) Receivers (3) Both (4) Not Specified. These titles refer to the directionality of the funding meaning if they receive or provide funding for quantum technologies or do both simultaneously. Hence the actors were first distributed according to their funding role which was subdivided into providing, receiving, doing both simultaneously, and not specifying it.</p>
<p>Additionally, the role and activities of the actors in the ecosystem have also been categorized according to broad innovation types. The actors were classified by quantum technology field meaning which area of the industry they state they are working in or for. Such fields were (1) Computing (2) Cryptography (3) Communication (4) Sensing (5) Simulation and (6) Chemistry. Note that one actor may be working in more than one of these fields.</p>
<p>Finally, the last established variable was the type of actor. Consequently, the actors can also be (1) University Research Centres (2) Startups (3) SMEs (4) Large Companies (5) Governments (6) Independent Research Centres (7) Banks (8) Projects and (9) Hubs. This variable thus determines the nature of the actors and helps in comprehending their role inside the ecosystem as well as further characterizing its funding relationships (see Section IV). A detailed classification of every actor under these three variables is also offered on <xref ref-type="supplementary-material" rid="pone.0305140.s002">S2 Table</xref>.</p>
<p>There is one important consideration to be made about this methodology. As the reader may have already guessed, this is not an exhaustive method meaning that our database contains only some possible actors under the set characteristics. In other words, some entities with funding schemes for quantum technologies do not appear on the list simply because some institutions do not declare them. Moreover, we may have missed some that make their funding schemes public since cross-referencing our criteria with every Spanish company and institution is impossible.</p>
<p>Yet this lack of exhaustivity does not invalidate our methodology. Since our overall aim is to provide a general picture of the ecosystem’s character (rather than a list of all its actors), having some gaps in the number of actors is acceptable given our objective. As shown in section III and IV, we are confident that we have found its key actors which provide the ecosystem’s general trends. Therefore, although not exhaustive, the methodology chosen perfectly serves our aims thus validating its use in this paper.</p>
</sec>
</sec>
<sec id="sec010" sec-type="results">
<title>Section III: Results</title>
<sec id="sec011">
<title>Descriptive statistics</title>
<p>As stated above, an initial objective of the project was to determine the different areas that the actors report to be working in. First, the data shows that 32% of the total number of actors are involved in developing Q-Computing technologies as illustrated in <xref ref-type="fig" rid="pone.0305140.g003">Fig 3</xref>. Thus, Q-Computing is the most populated field. Second, Q-Communication technologies contain 20% of the total actors. Third, Q-Sensing and Q-Cryptography are tied with 14% of the actors respectively. Finally, the more niche fields of Q-Simulation and Q-Chemistry only involve 10% each. An exhaustive breakdown of this variable is displayed in Figs <xref ref-type="fig" rid="pone.0305140.g002">2</xref> and <xref ref-type="fig" rid="pone.0305140.g003">3</xref>.</p>
<fig id="pone.0305140.g002" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g002</object-id>
<label>Fig 2</label>
<caption>
<title>Q-Technology field total count.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g002" xlink:type="simple"/>
</fig>
<fig id="pone.0305140.g003" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g003</object-id>
<label>Fig 3</label>
<caption>
<title>Q-Technology field by percentage.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g003" xlink:type="simple"/>
</fig>
<p>Another defined variable was the type of actor which indicates their nature. According to our data, the most common actors are the projects. This is because they make up 55 out of the 221 total actors (see <xref ref-type="fig" rid="pone.0305140.g004">Fig 4</xref>) or an even 25% as illustrated by <xref ref-type="fig" rid="pone.0305140.g005">Fig 5</xref>. SMEs follow with 20% of the total share but Large Companies only account for 8%. Moreover, Research Centres constitute 23% of the ecosystem but startups are limited to 7% of the split. Finally, Hubs and Governments form 8% and 7% while Banks make up only 2% of the actors.</p>
<fig id="pone.0305140.g004" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g004</object-id>
<label>Fig 4</label>
<caption>
<title>Type of actor total count.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g004" xlink:type="simple"/>
</fig>
<fig id="pone.0305140.g005" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g005</object-id>
<label>Fig 5</label>
<caption>
<title>Type of actor by percentage.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g005" xlink:type="simple"/>
</fig>
<p>However, our principal aim was to establish funding relations between the actors in the ecosystem. Therefore, this section will present the results of our research within the parameters presented in Section II which is to say the split between Provider, Receiver, Both, and Non-Specified actors. Furthermore, these descriptive statistics will be the backbone of the following network analysis.</p>
<p>To begin with, as shown in <xref ref-type="fig" rid="pone.0305140.g006">Fig 6</xref>, most of the actors in the Spanish ecosystem fall under the category of Receivers. What stands out in the graph is that the number of Receivers barely falls short of half the total number of actors. Concretely, 109 actors out of the 221 total ones exclusively receive funding. This is followed by the Both category which gathers 60 actors and the NS actors which amount to 30. In contrast, the Provider category only numbers 22 actors (see <xref ref-type="fig" rid="pone.0305140.g006">Fig 6</xref>).</p>
<fig id="pone.0305140.g006" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g006</object-id>
<label>Fig 6</label>
<caption>
<title>Funding roles total count.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g006" xlink:type="simple"/>
</fig>
<p>This imbalance is further illustrated by <xref ref-type="fig" rid="pone.0305140.g007">Fig 7</xref> which details the split between categories in terms of percentage. Again, Receivers account for 49.3% of the total network compared to the 10% of pure Funders in the ecosystem. The gap is worsened if we consider that the category Both is the second most numerous amounting to 27.1%. This is significant because the actors in that category simply transfer funding between institutions and do not generate funding from within themselves.</p>
<fig id="pone.0305140.g007" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g007</object-id>
<label>Fig 7</label>
<caption>
<title>Funding roles by percentage.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g007" xlink:type="simple"/>
</fig>
<p>This recurrence of the Both category is interesting because it displays that one-quarter of the total actors act simply as intermediaries between Funder and Receiver institutions. We will discuss later the nature of these actors in Section IV. Suffice to say for now that there is a clear increase in the number of actors going from the Provider to the Receiver categories which is mediated by the Both categories. In short, Figs <xref ref-type="fig" rid="pone.0305140.g006">6</xref> and <xref ref-type="fig" rid="pone.0305140.g007">7</xref> show that there are few Funders and many Receivers in the Spanish quantum ecosystem.</p>
<p>Finally, another remarkable outcome of our research is the high percentage of NS actors in the network which adds up to 13.6%. This, as justified in Section II, does not indicate a methodological failure but rather a feature of the ecosystem, a lack of transparency and a tendency of many actors to not declare their activities. Moreover, this grants credence to further investigation around these actors given that one tenth of the total ecosystem does not provide clear indicators of their role in it (since it is not involved in any of the projects or initiatives found by our investigation).</p>
<p>To conclude, we have stated that the most numerous type of actor are the projects. Therefore, further analysis of the funding sources for this particular type of actor is warranted. Again, the investigation has shown that of these 55 projects, 34 of them receive funding from the European Commission which accounts for 62% (see <xref ref-type="fig" rid="pone.0305140.g008">Fig 8</xref>). In contrast, the Spanish Government, the Generalitat, and the Basque Government (all national institutions) combined only fund 36% of the projects as they are responsible for funding 8, 7, and 2 respectively (plus 3 that combine Catalan and Spanish funding).</p>
<fig id="pone.0305140.g008" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g008</object-id>
<label>Fig 8</label>
<caption>
<title>Funding sources for projects by percentages.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g008" xlink:type="simple"/>
</fig>
</sec>
<sec id="sec012">
<title>Network visualizations</title>
<p>To describe the emerging quantum ecosystem and its development, we use a network analysis approach based on the relation receiver-provider (links) between the different institutions or actors (nodes). In this representation, each node has a funding role that characterizes it as provider (P), receiver (R), receiver and provider (RP), and non-specified (NS). The funding roles will be represented by the colours in <xref ref-type="fig" rid="pone.0305140.g009">Fig 9</xref>. Thus yellow will be NS, blue will represent P, purple will stand for R, and green for RP.</p>
<fig id="pone.0305140.g009" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g009</object-id>
<label>Fig 9</label>
<caption>
<title>Colour code for network analysis.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g009" xlink:type="simple"/>
</fig>
<p>An arrow emerges from a P or an RP node, whereas R nodes are connected to others only through the tip of an arrow giving the structure of a directed graph. The NS state of a node indicates that its funding relation with any other actor could not be identified by the application of our methodology, hence it appears as an isolated node in the network. The network consists of 221 nodes and 297 edges as represented in <xref ref-type="fig" rid="pone.0305140.g010">Fig 10a</xref>. For a first imaging of the network, we have chosen a circular layout where the main P nodes appear at the centre of an inner circle of PR nodes and an external circle of R nodes and the remaining NS nodes in peripheral regions.</p>
<fig id="pone.0305140.g010" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g010</object-id>
<label>Fig 10</label>
<caption>
<title/>
<p><bold>a.</bold> Overview of the Spanish Quantum Network. <bold>b.</bold> Network by Total degree. <bold>c</bold>. Network by In-degree. <bold>d</bold>. Network by Out-degree.</p>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g010" xlink:type="simple"/>
</fig>
<p>In <xref ref-type="fig" rid="pone.0305140.g010">Fig 10A</xref>, we present a visualization of the Spanish quantum ecosystem where all the nodes have the same size but colour differentiates their funding status (see <xref ref-type="fig" rid="pone.0305140.g009">Fig 9</xref>). In <xref ref-type="fig" rid="pone.0305140.g010">Fig 10B</xref>, nodes are sized according to their total degree and highlighted those that have a degree bigger equal than 2. <xref ref-type="fig" rid="pone.0305140.g010">Fig 10C and 10D</xref> show a similar representation as <xref ref-type="fig" rid="pone.0305140.g010">Fig 10B</xref> but with In-degree and out-degree respectively.</p>
</sec>
<sec id="sec013">
<title>Degree of centrality</title>
<p>We describe statistical features of the network by their degree of centrality which measures how connected a node is. Since this is a directed graph, we must differentiate between three types: (1) The total degree accounts for the total number of edges for each node. (2) The In-degree represents the number of incoming relations meaning how many tips of arrow edges a node receives. (3) The Out-degree orders the nodes according to the number of tails of arrow edges and therefore a node with high out-degree indicates a more active provider in the network.</p>
<p>As it is observed in <xref ref-type="fig" rid="pone.0305140.g011">Fig 11</xref>, histograms in all cases are skewed to the left showing that in this initial stage of the Q-ecosystem most of nodes have very few connections. Total degree plot presents a maximum at value 1 meaning that most of the nodes have only one interaction of any kind with the rest of the networks. In-degree have a maximum at value 1 saying that most of the nodes have only one source of funding. Out-degree has a maximum at 0 value reflecting the fact that most of the nodes do not provide any resources. Given the observed sparseness of the network and for the purposes of visualization in <xref ref-type="fig" rid="pone.0305140.g010">Fig 10B-10D</xref>, we weight nodes according to its degree.</p>
<fig id="pone.0305140.g011" position="float">
<object-id pub-id-type="doi">10.1371/journal.pone.0305140.g011</object-id>
<label>Fig 11</label>
<caption>
<title>Node breakdown by degree of centrality.</title>
</caption>
<graphic mimetype="image" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.g011" xlink:type="simple"/>
</fig>
<p>At the tails of the distributions, we found the highest values of centrality and hence the most interacting actors in this network. To identify the most active nodes in the network, we look for the percentage of actors that have centrality values bigger equal than 2 which for Total degree it is 46.6%, In-degree is 21.2%, and Out-degree is 19.5%.</p>
</sec>
</sec>
<sec id="sec014" sec-type="conclusions">
<title>Section IV: Discussion</title>
<p>The data presented above allows for several structural inferences to be made. Once the funding links between the ecosystem’s actors have been established, we offer a different perspective on the processes involved in quantum technological innovation in Spain.</p>
<p>The first notable finding is the determinant role that projects play in this ecosystem. This is signaled by the fact that they make up 1/4 of the total number of actors. This raises the question, therefore, of the contribution of projects to the development of quantum technologies and relatedly of the role played by projects in coordinating relationships between other parts of the ecosystem.</p>
<p>From our data, projects can be seen to have several common traits that indicate their role in the ecosystem. First, they do not have a physical location, unlike all the other actors. Second, they are always limited in time with a start and end date. Third, they tend to involve several other actors or at least two. Finally, they invariably fall under the category of both providing and receiving funding. All these indicators point out that projects function as intermediaries between funder and receiver institutions, thus acting as hubs to concentrate funding towards one specific avenue of innovation. In this sense, the projects may be understood at present as a key feature in defining the current ecosystem structure and its possible transformations over time. This is particularly significant because in current surveys and reports on quantum ecosystems, projects have been conflated with other types of actor thus obscuring the distinct roles they potentially play.</p>
<p>The second notable finding is that most of the actors receive their funding from almost exclusively public institutions. The European Commission—as part of the European Union—clearly accounts for a large share of the invested capital, funding 43.9% of the total actors, followed by the Spanish and Catalan governments with 42% and 13.9% respectively. In contrast, private institutions such as the laCaixa Foundation or Kutxa Fundatioa only fund one single actor respectively. This suggests that quantum technological innovation in Spain is currently driven largely by the public sector since the capital for research is mainly provided by public institutions. Moreover, their funding tends to go through the aforementioned projects which is also relevant in analyzing the visibility of the public sector in innovation ecosystems and the wider sociopolitical reasons behind this ‘screening’ of public involvement.</p>
<p>The third notable finding is the prominence of research centres (both universities and independent institutes) in the category of Receivers which is already the most populated one. For instance, ICFO gathers funding from 25 different actors pointing out its enormous influence in the ecosystem. Consequently, further definition of its activities will be crucial in determining the state of the industry. Moreover, other research centres such as the BSC, UAB, DIPC, or UPV also participate in multiple projects. This suggests that innovation activity is still in—or dependent upon resources from—the research phase in most cases and the ecosystem is far from that of implementation or commercialization, a conclusion supported by the low number of Large Companies involved in it. This is significantly different impression compared to what has been called the ‘hype’ of quantum innovative activity.</p>
<p>There are other interesting trends shown by the findings such as the high concentration of actors in a few regional areas (Catalonia, Galicia, and the Basque country) which are also the headquarters of the national supercomputing initiatives, pointing out the potential symbiotic relationship between high-tech industries. In the same line, we observe that the technological subsector with more allocated funding is quantum computing which is consistent with the emphasis placed on the sector by the existing literature. Finally, there is a significant presence of publicly financed ‘hubs’ and ‘ecosystems’ which gives further credence to the innovation ecosystems theoretical approach.</p>
</sec>
<sec id="sec015" sec-type="conclusions">
<title>Section V: Conclusions</title>
<p>Current literature on the development of quantum technologies has done much to emphasize the number of active-interested parties related to the development and the implementation of quantum innovations. However, there has been an absence of attention to the particular connections between those listed parties and the character of those relations.</p>
<p>Drawing upon those institutions listed in current academic literature and private sector reports, this paper has taken one of the possible connections that typically exist between institutions in an innovation ecosystem—namely that of funding—to offer a new characterization of the quantum ecosystem in Spain.</p>
<p>This paper has found that with regards to this relationship, there are three key features of this ecosystem that are largely invisible in current literature. First, the significance and distinction of projects as actors in this ecosystem. Second, the strong degree to which funding both to and from projects comes from the public sector, particularly through institutions that make up the European Union. Third, the high degree of funding going from project to research centres, suggesting the relative importance of universities and research institutions relative to private sector companies in the ecosystem at this stage of its development.</p>
<p>Based on these findings, we suggest that these results may not be specific to the Spanish case but may well be a feature of quantum ecosystems in Europe more generally. Importantly, these results also suggest that to understand the characteristics and potential development of quantum technologies globally, further work on the specific relations between those actors in regions in the United States, China, and Israel is required.</p>
</sec>
<sec id="sec016" sec-type="supplementary-material">
<title>Supporting information</title>
<supplementary-material id="pone.0305140.s001" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.s001" xlink:type="simple">
<label>S1 Table</label>
<caption>
<title>Literature review breakdown.</title>
<p>(DOCX)</p>
</caption>
</supplementary-material>
<supplementary-material id="pone.0305140.s002" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" position="float" xlink:href="info:doi/10.1371/journal.pone.0305140.s002" xlink:type="simple">
<label>S2 Table</label>
<caption>
<title>Actor breakdown.</title>
<p>(DOCX)</p>
</caption>
</supplementary-material>
</sec>
</body>
<back>
<ref-list>
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<sub-article article-type="aggregated-review-documents" id="pone.0305140.r001" specific-use="decision-letter">
<front-stub>
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<surname>Khan</surname>
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<role>Academic Editor</role>
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<copyright-year>2024</copyright-year>
<copyright-holder>Mudassir Khan</copyright-holder>
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<p>
<named-content content-type="letter-date">20 Mar 2024</named-content>
</p>
<p><!-- <div> -->PONE-D-23-43053<!-- </div> --><!-- <div> -->Visualising Quantum Innovation: A regional case study<!-- </div> --><!-- <div> -->PLOS ONE</p>
<p>Dear Dr. Jiménez Farías,</p>
<p>Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.</p>
<p><bold>ACADEMIC EDITOR: </bold></p>
<p>Accepted after minor changes. </p>
<p>The introduction provides a good, generalized background of the topic that quickly gives the reader an appreciation of the wide range of applications for this technology. This section helpfully explains the motivation for the research to current and potential funding agencies. However, to make the motivation clearer and to differentiate the paper some more from other applied papers, the author may wish to provide another sentence giving examples of some of the applications of this technology, along with appropriate references.</p>
<p>The objective is clearly defined in the last paragraph of introduction section and clearly mentions the flow of the paper. The experimental apparatus is quite standard, and is appropriate for the study, especially given that the focus of the paper is to develop a privacy preserving platform for industrial applications.</p>
<p>Author may wish to elaborate the problem formulation section and add some more details which will make the paper look more vital. I do not think any additional graphics are necessary. The author may also wish to give a more detailed discussion on blockchain and machine learning implementation.</p>
<p>The author may wish to mention why it is important to leverage blockchain to explain the motivation for his choice of specimens and accompany this with some references to other studies that demonstrate this importance. The authors are advised to add few latest citations, kindly read and cite: a) Smart Contract-Enabled Secure Sharing of Health Data for a Mobile Cloud-Based E-Health System. Appl. Sci. 2023, 13, 3970. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3390/app13063970" xlink:type="simple">https://doi.org/10.3390/app13063970</ext-link>, b) A deep learning approach for facial emotions recognition using principal component analysis and neural network techniques. The Photogrammetric Record, 37, 435–452.c) A secure framework for IoT-based smart climate agriculture system: Toward blockchain and edge computing" Journal of Intelligent Systems, vol. 31, no. 1, 2022, pp. 221-236. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1515/jisys-2022-0012" xlink:type="simple">https://doi.org/10.1515/jisys-2022-0012</ext-link></p>
<p>==============================</p>
<p>Please submit your revised manuscript by May 04 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at <email xlink:type="simple">plosone@plos.org</email>. When you're ready to submit your revision, log on to <ext-link ext-link-type="uri" xlink:href="https://www.editorialmanager.com/pone/" xlink:type="simple">https://www.editorialmanager.com/pone/</ext-link> and select the 'Submissions Needing Revision' folder to locate your manuscript file.</p>
<p>Please include the following items when submitting your revised manuscript:<list list-type="bullet"><list-item><p>A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.</p></list-item><list-item><p>A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.</p></list-item><list-item><p>An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.</p></list-item></list><!-- <div> -->If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.</p>
<p>If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: <ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols" xlink:type="simple">https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols</ext-link>. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at <ext-link ext-link-type="uri" xlink:href="https://plos.org/protocols?utm_medium=editorial-email&amp;utm_source=authorletters&amp;utm_campaign=protocols" xlink:type="simple">https://plos.org/protocols?utm_medium=editorial-email&amp;utm_source=authorletters&amp;utm_campaign=protocols</ext-link>.</p>
<p>We look forward to receiving your revised manuscript.</p>
<p>Kind regards,</p>
<p>Mudassir Khan, Ph.D</p>
<p>Academic Editor</p>
<p>PLOS ONE</p>
<p>Journal requirements:</p>
<p>When submitting your revision, we need you to address these additional requirements.</p>
<p>1. Please ensure that your manuscript meets PLOS ONE's style requirements, including those for file naming. The PLOS ONE style templates can be found at</p>
<p><ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf" xlink:type="simple">https://journals.plos.org/plosone/s/file?id=wjVg/PLOSOne_formatting_sample_main_body.pdf</ext-link> and</p>
<p><ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf" xlink:type="simple">https://journals.plos.org/plosone/s/file?id=ba62/PLOSOne_formatting_sample_title_authors_affiliations.pdf</ext-link></p>
<p>2. In your Methods section, please include additional information about your dataset and ensure that you have included a statement specifying whether the collection and analysis method complied with the terms and conditions for the source of the data.</p>
<p>3. We note that the grant information you provided in the ‘Funding Information’ and ‘Financial Disclosure’ sections do not match.</p>
<p>When you resubmit, please ensure that you provide the correct grant numbers for the awards you received for your study in the ‘Funding Information’ section.</p>
<p>4. Please amend the manuscript submission data (via Edit Submission) to include author Rodón, N. Canseca.</p>
<p>5. Please amend your authorship list in your manuscript file to include author Nelly Canessa Araujo.</p>
<p>6. Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.</p>
<p>Additional Editor Comments:</p>
<p>The introduction provides a good, generalized background of the topic that quickly gives the reader an appreciation of the wide range of applications for this technology. This section helpfully explains the motivation for the research to current and potential funding agencies. However, to make the motivation clearer and to differentiate the paper some more from other applied papers, the author may wish to provide another sentence giving examples of some of the applications of this technology, along with appropriate references.</p>
<p>The objective is clearly defined in the last paragraph of introduction section and clearly mentions the flow of the paper. The experimental apparatus is quite standard, and is appropriate for the study, especially given that the focus of the paper is to develop a privacy preserving platform for industrial applications.</p>
<p>Author may wish to elaborate the problem formulation section and add some more details which will make the paper look more vital. I do not think any additional graphics are necessary. The author may also wish to give a more detailed discussion on blockchain and machine learning implementation.</p>
<p>The author may wish to mention why it is important to leverage blockchain to explain the motivation for his choice of specimens and accompany this with some references to other studies that demonstrate this importance. The authors are advised to add few latest citations, kindly read and cite: a) Smart Contract-Enabled Secure Sharing of Health Data for a Mobile Cloud-Based E-Health System. Appl. Sci. 2023, 13, 3970. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3390/app13063970" xlink:type="simple">https://doi.org/10.3390/app13063970</ext-link>, b) A deep learning approach for facial emotions recognition using principal component analysis and neural network techniques. The Photogrammetric Record, 37, 435–452.c) A secure framework for IoT-based smart climate agriculture system: Toward blockchain and edge computing" Journal of Intelligent Systems, vol. 31, no. 1, 2022, pp. 221-236. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1515/jisys-2022-0012" xlink:type="simple">https://doi.org/10.1515/jisys-2022-0012</ext-link></p>
<p>[Note: HTML markup is below. Please do not edit.]</p>
<p>Reviewers' comments:</p>
<p>Reviewer's Responses to Questions</p>
<p><!-- <font color="black"> --><bold>Comments to the Author</bold></p>
<p>1. Is the manuscript technically sound, and do the data support the conclusions?</p>
<p>The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented. <!-- </font> --></p>
<p>Reviewer #1: Yes</p>
<p>Reviewer #2: Yes</p>
<p>**********</p>
<p><!-- <font color="black"> -->2. Has the statistical analysis been performed appropriately and rigorously? <!-- </font> --></p>
<p>Reviewer #1: Yes</p>
<p>Reviewer #2: Yes</p>
<p>**********</p>
<p><!-- <font color="black"> -->3. Have the authors made all data underlying the findings in their manuscript fully available?</p>
<p>The <ext-link ext-link-type="uri" xlink:href="http://www.plosone.org/static/policies.action#sharing" xlink:type="simple">PLOS Data policy</ext-link> requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.<!-- </font> --></p>
<p>Reviewer #1: Yes</p>
<p>Reviewer #2: Yes</p>
<p>**********</p>
<p><!-- <font color="black"> -->4. Is the manuscript presented in an intelligible fashion and written in standard English?</p>
<p>PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.<!-- </font> --></p>
<p>Reviewer #1: Yes</p>
<p>Reviewer #2: Yes</p>
<p>**********</p>
<p><!-- <font color="black"> -->5. Review Comments to the Author</p>
<p>Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)<!-- </font> --></p>
<p>Reviewer #1: The article is based on country specific. The author present a literature review that considers a set of reports by several organizations.</p>
<p>Author should mention the name of organization too.</p>
<p>All the tables and figures should be described within the article.</p>
<p>Reviewer #2: this research has collected comprehensive data and conducted extensive analysis regarding the quantum technological innovation Spain. the results of this research may be expanded to other regions in Europe, as well as help in the potential development of quantum technologies globally.</p>
<p>**********</p>
<p><!-- <font color="black"> -->6. PLOS authors have the option to publish the peer review history of their article (<ext-link ext-link-type="uri" xlink:href="https://journals.plos.org/plosone/s/editorial-and-peer-review-process#loc-peer-review-history" xlink:type="simple">what does this mean?</ext-link>). If published, this will include your full peer review and any attached files.</p>
<p>If you choose “no”, your identity will remain anonymous but your review may still be made public.</p>
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<p>Reviewer #1: <bold>Yes: </bold>Dr Mahtab Alam</p>
<p>Reviewer #2: No</p>
<p>**********</p>
<p>[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]</p>
<p>While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, <ext-link ext-link-type="uri" xlink:href="https://pacev2.apexcovantage.com/" xlink:type="simple">https://pacev2.apexcovantage.com/</ext-link>. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at <email xlink:type="simple">figures@plos.org</email>. Please note that Supporting Information files do not need this step.</p>
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<sub-article article-type="author-comment" id="pone.0305140.r002">
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<article-id pub-id-type="doi">10.1371/journal.pone.0305140.r002</article-id>
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<article-title>Author response to Decision Letter 0</article-title>
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<named-content content-type="author-response-date">8 May 2024</named-content>
</p>
<p>Dear Editor</p>
<p>We are very happy to know that our paper “Visualizing Quantum Innovation: A regional Case Study” meets the merits for publication in PLOS One while requiring minor revisions. </p>
<p> In what follows we, present a point-by-point response to the editor and reviewer’s comments and suggestions as well an important modification to the authors list that that has been decided internally.</p>
<p>Academic editor: “The introduction provides a good, generalized background of the topic that quickly gives the reader an appreciation of the wide range of applications for this technology.”</p>
<p>Authors: We would like to thank the editor for appreciating this value of our article</p>
<p>Academic editor: “However, to make the motivation clearer and to differentiate the paper some more from other applied papers, the author may wish to provide another sentence giving examples of some of the applications of this technology, along with appropriate references.” </p>
<p>Authors: We have added 8 new citations including those that the editor kindly recommend in the introductory sentence:  “Potential application of quantum technology range drug discovery (Santagati et al, 2024) , financial modelling (Herman et al, 2023) , weather forecasting (Tennie et al, 2023), cybersecurity (Neil, 2023) , machine learning algorithms (Biamonte et al, 2017, Khan et al, 2022) and Bloch chain (Wang et al, 2022, Chinnasamy et al, 2023)”</p>
<p>Academic editor: The objective is clearly defined in the last paragraph of introduction section and clearly mentions the flow of the paper. The experimental apparatus is quite standard, and is appropriate for the study, especially given that the focus of the paper is to develop a privacy preserving platform for industrial applications. </p>
<p>Authors: We thank the editor </p>
<p>Reviewer #1: The article is based on country specific. The authors present a literature review that considers a set of reports by several organizations.</p>
<p>Author should mention the name of organization too.</p>
<p>All the tables and figures should be described within the article.</p>
<p>Authors: We have included the name of the organizations in the section “Structure of the Study” in the sentence: “we present a literature review that considers a set of reports by several organizations, like the World Economic Forum, Ametic, McKinsey, Quantum Flagship, IBM, IQM, among others,”</p>
<p>Reviewer #2: this research has collected comprehensive data and conducted extensive analysis regarding the quantum technological innovation Spain. the results of this research may be expanded to other regions in Europe, as well as help in the potential development of quantum technologies globally.</p>
<p>Authors: We thank reviewer #2 for her/his encouraging comment.</p>
<p>Yours sincerely,</p>
<p>Osvaldo Jiménez Farías and Eóin Phillips</p>
<p>On behalf of the authors.</p>
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<article-title>Decision Letter 1</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name name-style="western">
<surname>Khan</surname>
<given-names>Mudassir</given-names>
</name>
<role>Academic Editor</role>
</contrib>
</contrib-group>
<permissions>
<copyright-year>2024</copyright-year>
<copyright-holder>Mudassir Khan</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
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<p>
<named-content content-type="letter-date">27 May 2024</named-content>
</p>
<p>Visualising Quantum Innovation: A regional case study</p>
<p>PONE-D-23-43053R1</p>
<p>Dear Dr.Osvaldo Jiménez Farías</p>
<p>We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.</p>
<p>Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.</p>
<p>An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at <ext-link ext-link-type="uri" xlink:href="https://www.editorialmanager.com/pone/" xlink:type="simple">Editorial Manager®</ext-link> and clicking the ‘Update My Information' link at the top of the page. If you have any questions relating to publication charges, please contact our Author Billing department directly at <email xlink:type="simple">authorbilling@plos.org</email>.</p>
<p>If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact <email xlink:type="simple">onepress@plos.org</email>.</p>
<p>Kind regards,</p>
<p>Mudassir Khan, Ph.D</p>
<p>Academic Editor</p>
<p>PLOS ONE</p>
<p>Additional Editor Comments (optional):</p>
<p>Thanks to the authors for the detailed response and additions. I read through the comments and skimmed the revised PDF, and the updates significantly improved the paper. I would be happy to recommend this paper for publication.</p>
<p>Reviewers' comments:</p>
</body>
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<title-group>
<article-title>Acceptance letter</article-title>
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<name name-style="western">
<surname>Khan</surname>
<given-names>Mudassir</given-names>
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<copyright-year>2024</copyright-year>
<copyright-holder>Mudassir Khan</copyright-holder>
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<license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/" xlink:type="simple">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
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<p>
<named-content content-type="letter-date">30 May 2024</named-content>
</p>
<p>PONE-D-23-43053R1 </p>
<p>PLOS ONE</p>
<p>Dear Dr.  Jiménez Farías, </p>
<p>I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now being handed over to our production team.</p>
<p>At this stage, our production department will prepare your paper for publication. This includes ensuring the following:</p>
<p>* All references, tables, and figures are properly cited</p>
<p>* All relevant supporting information is included in the manuscript submission,</p>
<p>* There are no issues that prevent the paper from being properly typeset</p>
<p>If revisions are needed, the production department will contact you directly to resolve them. If no revisions are needed, you will receive an email when the publication date has been set. At this time, we do not offer pre-publication proofs to authors during production of the accepted work. Please keep in mind that we are working through a large volume of accepted articles, so please give us a few weeks to review your paper and let you know the next and final steps. </p>
<p>Lastly, if your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact <email xlink:type="simple">onepress@plos.org</email>.</p>
<p>If we can help with anything else, please email us at <email xlink:type="simple">customercare@plos.org</email>.</p>
<p>Thank you for submitting your work to PLOS ONE and supporting open access. </p>
<p>Kind regards, </p>
<p>PLOS ONE Editorial Office Staff</p>
<p>on behalf of</p>
<p>Dr. Mudassir Khan </p>
<p>Academic Editor</p>
<p>PLOS ONE</p>
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