Overview of Exendin 4 Increases Scavenger Receptor Class Bi Expression Via
Mutation of FoxO1-binding or silencing of FoxO1 cancelled the effect of exendin-4 on hSR- BI /CLA-1 expression . Exendin-4 reduced FoxO1 phosphorylation and induced its nuclear accumulation, while this effect was altered by the blocking of GLP-1R or inhibition of AMPK pathway.
In summary, our results proved that exendin-4 increased hSR- BI /CLA-1 expression via the AMPK/FoxO1 pathway to activate eNOS, providing a basic mechanism underlining the protective effect of GLP-1RA on endothelial function.
Key Details About Exendin 4 Increases Scavenger Receptor Class Bi Expression Via
In summary, our results proved that exendin-4 increased hSR- BI /CLA-1 expression via the AMPK/FoxO1 pathway to activate eNOS, providing a basic mechanism underlining the protective effect of GLP ...
Exendin-4 Increases Scavenger Receptor Class BI Expression via Activation of AMPK/FoxO1 in Human Vascular Endothelial Cells Jingya Lyu 1, Hitomi Imachi 2, Kensaku Fukunaga 2, Seisuke Sato 2 ...
Useful Notes on Exendin 4 Increases Scavenger Receptor Class Bi Expression Via
Exendin-4 increased hSR- BI /CLA-1 expression via the AMPK/FoxO1 pathway to activate eNOS, providing a basic mechanism underlining the protective effect of GLP-1RA on endothelial function. Glucagon-like peptide-1 receptor agonist (GLP-1RA) has been clinically proven to protect endothelial function. Previously, we demonstrated that endothelial NO synthase (eNOS) was activated by high-density ...
In summary, our results proved that exendin-4 increased hSR- BI /CLA-1 expression via the AMPK/FoxO1 pathway to activate eNOS, providing a basic mechanism underlining the protective effect of GLP-1RA on endothelial function.
Overview of Exendin 4 Increases Scavenger Receptor Class Bi Expression Via
It is proposed that exendin-4 increases ABCA1 expression in glomerular endothelial cells, which plays an important role in alleviating renal lipid accumulation, inflammation, and proteinuria in mice with type 2 diabetes.
Glucagon-like peptide-1 receptor agonist (GLP-1RA) has been clinically proven to protect endothelial function. Previously, we demonstrated that endothelial NO synthase (eNOS) was activated by high-density lipoprotein (HDL) via its scavenger receptor of the B class /human homologue of SR- BI , CD36 and…
Key Details About Exendin 4 Increases Scavenger Receptor Class Bi Expression Via
Here, we investigated the effect of GLP-1RA and exendin-4 on the expression of hSR- BI /CLA-1 in HUVECs. Our results confirmed that GLP-1R was expressed in HUVECs by PCR and exendin-4 significantly enhanced HDL-induced eNOS activation. Next, exendin-4 increased the expression of hSR- BI /CLA-1 and a blockade of GLP-1R cancelled this effect.
Exendin-4 Increases Scavenger Receptor Class BI Expression via Activation of AMPK/FoxO1 in Human Vascular Endothelial Cells Jingya Lyu 1, Hitomi Imachi 2, Kensaku Fukunaga 2, Seisuke Sato 2, Toshihiro Kobayashi 2, Takanobu Saheki 2, Salimah Japar 2, Hisakazu Iwama 3, Yuta Matsumura 4 , Miyo Ozaki 4 , Takafumi Yoshimura 2 and Koji Murao 2,*